Skip to main content
SpringerLink
Log in
Book cover

Ergebnisse der Inneren Medizin und Kinderheilkunde pp 321–389Cite as

Moderne Gichtprobleme Ätiologie, Pathogenese, Klinik

  • Conference paper

Part of the book series: Ergebnisse der Inneren Medizin und Kinderheilkunde ((KINDERHEILK. NF,volume 14))

Zusammenfassung

Die Gicht, in Zeiten der Not selten, begegnet uns heute wieder häufig. Wie alle Stoffwechselkrankheiten scheint sie experimentellen Untersuchungen besonders leicht zugänghch zu sein, und die Zahl der einschlägigen Publikationen hat in den letzten fünfzehn Jahren wieder rasch zugenommen.

Viele neue Tatsachen wurden bekannt. Eine klare Einsicht in das Wesen der gichtischen Stoffwechselstörung ist aber nicht erlangt.

C. Von Noorden 1907

Aus der Medizinischen Poliklinik der Universität München (Direktor: Prof. Dr. Walter Seitz)

Siegfried J. Thannhauser in Verehrung und Freundschaft zum 75. Geburtstag.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Achenbach, W.: Aurpische Polyzythämie, Myelosklerose und Gicht. Medizinische 1955, 807.

    Google Scholar 

  2. Adler, M., B. Weissmann and A. B. Gutman: Occurrence of methylated purine bases in yeast ribonucleic acid. J. biol. Chem. 230, 717 (1958).

    PubMed  CAS  Google Scholar 

  3. Agner, K.: Effect of uric acid on the peroxidative detoxification of diphtheria toxin. Fed. Proc. 8, 178 (1949).

    Google Scholar 

  4. Almagia, M.: Über das Absorptionsvermögen der Knorpelsubstanz für Harnsäure. Hofm. Beitr. 7, 466 (1906).

    Google Scholar 

  5. Baldini, M.: Persönliche Mitt.

    Google Scholar 

  6. Barrick, L. E., and J. R. Miller: Gout. Quart. Bull. Northw. Univ. med. Sch. 17, 133 (1943).

    Google Scholar 

  7. Bartels, E. C.: Gout - now amenable to control. Ann. intern. Med. 42, 1 (1955).

    PubMed  CAS  Google Scholar 

  8. Bartlett, G. R.: Human red cell glycolytic intermediates. J. biol. Chem. 234,449 (1959).

    PubMed  CAS  Google Scholar 

  9. Bauter, W., E. Calkins., and Gout, Yü: Diseases of Metabolism, p.643, Philadelphia and London: Garfield, G. D., ed., Saunders and Co. 1959.

    Google Scholar 

  10. Bauter, W and P. Klemperer: The treatment of gout. New Engl. J. Med. 231, 681 (1944).

    Google Scholar 

  11. Bauter, W and M. M. Singh: Management of gout. New Engl. J. Med. 256, 171, 214 (1957).

    Google Scholar 

  12. Bearn, A. O., T. p. Yü and a. B. Gftman: Renal function in Wilson’s disease. J. clin. Invest. 36, 1107 (1957).

    PubMed  CAS  Google Scholar 

  13. Benedict, J. D., P. H. Porsham and D. Stetten Jr.: The metabolism of uric acid in the normal and gouty human, studied with the aid of isotopic uric acid. J. biol. Chem. 181, 183 (1949).

    PubMed  CAS  Google Scholar 

  14. Benedict, J. D., P. H. Porsham, M. Roche, S. Soloway and D. Stetten Jr.: The effect of salicylates and adrenocorticotropic hormone upon the miscible pool of uric acid in gout. J. clin. Invest. 29, 1104 (1950).

    PubMed  CAS  Google Scholar 

  15. Benedict, J. D., M. Roche, T. P. Yü, E. J. Bien, A. B. Gutman and D. Stetten Jr.: Incorporation of glycine nitrogen into uric acid in normal and gouty man. Metabolism 1, 3 (1952).

    PubMed  CAS  Google Scholar 

  16. Benedict, J. D., T. P. Yü, E. J. Bien, A. B. Gxjtman and D. Stetten Jr.: A further study of the utilization of dietary glycine nitrogen for uric acid synthesis in gout. J. clin. Invest. 32, 775 (1953).

    PubMed  CAS  Google Scholar 

  17. Berliner, R. W., J. G. Hilton, T. P. Yü and T. J. Kennedy Jr.: The renal mechanism for urate excretion in man. J. clin. Invest. 29, 396 (1950)

    PubMed  CAS  Google Scholar 

  18. Berliner, R. W., and T. J. Kennedy Jr.: Renal tubular secretion of potassium in the normal dog. Proc. Soc. exp. Biol. (N.Y.) 67, 542 (1948).

    CAS  Google Scholar 

  19. Berliner, R. W. and J. G. Hilton: Renal mechanism for excretion of potassium. Amer. J. Physiol. 162, 348 (1950).

    PubMed  CAS  Google Scholar 

  20. Berliner, R. W., N. G. Levinsky, D. D. Davidson and M. Eden: Dilution and concentration of the urine and the action of antidiuretic hormone. Amer. J. Med. 24, 730 (1958).

    PubMed  CAS  Google Scholar 

  21. Beyer, K. H., H. P. Russo, E. K. Tillson, A. K. Miller, W. P. Verwey and S. R. Gass: “Benemid”, p-(di-n-propylsulfamyl)-benzoic acid: its renal affinity and its elimination. Amer. J. Physiol. 166, 625 (1951).

    PubMed  CAS  Google Scholar 

  22. Bien, E. J., T. P. Yü, J. D. Benedict, A. B. Gutman and D. Stetten Jr.: The relation of dietary nitrogen consumption to the rate of uric acid synthesis in normal and gouty man. J. clin. Invest. 32, 778 (1953).

    PubMed  CAS  Google Scholar 

  23. Bishop, C., W. Garner and J. H. Talbott: Pool size, turn over rate, and rapidity of equilibration of injected isotopic uric acid in normal and pathological subjects. J. clin. Invest. 30, 879 (1951).

    PubMed  CAS  Google Scholar 

  24. Bishop, C., R. Rand and J. H. Talbott Jr.: The effect of Benemid [p-(di-n-propylsulfamyl)-benzoic acid] on uric acid metabolism in one normal and one gouty subject. J. clin. Invest. 30, 889 (1951).

    PubMed  CAS  Google Scholar 

  25. Bishop, C.: Rate of conversion of isotopic glycine to uric acid in the normal and gouty human and how this is affected by vitamin E and folic acid. Metabolism 4, 174 (1955).

    CAS  Google Scholar 

  26. Bishop, C. D., M. Rankine and J. H. Talbott: The nucleotides in normal human blood. J. biol. Chem. 234, 1233 (1959).

    PubMed  CAS  Google Scholar 

  27. Bishop, C., and J. H. Talbott: Uric acid: its role in biological processes and the innuence upon it of physiological, pathological and pharmacological agents. Pharmacol. Rev. 5, 231 (1953).

    PubMed  CAS  Google Scholar 

  28. Bishop, C. W., T. Zimdahl and J. H. Talbott: Uric acid in two patients with Wilson’s disease (hepatolenticular degeneration). Proc. Soc. exp. Biol. (N. Y.) 86, 440 (1954).

    CAS  Google Scholar 

  29. Blanton, P. M.: Acute gout associated with chronic myelogenous leukemia. Ann. intern. Med. 48, 1118 (1958).

    PubMed  CAS  Google Scholar 

  30. Blazsek, V: Zur Bestimmung von Purinen und Pyrimidinen auf Papierchromatogrammen. Naturwissenschaften 45, 42 (1958).

    CAS  Google Scholar 

  31. Bloomfield, A. L.: A bibliography of internal medicine: Gout. Stanf. med. Bull. 16, 69 (1958).

    CAS  Google Scholar 

  32. Bonsnes, R. W., L. V. Dell and E. S. Dana: The effect of Diodrast on the normal uric acid clearance. J. clin. Invest. 23, 776 (1944).

