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Angiotensin II AT1-Rezeptorantagonisten pp 1–38Cite as

Das Renin-Angiotensin-System: Physiologie und Pathophysiologie

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Zusammenfassung

Das Renin-Angiotensin-System (RAS) mit seinem Effektorpeptid Angiotensin II (Ang II) als zirkulierendem Hormon wird seit langem als ein klassisches endokrines System angesehen. Die Entdeckung des Renins geht auf das Jahr 1898 zurück, als Tigerstedt und Bergmann die Beobachtung machten, daß durch Injektion eines Kaninchennierenextrakts eine Blutdrucksteigerung bei Kaninchen erzielt werden kann [283]. In den folgenden Jahrzehnten wurde die Existenz des Vasopressors Renin kontrovers diskutiert, und erst 1934 wurde die Bedeutung von Renin für die Blutdruckregulation von Goldblatt erneut erkannt [101]. Seiner Forschungsgruppe gelang es, einen Zusammenhang zwischen Renin-Freisetzung und renaler Ischämie nachzuweisen. Nur wenige Jahre später, 1937, diskutierten Blalock und Levy die Abhängigkeit der Renin-Freisetzung vom renalen Perfusionsdruck [20] und kamen zu dem Schluß, daß renale Barorezeptoren dabei eine Rolle spielen mußten [285]. Die physiologische und biochemische Charakterisierung von Renin wurde in den folgenden Jahren vervollständigt.

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Literatur

  1. Abhold RH, Sullivan MJ, Wright JM, Harding JW (1987) Binding, degradation and pressor activity of angiotensin II and III after amino peptidase inhibition with amastatin and bestatin. J Pharmacol Exp Ther 242: 957–962

    CAS  PubMed  Google Scholar 

  2. Aceto JF, Baker KM (1990) [Sari] angiotensin II receptor-mediated stimulation of protein synthesis in chick heart cells. Am J Physiol 258: H806-H813

    CAS  PubMed  Google Scholar 

  3. Admiraal PJJ, Danser AHJ, Sjoukje-Jong M, Pieterman H, Derkx FHM, Schalekamp MADH (1993) Regional angiotensin II production in essential hypertension and renal artery stenosis. Hypertension 21: 173–184

    CAS  PubMed  Google Scholar 

  4. Ahmed A, Li XF, Shams M, Gregory J, Rollason T, Barnes NM, Newton JR (1995) Localization of the angiotensin II and its receptor subtype expression in human endometrium and identification of a novel high- affinity angiotensin II binding site. J Clin Invest 96: 848–857

    CAS  PubMed Central  PubMed  Google Scholar 

  5. Alhenc-Gelas F, Soubrier F, Hubert C, Allegrini J, Corvol P (1989) The peculiar characteristics of the amino acid sequence of angiotensin I converting enzyme, as determined by cDN A cloning of the human endothelial enzyme. J Cardiovasc Pharmacol 14 [suppl 4]: S6-S9

    CAS  PubMed  Google Scholar 

  6. Ames RP, Borkowski AJP, Sicinski ALMM, Laragh JH (1965) Prolonged infusions of angiotensin II and norepinephrine on blood pressure, electrolyte balance, aldosterone and cortisole secretion in normal man in cirrhosis with ascites. J Clin Invest 44: 1171–1186

    CAS  PubMed Central  PubMed  Google Scholar 

  7. Anderson PW, Do YS, Hsueh WA (1993) Angiotensin 11 causes mesanglial cell hypertrophy. Hypertension 21:29–35

    CAS  PubMed  Google Scholar 

  8. Andre P, Schott C, Nehlig H, Stoclet JC (1990) Aortic smooth muscle cells are able to convert angiotensin I to angiotensin II. Biochem Biophys Res Commun 173: 1137–1142

    CAS  PubMed  Google Scholar 

  9. Ayers CR (1967) Plasma renin activity and renin substrate concentration in patients with liver disease. Circ Res 20: 594–598

    CAS  PubMed  Google Scholar 

  10. Bachmann S, Peters J, Engler E, Ganten D, Mullins JJ (1992) Transgenic rats carrying the mouse renin gene. Morphological characterization of a low-renin hypertension model. Kidney Int 41: 24–36

    CAS  Google Scholar 

  11. Baker KM, Booz GW, Dostal DE (1992) Cardiac actions of angiotensin II: role of an intracardiac renin- angiotensin system. Ann Rev Physiol 54: 227–241

