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Mechanism of Action of α-Methyl-Dopa

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Neuroblastomas

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 2))

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Abstract

Chemically α-methyldopa (AMD) or Aldomet® is the 3,4-dihydroxy-L-phenylalanine methylated in the α-position (Fig. 1). Sourkes [28] first showed in 1954 that higher concentrations of this substance in vitro inhibit the decarboxylation of dopa (= 3,4-dihydroxyphenylalanine) to dopamine ( = 3,4-dihydroxyphenylethylamine), one step in the main pathway of noradrenaline synthesis. This observation, confirmed by Dengler and Reichel [8] in animals, and by Oates, Sjoerdsma et al. [16, 25–27] in humans, led to the clinical trial of this substance in hypertensive patients which established its usefullness in the therapy of hypertension [1, 2, 4, 9, 10, 15, 17, 22, 24].

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Authors and Affiliations

  1. Swiss Center of Clinical Tumor Investigation (Metabolic Laboratory) Institute for Clinical Protein Research and Pediatric Clinic, University of Berne, Berne, Switzerland

    H. Käser & H. P. Wagner

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  1. H. Käser
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  2. H. P. Wagner
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C. Bohuon

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Käser, H., Wagner, H.P. (1966). Mechanism of Action of α-Methyl-Dopa. In: Bohuon, C. (eds) Neuroblastomas. Recent Results in Cancer Research, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-94971-5_5

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  • DOI: https://doi.org/10.1007/978-3-642-94971-5_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-94972-2

  • Online ISBN: 978-3-642-94971-5

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