    PubMed  CAS  Google Scholar 

  33. Boyce, W. H.: Persönliche Mitteilung an J. H. Talbott; zitiert nach J. H. Talbott (226): Gout. New York and London: Grune and Stratton 1957.

    Google Scholar 

  34. Bredereck, H.: Purin- und Pyrimidinverbindungen in: Flaschenträger, B. u. H. Lehnartz. Physiologische Chemie - Die Stoffe. Berlin, Göttingen, Heidelberg: Springer-Verlag 1951.

    Google Scholar 

  35. Brocliner-Mortensen, K.: Uric acid in blood and urine. Acta med. scand. Suppl. 134, (1937).

    Google Scholar 

  36. Brocliner-Mortensen, K.: The uric acid content in blood and urine inhealth and disease. Medicine 19, 161 (1940).

    Google Scholar 

  37. Broohnbr-Mortensen, K.: 100 gouty patients Acta med. scand. 106, 81 (1941).

    Google Scholar 

  38. Broohnbr-Mortensen, K.: Heberden Oration, 1957 - Gout. Ann. rheum. Dis. 17, 1 (1958).

    Google Scholar 

  39. Brown, J., and G. K. Mallory: Renal changes m gout. New Engl. J. Med. 243, 325 (1950).

    PubMed  CAS  Google Scholar 

  40. Brugsch, h.: Persönhche Mitt.

    Google Scholar 

  41. Brugsch, T., u. J. Citron: Über die Absorption der Harnsäure durch Knorpel. Z. exp. Path. Ther. 5, 401 (1908).

    Google Scholar 

  42. Brugsch, T., u. J. Rother: Die Rolle der Gahe im HamsäurestofiFwechsel; - Die enterotropische Harnsäure. Klm. Wschr. 1, 1495 (1922); Khn. Wschr. 1, 1729 (1922).

    CAS  Google Scholar 

  43. Buchborn, E., u. M. Wenk: Harnsäureausscheidung unter Longacid beim Gesimden und bei chronischer Gicht. Khn. Wschr. 32, 564 (1954).

    CAS  Google Scholar 

  44. Buzard, J., C. Bishop and J. H. Talbott: Recovery in humans of intravenously injected isotope uric acid. J. biol. Chem. 196, 179 (1952).

    PubMed  CAS  Google Scholar 

  45. Campagna, M., A. A. Calix and G. Hauser: Observations on the combined use of pyrazinamide (aldinamide) and isoniazid in the treatment of pulmonary tuberculosis. Amer. Rev. Tuberc. 69, 334 (1954).

    CAS  Google Scholar 

  46. Carter, C. E.: Metabohsm of purines and pyrimidines. Ann. Rev. Biochem. 25, 123 (1956).

    PubMed  CAS  Google Scholar 

  47. Catel, W., u. J. Schmidt: Über famihäre gichtische Diathese in Verbindung mit zerebralen und renalen Symptomen bei einem Kleinkind. Dtsch. med. Wschr. 84, 2145 (1959).

    PubMed  CAS  Google Scholar 

  48. Chabanier, H., et H. Lobo-Onell: Exploration functionnelle des reins. Paris 1930.

    Google Scholar 

  49. Chargapf, E., and J. N. Davidson ed: The nucleic acids, 2 Bd. New York: Academic Press: 1955.

    Google Scholar 

  50. Chauffard, A., P. Brodin et A. Grigant: Diffusibihté clinique comparée de l’acid urique et de l’urée. C. R. Soc. biol. Paris 86, 355 (1922).

    CAS  Google Scholar 

  51. Chini, V.: Über die lokale Einwirkung der Harnsäure auf die Gewebe. Krkh. forsch. 8, 301 (1930).

    CAS  Google Scholar 

  52. Colsky, J., S. Wallace and M. M. Banowitch: Desacetylmethylcolchicine in acute gouty arthritis. New Engl. J. Med. 253, 730 (1955).

    PubMed  CAS  Google Scholar 

  53. Colsky, J.: Treatment of acute gouty arthritis with Demecolcine. A. M. A. Arch. Intern. Med. 100, 765 (1957).

    CAS  Google Scholar 

  54. Coombs, P. S., L. J. Pecora, E. Thorogood, W. V. Consolazio and J. H. Talbott: Renal function in patients with gout. J. clin. Invest. 19, 525 (1940).

    PubMed  CAS  Google Scholar 

  55. Cullen, J. H., L. J. A. Early and J. M. Fiore: The occurrence of hyperuricemia during pyrazinamide - isoniazid therapy. Amer. Rev. Tuberc. 74, 289 (1956).

    CAS  Google Scholar 

  56. Cullen, J. H., M. Le Vine and J. M. Fiore: Studies of hyperuricemia produced by pyrazinamide. Amer. J. Med. 23, 587 (1957).

    PubMed  CAS  Google Scholar 

  57. De Galantha, E.: Teclinic for preservation and microscopic demonstration of nodules in gout. Amer. J. clin. Path. 5, 165 (1935).

    Google Scholar 

  58. De Graciansky, P.: Recherches sur l’acide urique dans la goutte. Thèse de Paris, 1938 (zit. nach Sokoloff).

    Google Scholar 

  59. Deitrick, J. E.: The association of congenital hemolytic jaundice and gout. Int. Clin. 3, 264 (1940).

    Google Scholar 

  60. De Sèze, S., A. Ryckewaert, J. Levernibux and R. Marteau: Physiopathology, clinical manifestation and treatment of gout. Part 2. Clinical and therapeutic studies. Ann. rheum. Dis. 17, 15 (1958).

    Google Scholar 

  61. Diamond, M. T.: Thrombophlebitis associated with gout. N. Y. St. J. Med. 53, 3011 (1953).

    CAS  Google Scholar 

  62. Dikstein, S., F. Bergmann and M. Chaimovitz: On the quantitative determination of xanthines and uric acids in urine. J. biol. Chem. 230, 203 (1958).

    PubMed  CAS  Google Scholar 

  63. Dittman, W. A., and J. R. Ward: Demecolcine toxicity. A case report of severe hematopoietic toxicity and a review of the hterature. Amer. J. Med. 27, 519 (1959).

    PubMed  CAS  Google Scholar 

  64. Drube, C.-H., u. H. Reinwein: Zur Khnik der Gicht, “der vergessenen Krankheit”. Med. Khn. 54, 631 (1959).

    CAS  Google Scholar 

  65. Falta, W., u. J. Nowaszynski: Über die Harnsäureausscheidung bei Erkrankungen der Hypophyse. Berl. khn. Wschr. 49, 1781 (1912).

    Google Scholar 

  66. Fischer, E., u. G. W. Klinghardt: Osteomyeloreticulose mit Gicht. Acta haemat. (Basel) 19, 82 (1958).

    CAS  Google Scholar 

  67. Fitz, R.: Three cases with intermittently painful joints, splenomegaly and anemia. Med. Clin. N. Amer. 18, 1053 (1935).

    Google Scholar 

  68. Folin, O.: Laws governing the chemical composition of the urine. Amer. J. Physiol. 13, 66 (1905).

    Google Scholar 

  69. Folin, O., H. Berglund and C. Derick: The uric acid problem - an experimental study on animals and men, including gouty subjects. J. biol. Chem. 60, 361 (1924).

    CAS  Google Scholar 

  70. Folin, O. and H. Lyman: On the influence of phenylquinolin carbonic acid (Atophan) on uric acid elimination. J. Pharmac. (Lond.) 4, 539 (1913).

    CAS  Google Scholar 

  71. Forkner, C.E.: Leukemia and alhed disorders, p. 42, New York: The MacMilan Co. 1938.

    Google Scholar 

  72. Friedman, M., and S. O. Byers: Observations concerning the causes of the excess excretion of uric acid in the Dalmatian dog. J. biol. Chem. 175, 727 (1948).

