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Teilungsstörungen der Erythropoese: Perniciosa-Syndrom und Erythroblastopenie-Syndrom

Perniciosa-Syndrom
  • H. Weicker
Part of the Handbuch der Kinderheilkunde book series (HDB KINDERHEIL, volume 6)

Zusammenfassung

Wir sprechen von einem Perniciosa-Syndrom, wenn im Knochenmark die Erythroblasten durch Megaloblasten und im peripheren Blut die Erythrocyten durch Megalocyten ersetzt oder verdrängt sind; auch die Granulopoese weist Charakteristika auf: Riesenstabkernige im Knochenmark und hochsegmentierte Granulocyten im peripheren Blut. Außer einer hyperchromen Anämie besteht eine Granulocytopenie und eine Thrombopenie.

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Literatur

Perniciosa-Syndrom

  1. Weicker, H.: Haemo-Cytomorphologie des B12-Mangels in vivo. In: Vitamin B12 und Intrinsic Factor. 1. Europ. Symposium, Hamburg 1956. Stuttgart: Ferdinand Enke 1957, S. 361.Google Scholar
  2. Weicker, H., u. H. Scharfenberger: Das Megaloblasten- Erythroblasten-Problem unter karyo- und cytometrischen Gesichtspunkten. Dtsch. Arch. klin. Med. 202, 133 (1955).PubMedGoogle Scholar

Perniziöse Anämie

  1. Mollin, D. L.: Radioactive vitamin B12 in the study of blood diseases. Brit. med. Bull. 15, 8 (1959).Google Scholar
  2. Nelp, W. B., J. G. Mcafee u. H. N. Wagner jr.: Einzelmessung der Vitamin B12-Plasmaradioaktivität als ein Test für die perniziöse Anämie. J. Lab. clin. Med. 61, 158–165 (1963).PubMedGoogle Scholar
  3. Pribilla, W.: Der Vitamin B12-Stoffwechsel und seine Störungen. Blut 8, 487–501 (1962).PubMedCrossRefGoogle Scholar
  4. Reisner jr., E. H.: The nature and significance of megaloblastic blood formation. Blood 13, 313 (1958).Google Scholar

Genetik

  1. Kaufmann, O., u. K. Thiessen: Zur Erbbiologie der perniciösen Anämie. Z. klin. Med. 136 (1939).Google Scholar
  2. Lamy, M., et F. Besancon: Nouvelle classification des anémies megaloblastiques infantiles par avitaminose B12 primitive. Arch, franç. Pédiat. 18, 1117 (1961).Google Scholar
  3. Mcintyre, O. R., L. W. Sullivan, G. H. Jeffries, and R. H. Silver: Pernicious anemia in childhood. New Engl. J. Med. 272, 981 (1965).Google Scholar
  4. Mcintyre, P. A., R. Hahn, C. L. Conley, and B. Glass: Genetic factors in predisposition to pernicious anemia. Bull. Johns Hopk. Hosp. 104, 309–342 (1959).Google Scholar
  5. Schemm, F.: A pernicious anemia. Five authenticated cases in the same generation. Amer. J. med. Sci. 199, 167 (1940).CrossRefGoogle Scholar
  6. Stamos, H. F.: Hereditary in pernicious anemia. Amer. J. med. Sci. 200, 586 (1940).Google Scholar

Anaemia perniciosa infantum

  1. Benjamin, B.: Addisonian pernicious anemia in infancy. Amer. J. Dis. Child. 50, 1336 (1935).Google Scholar
  2. Benjamin, B.: Infantile form of pernicious anemia. Report of a long term study of a case. Amer. J. Dis. Child. 75, 143 (1948).Google Scholar
  3. Brunecky, Z.: Hyperchromic megaloblastic anemia in a child. Z. Pediat. Listy 5, 32 (1950).Google Scholar
  4. Clement, D.H., C. A. Nichol, and A.D. Welch: A case of juvenile pernicious anemia: Study of the effects of folic acid and vitamin B12. Blood 17, 618 (1961).PubMedGoogle Scholar
  5. Davis, R. W., R. M. Christian, D. M. Ervin, and L.E. Young: Pernicious anemia in childhood. Report of case in six year old girl responding to refined liver extract, folic acid and vitamin B12 in successive relapses. Blood 4, 1361 (1949).PubMedGoogle Scholar
  6. Dedichen, J.: Anémie à type pernicieux chez un enfant de 9 mois. Acta med. scand. Ill, 90 (1942).Google Scholar
  7. DelbÉke, M.-J.: Anémie pernicieuse de l’enfant constatée chez deux frères. Arch, franç. Pédiat. 9, 837 (1952).Google Scholar
  8. Giuntini, R.: L’anemia perniciosa nell’ eta infantile. Riv. Clin, pediat. 44, 207 (1946).Google Scholar
  9. Herbert, V., R. R. Streiff, and L. W. Sullivan: Notes on vitamin B12 absorption: auto-immunity and pernicious anemia: relation of intrinsic factor to blood group substance. Medicine (Baltimore) 48, 679–687 (1964).Google Scholar
  10. Jonsson, B. J.: Pernicious anaemia in children. Acta paediat. (Uppsala) 32, 485 (1945).CrossRefGoogle Scholar
  11. Kaplan, M., et J. Bernard: Maladie de Biermer chez un enfant des deux ans. Arch, franç. Pédiat. 3, 161 (1946).Google Scholar
  12. KarlstrÖm, P., and G. Nordensen: Hyperchronic (pernicious ?) anaemia in infants. Acta paediat. (Uppsala) 32, 58 (1944).Google Scholar
  13. Lambert, H. P., T. A. J. Prankerd, and J. M. Smellie: Pernicious anaemia in childhood. Quart. J. Med. 30, 71 (1961).PubMedGoogle Scholar
  14. Langmead, F. S., and I. Doniach: Pernicious anaemia in an infant. Lancet 19381, 1048.Google Scholar
  15. Leikin, S. L.: Pernicious anemia in childhood. Pediatrics 25, 91 (1960).PubMedGoogle Scholar
  16. Mollin, D. L., S. J. Baker, and I. Doniach: Addisonian pernicious anaemia without gastric atrophy in a young man. Brit. J. Haemat. 1, 278 (1955).PubMedCrossRefGoogle Scholar
  17. Neimann, N., M. Pierson et M. Manciaux: Anémie de Biermer chez, l’enfant. Arch, franç. Pédiat. 11, 361 (1954).Google Scholar
  18. Oehme, J., H. Hundeshagen u. U. Willenbockel: Über die perniziöse Anämie des Kindes: zugleich ein Beitrag zur Brauchbarkeit des Urinexkretions- testesnach Schilling. Z. Kinderheilk. 87, 289–298 (1962).PubMedCrossRefGoogle Scholar
  19. Pearson, H. A., R. Vinson, and R. T. Smith: Pernicious anemia with neurologic involvement in childhood: Report of a case with emphasis on dangers of folic acid therapy. J. Pediat. 65, 334–339 (1964).PubMedCrossRefGoogle Scholar
  20. Peterson, J. C.: Pernicious anemia in childhood. II. Response to folic acid. Amer. J. Dis. Child. 73, 578 (1947).Google Scholar
  21. Peterson, J. C., and S. C. Dunn: Pernicious anemia in childhood. Amer. J. Dis. Child. 71, 252 (1946).Google Scholar
  22. Stevenson, T. D., J. A. Little, and L. Langley: Pernicious anemia in childhood. New Engl. J. Med. 255, 1219 (1956).Google Scholar
  23. Waagstein, P. H. D.: A case of perniciosiform anemia in a child nineteen months old. Acta med. scand. 121, 547 (1948).Google Scholar
  24. Waters, A. H., and M. E. B. Murphy: Familial juvenile pernicious anaemia: A study of the hereditary basis of pernicious anaemia. Brit. J. Haemat. 9, 1–12 (1963).PubMedCrossRefGoogle Scholar

