Advertisement

Aktuelle Probleme antikörperbedingter hämolytischer Erkrankungen

  • A. Marmont
Part of the Freiburger Symposion an der Medizinischen Universitäts-Klinik book series (FREIBURGER, volume 7)

Zusammenfassung

Es sind ohne Zweifel die erworbenen hämolytischen Anämien mit inkompletten Wärmeautoantikörpern (I.W.A.) die bedeutendste Kategorie der sogenannten Autoimmunerythropathien. Das erste noch ungelöste sowie prägnante Problem bildet unbedingt die Ätiopathogenese der sogenannten idiopathischen Formen: handelt es sich um eine echte Autoimmunisierung oder um eine primäre endogene Partialmodifikation der Eiweißkörperbildung im Sinne einer Paraproteinämie Es ist sicher, daß eine Reihe biologischer Aspekte der Antikörperbildung, wie die Temperatur- und Zeitbindungskurven, die Eluierbarkeit, Opsonierung usw. (Schubothe, 1958, 1959) bei den sogenannten Autoantikörpern streng ihrem immunologischen Prototyp, den inkompletten Isoantikörpern, entsprechen. Aber was kann z. B. die Beobachtung Pirofskys (1958) bedeuten, daß die immunologische Kombination zwischen eluierten Autoantikörpern und Antiglobulinseren nur dann stattfindet, wenn die Autoantikörper auf ihren Antigenen, also den Erythrocyten, fixiert sind ? Das ist nicht der Fall mit den Isoantikörpern und erinnert etwa an den Rheumafaktor, bei dem ebenfalls die Demaskierung der reaktiven Gruppen des γ-Globulinmoleküls durch dessen Fixierung an das Antigen ein erforderlicher Faktor für die definitive Reaktion ist (Christian, 1958; Kunkel, 1959; Vaughan, 1959).

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Aubert, A., and O. J. Brendemoen: Acquired hemolytic anaemia and lymphoblastoma. Scand. J. clin. Lab. Invest. 1, 95 (1949).CrossRefGoogle Scholar
  2. Baldini, M., e I. Pannacciulli: La cultura in vitro dei reticolociti nello studio di alcuni problemi di fisiopatologia ematologica. Atti XI Congr. Soc. It. Ematol., E.M.E.S. Roma 1953.Google Scholar
  3. Bartholomew, L. G., A. B. Hagedorn, J. C. Cain and A. H. Baggenstoss: Hepatitis and cirrhosis in women with positive clot tests for lupus eythematosus. New Engl. J. Med. 259, 947 (1958).Google Scholar
  4. Bearne, A. G., H. G. Kunkel and R. J. Slater: The problem of liver disease in young women. Amer. J. Med. 21, 3 (1956).CrossRefGoogle Scholar
  5. Beickert, A.: Immunologisch bedingte, chronische hämolytische Anämie als Frühsymptom eines Lupus erythematosus disseminatus. Z. ges. inn. Med. 11, 50 (1956a).PubMedGoogle Scholar
  6. Beickert, A.: Eine aregeneratorische Variante der chronischen erworbenen hämolytischen Anämie vom Typ Loutit. Klin. Wschr. 34, 195 (1956b).PubMedCrossRefGoogle Scholar
  7. Beickert, A.: Die hämolytische Verlaufsform der chronischen lymphatischen Leukämie. Munch. med. Wschr. 101, 2067 (1959).PubMedGoogle Scholar
  8. Bernard, J.: Hémopathies avec auto-anticorps; in Les acquisitions médicales récentes. S. 211. Paris: Flammarion 1956.Google Scholar
  9. Bonham-Carter, R. E., J. A. B. Cathie and C. Gasser: Aplastische Anämie (chronische Erythroblastophthise) bedingt durch Autoimmunisierung. Schweiz. med. Wschr. 84, 1114 (1954).PubMedGoogle Scholar
  10. Brady, J. H., and W. S. Neal: Splenectomy in case of disseminated lupus erythematosus with thrombocytopenic purpura. Calif. Med. 68, 448 (1958).Google Scholar
  11. Burnet, M.: Autoimmune disease. Brit. med. J. 2, 645 (1959a).PubMedCrossRefGoogle Scholar
  12. Burnet, M.: Autoimmune disease. Brit. med. J. 2, 720 (1959b).PubMedCrossRefGoogle Scholar
