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The Mode of Action and Clinical Uses of the Thiouracil Group of Drugs

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Ergebnisse der Inneren Medizin und Kinderheilkunde

Part of the book series: Ergebnisse der Inneren Medizin und Kinderheilkunde ((KINDERHEILK. NF,volume 1))

Abstract

The association of endemic goitre with depressed function of the thyroid gland has long been known. The idea that in such cases the goitre might represent an attempt at overcoming the hypothyroid state has been current for some time; and it must have occurred to many that any agent capable of causing this type of goitre might be used for controlling thyrotoxicosis. This suggestion could not be tried out in practice until sufficiently potent and non-toxic goitrogenic substances had been discovered.

From University College Hospital Medical School, London, Medical Unit.

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References

  1. Albert, A., R. W. Rawson, P. Merrill, B. Lemmon and C. Riddell: J. of biol. Chem. 166, 637 (1946).

    CAS  Google Scholar 

  2. Albert, A.: Endocrinology 40, 299 (1947).

    PubMed  CAS  Google Scholar 

  3. Anderson, G. W., I. F. Halverstadt, W. H. Miller and R. O. Robltn: J. amer. chem. Soc. 67, 2197 (1945).

    CAS  Google Scholar 

  4. Astwood, E. B.: J. of Pharmacol. 78, 79 (1943).

    CAS  Google Scholar 

  5. Astwood, E. B.: J. amer. med. Assoc. 122, 78 (1943).

    CAS  Google Scholar 

  6. Astwood, E. B.: J. clin. Endoc. 4, 229 (1944).

    Google Scholar 

  7. Astwood, E. B.: Harvey Lectures. 1944-5, p. 195.

    Google Scholar 

  8. Astwood, E. B.: J. clin. Endoc. 5, 345 (1945).

    Google Scholar 

  9. Astwood, E. B., A. Bissell: Endocrinology 34, 282 (1944).

    CAS  Google Scholar 

  10. Astwood, E. B., A. M. Hughes: Endocrinology 87, 456 (1945).

    Google Scholar 

  11. Astwood, E. B., J. Sullivan, A. Bissell and R. Tyslowitz: Endocrinology 32. 210 (1943).

    CAS  Google Scholar 

  12. Baumann, E. J., N. Metzger and D. Marine: Endocrinology 34, 44 (1944).

    CAS  Google Scholar 

  13. Barker, M. H., H. A. Lindberg and M. H. Wald: J. amer. med. Assoc. 117, 1591 (1941).

    CAS  Google Scholar 

  14. Barr, D. P. and E. Schorr: An. int. Med. (Am.) 28, 754 (1945).

    Google Scholar 

  15. Bartels, E. C.: Trans, amer. Assoc. Study Goiter 1942-6, 128.

    Google Scholar 

  16. Bartels, E. C.: Amer. J. Med. 2, 150 (1947).

    PubMed  CAS  Google Scholar 

  17. Beierwaters, W. H. and C. C. Sturgis: J. amer. med. Assoc. 131, 735 (1946).

    Google Scholar 

  18. Amer. J. med. Sei. 212, 513 (1946).

    Google Scholar 

  19. Bevelander, G.: Proc. Soc. exper. Biol. a. Med. (Am.) 61, 268 (1946).

    CAS  Google Scholar 

  20. BieLschowsky, F.: Brit. J. exper. Path. 25, 90 (1945).

    Google Scholar 

  21. Campbell, D., F. W. Landgrebe and T. N. Morgan: Lancet 1, 630 (1944).

    Google Scholar 

  22. Chapman, E. M.: Quoted by 77.

    Google Scholar 

  23. Chapman, C. J.: Quart. J. Pharmacy 17. 314 (1944).

    CAS  Google Scholar 

  24. Chesley, L. C.: J. clin. Invest. (Am.) 23, 856 (1944).

    CAS  Google Scholar 

  25. Chesley, L. C.: J. biol. Chem. (Am.) 152, 571 (1944).