Anaemia perniciosa adolescentium

  1. Adams, J. M., and I. Macquarrie: Severe functional anemia in a child resembling pernicious anemia of adults. A case study. J. Pediat. 12, 176 (1938).CrossRefGoogle Scholar
  2. Andreasen, J. P.: Anaemia perniciosa hos et aars barn. Ugeskr. Laeg. 103, 783 (1941).Google Scholar
  3. Birnboim, H.: Pernicious anemia in 19-year-old girl. Canad. med. Ass. J. 87, 561–564 (1962).Google Scholar
  4. Birke, E.: Perniciöse Anaemie bei einem 13jährigen Jungen. Kinderärztl. Prax. 28, 69 (1960).Google Scholar
  5. BrÜckner, M.: Zur Kasuistik der Biermerschen Anaemie im Kindesalter. Jb. Kinderheilk. 114, 376 (1926).Google Scholar
  6. DebrÉ, R., F. M. Levy et J. P. Soulier: A propos d’une anémie de type Biermérien à debut aigu fébrile chez une adolescente. Arch, franç. Pédiat. 7, 161 (1950).Google Scholar
  7. Eckman, P. F., and O. W. Rowe: Pernicious anemia in boy age 11. Minn. Med. 12, 788 (1929).Google Scholar
  8. Furno, M., e G. M. Mongilardi: Du si un caso di anemia perniciosa in un bambino di 7 anni. Minerva pediat. 8, 1615 (1956).PubMedGoogle Scholar
  9. Hamilton, H. E., and W. M. Fowler: Pernicious anemia in early adolescence. Arch, intern. Med. 84, 445 (1949).Google Scholar
  10. Harris-Jones, J. N., H. T. Swan, and C. R. Tudhope: Pernicious anemia without gastric atrophy and in the presence of free hydrochloric acid. Blood 12, 461 (1957).PubMedGoogle Scholar
  11. Herbert, V., R. R. Streiff, and L. W. Sullivan: Notes on vitamin B12 absorption: autoimmunity and pernicious anemia: relation of intrinsic factor to blood group substance. Medicine (Baltimore) 43, 679–687 (1964).Google Scholar
  12. Hotz, A.: Über Anaemia perniciosa und perniciosa- ähnliche Anämien im Kindesalter. Jb. Kinderheilk. 105, 161 (1924).Google Scholar
  13. Jonsson, B. J.: Pernicious anaemia in children. Acta paediat. (Uppsala) 32, 485 (1945).CrossRefGoogle Scholar
  14. Kade, M.: Perniciöse Anämie im Kindesalter. Z. Kin- derheilk. 65, 47 (1948).CrossRefGoogle Scholar
  15. Murphy, W. P.: Anaemia in practice, p. 197. Philadelphia 1939.Google Scholar
  16. Pohl, C.: Über perniciöse Anämie im Kindesalter. Mschr. Kinderheilk. 84, 192 (1940).Google Scholar
  17. Reisner, E. H., J. A. Wolff, R. J. Mckay, and E. F. Doyle: Juvenile pernicious anemia. Pediatrics 8, 1 (1951).Google Scholar
  18. Rosenzweig, L., and O. C. Bruton: Pernicious anemia in an eight year old girl. Pediatrics 6, 269 (1950).PubMedGoogle Scholar
  19. Vecchio, F.: L’anemia perniciosa nell’infanzia. Haematologica 24, 815 (1942).Google Scholar
  20. Wilkins, L. A.: The diagnosis and treatment of endocrine disorders in childhood and adolescence, 2nd ed., 556 p. Springfield (111.): Ch. C. Thomas 1957, p. 430.Google Scholar

Perniziöse Anämie bei Hypoparathyreoidismus

  1. Hurwitz, L. J.: Spontaneous hypoparathyroidism with megaloblastic anemia. Lancet 19561, 234–235.Google Scholar
  2. Mcintyre, P. A., R. Hahn, C. L. Conley, and B. Glass: Genetic factors in predisposition to pernicious anemia. Bull. Johns Hopk. Hosp. 104, 309–342 (1959).Google Scholar
  3. Morse, W. I., W. A. Cochrane, and P. L. Landrigan: Familial hypoparathyreoidism with pernicious anemia, steatorrhoe, adrenocortical insufficiency. A variant mucoviscidosis. New Engl. J. Med. 264, 1021 (1961).Google Scholar
  4. Quinto, M. G., S. L. Leikin, and W. Hung: Pernicious anemia in a young girl associated with idiopathic hypoparathyroidism, familial Addison’s disease and moniliasis. J. Pediat. 64, 241–247 (1964).PubMedCrossRefGoogle Scholar
  5. Reisner, D. J., and R. M. Ellsworth: Co-existent idiopathic hypoparathyroidism and pernicious anemia in a young girl. Ann. intern. Med. 43, 1116 (1955).PubMedGoogle Scholar

B12-Malabsorptionsperniciosa

  1. BjÖrnstad, P., and O. Imerslund: Studies of patients with familial vitamin B12 malabsorption. The lack of effect of normal intestinal juice on the absorption of vitamin B12. Acta haemat. (Basel) 30, 340 (1963).Google Scholar
  2. Bousser, J., R. Zittoun et P. Boivin: Anémie mé- galoblastique symptomatique de malabsorption occulte. Nouv. Rev. franç. Hémat. 4, 557 (1964).Google Scholar
  3. Chavelet, F., Y. Najean, J. Ravailleau, P. Grenet et J. Bernard: Etude d’un cas d’anémie pernicieuse de l’enfant avec activité facteur intrinsèque normale du suc gastrique. Nouv. Rev. franç. Hémat. 4, 311 (1964).Google Scholar
  4. Colle, E., L. Greenberg, and W. Krivit: Studies of a patient with selective deficiency in malabsorption of vitamin B12. Blood 18, 48 (1961).PubMedGoogle Scholar
  5. DebrÉ, R., M. Lamy, M. Aussanaire, M. L. Jammet et Ch. Nezelof: Anémie pernicieuse de Biermer chez deux frères. Arch, franç. Pédiat. 8, 175 (1951).Google Scholar
  6. DebrÉ, R., M. Lamy, M. Aussanaire, M. L. Jammet et CH. Nezelof: L’anémie pernicieuse de l’enfance. Bull. Soc. méd. Hôp. Paris 67, 1149 (1951).PubMedGoogle Scholar
  7. DebrÉ, R., J. Marie, M. Lamy et G. Lendoux-Lebard: Un cas d’anémie pernicieuse observé chez un enfant de six ans. Bull. Soc. méd. Hôp. Paris 26, 1286 (1939).Google Scholar
  8. GrÄsbeck, R., R. Gordin, R. Kantero, and B. KuhlbÄck: Selective vitamin B12 malabsorption and proteinuria in young people. A syndrome. Acta med. scand. 167, 289 (1960).PubMedCrossRefGoogle Scholar
  9. GrÄsbeck, R., and I. Kantero: A case of juvenile vitamin B12 deficiency. Acta paediat. (Uppsala) 48, Suppl. 118, 140 (1959).Google Scholar
  10. Imerslund, O.: Idiopathic chronic megaloblastic anemia in children. Acta paediat. (Uppsala) 49, Suppl. 119, 1 (1960).Google Scholar
  11. Imerslund, O., and P. BjÖrnstad: Familial vitamin B12 malab-sorption. Acta haemat. (Basel) 30, 1 (1963).Google Scholar
  12. Lamy, M., F. Besancon, A. Loverdo et F. Afifi: Le mal absorption spécifique de la vitamine B12 avec Proteinurie. L’anémie megaloblastique d’Imers- lund-Najman- Gräsbeck. Étude de quatre cas. Arch, franç. Pédiat. 18, 1109 (1961).Google Scholar
  13. Movitt, E. R., J. F. Magnum, J. I. Cohen, and W. R. Porter: Selective malabsorption of vitamin B12. Amer. J. med. Sci. 245, 699 (1963).PubMedCrossRefGoogle Scholar
  14. Najman, E., u. B. Brausil: Megaloblastische Anämie mit Relapsen ohne Achylia gastrica im Kindesalter. Ann. paediat. (Basel) 178, 47 (1952).Google Scholar
  15. Nja, A.: Et tilfelle av hyperkrom anemi behandlet med folic acid. T. norske Laegeforen. 66, 738 (1946).PubMedGoogle Scholar
  16. Nja, A.: Pernicious anemia in childhood. Acta paediat. (Uppsala), Suppl. 77, 174 (1949).CrossRefGoogle Scholar
  17. Schraagen, M. J. C.: Rezidivierende megaloblastische Anämie bei Kindern infolge einer spezifischen Resorptionsstörung für Vitamin B12. Maandschr. Kindergeneesk. 24, 81 (1961).Google Scholar
  18. Sievers, C. J.: Megaloblastaer anaemi hos et 3 — ars barn. Ugeskr. Laeg. 125, 1744 (1963).PubMedGoogle Scholar
  19. Smrhova, I., M. Wiedermann u. B. Wiedermann: Megaloblastische Anämie als Folge einer selektiven Vitamin-B12-Malabsorption. Syndrom Imerslund- Gräsbeck. Folia haemat. (Lpz.) 86, 70 (1966).Google Scholar
  20. Spurling, C. L., M. S. Sacks, and R. M. Jui: Juvenile pernicious anemia. New Engl. J. Med. 271, 995–1003 (1964).Google Scholar
  21. Telegina, E.: Rezidivierende kindliche Megalo- blastenanämie. Vnitrni Lek. 2, 794 (1950).Google Scholar