  13. Callender, S. T., and R. R. Race: A serological and genetical study of multiple antibodies formed in response to blood transfusion by a patient with lupus erythematosus diffusus. Ann. Eugen. (Loud.) 13, 102 (1946–1947).Google Scholar
  14. Castle, W. B.: Bemerkungen zum Artikel Giblett u. Mitarb.: Yearbook of Medicine 1957–1958. S. 292. Chicago: Yearbook Publ. 1958.Google Scholar
  15. Chonos, R. B.: Clinical application of radioiron and radiochromium in the diagnosis and management of anemias. Proc. Sixth Congr. Int. Soc. Hematol. New York: Grune & Stratton 1958.Google Scholar
  16. Christian, C. L.: Characterization of the “reactant” (gamma globulin factor) in the F II precipitin reaction and in the F II tanned sheep cell agglutination test. J. exp. Med. 108, 139 (1958).PubMedCrossRefGoogle Scholar
  17. Clough, P. W.: Recent observations regarding the pathogenesis and treatment of acquired hemolytic anemia. Ann. intern. Med. 46, 819 (1957).PubMedGoogle Scholar
  18. Cregei W. C., S. H. Choy and L. A. Rantz: Experimental determination of hypersensitive diathesis in man. J. Immunol. 66, 445 (1951).Google Scholar
  19. Cregei., W. C., E. H. Tulley and D. G. Hansen: A note on the effect of hydrocortisone on the microelectrophoretic characteristics of human red cell-antibody unions. J. Lab. clin. Med. 47, 686 (1956).Google Scholar
  20. Crosby, W. H.: Diskussionsbemerkung. Acta haemat. (Basel) 29, 146 (1958).Google Scholar
  21. Crosby, W. H.: Hemolytic anemia-aspects of treatment. 7th-Congr. int. Soc. Hematology. Rome 1958.Google Scholar
  22. Crosby, W. H.: Normal functions of the spleen relative to red blood cells: a review. Blood 14, 399 (1959).PubMedGoogle Scholar
  23. Crosby, W. H. and H. Rappaport: Reticulocytopenia in autoimmune hemolytic anemia. Blood 11, 929 (1956).PubMedGoogle Scholar
  24. Crosby, W. H. and H. Rappaport: Autoimmune hemolytic anemia: II. Morphologic observations and clinicopathologic correlations. Amer. J. Path. 33, 429 (1957).PubMedGoogle Scholar
  25. Dacie, J. V.: Auto-immune haemolytic anaemias. Acta haemat. (Basel) 20, 131 (1958).CrossRefGoogle Scholar
  26. Dacie, J. V.: Acquired haemolytic anemias. Brit. med. Bull. 15, 67 (1959).PubMedGoogle Scholar
  27. Dameshek, W.: Systemic lupus erythematosus: a complex autoimmune disorder. Ann intern. Med. 48, 717 (1958).Google Scholar
  28. Dameshek, W. and W. H. Reeves: Exacerbation of lupus erythematosus following splenectomy in idiopathic thrombocytopenic purpura, and autoimmune hemolytic anemia. Amer. J. Med. 21, 560 (1956).PubMedCrossRefGoogle Scholar
  29. Dameshek, W., F. Rubio, J. P. Mahoney and W. H. Reeves: Treatment of idiopathic thrombocytopenic purpura (IPT) with prednisone. J. Amer. med. Ass. 166, 1805 (1958).CrossRefGoogle Scholar
  30. Davis, L. J., A. C. Kennedy, A. G. Baikie and A. Brown: Haemolytic anaemias of various types treated with ACTH and cortisone. Report of ten cases, including one of acquired type in which erythropoetic arrest occurred during a crisis. Glasg. med. J. 33, 263 (1952).Google Scholar
  31. Doan, C. A., B. A. Bouroncle and B. K. Wiseman: Hypersplenic cytopenic syndromes: a 25 year experience with special reference to splenectomy. Proc. VI Congr. Int. Soc. Hematol. New York: Grune & Stratton 1958.Google Scholar
  32. Draper, L. R., and D. H. Süssnorf: The serum hemolysin response in intact and splenectomized rabbits following immunization by various routes. J. infect. Dis. 100, 147 (1957).PubMedCrossRefGoogle Scholar
  33. Dubois, E. L.: Acquired hemolytic anemia as the presenting syndrome of lupus erythematosus. Amer. J. Med. 12, 197 (1952).PubMedCrossRefGoogle Scholar