    CAS  Google Scholar 

  12. Bauer PH, Chiù AT, Garrison JC (1991) DuP 753 can antagonize the effects of angiotensin II in rat liver. Mol Pharmacol 39: 579–585

    CAS  PubMed  Google Scholar 

  13. Bellucci A, Wilkes BM (1984) Mechanism of sodium modulation of glomerular angiotensin receptors in the rat. J Clin Invest 74: 1593–1600

    CAS  PubMed Central  PubMed  Google Scholar 

  14. Benjamin N, Collier JG, Webb DJ (1988) Angiotensin II augments sympathetically induced venoconstric- tion in man. Clin Sci 5 [suppl 4]: 337–340

    Google Scholar 

  15. Berk BC, Vekshtein V, Gordon HM,Tsuda T (1989) Angiotensin Il-stimulated protein synthesis in cultured vascular smooth muscle cells. Hypertension 13: 305–314

    CAS  PubMed  Google Scholar 

  16. Bernstein KE, Martin BM, Bernstein EA, Linton J, Striker L, Striker G (1988) The isolation of angiotensin converting enzyme cDNA. J Biol Chem 263: 11021–11024

    CAS  PubMed  Google Scholar 

  17. Bernstein KE, Martin BM, Edwards AS, Berstein EA (1989) Mouse angiotensin converting enzyme is a protein composed of two homologous domains. J Biol Chem 264: 11945–11951

    CAS  PubMed  Google Scholar 

  18. Beyer C, Rohmeiss P, Qadri F, Strauch M, Unger Th (1992) Characterization and localization of the central osmoreceptor. FASEB J 7: A406

    Google Scholar 

  19. Bickerton RK, Buckley JP (1961) Evidence for a central mechanism in angiotensin-induced hypertension. Proc Soc Exp Biol Med 106: 834

    CAS  Google Scholar 

  20. Blalock A, Levy SE (1937) Studies of the ethiology of hypertension. Ann Surg 106: 826–847

    CAS  PubMed Central  PubMed  Google Scholar 

  21. Blume A, Lebrun C, Herdegen Th, linger Th (1993) Angiotensin II induces receptor-mediated expression of immediate-early genes in the rat central nervous system (abstract). FASEB J 7 (3): 1427

    Google Scholar 

  22. Blume A, Lebrun CJ, Herdegen T, Linz W, Bravo R, Möllenhoff E, Unger Th (1997) Angiotensin II induces an increased expression of inducible transcription factors in the brain of spontaneously hypertensive rats. Hypertension, in press

    Google Scholar 

  23. Blundell T, Sibanda BL, Pearl L (1983) Three dimensional structure, specificity and catalytic mechanism of renin. Nature 304:273–275

    CAS  PubMed  Google Scholar 

  24. Bock KD, Gross F (1961) Renin and angiotensin tachyphylaxis. Circ Res 9: 1044–1055

    CAS  PubMed  Google Scholar 

  25. Bottari SP, King IN, Reichlin IS, Dahlstroem I, Lyden N, deGasparo M (1992) The angiotensin AT, receptor stimulates protein tyrosine phosphatase activity and mediates inhibition of particulate guanylate cyclase. Biochem Biophys Res Commun 183: 206–211

    CAS  PubMed  Google Scholar 

  26. Braun-Menendez E, Fasciolo JC, Leloir JF, Munoz JM. The substance causing renal hypertension. J Physiol 98: 283–298

    Google Scholar 

  27. Brechler V, Jones PW, Levens NR, deGasparo M, Bottari SP (1993) Agonistic and antagonistic properties of angiotensin analogs at the AT, receptor in PC12W cells. Regul Pept 44: 207–213

    CAS  PubMed  Google Scholar 

  28. Brechler V, Reichlin S, deGasparo M, Bottari SP (1994) Angiotensin 11 stimulates protein phosphatase activity through a G-protein independent mechanism. Receptors and Channels 2: 89–97

    CAS  PubMed  Google Scholar 

  29. Bruneval P, Hinglais N, Alhenc-Gelas F (1986) Angiotensin I converting enzyme in human intestine and kidney. Ultrastructural immunohistochemical localization. Histochem 85: 73–80

    CAS  Google Scholar 

  30. Buisson B, Bottari SP, deGasparo M, Gallo-Payet N, Payet MD (1992) The angiotensin AT, receptor modulates T-type calcium current in non-differentiated NG 108–15 cells. FEBS Lett 309: 161–164