Orotacidurie-Perniciosa

  1. Becroft, D. M. O., and L. I. Phillips: Hereditary orotic aciduria and megaloblastic anaemia: a second case, with response to uridine. Brit. med. J. 19651, 547.Google Scholar
  2. Fallon, H. J., M. Lotz, and L. H. Smith jr.: Congenital orotic aciduria: Demonstration of an enzyme defect in leukocytes and comparison with drug-induced orotic aciduria. Blood 20, 700 (1962).Google Scholar
  3. Haggard, M. E.: Unpublished observations.Google Scholar
  4. Haurani, F. I., G. Wang, and L. M. Tocantins: Megaloblastic anemia probably caused by defective utilization of folinic acid. Blood 16, 1546 (1960).PubMedGoogle Scholar
  5. Hugttley jr., C. M., J. A. Bain, S. Kivers, and R. Scoggins: Refractory megaloblastic anemia associated with excretion of orotic acid. Blood 14, 615 (1959).Google Scholar
  6. Krooth, R. S.: Properties of diploid cell strains developed from patients with an inherited abnormality of uridine biosynthesis. Cold Spr. Harb. Symp. quant. Biol. 29, 189 (1964).Google Scholar
  7. Smith jr., L. H., M. Sullivan, and C. M. Huguley jr.: Pyrimidine metabolism in man. IV. The enzymatic defect of orotic aciduria. J. clin. Invest. 40, 656 (1961).PubMedCrossRefGoogle Scholar

Perniziosiforme Anämie (Gesamtdarstellungen)

  1. Gelin, G., et M. Iborra: Les anémies megaloblastiques de l’enfance et les problèmes de la megaloblastose. Paris: Masson & Cie. 1955.Google Scholar
  2. Girdwood, R. H.: Role of folic acid in blood disorders. Brit. med. Bull. 15, 14 (1959).Google Scholar
  3. Maciver, J. E.: Megaloblastic Anaemias. Pediat. Clin. N. Amer. 9, 727 (1962).PubMedGoogle Scholar
  4. Silber, R.: Recent developments in non-Addisonian megaloblastic anemias. Sem. Hemat. 1, 250 (1964).Google Scholar
  5. Zuelzer, W. W., and J. Rutzky: Megaloblastic anemia of infancy. Advanc. Pediat. 6, 243 (1953).Google Scholar
  6. ZiegenmilchanämieGoogle Scholar
  7. Baar, H.: Ein Fall von Ziegenmilchanämie. Mitt. Ges. inn. Med. Kinderheilk. 28, 106 (1924).Google Scholar
  8. Baar, H.: Pathogenese und Therapie alimentärer Klein-kinderanämien mit besonderer Berücksichtigung der sogenannten Ziegenmilchanämie. Abh. Kinderheilk. Grenzgeb. 16, 1 (1927).Google Scholar
  9. Baar, H.: Zur Frage der Ziegenmilchanämie. Bemerkungen zur Arbeit von W. GrÄvinghoff, Untersuchungen über die Ziegenmilchanämie. Jb. Kinderheilk. 20, 242 (1928).Google Scholar
  10. Barbacci, P.: Contributo alio studio delle anemie da latte di capra. Riv. Clin, pediat. 26, 489 (1928).Google Scholar
  11. Bentegeat, J., M. Traissac, Y. Marc et Y. Mortureux: Un cas d’anémie mégaloblastique du lait de chèvre. Ann. Pédiat. 37, 258 (1961).Google Scholar
  12. Betke, K., u. L. Gantert: Zur Ätiologie und Therapie der Ziegenmilchanämie. Dtsch. med. Wschr. 76, 1341 (1951).CrossRefGoogle Scholar
  13. Beumer, H., u. G. Wieczoreck: Zur Pathogenese der Ziegenmilchanämie. Jb. Kinderheilk. 107, 311 (1924).Google Scholar
  14. BlÜhdorn, B.: Über alimentäre Anämien im Säuglings- und frühen Kindesalter. Berl. klin. Wschr. 1919, 169.Google Scholar
  15. BlÜhdorn, B.: Zur Frage der Ziegenmilchanämie des Säuglings. Münch, med. Wschr. 69, 1220 (1922).Google Scholar
  16. Brouwer, E.: Geitenmelkanaemie. Ned. Maandschr. Geneesk. 11, 115 (1922).Google Scholar
  17. Brouwer, E.: Ziegenmilchanämie mit Ziegenmilchernährung. Jb. Kinderheilk. 102, 257, 357 (1923); 103, 51 (1923).Google Scholar
  18. BrÜning, H., u. W. Fischer: Zur Frage der Ziegen-milchanämie im Säuglingsalter. Med. Klin. 21, 12 (1925).Google Scholar
  19. Buffoni, L., e A. M. Piga: Considerazione su due casi di latte di dapra. Minerva pediat. 7, 1514 (1955).PubMedGoogle Scholar
  20. Cap, J.: Beitrag zum klinischen Bild der Ziegenmilch-anämie. Cs. Pediat. 12, 788 (1957).Google Scholar
  21. Chaptal, J., et P. Cazal: Sur les anémies nutri- tionnelles; l’anémie au lait de chèvre, etude hématologique. Arch, franç. Pédiat. 7, 680 (1950).Google Scholar
  22. Collins, R. A.: Goats’ milk anemia in retrospect. Amer. J. clin. Nutr. 11, 169 (1902).Google Scholar
  23. Czerny, A.: Vortrag auf dem Kongr. der Ass. internat. de Pédiatrie. Paris 1912.Google Scholar
  24. Czickeli, H.: Beitrag zur Therapie der Ziegenmilch-anämie im Säuglingsalter. Wien. klin. Wschr. 37, 895 (1924).Google Scholar
  25. Dettweiler: Über Ziegenmilchanämie. Münch. med. Wschr. 69, 1013 (1922).Google Scholar
  26. Gargye, A. K., and D. V. Datta: Infantile megalo- blastic anaemia. Indian J. Pediat. 27, 288 (1960).Google Scholar
  27. Gasser, C.: Folsäure bei perniciosiformer Ziegen-milchanämie. Hämatologische und blutchemische Beobachtungen. Helv. paediat. Acta 3, 301 (1948).Google Scholar
  28. Glanzmann, E.: Klinische und experimentelle Studien über Ziegenmilchanämie. Jb. Kinderheilk. 111, 127 (1926).Google Scholar
  29. GrÄvinghoff, W.: Über Säuglingsanämie. Fortschr. Med. 42, 97 (1924).Google Scholar
  30. GrÄvinghoff, W.: Untersuchungen über die Ziegenmilchanämie. Abh. Kinderheilk. Grenzgeb. 18, 1 (1928).Google Scholar
  31. GrÄvinghoff, W., u. C. Neuhaus: Über Ziegenmilchanämie. Ein Beitrag zu ihrem klinischen und pathologischanatomischen Bild. Mschr. Kinderheilk. 40, 71 (1928).Google Scholar
  32. GyÖrgy, P.: Beobachtungen bei Ziegenmilchernährung. Mschr. Kinderheilk. 54, 330 (1932).Google Scholar
  33. GyÖrgy, P.: Beitrag zur Pathogenese der Ziegenmilchanämie. Z. Kinderheilk. 56, 1 (1934).CrossRefGoogle Scholar
  34. Hyland, C. M.: Goats’ milk anemia. Arch. Pediat. 46, 1313 (1929).Google Scholar
  35. Kirsch-Hoffer, E., u. O. Kirsch: Über Ziegenmilch-anämie im Säuglingsalter. Wien. klin. Wschr. 37, 568 (1924).Google Scholar
  36. Kirsch-Hoffer, E., u. O. Kirsch: Zur Kuhmilchtherapie der Ziegenmilchanämie. Bemerkungen zu der Arbeit von H. Czickeli. Wien. klin. Wschr. 37, 1290 (1924).Google Scholar
  37. Kleinschmidt, H.: Über alimentäre Anämie und ihre Stellung unter den Anämien des Kindesalters. I. und II. Jb. Kinderheilk. 83, 97 u. 221 (1916).Google Scholar
  38. Kohler, G. O., C. A. Elvehjem, and E. B. Hart: Goats’ milk anemia. Ann. J. Physiol. 113, 279 (1935).Google Scholar
  39. Korteweg, R.: Over alimentaire anaemieën. Ned. Maandschr. Verlosk. Vrouwenz. 5, 337 (1916).Google Scholar
  40. Launay, C., et J. Bern ARD: Anémie mégaloblastique grave du nourrisson au lait du chèvre, échec de la vitamine B12, guérison par l’acide folique. Presse méd. 58, 872 (1950).Google Scholar
  41. Letterer, E.: Das pathologisch-anatomische Bild der Ziegenmilchanämie. Jb. Kinderheilk. 130, 1 (1930).Google Scholar
  42. MÖdlinger, P.: Ein Fall von Ziegenmilchanämie. Kinderärztl. Prax. 9, 425 (1938).Google Scholar
  43. Ockel, G.: Über die Polychromasie im roten Blutbild des Säuglings und neue Gesichtspunkte zur Frage der Säuglingsanämie und der Wirkungsweise intravenöser Bluttransfusionen. Münch, med. Wschr. 71, 1356 (1924).Google Scholar
  44. Ockel, G.: Ist die Ziegenmilchanämie ein selbständiges Krankheitsbild? Ergänzende Bemerkung zu der gleichnamigen Arbeit von Opitz in Bd. 108. Jb. Kinderheilk. 110, 62 (1925).Google Scholar
  45. Opitz, H.: Zur Pathogenese der Anämien im Kindes-alter. Klin. Wschr. 1, 1769 (1922).CrossRefGoogle Scholar
  46. Opitz, H.: Ist die Ziegenmilchanämie ein selbständiges Krankheitsbild? Jb. Kinderheilk. 108, 311 (1925).Google Scholar
  47. Orten, J. M., and A. H. Smith: Goats’ milk anemia. Yale J. Biol. Med. 8, 637 (1936).Google Scholar
  48. Ragaz, L.: Lassen sich bei Kindern, die eine Ziegen-milchanämie durchgemacht haben, später Blutveränderungen nachweisen ? Diss. Zürich 1939.Google Scholar
  49. Reale, V., e T. Feliciangeli: L’anemia de latte di dapra (considerazioni su due casi). Lattante 29, 743 (1958).PubMedGoogle Scholar
  50. Ren, G. DE: Les hémopathies megaloblastiques. Thèse méd. Nancy 1948.Google Scholar
  51. Rominger, E., H. Meyer u. C. Bomskov: Anämiestudien am wachsenden Organismus: Über die Pathogenese der Ziegenmilchanämie. Z. ges. exp. Med. 89, 786 (1933).Google Scholar
  52. Rudder, B. DE: Über Ziegenmilchanämie. Klin. Wschr. 3, 876 (1924).CrossRefGoogle Scholar
  53. Scheltema, G.: Geitemelk als zuigelingenvoedsel. Ned. Maandschr. Verlosk. Vrouwenz. 5, 407 (1916).Google Scholar
  54. Schwenke, J.: Über schwere Anämien im frühen Kindesalter. Jb. Kinderheilk. 88, 181, 284, 356 (1919).Google Scholar
  55. Stettner, E.: Über Ziegenmilchanämie. Mschr. Kinderheilk. 29, 587 (1925).Google Scholar
  56. Stoeltzner, W.: Über Ziegenmilchanämie. Münch, med. Wschr. 69, 4 (1922).Google Scholar
  57. Veeneklaas, G. M. H.: Over megalocytaire deficientie-anaemien. Ned. T. Geneesk. 84, 3860, 4517 (1940).Google Scholar
  58. Veeneklaas, G. M. H.: Über megalocytäre Mangelanämien bei Klein-kindern. Folia haemat. (Lpz.) 65, 303 (1942).Google Scholar
  59. Verger, P., J. Bentegeat, Y. Marc, M. L. Etcheverry et M. Lassere: Une nouvelle Observation d’anémie du lait de chévre. Arch. fran§. Pédiat. 17, 1376 (1960).Google Scholar