    PubMed  CAS  Google Scholar 

  73. Friedman, M.: Increased renal excretion of urate in young patients with gout. Amer. J. Med. 9, 31 (1950).

    PubMed  CAS  Google Scholar 

  74. Fritze, E.: Der Purinstoffwechsel bei Leukämie unter Urethanbehandlung. Klin Wschr. 27, 366 (1949).

    CAS  Google Scholar 

  75. Gamp, A.: Zur medikamentösen Behandlung der chronischen Gicht. Ärztl. Wschr. 12, 779 (1957).

    CAS  Google Scholar 

  76. Garrod, A. B.: Eczema and albxmiinuria in relation to gout, in: Transactions of the International Medical Congress, Seventh Session, 2. Bd., S. 99, London 1881.

    Google Scholar 

  77. Geren, W., a. Bendich, O. Bodansky and G. B. Brown: The fate of uric acid in man J. biol. Chem. 183, 21 (1950).

    CAS  Google Scholar 

  78. Gibson, H. V., and E. A. Doisy: A note on the effect of some organic acids upon the uric acid excretion of man. J. biol. Chem. 55, 605 (1923).

    Google Scholar 

  79. Gibson, R. R., and C. P. Howard: Metabolic studies in pernicious anemia. Arch. Intern. Med. 32, 1 (1923).

    CAS  Google Scholar 

  80. Grayzel, A. I., and J. E. Seegmiller: Suppression of uric acid synthesis in the gouty human by the use of 6-diazo-5-oxo-1-norleucine (DON). J. clin. Invest. 38, 1008 (1959).

    Google Scholar 

  81. Greenbaum, D., and H. F. H. Stone: Dangers of uric-acid excretion during treatment of leukaemia and lymphosarcoma. Lancet 1959 I, 73.

    Google Scholar 

  82. Gremels, H., and R. Bodo: The excretion of uric acid by the kidney. Proc. roy. Soc. B 100, 336 (1926).

    CAS  Google Scholar 

  83. Grümer, H.-D.: Persönliche Mitt.

    Google Scholar 

  84. Gutman, A. B.: Primary and secondary gout. Ann. intern. Med. 39, 1062 (1953).

    PubMed  CAS  Google Scholar 

  85. Gutman, A. B., and T. F. Yü: Benemid [p-(di-n-propylsuKamyl)-benzoic acid] as uricosuric agent in chronic gouty arthritis. Trans. Ass. Amer. Phycns 64, 279 (1951).

    CAS  Google Scholar 

  86. Gutman, A. B.: Gout, a derangement of purine metabohsm. Advanc. intern. Med. 5, 227 (1952).

    CAS  Google Scholar 

  87. Gutman, A. B.: Current principles of management of gout. Amer. J. Med. 13, 744 (1952).

    PubMed  CAS  Google Scholar 

  88. Gutman, A. B.: Renal function in gout. Amer. J. Med. 23, 600 (1957).

    PubMed  CAS  Google Scholar 

  89. Gutman, A. B., and L. Berger: Tubular secretion of urate in man. J. clin. Invest. 38, 1778 (1959).

    PubMed  CAS  Google Scholar 

  90. Gutman, A. B., H. Black, R. S. Yalow and S. A. Berson: Incorporation of glycine-1-C14, glycine-2-C14 and glycine-N15 into uric acid in normal and gouty subjects. Amer. J. Med. 25, 917 (1958).

    PubMed  CAS  Google Scholar 

  91. Gutman, A. B., and B. Weissmann: The concept of secondary gout; relation to purine metabohsm in polycythemia and myeloid metaplasia. Trans. Ass. Amer. Phycns 69, 229 (1956).

    CAS  Google Scholar 

  92. Hansen, O. E., and C. Holten: Uricosuric effect of dicoumarol. Lancet 19581, 1047.

    Google Scholar 

  93. Harris, H.: Genetic aspects of tubular function. In: Modern views on the secretion of urine. The Cushing memorial lectures. Boston: Little, Brown and Co. 1956.

    Google Scholar 

  94. Hartman, S. C., and J. M. Buchanan: The biosynthesis of the purines. Ergebn. Physiol. 50, 75 (1959).

    PubMed  CAS  Google Scholar 

  95. Hauge, M., and B. Harvald: Heredity in gout and hyperuricemia. Acta med. scand. 152, 247 (1955).

    PubMed  CAS  Google Scholar 

  96. Healey, L. A., G. J. Magid and J. L. Decker: Uric acid retention due to hydrochlorothiazide. New. Engl. J. Med. 261, 1358 (1959).

    PubMed  CAS  Google Scholar 

  97. Heilmeyer, L., u. H. Begemann: Handbuch der Inneren Medizui, 2. Bd. Berlin-Göttingen-Heidelberg: Springer 1951.

    Google Scholar 

  98. Heller, J.: Über den Harnsäuregehalt der menschhchen Blutkörperchen. Biochem. Z. 279, 149 (1935).

    CAS  Google Scholar 

  99. Hench, P. S.: Gout and gouty arthritis. In: Cecü, R. L., and R. F. Loeb: A Textbook of Medicine. Philadelphia, London: W. B. Saunders Co. 1959.

    Google Scholar 

  100. Herrick, W. W., and T. L. Tyson: Gout - a forgotten disease. Amer. J. med. Sci. 192, 483 (1936).

    Google Scholar 

  101. Hickling, R. A.: Gout, leukaemia and polycythaemia. Lancet 1953 1, 57.

    PubMed  CAS  Google Scholar 

  102. His, W.: Die Ausscheidung von Harnsäure im Urin der Gichtkranken, mit besonderer Berücksichtigung der Anfallszeiten und bestimmter Behandlungsmethoden. Dtsch. Arch, kün. Med. 65, 156 (1899).

    Google Scholar 

  103. His, W.: Schicksal und Wükungen des sauren harnsauren Natrons in Bauch- und Gelenkhöhle des Kaninchens. Arch. kün. Med. 67, 81 (1900).

    Google Scholar 

  104. Hoffman, W. S.: Metabolism of uric acid and its relation to gout. J. Amer. med. Ass. 154, 213 (1954).

    CAS  Google Scholar 

  105. Hoffman, W. S.: Modern advances in the management of gout. Med. Clin. N. Amer. 39, 307 (1955).

    Google Scholar 

  106. Hoffman, W. S.: Some unsolved problems of gout. Med. Clin. N. Amer. 43, 595 (1959).

    PubMed  CAS  Google Scholar 

  107. Holboll, S. A.: Untersuchungen über den Grundumsatz bei Patienten mit Leukämie und Lymphogranulomatose. Acta med. scand. 72, 326 (1929).

    CAS  Google Scholar 

  108. Hutchinson, J.: On the importance of perseverance in inquiries as to the inheritance of gout. Arch. Surg. (London) 7, 197 (1896).

    Google Scholar 

  109. Hutchison, R., and P. N. Panton: A contribution of the study of congenital family cholaemia. Quart. J. Med. 2, 432 (1908/1909).

    Google Scholar 

  110. Jackson, H. Jr.: Studies in nuclein metabohsm - I. Adenine nucleotide in human blood. J. biol. Chem. 57, 121 (1923).

    CAS  Google Scholar 

  111. Jacobson, B. M.: Uric acid in serum of gouty and non-gouty individuals; its determination by Polin’s recent method and ist significance in the diagnosis of gout. Ann. intern. Med. 11, 1277 (1938).

    CAS  Google Scholar 

  112. Jeune, M., A. Charrat et J. Bertrand: Polycorie hépatique, hyperuricémie et goutte. Arch, franç. Pédiat. 14, 897 (1957).

    CAS  Google Scholar 

  113. Jorgensen, S.: Adenine nucleotides and oxypurines in stored donor blood. Acta pharmacol. (Kbh.) 13, 102 (1957).

    CAS  Google Scholar 

  114. Jorgensen, S., and M. Grove-Rasmussen: Effect of pn on accumulation of oxypurines in blood collected through an ion-exchange resin column. Amer. J. clin. Path. 28, 579 (1957).

