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Polypeptides Active on Plain Muscle in the Amphibian Skin

  • V. Erspamer
  • A. Anastasi

Abstract

This report describes the main findings obtained in the field of active polypeptides of the amphibian skin by the research groups of the Institute of Pharmacology of the University of Parma and of the Farmitalia Research Laboratories, Milan, which were joined by Dr. J. M. Cei, Mendoza, Argentina, and Dr. R. Endean, Brisbane, Australia, who were responsible for collection, classification, and occasional extraction of the amphibian material.

Keywords

Amphibian Species Diazonium Salt Skin Extract Hypotensive Action Crude Methanol Extract 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Anastasi, A., V. Erspamer, and J. M. Cei: Isolation and amino acid sequence of physalaemin, the main active polypeptide of the skin of Physalaemus fuscumaculatus. Arch. Biochem. 108, 341 (1964).CrossRefGoogle Scholar
  2. Anastasi, A., V. Erspamer, and G. Bertaccini: Occurrence of bradykinin in the skin of Rana temporaria. Comp. Biochem. Physiol. 14, 43 (1965).CrossRefGoogle Scholar
  3. Bertaccini, G., J. M. Cei, and V. Erspamer: Occurrence of physalaemin in extracts of the skin of Physalaemus fuscumaculatus and its pharmacological actions on extravascular smooth muscle. Brit. J. Pharmacol. 25, 363 (1965a).Google Scholar
  4. Bertaccini, G., J. M. Cei, and V. Erspamer: The action of physalaemin on the systemic arterial blood pressure of some experimental animals. Brit. J. Pharmacol. 25, 380 (1965b).Google Scholar
  5. Erspamer, V., G. Bertaccini, and J. M. Cei: Occurrence of an eledoisin-like polypeptide (physalaemin) in skin extracts of Physalaemus fuscumaculatus. Experientia (Basel) 18, 562 (1962).CrossRefGoogle Scholar
  6. Haefely, W., and A. Hürlimann: Substance P, a highly active naturally occurring polypeptide. Experientia (Basel), 18, 297 (1962).CrossRefGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1966

Authors and Affiliations

  • V. Erspamer
    • 1
    • 2
  • A. Anastasi
    • 1
    • 2
  1. 1.Institute of PharmacologyUniversity of ParmaItaly
  2. 2.Farmitalia Research LaboratoriesMilanItaly

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