Perniziosiforme Anämie des Brustkindes (Gerbasi)

  1. Amato, M.: Rilievi anamnestico-clinici, ematologici e biochemici e considerazioni patogenetiche su 25 casi di anemie iperchromiche megaloblastiche osservate in bambini della prima infanzia. Pediatria (Napoli) 54, 71 (1946).Google Scholar
  2. Amato, M.: Tentativi di impiego terapeutico di dose unica massiva di estratto epatico nelle anemie megaloblastiche della prima infanzia. Riv. Clin, pediat. 45, 53 (1947).Google Scholar
  3. Amato, M.: Die neurologischen Erscheinungen der reversiblen Megaloblastenanämie im Kleinkindesalter. Helv. paediat. Acta 7, 291 (1952).Google Scholar
  4. Amato, M., e G. DE Gruttola: Sull’impegio dell’acido folinico (citrovorum factor) nella terapia dell’anemia megaloblastica reversibile dell’infanzia. Pediatria (Napoli) 64. 1 (1956).Google Scholar
  5. Bentivoglio, G. C.: L’anemia di Biermer nell’infanzia. Haematologia 10, 531 (1929).Google Scholar
  6. Buccellato, G., e A. Consello: Considerazione patogenetiche sulle sindromi nervose dell’anemia perniciosiforme del lattante. Contributo clinico. Riv. pediat. sicil. 4, 73 (1949).Google Scholar
  7. Burgio, G. R.: Considerazione su una sindrome nervosa in corso di anemia perniciosiforme del lattante. Atti Acc. Science Mediche, Palermo, 3 marzo 1945.Google Scholar
  8. Burgio, G. R.: Sull’anemia perniciosiforme del lattante. Considerazioni ezio patogenetiche e nosografiche. Minerva pediat. 4, 130 (1952).PubMedGoogle Scholar
  9. Burgio, G. R.: Anémie pseudopernicieuse et autres anémies megaloblastiques du nourrison. Acta haemat. (Basel) 11, 355 (1954).Google Scholar
  10. Burgio, G. R.: Osservazioni sulla morfologica ematica e midollare in alcuni stati distrofico-carenziali della infanzia (in eollab. con il Dott. E. F. Fonti). Pediatria (Napoli) 68, 337 (1960).Google Scholar
  11. Burgio, G. R., e F. Lo Jacono: La sideremia nell’anemia perniciosiforme del lattante. Boll. Soc. ital. Biol. sper. 28, 1948 (1952).Google Scholar
  12. Burgio, G. R., e F. Lo Jacono: Sul comportamento del ferro serico e della transferrina nell’anemia perniciosiforme del lattante, con riferimento ai valori del lattante sano. Clin, pediat. (Bologna) 36, 323 (1954).Google Scholar
  13. Burgio, G. R., e G. Russo: Effetti della vitamina B12 a piccole dosi, per via orale nella anemia perniciosiforme del lattante. Minerva pediat. 4, 872 (1952).PubMedGoogle Scholar
  14. Burgio, G. R., G. Russo, u. F. Lo Jacono: Die hämatologische Reaktion auf kleine perorale Dosen von Vitamin B12 bei der perniciosiformen Anämie des Säuglings. Arch. Kinderheilk. 152, 109 (1956).PubMedGoogle Scholar
  15. Cassorla, E., G. Ducach y N. Avodovsky: Anemia megaloblastica della infanzia. Rev. chil. Pediat. 31, 237 (1960).PubMedGoogle Scholar
  16. Fonti, F. E.: Considerazioni su 102 casi di anemia perniciosiforme del lattante, osservati nel decenio 1950–1959. Pediatria (Napoli) 68, 574 (1960).Google Scholar
  17. Gatto, I.: Perniciosiforme Anämie des Säuglings (Gerbasi-Anämie). Blut 3, 31 (1957).PubMedCrossRefGoogle Scholar
  18. Gerbasi, M.: Anemia perniciosa rigenerativa tipo Biermer in un lattante. Pediatria Riv. 37, 1343 (1929).Google Scholar
  19. Gerbasi, M.: Anemia perniciosiforme in lattanti alimentati in modo esclusivo e protrato alseno materno. Pediatria (Napoli) 48, 505 (1940).Google Scholar
  20. Gerbasi, M.: L’anemia perniciosiforme del lattante. Helv. paediat. Acta 5, 299 (1950).Google Scholar
  21. Gerbasi, M.: Le anemie megaloblastiche nell’infanzia. Pediatria int. (Roma) 9, 355 (1955).Google Scholar
  22. Gerbasi, M.: Le anemie megaloblastiche nell’infanzia. Arch. ital. Pediat. 20, 395 (1960).Google Scholar
  23. Gerbasi, M., e G. R. Burgio: Observations et recherches sur la hyporiboflavinose de l’enfance. Sci. med. ital. 4, 49 (1955).Google Scholar
  24. Iborra, M.: Contribution à l’étude des chémies mégaloblastiques, les anémies mégaloblastiques de la première enfance. Diss. Algier 1955.Google Scholar
  25. La Grutta, A.: Le proteine del plasma nell’anemia perniciosiforme del lattante. Lattante 27, 335 (1956).Google Scholar
  26. Lo Jacono, F.: Curve glicemiche da carico orale di glucosi nell’anemia perniciosiforme del lattante. Pediatria (Napoli) 63, 45 (1955).Google Scholar
  27. Lo Jacono, F.: L’eliminazione dei grassi nella anemia perniciosiforme dell lattante. Pediatria (Napoli) 63, 260 (1955).Google Scholar
  28. Lo Jacono, F.: Citometria della serie bianca midollare nella anemia perniciosiforme del lattante. Haematologica 41, 269 (1956).Google Scholar
  29. Orsini, M., e G. Maggioni: Anemia megaloblastica con steatorrea in bambini allattati al guarita con acido folico. Haematologica 36, 877 (1952).PubMedGoogle Scholar
  30. Pecorella, F., G. R. Burgio e T. Aversa: Osservazioni cliniche ed etiopatogenetiche su 18 casi di anemia perniciosiforme megaloblastica nel lattante. Riv. Clin, pediat. 45, 65 (1947).Google Scholar
  31. Piovanelli, G.: Osservazioni su di un caso anemia perniciosiforme del lattante a porpora nodulare. Lattante 31, 162 (1960).PubMedGoogle Scholar
  32. Riecke, H.: Perniciosiforme Anämie (Gerbasi) im Säuglingsalter. Arch. Kinderheilk. 148, 71 (1954).PubMedGoogle Scholar
  33. Russo, G.: Evoluzione in anemia perniciosiforme del lattante di tre casidi malattia carenziale. Haematologica 39, 821 (1955).PubMedGoogle Scholar