    CAS  Google Scholar 

  115. Jorgensen, S., and H. E. Poulsen: On accumulation of hypoxanthine plus xanthine in withdrawn human blood. Acta pharmacol. (Kbh.) 11, 287 (1955).

    CAS  Google Scholar 

  116. Jorgensen, S., and A. Theil Nielsen: Uric acid in human blood corpuscles and plasma. Scand. J. clin. Lab. Invest. 8, 108 (1956).

    PubMed  CAS  Google Scholar 

  117. Kersley, G. D., E. R. Cook and D. C. J. Tovey: Value of uricosuric agents and in particular of G 28 315 m gout. Ann. rheum. Dis. 17, 326 (1958).

    PubMed  CAS  Google Scholar 

  118. Kersley, G. D., L. Mandel and M. R. Jeffrey: Gout: an unusual case with softening and subluxation of the first cervical vertebra and splenomegaly. Ann. rheum. Dis. 9, 282 (1950).

    PubMed  CAS  Google Scholar 

  119. Kessler, R. H., K. Hierholzer and R. S. Gurd: Localisation of urate transport in the nephron of mongrel and Dalmatian dog kidney. Amer. J. Physiol. 197, 601 (1959).

    PubMed  CAS  Google Scholar 

  120. Kilinge, F., u. H. Rodriguez: Experimentelle Untersuchungen zur Frage Gicht und Allergie (Durch Urate lokahsierte allergische Arthritis.) Beitr. path. Anat. 103, 350 (1939).

    Google Scholar 

  121. Königer, H.: Stoffwechsel bei chronischer myeloider Leukämie. Dtsch. Arch. khn. Med. 87, 31 (1906).

    Google Scholar 

  122. Korpmacher, I., u. N. Zöllner: Vor- und Nachteile der Behandlung des Gichtanfalls mit dem Colchicinabkömmling Demecolcin. München, med. Wschr. 102, 550 (1960).

    Google Scholar 

  123. Koskoff, Y. D., L. E. Morris and L. G. Lubic: Paraplegia as a complication of gout. J. Amer. med. Ass. 152, 37 (1953).

    CAS  Google Scholar 

  124. Krakofp, I. H.: Urinary uric acid excretion in leukemia. In: The Leukemias, Etiology, Pathophysiology, Treatment. S. 407. New York: Academic Press 1957.

    Google Scholar 

  125. Krakofp, I. H., and M. E. Balis: Studies of the uricogenic effect of 2-substituted thiadiazoles in man. J. clin. Invest. 38, 907 (1959).

    Google Scholar 

  126. Krakofp, I. H., and D. A. Karnopsky: Inhibition of uric acid biosynthesis in birds by o-diazoacetyl-1-serine (Azaserine) and 6-diazo-5-oxo-1-norleucine (DON). Amer. J. Physiol. 195, 244 (1958).

    Google Scholar 

  127. Kramer, K.: Fortschritte der normalen Physiologie der Niere. Klin. Wschr. 37, 109 (1959).

    PubMed  CAS  Google Scholar 

  128. Krauss, E.: Über die Hamsäureausscheidung bei Erkrankungen der Hypophyse. Klin. Wschr. 5, 700 (1926).

    CAS  Google Scholar 

  129. Kravitz, S. C., and L. F. Graver: Uremia comphcating leukemia chemotherapy. J. Amer. med. Ass. 146, 1595 (1951).

    CAS  Google Scholar 

  130. Kress, H. von: Die Leukämien im Rahmen allgemein-pathologischer Probleme. Dtsch. Arch. khn. Med. 176, 359 (1934).

    Google Scholar 

  131. Kuzell, W. G., R. W. Schapparzick and W. E. Naugler: The effect of intravenous demecolcine (Golcemid) on acute gout. Arch, intern. Med. 96, 153 (1955).

    CAS  Google Scholar 

  132. Kuzell, W. G., G. Gaudin, E. A. Mankle and B. Brown: Phenylbutazone (Butazohdin) in gout. Amer. J. Med. 16, 212 (1954).

    PubMed  CAS  Google Scholar 

  133. Lang, F. J.: Gelenkgicht (Arhtritis urica) In: Handbuch der speziellen pathologischen Anatomie und Histologie. 9. Bd., 3 Teil, S. 309. Berhn 1937.

    Google Scholar 

  134. Laragh, J. H., H. O. Heinemann and F. E. Demartini: Effect of Chlorothiazide on electrolyte transport in man: its use in treatment of edema of congestive heart faüure, nephrosis, and cirrhosis. J. Amer. med. Ass. 166, 145 (1958).

    CAS  Google Scholar 

  135. Laster, L., and A. P. Muller: Uric acid production in a case of myeloid metaplasia associated with gouty arthritis, studied with N15-labeled glycine. Amer. J. Med. 15, 857 (1953).

    PubMed  CAS  Google Scholar 

  136. Lawrence, J. S.: Physiology and function of the white blood cells. J. Amer. med. Ass. 157, 1212 (1955).

    CAS  Google Scholar 

  137. Lear, H., and G. D. Oppenheimer: Anuria following radiation therapy in leukemia. J. Amer. med. Ass. 143, 806 (1950).

    CAS  Google Scholar 

  138. Lendle, L., u. H. dal Ri: Zur Frage der Enteritis-Reaktion und Capillargiftwirkung von Colchicin, Arsenik und Cytostatica. Klin. Wschr. 37, 1230 (1959).

    PubMed  CAS  Google Scholar 

  139. Lennox, W. G., and J. H. Means: Study of basal and nitrogenous metabolism in case of acute leukemia during roentgen-ray treatment. Arch, intern. Med. 32, 705 (1923).

    CAS  Google Scholar 

  140. Leschke, E.: Hämolytischer Ikterus und Gicht. Med. Klin. 13, 896 (1922).

    Google Scholar 

  141. Leslie, A.: Alkaptonuria with hyperuricemia. Arch, intern. Med. 71, 68 (1943).

    CAS  Google Scholar 

  142. Lichtenstein, L., H. W. Scott and M. H. Levin: Pathologic changes in gout - Survey of eleven necropsied cases. Amer. J. Path. 32, 871 (1956).

    PubMed  Google Scholar 

  143. Linke, A.: Über die Herkunft der endogenen Harnsäure und ihr Verhalten bei Anämien mit besonderer Berücksichtigung der Perniciosaremission während der Therapie mit Leber, Thymin und Folmsäure. Foüa hämat. 70, 103 (1950).

    Google Scholar 

  144. Linke, A.: Erythroleukämie und erythroleukämische Reaktion. Habiütationsschrüt, Heidelberg 1954.

    Google Scholar 

  145. Linke, A.: Über die Behandlung von Hämoblastosen und maügnen Tumoren mit Äthyleninüno- benzochinon-Derivaten. Sjrmp. akt. therap. Probi. 1, 51 (1959).

    Google Scholar 

  146. Linman, J. W., and F. H. Bethell: Agnogenic myeloid metaplasia. Amer. J. Med. 22, 107 (1957).

    PubMed  Google Scholar 

  147. Linser, P., u. K. Sick: Über das Verhalten der Harnsäure und Purinbasen im Urin und Bhit bei Röntgenbestrahlungen. Dtsch. Arch. klin. Med. 89, 413 (1906).

    Google Scholar 

  148. Löefler, W., u. F. Koller: Die Gicht. Handbuch der inneren Medizin. Bd. 7, 2. Teil, S. 435. Berlin-Göttingen-Heidelberg: Springer-Verlag 1955.

    Google Scholar 

  149. Lücke, H.: Das Hamsäureproblem und seine künische Bedeutung. Ergebn. inn. Med. Kinderheük. 44, 499 (1932).

    Google Scholar 

  150. Ludwig, A. O., G. A. Benett and W. Bauer: A rare manüestation of gout; widespread ankylosis simulating rheumatoid arthritis. Ann. intern. Med. 11, 1248 (1938).