  34. Ehrich, W. E.: Nature of collagen diseases. Amer. Heart J. 43, 121 (1952).PubMedCrossRefGoogle Scholar
  35. Eiseman, G., and W. Dameshek: Splenectomy for pure red cell hypoplastic (aregenerative) anemia associated with autoimmune hemolytic disease; report of a case. New Engl. J. Med. 251, 1044 (1954).CrossRefGoogle Scholar
  36. Emlinger, P. J., R. L. Huff, C. A. Tobias and J. H. Lawrence: Iron turnover abnormalities in patients having anemia: serial blood and in vivo tissue studies with Fe 59. Acta haemat. (Basel) 9, 73 (1953).CrossRefGoogle Scholar
  37. Fieschi, A., I. Pannacciulli and A. Tizianello: L’impiego di emazie marcate con Cr 51 nello studio della splenomegalia e delle sedi dell’emocateresi. Minerva nucleare (Torino) 3, 85 (1959).Google Scholar
  38. Fieschi, A., A. Tizianello and I. Pannacciulli: La captazione spleno-epatica di globuli rossi targati con cromo radioattivo valutata mediante scintillatori direzionali. Minerva med. (Torino) 49, 1101 (1958).Google Scholar
  39. Fudenberg, H. H., I. Barry and W. Dameshek: The erythrocyte-coating substance in autoimmune hemolytic disease: its nature and significance. Blood 13, 201 (1958).PubMedGoogle Scholar
  40. Fudenberg, H. H., J. G. German and H. G. Kunkel: A study of rheumatoid and L. E. factors in relatives of patients with agammaglobulinemia and hypogammaglobulinemia. Im Druck [ref. von H. G. Kunkel: J. chron. Dis. 10 418 (1959)].Google Scholar
  41. Fusco, F.: L’anemia emolitica da autoimmunizzazione nella leucemia linfatica cronica. Arch. E. Maragliano Pat. Clin. 10, 755 (1955).Google Scholar
  42. Gajdusek, C. D.: An “autoimmune” reaction against human tissue antigens in certain acute and chronic diseases. I. Serological investigations. Arch. intern. Med. 101, 9 (1958).CrossRefGoogle Scholar
  43. Gasser, C.: Pure red cell anemia due to autoantibodies. Sang 26, 6 (1955).PubMedGoogle Scholar
  44. Goon, R. A.: Studies on agammaglobulinemia and hypogammaglobulinemia. In “Immun-pathology”, 1st Symposium, Basel-Seelisberg 1958. S. 41. Basel: Schwabe 1959.Google Scholar
  45. Goon, R. A., J. Rotstein and W. F. Mazzitello: The simultaneous occurrence of rheumatoid arthritis and agammaglobulinemia. J. Lab. clin. Med. 49, 343 (1957).Google Scholar
  46. Goodman, H. C., J. L. Fahey, R. A. Malmgren and G. Brecher: Separation Of factors in lupus erythrematosus serum reacting with components of cell nuclei. Lancet 1959II, 382.Google Scholar
  47. Gordon, L., and L. A. Löwenstein: A case of acquired hemolytic anemia with features resembling lupus erythematosus. Canad. med. Ass. J. 73, 207 (1955).Google Scholar
  48. Harders, H.: Zur Frage der Autoantikörper. Klin. Wschr. 32, 770 (1954).PubMedCrossRefGoogle Scholar
  49. Hargraves, M. M., and R. W. Opfell: Systemic lupus erythematosus and the blood. In “Progress in Hematology”. S. 249. New York-London: Grune & Stratton 1956.Google Scholar
  50. Heilmeyer, L.: Steuerungsreaktionen bei der Entzündung. I. Int. Symp Immunpathology, Basel-Seelisberg 1958. S. 191. Basel-Stuttgart: Schwabe 1959.Google Scholar
  51. Hollander, L., u. E. Batschelet: Beitrag zur Frage der Spezifität antierythrocytärer Autoantikörper. Proc. 6th Congr. Europ. Soc. Haematology, Kopenhagen 1957. S. 680. Basel: Karger 1958.Google Scholar
  52. Holman, H.: Serological studies in families of patients with lupus erythematosus. Im Druck [ref. von H. G. KUNKEL: J. chron. Dis. 10, 418 (1959)].Google Scholar