Sonstige nutritiv bedingte perniziosiforme Anämien

  1. Bachmann, A. L.: Macrocytic hyperchromic anemia in early infancy. Amer. J. Dis. Child. 52, 633 (1936).Google Scholar
  2. Baker, S. J., and H. J. Sinn: Megaloblastic anaemia of infancy. Med. J. Aust. 19521, 750.Google Scholar
  3. Bass, M. H.: Deficiency anemia in infants. Amer. J. Dis. Child. 67, 341 (1944).Google Scholar
  4. Carrier, J. W.: Megaloblastic anemia in infancy. Arch. Pediat. 69, 225 (1952).PubMedGoogle Scholar
  5. Chen, Y. S. et al.: Megaloblastic anemia in infancy. China med. J. 67, 519 (1949).Google Scholar
  6. Colebatch, J. H., and A. L. Williams: Megaloblastic anaemia of infancy. Med. J. Aust. 1952II, 151.Google Scholar
  7. Cooley, T. D., and P. Lee: Pernicious blood pictures in infancy. J. Pediat. 1, 184 (1932).CrossRefGoogle Scholar
  8. Davis, L. J.: Macrocytic anemia in children. Arch. Dis. Childh. 19, 147 (1944).PubMedCrossRefGoogle Scholar
  9. Gelin, G., G. Roux et P. Bougeot: Anemie mégaloblastique aigue chez une enfant de 19 mois — Syndrome biermérien ou anémie megaloblastiques nutritionelle ? Sang 24, 447 (1953).Google Scholar
  10. Hutchison, J. H., and P. Macabthub: Megaloblastic anaemia in an infant. Lancet 19491, 916.Google Scholar
  11. Kho, L.-K., and O. Odang: Megaloblastic anemia in infancy and childhood. Amer. J. Dis. Child. 97, 209 (1959).Google Scholar
  12. Kho, L.-K., S. D. Poesponegbo, and P.S. Hin: The bone marrow picture of Kwashiorkor in Djakarta. Docum. Med. geogr. trop. (Amst.) 9, 69 (1957).Google Scholar
  13. Kho, L.-K., and W. A. F. J. Tumbelaka: The pathogenesis of anaemia in Kwashiorkor. Ann. paediat. (Uppsala) 194, 257 (1960).Google Scholar
  14. Luhby, A. L.: Megaloblastic anemia in infancy. III. Clinical considerations and analysis. J. Pediat. 54, 617 (1959).PubMedCrossRefGoogle Scholar
  15. Luhby, A. L., J. M. Coopebman, D. N. Telleb, and A. M. Donnenfeld: Excretion of formiminoglutaminic acid in folic acid deficiency states. J. clin. Invest. 37, 915 (1958).Google Scholar
  16. Luhby, A. L., and W. E. Wheeleb: Megaloblastic anemia of infancy. II. Failure of response to vitamin B12 and the metabolic role of folic acid and vitamin C. Hlth Centre J. Ohio State Univ. 3, 1 (1949).Google Scholar
  17. Maciver, J. E., and E. H. Back: Megaloblastic anaemia of infancy in Jamaica. Arch. Dis. Childh. 35, 134 (1960).PubMedCrossRefGoogle Scholar
  18. Maurus, R., H. Vis et R. Denolin-Reubens: Les anémies mégaloblastiques de l’enfant. Acta paediat. belg. 14, 26 (1960).Google Scholar
  19. May, C. D., E. N. Nelson, R. A. Aldbich, R. J. Salmon, and R. I. Lienke: Megaloblastic anemia in infancy. Amer. J. Dis. Child. 77, 127 (1949).Google Scholar
  20. May, C. D., E. N. Nelson, C. U. Lowe, and R. J. Salmon: Pathogenesis of megaloblastic anaemia in infancy. Amer. J. Dis. Child. 80, 191 (1950).Google Scholar
  21. May, C. D., R. D. Sundbebg, F. Schaab, C. U. Lowe, and R. J. Salmon: Experimental nutritional megaloblastic anemia. Relation of ascorbic acid and pteroylglutaminic acid. Nutritional data and manifestations of animals. Amer. J. Dis. Child. 82, 282 (1951).Google Scholar
  22. Mcpherson, A. Z., U. Jonsson, and R. W. Rundles: Vitamin B12 therapy in megaloblastic anemia of infancy. J. Pediat. 34, 529 (1949).PubMedCrossRefGoogle Scholar
  23. Metz, J., V. Bbandt, and K. Stevens: Vitamin B12 and megaloblastic anemias in South African Bantu. Brit. med. J. 19621, 24.Google Scholar
  24. Moore, W., R. Vilteb, U. Monnich, and T. D. Spies: Nutritional macrocytic anemia in patients with pellagra or deficiency of the vitamin B-complex. J. Lab. clin. Med. 29, 1226 (1944).Google Scholar
  25. Mouriquand, C.: Contribution a l’étude des anémies nutritionelles du nourrisson. Thèse de Lyon 1952.Google Scholar
  26. Navarro, R. L.: Anemias por deficiencia de la nutrición. Revision de la entitad (Estudio basado en 160 medulogramms). Rev. cuba. med. trop. 12, 15 (1956).Google Scholar
  27. Parsons, L. G.: Studies in anaemias of infancy and early childhood. Arch. Dis. Childh. 8, 85 (1933).PubMedCrossRefGoogle Scholar
  28. Parsons, L. G., and J. C. Hawksley: Studies in anemias of infancy and early childhood: anhaemopoietic anaemias (deficiency diseases of the erythron); nutritional anaemia and anaemias of prematurity, scurvy and coeliac disease. Arch. Dis. Childh. 8, 117 (1933).PubMedCrossRefGoogle Scholar
  29. Rickards, A. C.: Megaloblastic anaemia of infancy. Brit. med. J. 1962 II, 1220.Google Scholar
  30. Scott, R. B.: Discussion on the pathogenesis of the megaloblastic anaemias. Proc. roy. Soc. Med. 43, 953 (1950).Google Scholar
  31. Shnier, M. H., and J. Metz: Megaloblastic anaemia in infancy with special reference to treatment with vitamin B12. S. Afr. med. J. 33, 1009 (1959).PubMedGoogle Scholar
  32. Siebenthal, B. J.: Megaloblastic anemia in infancy. J. Pediat. 32, 188 (1948).PubMedCrossRefGoogle Scholar
  33. Stubgeon, P., and G. Cabpenteb: Megaloblastic anemia of infancy. Blood 5, 458 (1950).Google Scholar
  34. Sundberg, R. D., F. Schaab, and C.D. May: Experimental nutritional megaloblastic anemia: II. Hematology. Blood 7, 1143 (1952).Google Scholar
  35. Taylor, F. M., and R. A. Hettig: Megaloblastic anemia of infancy. Texas St. J. Med. 45, 558 (1949).Google Scholar
  36. Veeneklaas, G. M.: Megaloblastic deficiency anaemia cured by small amounts of fresh endive. Arch. Dis. Childh. 27, 209 (1952).PubMedCrossRefGoogle Scholar
  37. Walt, F., S. Holman, and R. C. Hendrickse: Megaloblastic anaemia of infancy in Kwashiorkor and other diseases. Brit. Med. J. 19561, 1199.Google Scholar
  38. Walt, F., S. Holman, and P. Naidoo: Megaloblastic anaemia of infancy treated with folic acid. Brit. med. J. 195 7 II, 1464.Google Scholar
  39. Watson, G. M.: Discussion on the pathogenesis and treatment of the megaloblastic anemias. Proc. roy. Soc. Med. 43, 957 (1950).Google Scholar
  40. Witts, L. J.: Pathogenesis of the megaloblastic anaemias. Lancet 1951II, 367.Google Scholar
  41. Woodruff, C. W., W. R. Howard, J. C. Peterson, and J. D. Darby: Variable response to vitamin B12 of megaloblastic anemia of infancy. Pediatrics 4, 723 (1949).PubMedGoogle Scholar
  42. Woodruff, C. W., J. C. Peterson, and W. J. Darby: Citrovorum factor and folic acid in treatment of megaloblastic anemia in infancy. Proc. Soc. exp. Biol. (N.Y.) 77, 16 (1951).Google Scholar
  43. Zuelzer, W. W., L. Hutaff, and L. Apt: The relationship of anemia and scurvy. Amer. J. Dis. Child. 77, 127 (1949).Google Scholar
  44. Zuelzer, W. W., A. Newhall, and L. Hutaff: Changes in the bone marrow in megaloblastic anemias of infancy before and after folic therapy. J. Lab. clin. Med. 32, 1217 (1947).PubMedGoogle Scholar
  45. Zuelzer, W. W., and F. N. Ogden: Folic acid therapy in macrocytic anemias of infancy. Proc. Soc. exp. Biol. (N.Y.) 61, 76 (1946).Google Scholar
  46. Zuelzer, W. W., and F. N. Ogden: Megaloblastic anemia in infancy: a common syndrome responding specifically to folic acid therapy. Amer. J. Dis. Child. 71, 211 (1946).Google Scholar