    CAS  Google Scholar 

  151. Ludwig, G. D.: Saturnine gout - A secondary type of gout. A. M. A. Axch. intern. Med. 100, 802 (1957).

    CAS  Google Scholar 

  152. Magnus-Levy, A.: Uric acid m gout. Harvey Lect. 5, 251 (1909/1910).

    Google Scholar 

  153. March, H. W., S.M. Schlyen and S. E. Schwartz: Mediterranean hemopathic syndromes (Cooley’s anemia) in adults. Amer. J. Med. 13, 46 (1952).

    PubMed  CAS  Google Scholar 

  154. Marson, F. G. W.: Studies in gout, with particular reference to value of sodium sallcylate in treatment. Quart. J. Med. 22, 331 (1953).

    PubMed  CAS  Google Scholar 

  155. Marson, F. G. W.: Sodium saücylate and probenecid in treatment of chronic gout: assessment of theü relative effects in lowering serum uric acid levels. Ann. rheum. Dis. 13, 233 (1954).

    PubMed  CAS  Google Scholar 

  156. Marson, F. G. W.: Complete reüef of gout. Lancet 1955 11. 360.

    Google Scholar 

  157. Mayer von Schopf, E.: Gicht bei einem fünf Wochen alten Säugling. Klin. Wschr. 9, 2148 (1930).

    Google Scholar 

  158. Mayrs, E. B.: Secretion as a factor in elimination by the bild’s kidney. J. Physiol. 58, 276 (1923/1924).

    PubMed  CAS  Google Scholar 

  159. McWilliams, J. R.: Ocular findings in gout; report of a case of conjunctival tophi. Amer. J. Ophthal. 35, 778 (1952).

    Google Scholar 

  160. Mervdll, D., and H. Jackson: The renal comphcations of leukemia. New Engl. J. Med. 228, 271 (1943).

    Google Scholar 

  161. Mikkelsen, W. M., R. W. Salin and J. F. Duff: Alopecia totahs after desacetylmethyl-colchicine therapy of acute gout: report of a case. New Engl. J. Med. 255, 769 (1956).

    PubMed  Google Scholar 

  162. Modern, F. W. S., and L. Meister: The kidney of gout, a clinical entity. Med. Clin. N. Amer. 36, 941 (1952).

    Google Scholar 

  163. Morris, J. E.: The transport of uric acid in serum. Amer. J. Med. Sc. 235, 43 (1958).

    CAS  Google Scholar 

  164. Mudge, G. H., J. Foulks and A. Gilman: The renal excretion of potassium. Proc. Soc. exp. Biol. (N. Y.) 67, 545 (1948).

    CAS  Google Scholar 

  165. Mugler, A.: Extraits du colchique et maladies allergiques. Rev. Path. comp. 651, 1077 (1953).

    Google Scholar 

  166. Mugler, A., et G. Gazet du Chatelier: Données nouvelles sur le mode d’action de la colchicine à la lumière de recherches récentes. Rev. Rheum. 24, 1 (1957).

    Google Scholar 

  167. Mugler, A., et J. M. Grappe: Accès de goutte chez un polyglobuhque traité par phosphore radio- actü. Strasbourg-Méd. 4, 341 (1953).

    PubMed  CAS  Google Scholar 

  168. Mugler, A., J. L. Pernet, A. Pernet et S. Friedrich: Le pouvoü d’épuration du rein pour l’acide urique chez l’hyperuricémique d’après l’étude de 400 clearances. Contemp. Rheimi. 1956, 574.

    Google Scholar 

  169. Muller, A. f., and W. Bauer: Uric acid production in normal and gouty subjects determined by N15 labeled glycme. Proc. Soc. exp. Biol. (N. Y.) 82,47 (1953).

    CAS  Google Scholar 

  170. MuRcmson, C.: Clinical Lectures on Diseases of the Liver, Jaundice, and Abdominal Dropsy, 3rd ed., London 1885.

    Google Scholar 

  171. Myers, V. C., and M. S. Fine: The non-protein nitrogenous compounds of the blood in nephritis, with special reference to creatinine and uric acid. J. biol. Chem. 20, 391 (1915).

    CAS  Google Scholar 

  172. Naegeli, O.: Blutkrankheiten und Blutdiagnostik. Berhn u. Leipzig 1919.

    Google Scholar 

  173. Naugler, W. E., W. C. Kuzell and R. W. Schaffarzick: The use of intravenous colchicine and desacetylmethyl colchicine (Colcemide) in vertigo, acute sensitivity states, and painful lymphadenopathy. Stanf. med. Bull. 15, 97 (1957).

    CAS  Google Scholar 

  174. Neustadt, D. H.: Effect of desacetylmethylcolchicine (Colcemide) in acute gouty arthritis. Arthr. Rheum. 1, 91 (1958).

    CAS  Google Scholar 

  175. Nichols, J., A. T. Miller Jr., and E. P. Hiatt: Influence of muscular exercise on uric acid excretion in man. J. appl. Physiol. 3, 501 (1951).

    PubMed  CAS  Google Scholar 

  176. Nugent, C. A., and P. H. Tyler: The renal excretion of uric acid in patients with gout and in nongouty subjects. J. clin. Invest. 38, 1890 (1959).

    PubMed  CAS  Google Scholar 

  177. Opsahl, R.: Hematopoiesis and endogenous uric acid. Acta med. scand. 102, 611 (1939).

    CAS  Google Scholar 

  178. Oren, B. G., M. Rich and M. S. Belle: Chlorothiazide (Diurü) as a hyperuricacidemic agent. J. Amer. med. Ass. 168, 2128 (1958).

    CAS  Google Scholar 

  179. Overgaard-Hansen, K., and U. V. Lassen: Active transport of uric acid through the human erythrocyte membrane. Nature (Lond.) 184, 553 (1959).

    CAS  Google Scholar 

  180. Owen, T. K., and J. C. Roberts: Acholuric jaundice and gout. Brit Med. J. 2, 661 (1937).

    Google Scholar 

  181. Parker, H. V., K. H. Olesen, J. McMurrey and B. PRns-üansen: Body water compartments throughout the lifespan. In: Ciba Foundation Colloquia on Ageing. Water and Electrolyte Metabohsm in Relation to Age and Sex. Boston. 1958.

    Google Scholar 

  182. Pascale, L. R., A. Dubin, D. Bronsky and W. S. Hoffman: Inhibition of the uricosuric action of Benemid by sahcylate. J. Lab. clin. Med. 45, 771 (1955).

    PubMed  CAS  Google Scholar 

  183. Pascale, L. R., and W. S. Hoffman: Therapeutic value of probenecid (Benemid) in gout. J. Amer. med. Ass. 149, 1188 (1952).

    CAS  Google Scholar 

  184. Pasero, G., A. Bigalli M. Della Santa: La clearance deh’acido urico come espressione deha funzione del tubulo prossimale. Boil. Soc. med.-chir. Pisa 26, 314 (1958).

    Google Scholar 

  185. Pasero, G., et N. Marini: Suli’azioneuricurica del 2-fenil-5-bromo-1,3-indandione. Gazz. med. ital. 117, 561 (1958).

    PubMed  Google Scholar 

  186. Pasero, G., : Influenza della vitamina K sull’azione uricurica del 2-fenil-5-bromo-1,3-indandione. Boil. Soc. med.-chk. Pisa 26, 1 (1958).

    Google Scholar 

  187. Pasero, G., : Suil’azione uricurica degli antiprotrombinici di sintesi. Boil. Soc. med.- chk. Pisa 25, 124 (1957).

    Google Scholar 

  188. Pasero, G., : L’ipouricemia negh itteri colurici. Minerva med. (Torino) 49, 3155 (1958).

    CAS  Google Scholar 

  189. Pasero, G., : Suil’azione uricurica degh antiprotrombinici di sintesi. Arch. Maraghano pat. 14, 297 (1958).

    CAS  Google Scholar 

  190. Pasero, G., e G. Tamagnini: L’uricemia e l’escrezione urica nelle epatopatie non itteriche. Boil. Soc. med. clin. Pisa 26, 276 (1958).