    CAS  Google Scholar 

  26. Chesney, A. M., T. A. Clawson and B. Webster: Bull. Johns Hop. Hosp. 43, 261 (1928).

    Google Scholar 

  27. Chesley, L. C.:Bull. Johns Hop. Hosp. 43, 278 (1928).

    Google Scholar 

  28. Christensen, H. N.: J. biol. Chem. 162, 27 (1946).

    PubMed  CAS  Google Scholar 

  29. Danowski, P. S.: J. biol. Chem. 152, 201 (1944).

    CAS  Google Scholar 

  30. Dempsey, E. W.: Endocrinology 34, 27 (1944).

    CAS  Google Scholar 

  31. Dempsey, E. W., E. B. Astwood: Endocrinology: 32, 509 (1943).

    CAS  Google Scholar 

  32. Dieke, S. H., G. S. Allen and C, P. Richter: J. of Pharmacol. 90, 260 (1947).

    CAS  Google Scholar 

  33. Dobyns, B. M. and S. F. Haines: J. clin. Endoc. 6, 633 (1946).

    CAS  Google Scholar 

  34. Doniach, I. and E. P. Sharpey-Schäfer: J. clin. Endoc. 5, 131 (1947).

    CAS  Google Scholar 

  35. Dvoskin, S.: Endocrinology 40, 334 (1947).

    PubMed  CAS  Google Scholar 

  36. Editorial: Lancet 11, 512 (1947).

    Google Scholar 

  37. Franklin, A. L. and I. L. Chaikoff: J. biol. Chem. 148, 719 (1943).

    CAS  Google Scholar 

  38. Franklin, A. L., S. R. Lerner: J. biol. Chem. 153, 151 (1944).

    CAS  Google Scholar 

  39. Franklin, A. L., S. R. Lerner and I. L. Chaikoff: Endocrinology 34, 265 (1944).

    CAS  Google Scholar 

  40. Friesleben, E. and K. Kjerulf-Jensen: J. clin. Endoc. 7, 47 (1947).

    Google Scholar 

  41. Glock, G. E.: Nature (Lond.) 154, 460 (1944).

    CAS  Google Scholar 

  42. Goldsmith, E. D., A. S. Gordon, G. Finkelstein and H. A. Charipper: J. amer. med. Assoc. 125, 847 (1944).

    Google Scholar 

  43. Goldsmith, E. D., R. F. Nigrell, A. S. Gordon, H. A. Charipper and M. Gordon: Endocrinology 35, 132 (1944).

    CAS  Google Scholar 

  44. Griesbach, W. E.: Brit. J. exper. Path. 22, 245 (1941).

    Google Scholar 

  45. Griesbach, W. E., T. H. Kennedy and H. D. Purves: Brit. J. exper. Path. 22, 249 (1941).

    Google Scholar 

  46. Griesbach, W. E., Brit. J. exper. Path. 26, 18 (1945).

    CAS  Google Scholar 

  47. Hayh, F.: Münch, med. Wschr. 57, 350 (1910).

    Google Scholar 

  48. Harington, C. R.: J. chem. Soc. 1944, 193.

    Google Scholar 

  49. Harington, C. R.: Bull. Soc. Chem. biol. 28, 24 (1946).

    CAS  Google Scholar 

  50. Higgins, G. M.: Amer. J. med. Sei. 210, 347 (1945).

    CAS  Google Scholar 

  51. Higgins, G. M., O. R. Joneson: Amer. J. med. Sei. 212, 294 (1946).

    CAS  Google Scholar 

  52. Himsworth, H. P.. M. E. Morgans and W. R. Trotter: Lancet 1, 241 (1947).

    PubMed  CAS  Google Scholar 

  53. Hughes, A. M. and E. B. Astwood: Endocrinology 34, 138 (1944).

    CAS  Google Scholar 

  54. Jensen, K. A. and K. Kjerulf-Jensen: Acta pharm.-toxicol. 1, 280 (1945).

    CAS  Google Scholar 

  55. Kennedy, T. H.: Nature (Lond.) 150, 233 (1942).

    CAS  Google Scholar 

  56. Kennedy, T. H., H. D. Purves: Brit. J. exper. Path. 22, 241 (1941).

    Google Scholar 

  57. Keston, A. S., E. D. Goldsmith, A. S. Gordon and H. A. Charipper: J. biol. Chem. 152, 241 (1944).

    CAS  Google Scholar 

  58. Kjerulf-Jensen, K.: Acta med. scand. (Stockh.) 123, 511 (1946).

    CAS  Google Scholar 