Resorptiv und konsumtiv bedingte perniziosiforme Anämien

  1. BarbÉ, P.: Anémie du type pernicieux avec hypogranulocytose chez un jeune enfant atteint mégacolôn. Bull. Soc. Pédiat. Paris 87, 47 (1939).Google Scholar
  2. Bonsdorff, B. v.: Pathogenesis of vitamin B12 deficiency, with special reference to tapeworm pernicious anaemia. In: Vitamin B12 und Intrinsic Factor. 1. Europ. Symp. Hamburg. Stuttgart: Ferdinand Enke 1956, S. 311.Google Scholar
  3. Chanarin, I., J. V. Dacie, and D. L. Mollin: Folic acid deficiency in haemolytic anaemia. Brit. J. Haemat. 5, 245 (1959).PubMedCrossRefGoogle Scholar
  4. Delamore, I. W., J. Richmond, and S. H. Davies: Megaloblastic anaemia in congenital spherocytosis. Brit. med. J. 19611, 543.Google Scholar
  5. Ghosal, S. P., U. S. Sarkar, and J. Nagchandhuri: Megaloblastic anaemia associated with thalassaemia. Indian J. Pediat. 28, 239 (1961).Google Scholar
  6. Haenel, U.: Diskussion zu Gasser. Sang 21, 244 (1950).Google Scholar
  7. Helge, H.: Vitamin B12-Mangel nach Ileumresektion. Mschr. Kinderheilk. 111, 131 (1963).PubMedGoogle Scholar
  8. Knowles, J. P., and T. A. Prankerd: Megaloblastic anaemias of gastro-intestinal origin. Postgrad, med. J. 37, 755 (1961).CrossRefGoogle Scholar
  9. Levy, W., and S. A. Widrow: A case of megaloblastic anemia associated with steatorrhea and celiac syndrome. J. Pediat. 47, 100 (1955).PubMedCrossRefGoogle Scholar
  10. Maciver, J. E., and L. N. Went: Sickle-cell anaemia complicated by megaloblastic anaemia in infancy. Brit. J. Med. 1, 775 (1960).CrossRefGoogle Scholar
  11. Magnusson, J. H., and B. Hamne: Macrocytic hyperchromic anemia in children. Report of a case. Acta paediat. (Uppsala) 25, 189 (1939).CrossRefGoogle Scholar
  12. May, C. D., C. D. Stewart, A. Hamilton, and R. J. Salmon: Infection as a cause of folic acid deficiency and megaloblastic anemia. Amer. J. Dis. Child. 84, 718 (1952).Google Scholar
  13. Mikulowski, W.: Beitrag zu der durch Bothriocephalus latus verursachten perniciösen Anaemie. Pediat. pol. 6, 349 (1926).Google Scholar
  14. Parsons, L. G., and J. C. Hawksley: Studies in anaemias of infancy and early childhood: anhaemopoietic anaemias (deficiency diseases of the erythron); nutritional anaemia and anaemias of prematurity, scurvy and coeliac disease. Arch. Dis. Childh. 8, 117 (1933).PubMedCrossRefGoogle Scholar
  15. Plum, K.: Generalisierte Lymphdrüsentuberkulose im Kindesalter als Ursache einer haemolytischen Anämie mit achrestischer Megaloblastose. Mschr. Kinderheilk. 102, 309 (1954).PubMedGoogle Scholar
  16. Quinby, W. C., and J. J. Macgovern: Surgical correction of defective absorption of vitamin B12 in a child. New Engl. J. Med. 159, 755 (1958).Google Scholar
  17. Royston, N.J., and T. E. Parry: Megaloblastic anaemia complicating dietary treatment of phenylketonuria in infancy. Arch. Dis. Childh. 37, 430 (1962).PubMedCrossRefGoogle Scholar
  18. Shaldon, S.: Megaloblastic erythropoiesis associated with sickle-cell anaemia. Brit. med. J. 19611, 640.Google Scholar
  19. Watson, G. M., and L. J. Witts: Intestinal macrocytic anaemia. Brit. med. J. 19521, 13.Google Scholar
  20. Wegelius, R., and E. Malm: Pernicious tapeworm anaemia in a child. Ann. Paediat. Fenn. 1, 208 (1955).Google Scholar

Toxisch bedingte perniziosiforme Anämien

  1. Bass, B. H.: Megaloblastic anaemia due to nitro-furantoin. Lancet 19631, 530.Google Scholar
  2. Bethell, F. H., and D. S. Thompson: Treatment of leukemia and related disorders with 6-mercaptopurine. Ann. N.Y. Acad. Sci. 60, 436 (1954).PubMedCrossRefGoogle Scholar
  3. Brennan, M. J., V. K. Vaitcevicius, and J. W. Rebuck: Megaloblastic anemia associated with inhibition of thymine synthesis. Blood 16, 1535 (1960).Google Scholar
  4. Cardoso, S. S., P. Calabresi, and R. E. Handschumacher: Alterations in human pyrimidine metabolism as a result of therapy with 6-azauridine. Cancer Res. 21, 1551 (1961).PubMedGoogle Scholar
  5. Chanarin, I.: Studies in drug-induced megaloblastic anaemia. Scand. J. Haemat. 1, 280 (1964).PubMedCrossRefGoogle Scholar
  6. Condit, P. T., N.I. Berlin, and D.G. Nathan: Studies on the folic acid vitamins. VI. The effect of amethopterin on erythropoiesis in man. Scand. J. Haemat. 13, 245 (1960).Google Scholar
  7. Druskin, M. S., M. H. Wallen, and L. Bonagura: Anticonvulsant associated megaloblastic anemia: response to 25 micrograms of folic acid administered by mouth daily. New Engl. J. Med. 267, 483 (1962).Google Scholar
  8. Fallon, H. J., E. Frei III, and E. J. Freireich: Correlations of the biochemical and clinical effects of 6-azauridine in patients with leukemia. Amer. J. Med. (in press).Google Scholar
  9. Gasser, C., u. R. Cramer: Leukämie im Kindesalter unter Cortison und Aminopterin. Helv. paediat. Acta 8, 10 (1953).Google Scholar
  10. Handschumacher, R. E.: Orotidylic acid decarboxylase: inhibition studies with azauridine-5′-phosphate. J. biol. Chem. 235, 2917 (1960).PubMedGoogle Scholar
  11. Hawkins, C. F., and M. J. Meynell: Macrocytosis and macracocytic anaemia caused by anticonvulsant drugs. Quart. J. Med. 27, 45 (1958).PubMedGoogle Scholar
  12. Klipstein, F. A.: Subnormal serum folate and macro-cytosis associated with anticonvulsant drug therapy. Blood 23, 68 (1964).PubMedGoogle Scholar
  13. Levy, D., and A. Porgess: Hemolytic anaemia in a child receiving nitro furantoin. Arch. Dis. Childh. 33, 527 (1958).PubMedCrossRefGoogle Scholar
  14. Mannheimer, E., F. Pakesch, E. E. Reimer u. H. Vetter: Die hämatologischen Komplikationen der Epilepsiebehandlung mit Hydantoinkörpern. Med. Klin. 47, 1397 (1952).Google Scholar
  15. Penny, J. L.: Megaloblastic anemia during anticonvulsant drug therapy. Arch, intern. Med. Ill, 744 (1963).Google Scholar
  16. Speck, B., J. M. Kiely, and Gertrude L. Pease: Hematopoietic effects of folate antagonist in man. Cancer (Philad.) 20, 225 (1967).CrossRefGoogle Scholar
  17. Talley, R. W., and V. K. Vaitkevicius: Megaloblastosis produced by a cytosine antagonist 1-ß-D-arabinofuranosylcytosine. Blood 21, 352 (1963).PubMedGoogle Scholar
  18. Thiersch, J. B.: Marrow changes in man after treatment with aminopterin, amethopterin and aminoanfol, with special reference to megaloblastosis and tumor remission. Cancer (Philad.) 2, 877 (1949).CrossRefGoogle Scholar
  19. Veber, L. L. DE, and G. H. Valentine: Nitrofurantoin and megaloblastic anaemia. Lancet 1964II, 697.Google Scholar
  20. Wickes, I. G.: Megaloblastic anaemia and anticon-vulsants. Brit. med. J. 1961 II, 1435.Google Scholar