    Google Scholar 

  191. Peters, J. P., and D. D. van Slyke: Quantitative Clinical Chemistry, Interpretations, Bd. 1. Baltimore: Wühams and Willdns 1946.

    Google Scholar 

  192. Pommer, G.: Mikroskopische Untersuchungen über Gelenkgicht. Jena: Fischer 1929.

    Google Scholar 

  193. Poulsen, H.: Inhibition of uric acid excretion in rabbits given probenecid or sahcylic acid. Acta pharmacol. (Kbh.) 11, 277 (1955).

    CAS  Google Scholar 

  194. Poulsen, H., and E. Praetorius: Tubular excretion of uric acid in rabbits. Acta pharmacol. (Kbh.) 10, 371 (1954).

    CAS  Google Scholar 

  195. Praetorius, E., and J. E. Kirk: Hjrpouricemia: with evidence for tubular ehmination of uric acid. J. Lab. Clin. Med. 35, 865 (1950).

    PubMed  CAS  Google Scholar 

  196. Praetorius, E., and H. Poulsen: Enzymatic determination of uric acid with detaüed directions. Scand. J. dm. Lab. Invest. 5, 273 (1953).

    CAS  Google Scholar 

  197. Reed, E. B., T. V. Feichtmeier and F. M. Willett: Zoxazolamine - A potent uricosuric agent. New Engl. J. Med. 258, 894 (1958).

    PubMed  CAS  Google Scholar 

  198. Reifenstein, G. H.: A case of erythremia, gout and subleukemic myelosis. Amer. J. med. Sci. 197, 215 (1939).

    Google Scholar 

  199. Riddle, M. C.: The endogenous uric acid metabohsm in pernicious anemia. J. clin. Invest. 8, 69 (1929/1930).

    Google Scholar 

  200. Riddle, M. C.: Pernicious anemia. Arch, intern. Med. 46, 417 (1930).

    Google Scholar 

  201. Riddle, M. C., and C. C. Sturgis: The endogenous uric acid metabohsm in pernicious anemia. J. clin. Invest. 7, 498 (1929).

    Google Scholar 

  202. Rzentkowski, K.: Untersuchungen über den Purinstoffwechsel in einem FaU von lym- phatischer Leukämie. Zbl. Biochem. Biophys. 11, 717 (1911).

    Google Scholar 

  203. Rzentkowski, K.: Untersuchungen über den Stoffwechsel bei der lymphatischen Leukämie während der Röntgenbestrahlung. Dtsch. Arch. khn. Med. 110, 585 (1913).

    Google Scholar 

  204. Sala, G., C. B. Ballabio, A. Amira, G. Ratti et E. Cirla: Renal Mechanisms for urate excretion in normal and gouty subjects. Contemp. Rheum. 1956, 581.

    Google Scholar 

  205. Salteri, F., E. Cirla and A. Fasoli: Electromigration on filter papers of uric acid from serum and synovial fluid. Science 127, 85 (1958).

    PubMed  CAS  Google Scholar 

  206. Sandberg, A. A., G. E. Cartwright and M. M. Wintrobe: Studies on leukemia. I. Uric acid excretion. Blood 11, 154 (1956).

    PubMed  CAS  Google Scholar 

  207. Sclüttenhelm, A., u. K. Harpuder: Harnsäureumsatz und Harnsäureausfuhr bei Akro- megalie. Z. ges. exp. Med. 27, 50 (1922).

    Google Scholar 

  208. Schwartz, W. S., and R. E. Moyer: The chemotherapy of pulmonary tuberculosis with pyrazinamide used alone and in combination with streptomycin, para-aminosall- cylic acid, or isoniazid. Amer. Rev. Tuberc. 70, 413 (1954).

    CAS  Google Scholar 

  209. Sears, W. G.: The occurrence of gout during the treatment of pernicious anaemia. Lancet 1933 I, 24.

    Google Scholar 

  210. Seegmiller, J. E.: Ed. Combined Staff Clinic Nat. Inst, of Arthritis and Metabornc Diseases: Metabolic and clinical aspects of gout. Amer. J. Med. 22, 807 (1957).

    Google Scholar 

  211. Seegmiller, J. E., L. Laster and L. V. Liddle: Failure to detect consistent overincorporation of glycine-1-C14 into uric acid in primary gout. Metabolism 7, 376 (1958).

    PubMed  CAS  Google Scholar 

  212. Seegmiller, J. E., and D. Stetten Jr.: Incorporation of 4-amino-5-imidazolecarboxamide-4-C14 into uric acid in the normal human. J. biol. Chem. 216, 653 (1955).

    PubMed  CAS  Google Scholar 

  213. Seegmiller, J. E., and L. Sokoloff: Unveröffentlichte Befunde. Zitiert nach Sokoloff (211).

    Google Scholar 

  214. Segal, S., and J. B. Wyngaarden: Plasma glutamine and oxypurine content in patients with gout. Proc. Soc. exp. Biol. (N.Y.) 88, 342 (1955).

    CAS  Google Scholar 

  215. Shapiro, M., and L. Hyde: Hyperuricemia due to pyrazinamide. Amer. J. Med. 23, 596 (1957).

    PubMed  CAS  Google Scholar 

  216. Shetlar, M. R., R. W. Payne, J. A. Bullock, D. R. Patrick, A. A. Hellbaum and W. K. Ishmael: Comparative studies of serum polysaccharides in rheumatoid arthritis and degenerative joint disease. J. clin. Invest. 32, 1208 (1953).

    PubMed  CAS  Google Scholar 

  217. Sherwood, K. K.: Observation upon gout. West. J. Surg. 46, 596 (1938).

    Google Scholar 

  218. Shideman, P. E., and R. M. Rene: Succinate oxidation and Krebs cycle as an energy source for renal tubular transport mechanisms. Amer. J. Physiol. 166, 104 (1951).

    PubMed  CAS  Google Scholar 

  219. Shorvon, L. M.: Gout in leukaemia. Lancet 1946 I, 378.

    Google Scholar 

  220. Smota, J. H., and D. Hamerman: Renal function studies ki an adult subject with the Fanconi syndrome. Amer. J. Med. 16, 138 (1954).

    Google Scholar 

  221. Sivén, V. O.: Beitrag zur Kenntnis der Harnsäurebildimg im menschlichen Organismus unter normalen Bedingungen. Skand. Arch. Physiol. 11, 123 (1901).

    Google Scholar 

  222. Smith, H. W.: Principles of Renal Physiology. New York: Oxford University Press. 1956.

    Google Scholar 

  223. Smyth, C. J.: Hereditary factors in gout. Metabolism 6, 218 (1957).

    PubMed  CAS  Google Scholar 

  224. Smyth, C. J., C. W. Cotterman and R. H. Fryberg: The genetics of gout and hyperuricemia - an analysis of 19 families. J. Clin. Invest. 27, 749 (1948).

    CAS  Google Scholar 

  225. Smyth, C. J., E. R. Huffman and G. M. Wilson: Treatment of gout. A. M. A. Arch, intern. Med. 97, 783 (1956).

    CAS  Google Scholar 

  226. Sokoloff, L.: The pathology of gout. Metabolism 6, 230 (1957).

    PubMed  CAS  Google Scholar 

  227. Sorensen, L. B.: Degradation of uric acid in man. Metabolism 8, 687 (1959).

    PubMed  CAS  Google Scholar 

  228. Sougin-Mibashan, R., and M. Horwitz: The uricosuric action of ethyl biscoumacetate. Lancet 1955 I, 1191.

    Google Scholar 

  229. Spenge, J. C.: Liver and pernicious anemia. Lancet 1927 11, 1026.

    Google Scholar 

  230. Spilman, E. L.: Uric acid synthesis in the non-gouty and gouty human. Fed. Proc. 13, 302 (1954).

    Google Scholar 

  231. Spitz, H., O. Steinbrocker, S. Schwartz and M. Schittone: Fulminating fatal gout. Amer. J. Med. 6, 513 (1949).

    PubMed  CAS  Google Scholar 

  232. Spitzer, J. J., and J. A. Spitzer: The effect of colchicine on plasma unesterified fatty acids. Experientia (Basel), 15, 26 (1959).