  59. Larson, R. A., F. R. Keating, W. Peacock and R. W. Rawson: Endocrinology 36, 149 (1945).

    CAS  Google Scholar 

  60. Lawson, A. and C. Rimington: Lancet 1, 586 (1947).

    Google Scholar 

  61. Leathem, J. H.: Endocrinology 36, 98 (1945).

    CAS  Google Scholar 

  62. Leblond, C. P. and H. E. Hoff: Endocrinilogv 35, 229 (1944).

    CAS  Google Scholar 

  63. McGinty, D. A. and W. G. Bywater: J. of Pharmacol. 84, 342 (1945).

    CAS  Google Scholar 

  64. McGinty, D. A.: J. of Pharmacol. 85, 129 (1945).

    CAS  Google Scholar 

  65. McGinty, D. A., E. A. Sfarf: Endocrinology 39, 74 (1946).

    Google Scholar 

  66. Mackensie, C. G.: Endocrinology 40, 137 (1947).

    Google Scholar 

  67. Mackensie, C. G.: J. B. Mackensie: Endocrinology 32, 185 (1943).

    Google Scholar 

  68. Mackensie, C. G.: Proc. Soc. exper. Biol. a, Med. 54, 34 (1943).

    Google Scholar 

  69. Mackensie, J. B., C. G. Mackensie and E. V. McCallum: Science (N. Y.) 94 /518 (1941).

    Google Scholar 

  70. Mackensie, H.: Brit, med. J. 11, 1077 (1905).

    Google Scholar 

  71. Marine, D. and E. J. Baumann: Trans. Assoc. amer. Physicious 47, 261 (1932).

    Google Scholar 

  72. Marine, D., A. W. Spence and A. Cipra: Proc. Soc. exper. Biol. a. Med. 29, 772 (1932).

    CAS  Google Scholar 

  73. Malkiel, S.: Endocrinology 38, 58 (1946).

    PubMed  CAS  Google Scholar 

  74. Meulengracht, E., K. Kjerulf-Jensen and K. Schmidt: Nord. med. Ark. (schwed.) 32, 2806 (1946),

    Google Scholar 

  75. Meyer, A. E., M. B. Collins and D. Marine: Proc. Soc. exper. Biol. a. Med. 50, 221 (1944)

    Google Scholar 

  76. Miller, W. H., R. O. Rblin and E. B. Astwood: J. amer. chem. Soc. 67, 2201 (1945).

    Google Scholar 

  77. Moore, F. D.: J. amer. med. Assoc. 130, 315 (1946).

    CAS  Google Scholar 

  78. Moore, F. D., D. N. Sweeny, O. Cope, R, W. Rawson and J. H.Means: Ann. Surg. 120, 152 (1944).

    CAS  Google Scholar 

  79. Morgans. M. E.: Lancet 1, 519 (1947).

    PubMed  Google Scholar 

  80. Morton, J. H.: Amer. J. Med. 2, 53 (1947).

    PubMed  CAS  Google Scholar 

  81. Murray, G. R.: Lancet 11, 1612 (1902).

    Google Scholar 

  82. Newman, E. V. and B. F. Jones: J. amer. med. Assoc. 132, 77 (1946).

    CAS  Google Scholar 

  83. Payne, R. L., A. R, Crane and J. G. Price: Surg. 22, 496 (1947). etc.

    Google Scholar 

  84. Perrault, M. and D. Bovet: Lancet 1, 731 (1946).

    PubMed  CAS  Google Scholar 

  85. Poate, H. R, G.: Med. J. Austral. 11, 93 (1947).

    Google Scholar 

  86. Purves, H. D.: Brit. J. exper. Path. 24, 171 (1943).

    Google Scholar 

  87. Purves, H. D.: W. E. Griesbach: Brit. J. exper. Path. 27, 170 (1946).

    CAS  Google Scholar 

  88. Purves, H. D.: Brit. J. exper. Path. 28, 46 (1947).

    CAS  Google Scholar 

  89. Randall, L. O.: J. biol. Chem. (Am.) 164, 521 (1946).

    CAS  Google Scholar 

  90. Rawson, R. W., S. Hertz and J. H. Means: J. din. Invest. (Am.) 21, 624 (1942).

    Google Scholar 

  91. Rawson, R. W.: Ann. int. Med. (Am.) 19, 829 (1943).

    CAS  Google Scholar 

  92. Rawson, R. W., F. D. Moore, W. Peacock, J. H. Means, O. Cope and C. B. Riddell: J. clin. Invest. (Am.) 24, 869 (1945).