Literatur

  1. Barber, H.: Familial acholuric jaundice: family with 4 members affected. Guy’s Hosp. Rep. 84, 35 (1934).Google Scholar
  2. Battle, J. D.: Hereditary spherocytosis (congenital hemolytic jaundice): Pathogenesis of the hemolytic crisis. Amer. J. med. Sci. 224, 82 (1952).PubMedCrossRefGoogle Scholar
  3. Betke, K., F. Debutin u. R. Sauthoff: Aplastische Krise bei konstitutionellem hämolytischem Ikterus. Dtsch. med. Wschr. 1955, 1358.Google Scholar
  4. Bousser, J.: Episode érythroblastopénique prolongé ayant marqué le debut d’une anémie hémolytique chronique avec auto-anticorps. Sang 26, 804 (1955).PubMedGoogle Scholar
  5. Burston, J., O. A. Husain, M. S. Hutt, and E. I. Tanner: TWO cases of auto-immune haemolysis and aplasia. Brit. med. J. 19591, 83.Google Scholar
  6. Cazal, P., P. Izarn et J. M. Emberger: Erythroblastopénie aiguë de Gasser: Étude caryométrique. Sang 30, 1 (1959).PubMedGoogle Scholar
  7. Chanarin, I., P. Barkhan, M. Peacock, and T. C. B. Stamp: Acute arrest of haemopoiesis. Brit. J. Haemat. 10, 43 (1964).PubMedCrossRefGoogle Scholar
  8. Chanarin, I., D. Burman, and D. Bennett: The familial aplastic crisis in hereditary spherocytosis. Urocanic acid and formiminoglutamic acid excretion studies in a case with megaloblastic arrest. Blood 20, 33 (1962).PubMedGoogle Scholar
  9. Chernoff, A. I., and A. M. Josephson: Acute erythroblastopenia in sickle cell anemia. Amer. J. Dis. Child. 82, 310 (1951).Google Scholar
  10. Choremis, C. B., H. A. Megas, A. A. Liaromati, and S. C. Michael: Aplastic crisis in the course of infectious diseases. Report of 10 cases. Helv. paediat. Acta 16, 134 (1961).Google Scholar
  11. Crosby, W. H.: Paroxysmal nocturnal hemoglobinuria: Report of a case complicated by an aregenerative (aplastic) crisis. Ann. intern. Med. 39, 1107 (1953).PubMedGoogle Scholar
  12. Crosby, W. H., and H. Rappaport: Reticulocytopenia in autoimmune hemolytic anemia. Blood 11, 929 (1956).PubMedGoogle Scholar
  13. Dameshek, W.: Familial hemolytic crisis. New Engl. J. Med. 224, 52 (1941).Google Scholar
  14. Dameshek, W.: The hemolytic crisis. Blood 3, 307 (1948).PubMedGoogle Scholar
  15. Dameshek, W., and M. L. Bloom: The events in the hemolytic crisis of hereditary spherocytosis with particular reference to the reticulocytopenia, pancytopenia and an abnormal splenic mechanism. Blood 3, 1381 (1948).PubMedGoogle Scholar
  16. Davis, L. J., A. C. Kennedy, A. G. Baikie, and A. Brown: Haemolytic anaemias of various types treated with ACTH and cortisone. Glasg. med. J. 33, 263 (1952).Google Scholar
  17. Dedichen, H. G.: Hollasyken epidemisk optreden av anemiske kriser vel icterus haemolyticus. Norsk Mag. Laegevidensk. 98, 279 (1937).Google Scholar
  18. Denny, W. F., R. M. Bird, and M. K. Duval: Hereditary spherocytosis. Is the duration of the aplastic crisis influenced by splenectomy ? Arch. intern. Med. 101, 894 (1958).Google Scholar
  19. Emberger, J.-M.: Cytogénèse des cellules sanguines normales et pathologiques. Étude caryométrique. Diss. Montpellier 1960.Google Scholar
  20. Fessas, P.: In: Abnormal hemoglobins (ed. by J. H. P. Jonxis and J. F. Delafres-Naye), p. 134. Oxford 1959.Google Scholar
  21. Gasser, C.: Akute Erythroblastopenie. 10 Fälle akuter Ery throb] astenkrisen mit Riesenproerythro- blasten bei allergisch toxischen Zustandsbildern. Helv. paediat. Acta 4, 107 (1949).Google Scholar
  22. Gasser, C.: Akute Erythroblastopenie. Schweiz, med. Wschr. 79, 838 (1949).Google Scholar
  23. Gasser, C.: Erythroblastopénie aiguë dans les anémies hémolytiques. Sang 21, 237 (1950).PubMedGoogle Scholar
  24. Gasser, C., u. W. Adank: Akute Erythroblastopenie mit Auftreten abnormer Riesenproerythroblasten im Knochenmark. Helv. paediat. Acta 5, 37 (1950).Google Scholar
  25. Ginsburg, S. M.: Acute erythroid aplasia (erythroblastopenia) and vascular purpura in an otherwise hematologically normal child. Ann. intern. Med. 55, 317 (1961).PubMedGoogle Scholar
  26. Gordon, R. R., and S. Varadi: Congenital hypoplastic anaemia (pure red cell anaemia) with periodic erythroblastopenia. Lancet 19621, 296.Google Scholar
  27. Greig, H. B. W., J. Metz, B. A. Bradlow, J. J. Theron, and R. W. Morris: The familial crisis in hereditary spherocytosis: Report of five cases. A. Afr. J. med. Sci. 23, 17 (1958).Google Scholar
  28. Grunke, W.: Vorübergehende Hemmung der Erythropoese bei einem haemolytischen Ikterus. Folia haemat. (Lpz.) 63, 213 (1940).Google Scholar
  29. Haase, K. E.: Beitrag zur aplastischen Krise der Erythropoese bei konstitutioneller haemolytischer Anaemie. Z. Kinderheilk. 75, 443 (1954).CrossRefGoogle Scholar
  30. Hennemann, H.H., u. I. Falck: Über Kombinationen von aplastischen und hämolytischen Syndromen. Acta haemat. (Basel) 18, 219 (1957).Google Scholar
  31. Hilkovitz, G.: Sickle cell disease. The aplastic crisis and erythroid maturation defect occuring simultaneously in three members of a family. Arch. intern. Med. 105, 76 (1960).CrossRefGoogle Scholar
  32. Horne, J. L., H. Lederer, H. J. R. Kirkpatrick, and D. G. Leys: Familial crises in congenital hemolytic disease. Lancet 1945II, 33.Google Scholar
  33. Horsfall, W. R.: A case of congenital non-spherocytic haemolytic anaemia presenting with an aplastic crisis. Med. J. Aust. 1956II, 340.Google Scholar
  34. Ingham, W. N.: The familial crisis in congenital a jaundric. Arch. Dis. Childh. 27, 34 (1952).PubMedCrossRefGoogle Scholar
  35. Jandl, J. N., and M. S. Greenberg: Bone marrow failure due to relative nutritional deficiency in Cooley’s hemolytic anaemia. Painful erythropoetic crisis in response to folic acid. New Engl. J. Med. 260, 461 (1959).PubMedCrossRefGoogle Scholar
  36. Jepson, J. H., and L. Lowenstein: Inhibition of erythropoiesis by a factor present in the plasma of patients with erythroblastopenia. Blood 27, 425 (1966).PubMedGoogle Scholar
  37. Kho, L. K.: Erythroblastopenia with giant proerythroblasts in Kwashiorkor. Blood 12, 171 (1957).Google Scholar
  38. Kho, L. K., O. Odang, and A. H. Markum: Acute erythro-blastopenia (aplastic crisis) in children with megaloblastic anemia. Ann. paediat. (Basel) 196, 379 (1961).Google Scholar
  39. Kho, L. K., O. Odang, S. Thajeb, and A. H. Markum: Erythroblastopenia (pure red cell aplasia) in childhood in Djakarta. Blood 19, 168 (1962).PubMedGoogle Scholar
  40. KÖlbl, H.: Subsepsis allergic mit akuter Erythro-blastopenie und abnormer Riesenproerythro- blastenbildung. Z. Kinderheilk. 75, 525 (1954).PubMedCrossRefGoogle Scholar
  41. Leikin, S. L.: The aplastic crisis of sickle-cell disease. Amer. J. Dis. Child. 93, 128 (1957).Google Scholar
  42. Linke, A.: Klinische und experimentelle Beobachtungen über aplastische Krisen der Erythropoese bei hämolytischen Anämien. Verh. dtsch. Ges. inn. Med. 58, 724 (1952).Google Scholar
  43. Lyngar, E.: Samtidig optreden av anaemiske kriser hos 3 barn i en familie med haemolytisk ikterus. Nord. Med. 14, 1246 (1942).Google Scholar
  44. Maciver, J. E., and E. J. Parker-Williams: The aplastic crisis in sickle-cell anaemia. Lancet 19611, 1086.Google Scholar
  45. Maggioni, G.: Sull’eritroblastopenia acuta transitoria; praesentazione di 3 casi. Arch. ital. Pediat. 18, 260 (1957).Google Scholar
  46. Maggioni, G., e C. Sbraccia: Crisis eritroblastopenia transitoria in due fratelli con ittero emolitico costituzionale. Pediat. int. (Roma) 7, 1 (1957).Google Scholar
  47. Manios, S.: Acute benign erythroblastopenia. Thesis Saloniki 1956.Google Scholar
  48. Marson, F. G., J. M. Meynell, and H. Tabush: Familial crisis in acholuric jaundice. Brit. med. J. 1950II, 760.Google Scholar
  49. Martoni, L.: La mieloaplasia eritroblastica acuta. Clin, pediat. (Bologna) 39, 887 (1957).Google Scholar
  50. Martoni, L., e S. Musioni: Anemia emolitica acquisita idio- patica autoimmune compienta di mieloaplasia eritroblastica in un lattante di 6 mesi. Clin, pediat. (Bologna) 38, 483 (1956).Google Scholar
  51. Megas, H., E. Papadaki, and B. Constaninides: Sal-monella septicemia and aplastic crisis in a patient with sickle-cell anemia. Acta paediat. (Basel) 50, 517 (1961).Google Scholar
  52. Meyer, L. M., and R. W. Bertcher: Acquired hemolytic anemia and transient erythroid hypoplasia of bone marrow. Amer. J. Med. 28, 606 (1960).CrossRefGoogle Scholar
  53. Miesch, D. C., R. Baxter, and W. C. Levin: Acute erythroblastopenia, pathogenesis, manifestation and management. Arch, intern. Med. 99, 461 (1957).Google Scholar
  54. Murray-Lyon, R. M.: Familial acholuric jaundice simulating Lederers anaemia. Brit. med. J. 19351, 50.Google Scholar
  55. Owren, P.A.: Congenital hemolytic jaundice: The pathogenesis of the “hemolytic crisis”. Blood 3, 231 (1948).PubMedGoogle Scholar
  56. Prats-Vinas, J., y J. Sauleda-Parés: Eritroblastopenia aguda. Boi. Soc. catal. Pediat. 20, 281 (1959).Google Scholar
  57. Reerink, H.: Rhythmic erythroblastopenia. Vortrag auf dem 10. Internat. Kongr. f. Pädiatrie, Lissabon 1962.Google Scholar
  58. RÉvol, L., et Bianco: Anémie aigue curable (type Lederer-Brill) à la fois hémolytique et érythroblastopénique. Róle déclenchant possible d’une vermifuge. Pédiatrie 9, 504 (1954).PubMedGoogle Scholar
  59. Richet, G., D. Alagille et E. Fournier: L’érythro-blastopénie aigue de l’anurie. Presse méd. 62, 50 (1954).PubMedGoogle Scholar
  60. Sansone, G., e A. M. Piga: L’eritroblastopenia acuta nel bambino senza costituzione emolitica. Haematologica 43, 41 (1958).PubMedGoogle Scholar
  61. Scott, A.M.: Acholurie jaundice: Serial onset of acute blood crises in entire family. Lancet 1935II, 873.Google Scholar
  62. Seip, M.: Aplastic crisis in a case of immuno-hemolytic anemia. Acta med. scand. 153, 137 (1955).PubMedCrossRefGoogle Scholar
  63. Shaw, S.: Congenital spherocytic anaemia with temporary reticulocytopenia and secondary dificiency of maturation factor. Proc. 7th Internat. Congr. Haemat. Rome, p. 437. New York: Grune & Stratton 1958.Google Scholar
  64. Singer, K., A. G. Motulsky, and S.A. Wile: Aplastic crisis in sickle-cell anemia: A study of its mechanism and its relationship to other types of hemolytic crises. J. Lab. clin. Med. 35, 721 (1950).PubMedGoogle Scholar
  65. Smith, E. W., and C. L. Conley: In: Conference on hemoglobin. Publication 557 National Academy of Sciences, Washington 1958, p. 276.Google Scholar
  66. Tsevkenis, H., A. Papaspyrou, and N. Vorias: The aplastic crisis in sickle-cell anemia. Lancet 1961II, 56.Google Scholar
  67. Undritz, E.: Diskussion zu Gasser. Schweiz, med. Wschr. 79, 840 (1949).Google Scholar
  68. Vaughan, J.: Familial crises in haemolytic anaemia. Lancet 19381, 133.Google Scholar
  69. Veras, S., et S. Manios: Anémie hémolytique acquise par autoimmunisation ayant présenté dans son évolution une aplasie érythroblastique aigue. Arch, franç. Pédiat. 13, 1096 (1956).Google Scholar
  70. Walt, F., J. E. D. Taylor, F.B. Magill, and A. Nestadt: Erythroid hypoplasia in Kwashiorkor. S. Afr. J. med. Sci. 27, 73 (1962).Google Scholar
  71. Weicker, H.: Die Morphogenese der Anämien als Ergebnis der metrisch-kombinatorischen Analyse der Erythroblasten. Ärztl. Wschr. 9, 1017 (1954).Google Scholar
  72. Weicker, H.: Metrische Analyse und kombinatorische Logik als Methoden zur Aufschlüsselung erythropoetischer Probleme. Schweiz, med. Wschr. 84, 1124 (1954).Google Scholar
  73. Weicker, H.: Entstehung, Erkennung und Behandlung der Anämien des Kindes. Mschr. Kinderheilk. 105, 281 (1957).PubMedGoogle Scholar
  74. Weicker, H., u. H. Fichsel: Durch Masern ausgelöste Umwandlung einer subakuten Erythroblastopenie in eine aplastische Anämie. Schweiz, med. Wschr. 91, 1213 (1961).Google Scholar

