Pharmacologically Active Peptides in Trypanosome Infections

  • L. G. Goodwin
  • P. F. L. Boreham


The parasitic trypanosomes cover the whole range from harmless commensals to dangerous pathogens. They are motile, relatively large protozoa which are not difficult to separate from the blood of the host; they contain and produce antigens which provoke varying degrees of antibody response.


Active Peptide Trypanosoma Brucei Kinin Activity Histamine Content Trypanosome Infection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Amundsen, E., and H. E. Rugstad: Influence of some pathogenic bacteria on kinin formation and destruction. Brit. J. Pharmacol. 25, 67 (1965).Google Scholar
  2. Boreham, P. F. L.: Pharmacologically active peptides produced in the tissues of the host during chronic tyrpanosome infections. Nature (Lond.), in press (1965).Google Scholar
  3. Feldberg, W., and G. P. Lewis: The action of peptides on the adrenal medulla. Release of adrenaline by bradykinin and angiotensin. J. Physiol. (Lond.) 171, 98 (1964).Google Scholar
  4. Goodwin, L. G., and W. H. G. Richards: Pharmacologically active peptides in the blood and urine of animals infected with Babesia rodhaini and other pathogenic organisms. Brit. J. Pharmacol. 15, 152 (1960).Google Scholar
  5. Goodwin, L. G., C. R. Jones, W. H. G. Richards, and J. Kohn: Pharmacologically active substances in the urine of burned patients. Brit. J. exp. Path. 44, 551 (1963).Google Scholar
  6. Gray A. R.: The influence of antibody on serological variation in Trypanosoma brucei. Ann, trop. Med. Parsit. 56, 4 (1962).Google Scholar
  7. Jackson, S. H.: The urinary excretion of free and peptide amino acids by a patient with thermal burns. Clin, chim. Acta 12, 389 (1965).Google Scholar
  8. Maegraith, B. G., K. Devakul, and C. S. Leithead: Action of noradrenaline in medical shock in Plasmodium knowlesi malaria. Trans. roy. Soc. trop. Med. Hyg. 50, 311 (1956).Google Scholar
  9. Maegraith, B. G., H. M. Gilles, and K. Devakul: Pathological processes in Babesia canis infection. Z. Tropenmed. Parasit. 8, 485 (1957).Google Scholar
  10. Richards, W. H. G.: Pharmacologically active substances in the blood, tissues and urine of mice infected with Trypanosoma brucei. Brit. J. Pharmacol. 24, 124 (1965).Google Scholar
  11. Weitz, B: The properties of some antigens of Trypanosoma brucei. J. gen. Microbiol. 23, 589 (1960).Google Scholar

Copyright information

© Springer-Verlag New York Inc. 1966

Authors and Affiliations

  • L. G. Goodwin
    • 1
  • P. F. L. Boreham
    • 1
  1. 1.Nuffield Institute of Comparative MedicineThe Zoological Society of LondonLondonEngland

Personalised recommendations