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Contribution to the Sedative Action of Substance P

  • P. Stern
Conference paper

Abstract

We (Stern and Dobrić, 1957b), have put forward the hypothesis that substance P (SP) is a physiological tranquilizer. This was based particularly on the work of Zetler (1956a), and of Euler and Pernow (1956). Moreover, we were able to demonstrate some synergism between SP and mephenesin (Stern et al., 1957), and other central relaxants (Stern and Dobrić, 1957b). Some of our experiments support this hypothesis. Thus, SP tranquilizes Betta splendens fishes (Stern and Huković, 1958) and wild rabbits (Stern and Milin, 1957), ana suppresses the psychomotor anxiety produced by iminodipropionitrile (Stern and Dobric, 1957a). This view is also supported by findings of Krivoy and Kroeger (1963). During this period, Franz et al. (1961) isolated SP of a purity of 30,000 µ/mg. Even purer SP was prepared by Zuber and Jaques (1962) and by Vogler et al. (1962).Purity was assessed by the contraction of the guinea pig ileum in the presence of antagonists of acetylcholine, histamine, and serotonin. Haefely et al. (1962) injected SP of a purity of 24,000 µ/mg into the ventricles of cats, and even purer SP into mice parenterally, without obtaining a sedative effect.

Keywords

Sedative Effect Sedative Action Wild Rabbit Central Relaxant Betta Splendens 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag New York Inc. 1966

Authors and Affiliations

  • P. Stern
    • 1
  1. 1.Department of PharmacologyMedical FacultySarajevoYugoslavia

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