Literatur

  1. Berman, L.: The clinical significance of cellular gigantism in human erythropoiesis. J. Lab. clin. Med. 32, 793 (1947).PubMedGoogle Scholar
  2. Guglielmo, G. DI: Les hemipathies aigues dans le benzenisme chronique. Sang 16, 244 (1955).Google Scholar
  3. Guglielmo, G. DI, and A. Iannaccone: Inhibition of mitosis and regressive changes of erythroblasts in acute erythropathy caused by occupational benzene poisoning. Acta haemat. 19, 144 (1958).CrossRefGoogle Scholar
  4. Limarzi, L. R., and S. A. Levinson: An undescribed type of erythropoiesis observed in human sternal marrow. Arch. Path. 36, 127 (1943).Google Scholar
  5. Lozzio, C. B. DE, J.I. Valencia, and E. Acame: Chromosomal study in erythroblastic endopolyploidy. Lancet 19621, 1004.Google Scholar
  6. Roberts, P. D., P. G. Wallis, and A. D. M. Jackson: Haemolytic anaemia with multinucleated normo-blasts in the marrow. Lancet 19621, 1186.Google Scholar
  7. Rothlin, E., u. E. Undritz: Analyse und Bedeutung der polyploiden Zellen in Blut, Knochenmark und Tumoren. Arch. Klaus-Stift. Vererb.-Forsch. 28, 280 (1953).Google Scholar
  8. SchÄrer, K., H. R. Marti u. TH. Baumann: Konstitutionelle Anämie mit Kernteilungsstörung der Ery- throblasten. Schweiz, med. Wschr. 95, 1511 (1965).Google Scholar
  9. Schleicher, E. M.: Giant orthochromatic erythroblasts. J. Lab. clin. Med. 29, 127 (1944).Google Scholar
  10. Schwarz, E.: Cellular gigantism and pluripolar mitoses in human hematopoiesis. Amer. J. Anat. 79, 75 (1949).CrossRefGoogle Scholar
  11. Undritz, E.: Zwillings- und Mehrlingsmißbildungen, die Natur der Riesen, Zwillinge und Amitosen der Blutzellen. Folia haemat. (Lpz.) 68, 225 (1944).Google Scholar
  12. Weicker, H.: Zellteilung und Zellteilungsstörungen. In: Heilmeyer-Hittmair, Handbuch der allgemeinen und speziellen Hämatologie, 2. Aufl., Bd. 1, S. 148. München-Berlin-Wien: Urban & Schwarzenberg 1957.Google Scholar
  13. Wolff, J. A., and F. H. von Hofe: Familial erythroid multinuclearity. Blood 6, 1274 (1951).PubMedGoogle Scholar

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© Springer-Verlag Berlin · Heidelberg 1967

Authors and Affiliations

  • H. Weicker
    • 1
  1. 1.BonnDeutschland

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