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The nature of the erythrocyte defect and the haemolytic mechanism in hereditary spherocytosis and hereditary nonspherocytic haemolytic anaemia

  • T. A. J. Prankerd
Part of the Freiburger Symposion an der Medizinischen Universitäts-Klinik book series (FREIBURGER, volume 7)

Abstract

Crosstransfusion experiments have shown that in the group of haemolytic anaemias which appear to be congenital the defect causing haemolysis resides in the cell. It is my purpose to consider what we know of defects in red cells which may be transmitted within families and lead to premature red cell destruction, leaving aside the disorders due to chemical abnormalities in haemoglobin structure. The anaemias, therefore, with which I shall be concerned are those usually known as the hereditary spherocytic and nonspherocytic anaemias.

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References

  1. Emerson, C. P., S. C. Shen, T. H. Ham and W. B. Castle: The mechanism of blood destruction in congenital haemolytic jaundice. J. clin. Invest. 29, 1180 (1947).Google Scholar
  2. Ham, T. H., S. C. Shen, E. M. Flemming and W. B. Castle: Studies on the destruction of red cells. IV. Thermal Injury. Blood 3, 373 (1948).PubMedGoogle Scholar
  3. Maizels, M.: The anion and cation contents of normal and anaemic bloods. Biochem. J. 30, 821 (1936).PubMedGoogle Scholar
  4. Prankerd, T. A. J.: Studies on the pathogenesis of haemolysis in hereditary spherocytosis. Quart. J. Med. 29, 160 (1960).Google Scholar
  5. Prankerd, T. A. J., K. I. Altman and L. E. Young: Abnormalities of carbohydrate metabolism of red cells in hereditary spherocytosis. J. clin. Invest. 34, 1268 (1955).PubMedCrossRefGoogle Scholar
  6. Tabechian, H., K. I. Altman and L. E. Young: Inhibition of p32 orthophosphate exchange by sodium fluoride in erythrocytes from patients with hereditary spherocytosis. Proc. Soc. exp. Biol. (N. Y.) 92, 712 (1956).Google Scholar

Copyright information

© Springer-Verlag OHG. Berlin · Göttingen · Heidelberg 1961

Authors and Affiliations

  • T. A. J. Prankerd
    • 1
  1. 1.LondonUK

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