  53. Holman, H. and H. R. Deicher: The reaction of the lupus erythematosus (L.E.) cell factor with deoxyribonucleoprotein of the cell nucleus. J. Clin. Invest. 38, 2059 (1959).PubMedCrossRefGoogle Scholar
  54. Holman, H., H. R. G. Deicher and H. G. Kunkel: The L. E. cell and the L. E. serum factors. Bull. N. Y. Acad. Med. 35, 409 (1959).PubMedGoogle Scholar
  55. Hughes-Jones, N. C., and L. Szur: Determination of the site of red cell destruction using chromium 51 labelled cells. Brit. J. Haematol. 3, 320 (1957).CrossRefGoogle Scholar
  56. Introzzi, P.: Allgemeine Pathologie der Milz. In Heilmeier-Hittmair: Handbuch der gesamten Hämatologie. München: Urban & Schwarzenberg 1957.Google Scholar
  57. Jandl, J. H.: Observations on the pathway of destruction of red cells sensitized with incomplete antibodies. Proc. Sixth Congr. Soc. Int. Hematol. New York: Grune & Stratton 1958.Google Scholar
  58. Jandl, J. H., M. S. Greenberg, R. H. Yonemoto and W. B. Castle: Clinical determination of the sites of red blood cell sequestration in hemolytic anemias. J. Clin. Invest. 35, 842 (1956).PubMedCrossRefGoogle Scholar
  59. Janeway, C. A., D. Gitlin, J. M. Craig and D. S. Grice: Collagen disease in patients with congenital agammaglobulinemia. Trans. Ass. Amer. Phycns. 69, 93 (1956).Google Scholar
  60. Kaiser, I. H.: The specificity of periarterial fibrosis of the spleen in disseminated lupus erythematosus. Bull. Johns Hopk. Hosp. 71, 13 (1942).Google Scholar
  61. Korst, D. R., D. V. Klatanoff, and R. F. Schilling: External scintillation counting over the liver and spleen after the transfusion of radioactive erythrocytes. Clin. Res. Proc. 3, 195 (1955).Google Scholar
  62. Kosenow, W.: Lebende Blutzellen in Fluorescenz-and Phasenkontrastmikroskop. Basel-New York: Karger 1956.Google Scholar
  63. Kuhns, W. J., and T. C. Bauerlein: Exchange transfusion in hemolytic anemia complicating disseminated lupus erythematosus: report of a case of acquired hemolytic disease associated with rare blood group antibodies following whole blood transfusions. Arch. intern. Med. 92, 284 (1953).CrossRefGoogle Scholar
  64. Kunkel, H. G.: Immunologic aspects of rheumatoid arthritis. J. chron. Dis. 10, 418 (1959).CrossRefGoogle Scholar
  65. Kyle, R. A., J. M. Kiely and J. M. Stickney: Acquired hemolytic anemia in chronic lymphocytic leukemia and the lymphomas. Survival and response to therapy in 27 cases. Arch. intern. Med. 104, 61 (1959).CrossRefGoogle Scholar
  66. Lawrence, J. S., and J. Ball: Genetic studies on rheumatoid arthritis. Ann rheum. Dis. 17, 160 (1958).PubMedCrossRefGoogle Scholar
  67. Lee, S. L., and B. J. Davis: The blood in systemic lupus eythematosus. In Baehr-Klemperer: “Systemic lupus erythematosus”. New York: Grune & Stratton 1959.Google Scholar
  68. Leonhardt, T.: Familial hypergammaglobulinaemia and systemic lupus erythematosus. Lancet 1957II, 1200.Google Scholar
  69. Mackay, I. R., and C. Gajdusek: An “autoimmune” reaction against human tissue antigens in certain acute and chronic diseases. II. Clinical correlations. Arch. intern. Med. 101, 30 (1958).CrossRefGoogle Scholar
  70. Marcolongo, F.: Anemie emolitiche acquisite da autoimmunizzazione. Recenti Progr. Med. 15, 137 (1953).Google Scholar
  71. Marcolongo, F.: La milza nelle anemie emolitiche acquisite autoimmuni. In Cassano: „Splenopatie“. Roma: Pensiero Scientifico 1959.Google Scholar
  72. Marmont, A.: I fenomeni di autoaggressione nelle malattie del collageno. Atti II Convivio Internaz. „D. Ganassini“. Milano 1957.Google Scholar
