The Physiology of growth Hormone

Sirek, Otakar V.; Sirek, Anna

doi:10.1007/978-3-642-94886-2_5

Otakar V. Sirek &
Anna Sirek

Part of the book series: Ergebnisse der Inneren Medizin und Kinderheilkunde ((KINDERHEILK. NF,volume 21))

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2 Citations

Abstract

The presence of a substance in the human body capable of producing growth was already anticipated in the later part of the nineteenth century (c. f. Raben 1959). The actual proof that the pituitary gland is manufacturing a growth- promoting principle, however, was not brought until 1921, when Evans and Long injected a crude alkaline extract from this gland into young rats and produced experimental giantism. The metabolic effects of crude and partially purified extracts obtained from anterior lobes of the pituitary glands revealed the existence of intricate hormonal relationships and it became possible to study these more specifically when the first highly purified bovine growth hormone was prepared by Li, Evans and Simpson (1945). The work of Houssay (1936, 1942) has made us appreciate the role of the pituitary in carbohydrate metabolism and has focussed attention on the relationship of growth hormone to insulin. The me-chanism by which pancreatic diabetes is alleviated by hypophysectomy, the so- called ‘‘Houssay phenomenon”, has not been satisfactorily explained until the present day. While this and other aspects of the growth hormone problem have fascinated the experimentalist, the clinical investigator could take no more than an academic interest in the matter for many years. The metabolic effect of bovine and porcine growth hormones, so profound in the common laboratory animal like the rat, dog and cat, could not be duplicated in the human species. With a few exceptions (Carballeira et al. 1952; SHORR et al. 1955), administration of bovine growth hormone to man led to a negative nitrogen balance and prolonged administration produced hypersensitivity reactions.

Department of Physiology of the University of Toronto, Toronto, Canada.

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Otakar V. Sirek
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Anna Sirek
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Freiburg i.Br., Deutschland
L. Heilmeyer
Göttingen, Deutschland
R. Schoen
Zürich, Switzerland
A. Prader

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Sirek, O.V., Sirek, A. (1964). The Physiology of growth Hormone. In: Heilmeyer, L., Schoen, R., Prader, A. (eds) Ergebnisse der Inneren Medizin und Kinderheilkunde. Ergebnisse der Inneren Medizin und Kinderheilkunde, vol 21. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-94886-2_5

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DOI: https://doi.org/10.1007/978-3-642-94886-2_5
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