The Search for Peptides with Specific Antibradykinin Activity
Bradykinin and other related kinins present to the pharmacologist a complex and sometimes confusing spectrum of activities. The biochemical mechanisms by means of which these effects are produced are as yet unknown. The use of specific antimetabolites has in the past provided much insight into the mode of action of a number of biologically important substances. Work in this laboratory has been directed toward the goal of the design and synthesis of specific antimetabolites of bradykinin in the hope that these antimetabolites might be used to clarify some of the present uncertainties about the mode of action of that hormone. In addition, such specific antimetabolites might be useful in those clinical conditions that are characterized by the production of excessive amounts of bradykinin.
KeywordsCorrect Amino Acid Abnormal Amino Acid Bradykinin Activity Bradykinin Analog Italicize Residue
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