  73. Marmont, A.: Immunoematologia. In „Attualita“ in Ematologia. Roma: Abruzzini 1958.Google Scholar
  74. Marmont, A.: La milza nel quadro delle malattie da autoaggressione. Atti Giorn. Med. Internaz. Verona, 1.-4. Oktober 1959.Google Scholar
  75. Marmont, A.: Acridine orange fluorescence microscopy in haematology. Proc. VII Europ. Congr. Haematol. London 7.-12. Sept. 1959. ( Im Druck).Google Scholar
  76. Marmont, A. e E. Damasio: Il quadro immunologico del lupus eritematoso sistemico, con particulare riguardo al fattore L. E. VII Giornate Reumatologiche Romane, Roma, 20. März 1960. (In Vorbereitung).Google Scholar
  77. Marmont, A. e F. Fusco: Nuovi steroidi cortisonici ed anemie emolitiche acquisite. Minerva Med. (Torino) 47, 1679 (1956II).Google Scholar
  78. Marmont, A.: Sistema reticoloendoteliale, cortisonici ed emopatie autoimmuni. Arch. E. Maragliano Pat. Clin. 14, 1529 (1958).Google Scholar
  79. Marmont, A.: Perspectives on the role of the reticuloendothelial system (RES) in the steroid-induced remissions of autoimmune blood disorders, with special regard to acquired hemolytic anemias. Reticuloendothelial structure and function. S. 373. New York: Ronald Resa 1960.Google Scholar
  80. Marmont, A. e B. Fazio: Le anemie autoimmunoemolitiche delle linfoadenosi leucemiche croniche. Folla allerg. (Roma) 2, 17 (1955).Google Scholar
  81. Marmont, A., F. de Matteis and L. Mariotti: Observations biomicroscopiques sur la circulation conjonctivale dans la cryoagglutininémie chronique à hauts titres et dans les états conditionnant le phénomène du sludged blood“. Schweiz. med. Wschr. 85, 902 (1955).PubMedGoogle Scholar
  82. M. A. Piuma, C. A. Negrini and E. Maietta: La polyérythrophagocytose: un nouveau type de phagocytose simultanée immunologique des globules rouges par les histiocytes des épanchements. Séreux. Schweiz. med. Wschr. 88, 1064 (1958).Google Scholar
  83. Meacham, G. C., and A. S. Weisberger: Unusual manifestations of disseminated lupus erythematosus. Ann intern. Med. 43, 143 (1955).PubMedGoogle Scholar
  84. Miescher, P.: Hypersplénie. Helv. med. Acta 23, 457 (1956).PubMedGoogle Scholar
  85. Miescher, P. and R. Straessle: The pathogenesis of visceral lupus erythematosus as reflected in the sero-reactions. I. Int. Symp. Immunopathology, Basel-Seelisberg. S. 4M. 1958. Basel: Schwabe 1959.Google Scholar
  86. Moesohlin, S.: Physiopathologie des Hypersplenismus. Heiv. med. Acta 23, 416 (1956).Google Scholar
  87. Moesohlin, S.: Die Auto-Immunerkrankungen (Autoaggressionskrankheiten). Acta haemat. (Basel) 18, 13 (1957).CrossRefGoogle Scholar
  88. Mollison, P. L.: Measurement of survival and destruction of red cells in haemolytic syndromes. Brit. med. Bull. 15, 59 (1959).PubMedGoogle Scholar
  89. Oettgen, F., and M. Kindler: Die chronische erworbene hämolytische Anämie. Klinische und immunologirche Untersuchungen an 47 Fällen. Folia haemat. 4, 22 (1959).PubMedGoogle Scholar
  90. Pirofsky, B.: Immunologic differences between iso-antibodies and auto-antibodies. Amer. J. clin. Path. 29, 120 (1958).Google Scholar
  91. Rejiiolec, V.: Remarque sur la pathogénie des maladies d’auto-immunisation. Sang 28, 320 (1957).Google Scholar
  92. Rhumbler, L.: Das Protoplasma als physikalisches System. Ergebn. Physiol. 14, 474 (1924).CrossRefGoogle Scholar
  93. Rosenthal, M. C., A. V. Pisciotta, Z. D. Komninos, H. Goldenberg and W. Dameshek: The autoimmune hemolytic anemia of malignant lymphocytic disease. Blood 10, 197 (1955).PubMedGoogle Scholar