    CAS  Google Scholar 

  233. Stecher, R. M., A. H. Hersch and W. M. Solomon: Heredity of gout and its relationship to familial hjrperuricemia. Ann. intern. Med. 31, 595 (1949).

    PubMed  CAS  Google Scholar 

  234. Stetten, D. jr., J. H. Talbott, J. E. Seegmiller, J. B. Wyngaarden and L. Laster: The pathogenesis of gout. Metabolism 6, 88 (1957).

    PubMed  CAS  Google Scholar 

  235. Strobel, W., u. H. Losse: Über eine seltene Form von Gichtarthritis. Zschr. Rheumaforsch. 18, 177 (1959).

    PubMed  CAS  Google Scholar 

  236. Sunderman, F. W., and F. Boerner: Normal Values üi Clinical Medicine. Philadelphia and London: Saunders 1949.

    Google Scholar 

  237. Taggart, J. V.: Some biochemical features of tubular transport mechanisms. In: The Kidney, Ciba Foundation Symposium, Lewis, A. A. G. and G. E. W. Wolstenholme, ed. Boston, 1954.

    Google Scholar 

  238. Talbott, J. H.: Serum urate in relatives of gouty patients. J. clin. Invest. 19, 645 (1940).

    PubMed  CAS  Google Scholar 

  239. Talbott, J. H.: Remarks on gout and gouty arthritis. Bull. Hosp. Jt. Dis. (N. Y.) 18, 3 (1957).

    CAS  Google Scholar 

  240. Talbott, J. H.: Gicht und Gicht-Arthritis. Klin. Wschr. 35, 797 (1957).

    PubMed  CAS  Google Scholar 

  241. Talbott, J. H.: Symposium on gout. Metabolism 6, 193 (1957).

    Google Scholar 

  242. Talbott, J. H.: Gout. New York and London: Grune and Stratton 1957.

    Google Scholar 

  243. Talbott, J. H.: The sustained administration of Benemid (Probenecid) in the treatment of gouty arthritis. In: Progress in Arthritis, p. 352 New York and London: Grune and Stratton 1958.

    Google Scholar 

  244. Talbott, J. H.: Selected aspects of acute and chronic gouty arthritis. J. Bone Jt. Surg., Amer. Ed. 10-A, 994 (1958).

    Google Scholar 

  245. Talbott, J. H.: Gout and blood dyscrasias. Medicine 38, 173 (1959).

    PubMed  CAS  Google Scholar 

  246. Talbott, J. H.: The choice of a uricosuric drug in gout. Arthr. Rheum. 2, 182 (1959).

    CAS  Google Scholar 

  247. Talbott, J. H., and P. S. Cooms: Metabohc studies on patients with gout. J. Amer. med. Ass. 110, 1977 (1938).

    Google Scholar 

  248. Talbott, J. H., G. J. Culver, M. Mizraji and D. I. Crespo: Roentgenographic findings. Metabohsm 6, 277 (1957).

    CAS  Google Scholar 

  249. Talbott, J. H., and J. M. Sherman: The concentration of urate in cells and plasma as a function of PH. J. Clin. Invest. 15, 457 (1936).

    Google Scholar 

  250. Thannhauser, S. J.: Lehrbuch des Stoffwechsels und der Stoffwechselkrankheiten. München: J. F. Bergmann 1929.

    Google Scholar 

  251. Thannhauser, S. J.: Über die Pathogenese der Gicht. Dtsch. med. Wschr. 81, 492 (1956).

    PubMed  CAS  Google Scholar 

  252. Thannhauser, S. J.: The pathogenesis of gout. Metabohsm 5, 582 (1956).

    CAS  Google Scholar 

  253. Thannhauser, S. J., u. P. Curtius: Über den Eiweißumsatz im Stickstoffminimum eines Akromegalen und über seine Beeinflussung durch Röntgenbestrahlung des Kopfes. Dtsch. Arch. khn. Med. 143, 287 (1923).

    Google Scholar 

  254. Thannhauser, S. J., and G. Czoniczer: Kennen wir Erkrankungen des Menschen, die durch eine Störung des intermediären Purinstoffwechsels verursacht werden ? Dfcsch. Arch. khn. Med. 135, 224 (1921).

    Google Scholar 

  255. Tinney, W. S., H. P. Polley, B. E. Hall and H. Z. Gippin: Polycythemia vera and gout: report of eight cases. Proc. Mayo Clin. 20, 49 (1945).

    CAS  Google Scholar 

  256. Tileston, W., and W. A. Grippin: Chronic famüy jaundice. Amer. J. med. Sci. 139, 847 (1910).

    Google Scholar 

  257. Tivey, H.: The prognosis for survival in chronic granulocytic and lymphocytic leukemia. Amer. J. Roentgenol. 72, 68 (1954).

    PubMed  CAS  Google Scholar 

  258. Tivey, H.: The natural history of untreated acute leukemia. Ann. N.Y.Acad. Sci. 60, 322 (1954/1955).

    Google Scholar 

  259. Traut, E. F., A. A. Knight, P. B. Szanto and E. W. Passerelli: Specific vascular changes in gout. J. Amer. med. Ass. 156, 591 (1954).

    CAS  Google Scholar 

  260. Ullrich, K. J.: Über die Funktion des Nierenmarkes. Dtsch. med. Wschr. 84,1197 (1959).

    CAS  Google Scholar 

  261. Videbaek, A.: PolycjTthaemia vera. Course and prognosis. Acta med. scand. 138, 179 (1950).

    PubMed  CAS  Google Scholar 

  262. Villa, L., A. Robecchi and C. B. Ballabio: Physiopathology, clinical manifestation, and treatment of gout. Part 1. Physiopathology and pathogenesis. Ann. rheum. Dis. 17, 9 (1958).

    PubMed  CAS  Google Scholar 

  263. Vining, C. W., and J. G. Thomson: Gout and aleukaemic leukaemia in a boy aged five. Arch. Dis. Clim. 9, 277 (1934).

    CAS  Google Scholar 

  264. Weber, F. P.: Erythraemia with migraine, gout, and intracardiac thrombosis. Lancet 1934 I, 808.

    Google Scholar 

  265. Weisberger, A. S., and L. Persky: Renal calcuh and uremia as comphcations of lymphoma. Amer. J. med. Sci. 225, 669 (1953).

    PubMed  CAS  Google Scholar 

  266. Weissmann, B., P. A. Bromberg and A. B. Gutman: The purine bases of human urine. I. Separation and identification. II. Semiquantitative estimation and radioisotope incorporation. J. biol. Chem. 224, 407, 423 (1957).

    PubMed  CAS  Google Scholar 

  267. Widmann, H.: Verlaufsformen der Polycythämia vera. Medizinische 1958, 1374.

    Google Scholar 

  268. Wilkinson, J. F.: Megalocytic anaemias. Lancet 1949 I, 249, 292, 336.

    Google Scholar 

  269. Wilson, D., A. Beyer, C. Bishop and J. H. Talbott: Urinary uric acid excretion after the injection of isotopic yeast nucleic acid in the normal and gouty human. J. biol. Chem. 209, 227 (1954).

    PubMed  CAS  Google Scholar 

  270. Wilson, D., C. Bishop, and J. H. Talbott: A factorial experiment to test the effect of various types of diets on uric acid excretion of normal human subjects. J. appl. Physiol. 4,560 (1952).