    CAS  Google Scholar 

  93. Rawson, R. W., J. F. Tannheimer and W. Peacock: Endocrinology 34, 245 (1944).

    CAS  Google Scholar 

  94. Richter C. P.: J. amer. med. Assoc. 129, 927 (1945).

    CAS  Google Scholar 

  95. Richter C. P., K. H. Clisby: Proc. Soc. exper. Biol. a. Med. 48, 684 (1941).

    CAS  Google Scholar 

  96. Richter C. P.: Arch. Path. (Am.) 33, 46 (1942).

    CAS  Google Scholar 

  97. De Robertis, E. and R. Grasso: Endocrinology 38, 137 (1946).

    CAS  Google Scholar 

  98. Rose, E. and J. McConnell: Amer. J. med. Sci. 213, 74 (1947).

    PubMed  CAS  Google Scholar 

  99. Severinghans, A. E., G. K. Smelser and H. M. Clark: Proc. Soc. exper. Biol. a. Med. 31, 1127 (1934).

    Google Scholar 

  100. Sharpey-Schafer, E. P.: Brit. med. J. 11, 888 (1946).

    Google Scholar 

  101. Sharpless, G. R., J. Pearsons and G. S. Prato: J. Nutrit. (Am.) 17, 545 (1939).

    CAS  Google Scholar 

  102. Stanley M. M. and E. B. Astwood: Endocrinology 41, 66 (1947).

    PubMed  CAS  Google Scholar 

  103. Warren, C. O.: Science (N. Y.) 102, 175 (1945).

    CAS  Google Scholar 

  104. Williams, R. H., S. P. Asper, E. F. Rogers, J. D. Myers and C. W. Lioyd: New England J. Med. 236, 737 (1947).

    CAS  Google Scholar 

  105. Williams, R. H., E. G. Frame: Bull. Johns Hop. Hosp. 77, 314 (1945).

    CAS  Google Scholar 

  106. Williams, R. H., B. J. Jandorf and G. A. Kay: J. Labor, a. clin. Med. 29. 329 (1944>.

    Google Scholar 

  107. Williams, R. H., G. A. Kay: J. clin. Endoc. 4, 385 (1944).

    CAS  Google Scholar 

  108. Williams, R. H., Amer. J. med. Sci. 213, 198 (1947).

    PubMed  CAS  Google Scholar 

  109. Williams, R. H., B. J. Jandorf: J. clin. Invest. 23, 613 (1944).

    PubMed  CAS  Google Scholar 

  110. Williams, R. H., G. A. Kay: Arch. int. Med. 80, 37 (1947).

    CAS  Google Scholar 

  111. Williams, R. H., A. R. Weinglass, G. W. Bissell and J. B. Peters: Endocrinology 34, 317 (1944).

    CAS  Google Scholar 

  112. Williams, R. H., G. A. Kay: Amer. J. med. Sci. 207, 701 (1944).

    CAS  Google Scholar 

  113. Winkle, W. van, S. M. Hardy, G. R. Hazel, D. C. Hines, H. S. Newcomer, E. A. Sharp and W. N. Sisk: J. amer. med. Assoc. 130, 343 (1946).

    Google Scholar 

  114. Winkler, A. W., E. B. Man and T. S. Donastu: J. clin. Invest. 26, 446 (1947).

    CAS  Google Scholar 

  115. Wright, L. E. A. and V. M. Trikojus: Med. J. Austral. 11, 541 (1946).

    Google Scholar 

  116. Zeckwer, I. T., L. W. Davison, T. B. Keller and C. S. Livingood: Amer. J. med. Sci. 190, 145 (1935).

    Google Scholar 

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Authors and Affiliations

  1. London, UK

    W. R. Trotter & H. P. Himsworth

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  1. W. R. Trotter
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  2. H. P. Himsworth
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Editors and Affiliations

  1. Oldenburg I. OLDBG., Deutschland

    H. Assmann

  2. Rottach A. Tegernsee, Deutschland

    A. Schittenhelm

  3. Göttingen, Deutschland

    R. Schoen

  4. Bern, Switzerland

    E. Glanzmann

  5. Frankfurt A. M., Deutschland

    B. De Rudder

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© 1949 Springer-Verlag OHG. Berlin, Göttingen and Heidelberg

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Trotter, W.R., Himsworth, H.P. (1949). The Mode of Action and Clinical Uses of the Thiouracil Group of Drugs. In: Assmann, H., Schittenhelm, A., Schoen, R., Glanzmann, E., De Rudder, B. (eds) Ergebnisse der Inneren Medizin und Kinderheilkunde. Ergebnisse der Inneren Medizin und Kinderheilkunde, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-94558-8_2

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  • DOI: https://doi.org/10.1007/978-3-642-94558-8_2

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