  94. Rowley, D. A.: The formation of circulating antibody in the splenectomized human beings following intravenous injection of heterologous erythrocytes. J. Immunol. 65, 515 (1950).PubMedGoogle Scholar
  95. Sacchetti, C., V. Rossi and F. Diena: Behaviour of erythroblasts in vitro from cases of acquired haemolytic anaemia. Brit. J. Haemat. 4, 416 (1958).PubMedCrossRefGoogle Scholar
  96. Sarles, H. E., and W. C. Levin: The role of splenectomy in the management of acquired autoimmune hemolytic anemia complicating systemic lupus erythematosus. Amer. J. Med. 26, 547 (1959).PubMedCrossRefGoogle Scholar
  97. Schubothe, H.: Serologie und klinische Bedeutung der Autohämantikörper. Basel-New York: Karger 1958.Google Scholar
  98. Schubothe, H.: Serologie und Klinik der autoimmunhämolytischen Erkrankungen. Ergebn. inn. Med. Kinderheilk. 11, 466 (1959).PubMedGoogle Scholar
  99. Seif, M.: Aplastic crisis in a case of immunohemolytic anemia. Acta med. stand. 153, 137 (1955).Google Scholar
  100. Seligmann, M.: tudes immunologiques sur le lupus érythémateux disséminé. Rev. franç. Et. clin. biol. 3, 558 (1958).Google Scholar
  101. Steffen, C.: Untersuchung und Betrachtung der rheumatischen Erkrankung als Auto-Aggressionskrankheit im Zusammenhang mit dysregulierten Abwehrsystemen. Acta neuroveg. (Wien) 12, 154 (1955).Google Scholar
  102. Steffen, C.: Das Problem der Autoaggression. Wien. klin Wschr. 68, 865 (1956).PubMedGoogle Scholar
  103. Storti, E., F. Vaccari and E. Baldini: Changes in red cells’ metabolism in the presence of incomplete antibodies. Experientia (Basel) 12, 108 (1956).CrossRefGoogle Scholar
  104. Szilard, L.: On the nature of the aging progress. Proc. nat. Acad. Sci. (Wash.) 45, 30 (1959).CrossRefGoogle Scholar
  105. Tizianello, A., and I. Pannacciulli: The effect of splenomegaly on dilution curves of tagged erythrocytes and red blood cell volume. Comparative studies on normal, anaemic and splenomegalic patients. Acta haemat. (Basel) 21, 346 (1959).CrossRefGoogle Scholar
  106. Vaughan, J. H.: Serum responses in rheumatoid arthritis. Amer. J. Med. 26, 596 (1959).PubMedCrossRefGoogle Scholar
  107. Vaughan, J. H. and R. A. Goon: Relation of “agammaglobulinemia” sera to agglutination reactions. Arthritis a. Rheumatism. 1, 99 (1958).CrossRefGoogle Scholar
  108. Waller, R. K., and R. R. Race: Six blood group antibodies in the serum of a transfused patient. Brit. med. J. 1951I, 225.Google Scholar
  109. Wasastjerna, C.: Immunohemolytic mechanisms in vivo. The mode of destruction of sensitized red cells in the living organism. Blood 8, 1042 (1953).PubMedGoogle Scholar
  110. Weiner, W.: To be or not to be an antibody: the “agent” in autoimmune hemolytic anemia. Blood 14, 1057 (1959).PubMedGoogle Scholar
  111. Wiener, A. S., E. G. Gordon and C. Gallop: Studies on autoantibodies in human sera. J. Immunol. 72, 58 (1953).Google Scholar
  112. Witebsky, E.: Clinical significance of autosensitisation to thyroglobulin. Proc. Int. Symp. of Immunopathology, Seelisberg 1958. S. 162. Basel: Schwabe 1959.Google Scholar
  113. Witebsky, E., N. Rose, K. Terplan and J. R. Payne: Chronic thyroiditis and autoimmunisation. J. Amer. med. Ass. 164, 1439 (1957).CrossRefGoogle Scholar
  114. Ziff, M., F. R. Schmid, A. J. Lewis and M. Tanner: Familial occurrence of the rheumatoid factor. Arthritis and Rheumatism. 1, 392 (1958).PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag OHG. Berlin · Göttingen · Heidelberg 1961

Authors and Affiliations

  • A. Marmont
    • 1
  1. 1.GenuaItalien

Personalised recommendations