    PubMed  CAS  Google Scholar 

  271. Wilson, D., D. H. Collins and R. M. Mason: Gout: discussion. Proc. roy. Soc. Med. 44,285 (1951).

    PubMed  CAS  Google Scholar 

  272. Wirz, H.: The location of antidiuretic action in the mammahan kidney. In: The Neurohypophysis, Proceedings of the VIII. Symposium of the Colston Research Society. S. 157. New York: Academic Press 1957.

    Google Scholar 

  273. Wolpson, W. G., R. E. Thompson, W. D. Robinson, I. P. Dupp, C. Cohn, L. Lewis and H. D. Hunt: The development, evaluation and clinical use of long-acting ACTH preparations. In: Second Clinical ACTH Conference. Philadelphia: The Blakiston Company, 1951.

    Google Scholar 

  274. Wolfson, W. Q., C. Cohn and C. Shove: The renal mechansism for urate excretion in the Dalmatian coach-hound. J. exp. Med. 92, 121 (1950).

    PubMed  CAS  Google Scholar 

  275. Wood, D. J.: Inflammatory diseases in the eye caused by gout. Brit. J. Ophthalm. 20, 510 (1936).

    CAS  Google Scholar 

  276. Wu, H.: Separate analysis of the corpuscles and the plasma. J. biol. Chem. 51, 21 (1922).

    CAS  Google Scholar 

  277. Wyngaarden, J. B.: The effect of phenylbutazone on uric acid metabolism in two normal subjects. J. clin. Invest. 34, 256 (1955).

    PubMed  CAS  Google Scholar 

  278. Wyngaarden, J. B.: Intermediary purine metabolism and the metabolic defects of gout. Metabolism 6, 244 (1957).

    PubMed  CAS  Google Scholar 

  279. Wyngaarden, J. B.: Normal glycine-C14-incorporation into uric acid in primary gout. Metabolism 7, 374.

    Google Scholar 

  280. Wyngaarden, J. B.: The role of the kidney in the pathogenesis and treatment of gout. Arthr. Rheum. 1, 191 (1958).

    CAS  Google Scholar 

  281. Wyngaarden, J. B., A. E. Blair and L. Hilley: On the mechanism of overproduction of uric acid in patients with primary gout. J. clin. Invest. 37, 579 (1958).

    PubMed  CAS  Google Scholar 

  282. Wyngaarden, J. B., J. E. Seegmiller, L. Laster and A. E. Blair: Utilization of hypoxanthine, adenine, and 4-amino-5-imidazolecarboxamide for uric acid synthesis in man. Metabolism 8, 455. (1959).

    Google Scholar 

  283. Wyngaarden, J. B., and D. Stetten Jr.: Uricolysis in normal man. J. biol. Chem. 203, 9 (1953).

    PubMed  CAS  Google Scholar 

  284. Yeager, R. L., W. G. C. Munroe and F. J. Dessau: Pyrazinamide (aldinamide) in the treatment of pulmonary tuberculosis. Amer. Rev. Tuberc. 65, 523 (1952).

    CAS  Google Scholar 

  285. Yü, T. P., L. Berger, D. J. Stone, J. Wolf and A. B. Gutman: Effect of pyrazinamide and pyrazinoic acid on urate clearance and other discrete renal functions. Proc. Soc. exp. Biol. (N.Y.) 96, 264 (1957).

    Google Scholar 

  286. Yü, T. P., J. J. Burns and A. B. Gutman: Results of a clinical trial of G-28 315, a sulfoxide analog of phenylbutazone, as a uricosuric agent in gouty subjects. Arthr. Rheum. 1, 532 (1958).

    Google Scholar 

  287. Yü, T. P., and A. B. Gutman: Ultrafiltrability of plasma urate in man. Proc. Soc. exp. Biol.(N. Y.). 84, 21 (1953).

    Google Scholar 

  288. Yü, T. P.: Paradoxical retention of uric acid by uricosuric drags in low dosage. Proc. Soc. exp. Biol. (N. Y.) 90, 542 (1955).

    Google Scholar 

  289. Yü, T. P.: A study of the paradoxical effects of salicylate in low, intermediate and high dosage on the renal mechanism for excretion of urate in man. J. clin. Invest. 38, 1298 (1959).

    PubMed  Google Scholar 

  290. Yü, T. P., J. H. Sirota, L. Berger, M. Halpern and A. B. Gutman: Effect of sodium lactate infusion on urate clearance in man. Proc. Soc. exp. Biol. (N. Y.) 96, 809 (1957).

    Google Scholar 

  291. Yü, T. P., and A. B. Gutman: Effect of phenylbutazone (3,5 dioxo-1,2-diphenyl-4-n-butyl-pyrazolone) on renal clearance of urate and other discrete renal functions in gouty subjects. J. clin. Invest. 32, 1121 (1953).

    PubMed  Google Scholar 

  292. Yü, T. P., L. R. Wasserman, J. D. Benedict, E. J. Bien, A. B. Gutman and D. Stetten jr.: A simultaneous study of glycine-N15 incorporation into uric acid and heme, and of Fe59 utilization in a case of gout associated with polycythemia secondary to congenital heart disease. Amer. J. Med. 15, 845 (1953).

    PubMed  Google Scholar 

  293. Yü, T. P., B. Weissmann, L. Sharney, S. Kupfer and A. B. Gutman: On the biosynthesis of uric acid from glycine-N15 in primary and secondary polycythemia. Amer. J. Med. 21, 901 (1956).

    PubMed  Google Scholar 

  294. Zachau-Christiansen, B.: The variations in serum uric acid during 24 hours and from day to day. Scand. J. clin. Lab. Invest. 9, 244 (1957).

    PubMed  CAS  Google Scholar 

  295. Zachau-Christiansen, B.: The rise in the serum uric acid during muscular exercise. Scand. J. clin. Lab. Invest. 11, 57 (1959).

    PubMed  CAS  Google Scholar 

  296. Zevely, H. a., A. J. French, W. M. Mikkelsen and J. P. Duff: Synovial specimens obtained by knee joint punch biopsy. Amer. J. Med. 20, 510 (1956).

    PubMed  CAS  Google Scholar 

  297. Zöllner, N.: Die Behandlung der Gicht. Dtsch. med. Wschr. 81, 1997 (1956).

    Google Scholar 

  298. Zöllner, N.: Nucleinstoffwechsel. In: Thannnhausers Lehrbuch des Stoffwechsels und der Stoff-wechselkrankheiten. S. 511. Stuttgart: Georg-Thieme-Verlag 1957.

    Google Scholar 

  299. Zöllner, N.: Angeborene Stoffwechselstörungen. Dtsch. med. Wschr. 83, 609–688 (1958).

    PubMed  Google Scholar 

  300. Zöllner, N.: Inborn disorders of metabolism. J. chron. Dis. 10, 6 (1959).

    PubMed  Google Scholar 

  301. Zöllner, N., u. R. Alemzadeh: unveröffentlicht.

    Google Scholar 

  302. Zumoff, B.: Possible relationship of folic acid to uric acid metabolism as exemplified by a case of non-tropical sprue. Amer. J. med. Sci. 225, 674 (1953).

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. Nepomuk Zöllner
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Freiburg I.Br., Deutschland

    L. Heilmeyer

  2. Göttingen, Deutschland

    R. Schoen

  3. Frankfurt A.M., Deutschland

    B. De Rudder

Rights and permissions

Reprints and permissions

Copyright information

© 1960 Springer-Verlag oHG. Berlin · Göttingen · Heidelberg

About this paper

Cite this paper

Zöllner, N. (1960). Moderne Gichtprobleme Ätiologie, Pathogenese, Klinik. In: Heilmeyer, L., Schoen, R., De Rudder, B. (eds) Ergebnisse der Inneren Medizin und Kinderheilkunde. Ergebnisse der Inneren Medizin und Kinderheilkunde, vol 14. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-94773-5_6

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-94773-5_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-94774-2

  • Online ISBN: 978-3-642-94773-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation