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Paraneoplastische neurologische Syndrome

  • Chapter
Immunglobuline in der klinischen Neurologie

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Zusammenfassung

Paraneoplastische neurologische Syndrome (NPS) sind Tumorfernwirkungen („remote effects of cancer“) und bilden eine heterogene Gruppe von Krankheitsbildern. Bei diesen Tumorfernwirkungen sind autoimmunologische Phänomene entweder nachgewiesen oder es liegen aufgrund begleitender Befunde starke Verdachtsmomente vor.

Die Einteilung paraneoplastischer neurologischer Symptome kann unter verschiedenen Gesichtspunkten erfolgen: Ffir die folgende Zusammenfassung wird eine Einteilung in 3 Untergruppen verwendet:

  1. 1.

    NPS mit bekannten AntikOrpern und denen nachgewiesener Pathogenitat (Gruppe A),

  2. 2.

    NPS, bei denen antineuronale AntikOrper bekannt sind, aber der Pathomechanismus noch nicht geklârt ist (Gruppe B),

  3. 3.

    NPS, bei denen keine Antikfirperkonstellation bekannt ist (Gruppe C).

Entsprechend dieser Einteilung werden die therapeutischen Mdglichkeiten, insbesondere der Einsatz von IVIg, anhand der vorliegenden Literatur besprochen und durch eine eigene Serie von Behandlungsversuchen ergänzt.

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  1. W. Grisold
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  2. M. Drlicek
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  3. S. Urbanits
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  1. Neurologische Klinik mit Klinischer Neurophysiologie, Alfried Krupp Krankenhaus, Alfried-Krupp-Straße 21, 45117, Essen, Deutschland

    Peter Berlit

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Grisold, W., Drlicek, M., Urbanits, S. (2001). Paraneoplastische neurologische Syndrome. In: Berlit, P. (eds) Immunglobuline in der klinischen Neurologie. Steinkopff. https://doi.org/10.1007/978-3-642-93716-3_11

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