    CAS  PubMed  Google Scholar 

  31. Buisson B, Laflamme L, Bottari SP, deGasparo M, Gallo-Payet N, Payet MD (1995) A G-protein is involved in the angiotensin AT, receptor inhibition of the T-type Ca-+ current in non-differentiated NG 108–15 cells. JBiol Chem 270: 1670–1674

    CAS  Google Scholar 

  32. Bumpus FM, Catt KJ, Chiù AT (1991) Nomenclature for angiotensin receptors. A report of the nomenclature committee of the Council for High Blood Pressure Research. Hypertension 17: 720–722

    CAS  PubMed  Google Scholar 

  33. Burnham CE, Hawel-Johnson CL, Frank BM, Lynch KR (1987) Molecular cloning of rta renin cDNA and its gene. Proc Natl Acad Sci USA 84: 5605–5609

    CAS  PubMed Central  PubMed  Google Scholar 

  34. Burt DW, Beecroft LJ, Mullind JJ (1985) Mouse renin gene structure, evolution and function. In: Kosta V (ed) Aspartic proteinases and their inhibitors. Walter de Gruyter & Co, Berlin, 355–377

    Google Scholar 

  35. Caldwell PRB, Seegal BC, Hsu KC, Das M, Softer RL (1976) Angiotensin converting enzyme: vascular endothelial localization. Science 191: 1050–1051

    CAS  PubMed  Google Scholar 

  36. Cambien F, Poirier O, Lecerf L(1992) Deletion polymorphism in the gene for angiotensin converting enzyme is a potent risk factor for myocardial infarction. Nature 359: 641–644

    CAS  PubMed  Google Scholar 

  37. Campbell DJ, Bouhnik J, Menard J, Corvol P (1984) Identity of angiotensinogen precursors in rat brain and liver. Nature 308: 206–208

    CAS  PubMed  Google Scholar 

  38. Campell DJ, Habener FJ (1986) Angiotensinogen gene is expressed and differentially regulated in multiple tissues of the rat. J Clin Invest 78: 31–39

    Google Scholar 

  39. Campbell DJ, Habener DF (1987) Cellular localization of angiotensinogen gene expression in brown adipose tissue and mesentery: quantification of messenger ribonucleic acid abundance using hybridization in situ. Endocrinology 121: 1616–1626

    CAS  PubMed  Google Scholar 

  40. Campbell DJ (1987) Circulating and tissue angiotensin systems. J Clin Invest 79: 1–6

    CAS  PubMed Central  PubMed  Google Scholar 

  41. Campbell-Boswell M, Robertson AL (1981) Effects of angiotensin II and vasopressin on human smooth muscle cells in vitro. Exp Mol Pathol 35: 265

    CAS  PubMed  Google Scholar 

  42. Carretero O, Gross F (1967) Renin substrate in plasma under various experimental conditions in the rat. Am J Physiol 213: 695–700

    CAS  PubMed  Google Scholar 

  43. Cassis LA, Lynch KR, Peach MJ (1988) Localization of angiotensinogen messenger RNA in rat aorta. Circ Res 62: 1259–1262

    CAS  PubMed  Google Scholar 

  44. Cassis LA, Saye JA, Peach MJ (1988) Location and regulation of rat angiotensinogen messenger RNA. Hypertension 11: 591–596

    CAS  PubMed  Google Scholar 

  45. Chai SY, McKinley MJ, Mendelsohn FAO (1987) Distribution of angiotensin converting enzyme in sheep hypothalamus and medulla oblongata visualized by in vitro autoradiography. Clin Exper Theory and Practice A9 (2&3): 449–460

    CAS  Google Scholar 

  46. Chang RSL, Lotti VJ (1989) Selective ligands reveal subtypes of angiotensin receptors in rat vasculature and brain. Pharmacologist 31: 150

    Google Scholar 

  47. Chang SL, Lotti VL (1990) Two distinct angiotensin II receptor binding sites in rat adrenal revealed by new selective nonpeptide ligands. Mol Pharmacol 29: 347–351

    Google Scholar 

  48. Chang RSL, Lotti VJ (1991) Angiotensin receptor subtypes in rat, rabbit and monkey tissues: relative distribution and species dependency. Life Sci 49: 1485–1490

    CAS  PubMed  Google Scholar 

  49. Chappell MC, Diz DI, Jacobson DW (1992) Pharmacological characterization of angiotensin II binding sites in the canine pancreas. Peptides 13: 313–318

    CAS  PubMed  Google Scholar 

  50. Chiù AT, Herblin WF, McCall DE (1989) Identification of angiotensin II receptor subtypes. Biochem Biophys Res Commun 165: 196–203

    PubMed  Google Scholar 

  51. Chiù AT, Duncia JV, McCall DE (1989) Nonpeptide angiotensin II receptor antagonists. III. Structure function studies. J Pharmacol Exp Ther 250: 867–874

    PubMed  Google Scholar 

  52. Chung O, Rohmeiss P, Gretz N, Unger Th (1993) The transgenic mRen2rat. In: Gretz N, Strauch M (eds) Experimental and genetic rat models of chronic renal failure. Karger, Basel, 124–128

    Google Scholar 

  53. Chung O, Schips T, Qadri F, Ganten D, Mullins JJ, Unger Th (1991) Cardiovascular characterization of a new hypertensive animal model. J Hypertens 9 [suppl 6]: S340

    Google Scholar 

  54. Clouston WM, Evans BA, Haralambidis J, Richards RI (1988) Molecular cloning of the mouse angiotensinogen gene. Genomics 2: 240–248

    CAS  PubMed  Google Scholar 

  55. Cogan MG (1990) Angiotensin II: a powerful controller of sodium transport in the early proximal tubule. Hypertension 13: 451–458

    Google Scholar 

  56. Correa FMA, Plunkett LM, Saavedra JM, Hichens M (1985) Quantitative autoradiographic determination of angiotensin converting enzyme (kinase II) binding and individual rat brain nuclei with 1251–351 A, a specific enzyme inhibitor. Brain Res 347: 192–195

    CAS  PubMed  Google Scholar 

  57. Culman J, Höhle S, Qadri F, Edling O, Blume A, Lebrun C, Unger Th (1995) Angiotensin as neuromodulator/neurotransmitter in central control of body fluid and electrolyte homeostasis. Clin and Exp Hypertens 17:281–293

    CAS  Google Scholar 

  58. Dai WJ, Yao T (1995) Effects of dehydration and salt-loading on hypothalamic vasopressin mRNA level in male and female rats. Brain Res 676: 178–182

    CAS  PubMed  Google Scholar 

  59. Darnell JE, Kerr I A, Stark GR (1994) Jak/STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264: 1415–1421

    CAS  PubMed  Google Scholar 

  60. Deschepper CF, Bouhnik J, Ganong WF (1986) Colocalization of angiotensinogen and glial fibrillary acidic protein in astrocytes in rat brain. Brain Res 355: 195

    Google Scholar 

  61. Dhanaraj V, Deal wis CG, Frazao C (1992) X-ray analysis of peptide-inhibitor complexes define the structural basis of specificity for human and mouse renins. Nature 357: 466–472

    CAS  PubMed  Google Scholar 

  62. Dostal DE, Rothblum KN, Chernin MI, Cooper GR, Baker KM (1992) Intracardiac detection of angiotensinogen and renin: a localized renin-angiotensin system in neonatal rat heart. Am J Physiol 263: C838-C850

    CAS  PubMed  Google Scholar 

  63. Dudley DT, Panek RL, Major TC (1990) Subclasses of angiotensin II binding sites and their functional significance. Mol Pharmacol 38: 370–377

    CAS  PubMed  Google Scholar 

  64. Dudley DT, Hubbel SE, Summerfeit RM (1991) Characterization of angiotensin II (AT,) binding sites in R3T3 cells. Mol Pharmacol 40: 360–367

    CAS  PubMed  Google Scholar 

  65. Dudley DT, Summerfeit RM (1993) Regulated expression of angiotensin II (AT,) binding sites in R3T3 cells. Reg Pept 44: 199–206

    CAS  Google Scholar 

  66. Dzau VJ (1984) Vascular renin angiotensin: a possible autocrine or paracrine system in control of vascular function. J Cardiovasc Pharmacol 6: S377-S382

    PubMed  Google Scholar 

  67. Dzau VJ, Ellison KE, Brody T, Ingeliinger JR, Pratt RE (1987) A comparative study of the distribution of renin and angiotensinogen messenger ribonucleic acids in rat and mouse tissues. Endocrinology 120: 2334–2338

    CAS  PubMed  Google Scholar 

  68. Dzau VJ (1988) Cardiac renin-angiotensin system: molecular and functional aspects. Am J Med 84 [suppl 3A]: 22–27

    CAS  PubMed  Google Scholar 

  69. Dzau VJ (1988) Circulating versus local renin angiotensin systems in cardiovascular homeostasis. Circulation 77 [suppl I]: 14–113

    Google Scholar 

  70. Dzau VJ, Gibbons GH, Pratt RE (1991) Molecular mechanisms of vascular renin-angiotensin system in myointimal hyperplasia. Hypertension 18 [suppl II]:11100–11105

    Google Scholar 

  71. Eggena P, Krall F, Egena MP, Clegg K, Fittingoff M, Barrett JD (1990) Production of angiotensinogen by cultured rat aortic smooth muscle cells. Clin Exper Hyper Theory and Practice A12 (7): 1175–1189

    CAS  Google Scholar 

  72. Eggena P, Zhu JH, Clegg K, Barrett JD (1993) Nuclear angiotensin receptors transduce transcription of renin and angiotensin mRNA. Hypertension 22: 496–501

    CAS  PubMed  Google Scholar 

  73. Egleme C, Cressier F, Wood JM (1990) Local formation of angiotensin II in the rat aorta: effect of endothelium. Br J Pharmacol 100: 237–240

    CAS  PubMed Central  PubMed  Google Scholar 

  74. Eglen RM, Rapp JM, Leung E (1991) Characterization of angiotensin II receptors in guinea pig gastrointestinal tract. FASEB J 5: A869

    Google Scholar 

  75. Ehlers MRW, Riordan JF (1989) Angiotensin converting enzyme: new concepts concerning its biological role. Biochemistry 28: 5311–5318

    CAS  PubMed  Google Scholar 

  76. Ekker M, Tronik D, Rougeon F (1989) Extra-renal transcription of the renin genes in multiple tissues of mice and rat. Proc Natl Acad Sci USA 86: 155–158

    Google Scholar 

  77. Elton TS, Stephan TC, Taylor GR (1992) Isolation of two distinct type 1 angiotensin II receptor genes. Biochem Biophys Res Commun 184: 1067–1073

    CAS  PubMed  Google Scholar 

  78. Entzeroth M, Hadamovsky S (1991) Angiotensin II receptors in the rat lung are of the All-1 subtype. Eur J Pharmacol 206: 237–241

    CAS  PubMed  Google Scholar 

  79. Erdös EG (1975) Angiotensin I converting enzyme. Circ Res 36: 247–253

    PubMed  Google Scholar 

  80. Erdös EG (1990) Angiotensin I converting enzyme and the changes in our concepts through the year. Hypertension 16: 363–370

    PubMed  Google Scholar 

  81. Ernsberger P, Zhou J, Damon TH, Douglas JG (1992) Angiotensin 11 receptor subtypes in cultured rat renal mesangial cells. Am J Physiol 263: F411-F416

    CAS  PubMed  Google Scholar 

  82. Falkenhahn M, Franke F, Bohle RM, Zhu YZ, Stauss HM, Bachmann S, Danilov S, Unger Th (1994) Cellular distribution of angiotensin-converting enzyme after myocardial infarction. Hypertension 25: 219–226

    Google Scholar 

  83. Fischer J, Stoll M, Unger Th (1996) Thrombospondin mRNA expression in increased in endothelial cells following stimulation of AT, receptors (abstract). J Vase Res 33 (SI): 26

    Google Scholar 

  84. Freer RJ, Pappano AJ, Peach MJ (1976) Mechanisms for the positive inotropic effect of angiotensin II on isolated cardiac muscle. Circ Res 39: 178

    CAS  PubMed  Google Scholar 

  85. Fukamizu A, Nishi K, Cho T (1988) Structure of the rat renin gene. J Mol Biol 201: 443–450

    CAS  PubMed  Google Scholar 

  86. Furuta H, Guo DF, Inagami T (1992) Molecular cloning and sequencing of the gene encoding human angiotensin II type I receptor. Biochem Biophys Res Commun 183: 8–13

    CAS  PubMed  Google Scholar 

  87. Fyhrquist FY, Forslund T, Tikkanen I, Grönhagen-Riska C (1980) Induction of angiotensin-I-converting enzyme in rat lung with Captopril (SQ 14225). Eur J Pharmacol 67: 473–475

    CAS  PubMed  Google Scholar 

  88. Gaillard I, Clauser E, Corvol P (1989) Structure of human angiotensinogen gene. DNA 8: 87–99

    CAS  PubMed  Google Scholar 

  89. Gallinat S, Csikos T, Meffert S, Herdegen T, Stoll M, Unger Th (1997) The angiotensin II AT, receptor mediates down-regulation of neurofilament M in PC12W cells. Neurosci Lett 227: 29–32

    CAS  PubMed  Google Scholar 

  90. Gallinat S, Yu MH, Dorst A, Unger Th, Herdegen T (1998) Sciatic nerve transection evokes lasting up- regulation of angiotensin AT,- and AT-receptor mRNA in adult rat dorsal root ganglia neurons and sciatic nerves. Brain Res Mol Brain’Res 57: 111–121

    CAS  Google Scholar 

  91. Ganten D, Schelling P, Flugel RM, Ganten U (1975) Effect of angiotensin and an angiotensin antagonist on iso-renin and cell-growth in 3T3 mouse cells. Int Res Commun Med Sci 3: 327

    CAS  Google Scholar 

  92. Ganten D, Lang RE, Lehmann E, Unger Th (1984) Brain angiotensin: on the way to becoming a well-studied neuropeptide system. Biochem Pharmacol 33: 3523–3528

    CAS  PubMed  Google Scholar 

  93. deGasparo M, Whitebread S, Meie M (1990) Biochemical characterization of two angiotensin II receptor subtypes in the rat. J Cardiovasc Pharmacol 16 [suppl 4]: S31-S35

    CAS  Google Scholar 

  94. Gehlert DR, Gackenheimer SL, Reel JK, Lin HS, Steinberg MI (1990) Non-peptide angiotensin II receptor antagonists discriminate subtypes of 1251-angiotensin II binding sites in the rat brain. Eur J Pharmacol 187: 123–126

    CAS  PubMed  Google Scholar 

  95. Gehlert DR, Gackenheimer SL, Schober DA (1991) Autoradiographic localization of subtypes of angiotensin II antagonist bindins in the rat brain. Neurosci 44: 501–514

    CAS  Google Scholar 

  96. Geisterter AAT, Peach MJ, Owens GK (1988) Angiotensin II induces hypertrophy, not hyperplasia of cultured rat aortic smooth muscle cells. Circ Res 62: 749–756

    Google Scholar 

  97. Gibson RE, Thorpe HH, Cartwright ME (1991) Angiotensin II receptor subtypes in renal cortex of rats and rhesus monkeys. Am J Physiol 261: F512-F518

    CAS  PubMed  Google Scholar 

  98. Gohlke P, Unger Th, Biinning P(1992) Distribution of the angiotensin converting enzyme inhibitor ramiprilat in the blood vessel wall. Pharm Pharmacol Lett 2: 66–69

    CAS  Google Scholar 

  99. Gohlke P, Biinning P, Unger Th (1992) Distribution and metabolism of angiotensin I and II in the blood vessel wall. Hypertension 20: 151–157

    CAS  PubMed  Google Scholar 

  100. Gohlke P, Pees C, Unger Th (1998) AT2 receptor stimulation increases aortic cyclic GMP in SHRSP by a kinin-dependent mechanism. Hypertension 31: 349–355

    CAS  PubMed  Google Scholar 

  101. Goldblatt H, Lynch J, Hanzal RF, Summervill WW (1934) The production of persistent elevation of systolic blood pressure by mean of renal ischemia. J Exp Med 59: 347–379

    CAS  PubMed Central  PubMed  Google Scholar 

  102. Gomez RA, Lynch KR, Chevalier RL (1988) Renin and angiotensinogen gene expression in maturing rat kidney. Am J Physiol 254: F582-F587

    CAS  PubMed  Google Scholar 

  103. Gomez RA, Lynch KR, Chevalier RL (1988) Renin and angiotensinogen expression and intrarenal renin distribution during ACE inhibition. Am J Physiol 254: F900-F906

    CAS  PubMed  Google Scholar 

  104. Grady EF, Sechi LA, Griffin CA, Schambelan M, Kalinyak JE (1991) Expression of AT, receptors in the developing rat fetus. J Clin Invest 88: 921–933

    CAS  PubMed Central  PubMed  Google Scholar 

  105. Greene LA, Tischler AS (1982) PC12 pheochromocytoma cultures in neurobiological research. Adv Cell Neurobiol 3: 373–414

    CAS  Google Scholar 

  106. Griffin S A, Brown WCB, MacPherson F (1991) Angiotensin II causes vascular hypertrophy in part by a non- pressor mechanism. Hypertension 17: 626–635

    CAS  PubMed  Google Scholar 

  107. Grinstead WC, Young JB (1992) The myocardial renin-angiotensin system: existence, importance and clinical implications. Am Heart J 123: 1039–1045

    CAS  PubMed  Google Scholar 

  108. Gross F (1958) Renin and hypertension, physiologische und pathophysiologische Wirkstoffe. Klin Wochenschr 36: 693–705

    CAS  PubMed  Google Scholar 

  109. Guillot FL, Augus KL (1990) Angiotensin peptide regulation of fluid-phase endocytosis in brain microvessel endothelial cell monolayers. J Cereb Blood Flow Metab 10: 827–834

    CAS  PubMed  Google Scholar 

  110. Gyurko R, Wielbo D, Phillips MI (1993) Antisense inhibition of AT, receptor mRNA in the brain of spontaneously hypertensive rats reduces hypertension of neurogenic origin. Reg Pept 49: 167–174

    CAS  Google Scholar 

  111. Hackenthal E, Paul M, Ganten D, Taugner R (1990) Morphology, physiology and molecular biology of renin secretion. Physiol Rev 70: 1067–1116

    CAS  PubMed  Google Scholar 

  112. Harding JW, Jenses LL, Hanesworth JM, Roberts KA, Page TA, Wright JW (1992) Release of angiotensin in paraventricular nucleus of rat in response to physiological and chemical stimuli. Am J Physiol 262: F17-F23

    CAS  PubMed  Google Scholar 

  113. Harding JW, Wright JW, Swanson GN, Hanesworth JM, Krebs LT (1994) AT4 receptors: specificity and distribution. Kid Int 46: 1510–1512

    CAS  Google Scholar 

  114. Hardman JA, Hort YJ, Carazaro DF (1984) Primary structure of the human renin gene. DNA 3: 457–467

    CAS  PubMed  Google Scholar 

  115. Herblin WF, Diamond SM, Timmermans PBMWM (1991) Localization of angiotensin II receptor subtypes in the rabbit adrenal and kidney. Peptides 12: 581–584

    CAS  PubMed  Google Scholar 

  116. Herblin WF, Chiù AT, McCall DE (1991) Angiotensin II receptor heterogeinity. Am J Hypertens 4: 299S-302S

    CAS  PubMed  Google Scholar 

  117. Hilbert P, Lindpaintner K, Beckmann JS (1991) Chromosomal mapping of two genetic loci associated with blood-pressure regulation in hereditary hypertensive rats. Nature 353: 521–529

    CAS  PubMed  Google Scholar 

  118. Hodsman GP, Kohzuki M, Howes LG, Sumithran E, Tsunoda K, Johnston CI (1988) Neurohumoral responses to chronic myocardial infarction in rats. Circulation 78: 376–381

    CAS  PubMed  Google Scholar 

  119. Höhle S, Spitznagel H, Rascher W, Culman J, Unger Th (1995) Angiotensin AT, receptor-mediated vasopressin release and drinking are potentiated by an AT, receptor antagonist. Eur J Pharmacol 275: 277–282

    PubMed  Google Scholar 

  120. Höhle S, Culman J, Boser M, Qadri F, Unger Th (1996) Effect of angiotensin AT, and muscarinic receptor blockade on osmotically induced vasopressin release. Eur J Pharmacol 300: 119–123

    PubMed  Google Scholar 

  121. Hogarty DC, Speakman EA, Puig V, Philips MI (1992) The role of angiotensin AT, and AT, receptors in the pressor, drinking and vasopressin responses to central angiotensin. Brain Res 586: 289–294

    CAS  PubMed  Google Scholar 

  122. Holm I, Olio R, Panthier JJ, Rougeon F (1984) Evolution of aspartyl proteases by gene duplication: the mouse renin gene is organized in two homologous clusters of four exons. EMBO J 3: 557–562

    CAS  PubMed Central  PubMed  Google Scholar 

  123. Hooper NM(1991) Angiotensin converting enzyme: implications from molecular biology for its physiological functions. Int J Biochem 23: 641–647

    CAS  PubMed  Google Scholar 

  124. Horiuchi M, Hayashida W, Kambe T, Yamada T, Dzau VJ (1997) Angiotensin type 2 receptor dephosphorylates Bcl-2 by activating mitogen-activated protein kinase phosphatase-1 and induces apoptosis. J Biol Chem 272: 19022–19026

    CAS  PubMed  Google Scholar 

  125. Hsueh WA, Carlson EJ, Israel-Hagman M (1981) Mechanism of acid activation of renin: role of kallikrein in kinin activation. Hypertension 3 [suppl I]: 122–129

    Google Scholar 

  126. Ichikawa I, Pfeffer JM, Pfeffer MA, Hostetter TH, Brenner BM (1984) Role of angiotensin II in the altered renal function of congestive heart failure. Circ Res 55: 669–675

    CAS  PubMed  Google Scholar 

  127. Ichiki T, Herold CL, Kambayashi Y, Bardhan S, Inagami T (1994) Cloning of the cDNA and the genomic structure of the mouse angiotensin II type 2 receptor. Biochim Biophy Acta 1189: 247–250

    CAS  Google Scholar 

  128. Ikemoto F, Song GB, Tominaga M, Kanayama Y, Yamamoto K (1987) Angiotensin converting enzyme predominates in the inner cortex and medulla of the rat kidney. Biochem Biophys Res Commun 144: 915–921

    CAS  PubMed  Google Scholar 

  129. Ikemoto F, Song GB, Tominaga M, Kanayama Y, Yamamoto K (1990) Angiotensin converting enzyme in the rat kidney. Activity, distribution and response to angiotensin converting enzyme inhibitors. Nephron 55 [suppl 11]:3–9

    CAS  PubMed  Google Scholar 

  130. Imboden H, Harding JW, Hilgenfeldt U, Celio MR, Felix D (1987) Localization of angiotensinogen in multiple cells types of rat brain. Brain Res 410: 74–77

    CAS  PubMed  Google Scholar 

  131. Ingelfinger JR, Fon EA, Ellison KE, Dzau VJ (1988) Localization of the intrarenal renin angiotensin system (RAS) by in situ hybridization of renin and angiotensinogen mRNAs. labstractl. Kidney Int 33: 269A

    Google Scholar 

  132. Ingelfinger JR, Zuo WM, Fon EA, Ellison KE, Dzau VJ (1990) In situ hybridization evidence for angiotensinogen messenger RNA in the rat proximal tubule. An hypothesis for the intrarenal angiotensin system. J Clin Invest 85: 417–423

    CAS  PubMed Central  PubMed  Google Scholar 

  133. Iwai N, Inagami T (1992) Quantitative analysis of renin gene expression in extrarenal tissues by polymerase chain reaction method. J Hypertens 10: 717–724

    CAS  PubMed  Google Scholar 

  134. Jackson B, Cúbela RB, Sakaguchi K, Johnston CI (1988) Characterization of angiotensin converting enzyme (ACE) in the restis and assesment of in the in vitro effects of the ACE inhibitor perindopril. Endocrinology 123: 50–55

    CAS  PubMed  Google Scholar 

  135. Jacobsen J, Poulsen K(1990) In vivo generation and elimination of angiotensin in the rat. Clin Exp Pharmacol Physiol 17:445–451

    CAS  PubMed  Google Scholar 

  136. Jeunemaitre X, Soubrier F, Koteletsev YV (1992) Molecular basis of human hypertension: role of angiotensinogen. Cell 71: 169–180

    CAS  PubMed  Google Scholar 

  137. Jin M, Wilhelm MJ, Lang RE, Unger Th, Lindpaintner K, Ganten D (1988) Endogenous tissue renin- angiotensin systems: from molecular biology to therapy. Am J Med 84 Isuppl 3A]: 28–36

    CAS  PubMed  Google Scholar 

  138. Johnson H, Drummer OH (1988) Hydrolysis of angiotensin I by peptidase in homogenates of rat lung and aorta. Biochem Pharmacol 37: 113 l-l136

    Google Scholar 

  139. Johnson CI, Burrell LM, Perich R, Jandeleit K, Jackson B (1992) The tissue renin-angiotensin system and its functional role. Clin Exp Pharmacol Physiol 19 [suppl 19]: 1–5

    Google Scholar 

  140. Kageyama R, Ohkubo H, Nakanishi S (1984) Primary structure of human preangiotensinogen deduced from the cloned cDNA sequence. Biochemistry 23: 3603–3609

    CAS  PubMed  Google Scholar 

  141. Kambayashi Y, Bardhan S, Tahahashi K, Tsuzuki S, Inui H, Hamakobu T, Inagami T (1993) Molecular cloning of a novel angiotensin II receptor isoform involved in phosphotyrosine phosphatase inhibition. J Biol Chem 268: 24543–24546

    CAS  PubMed  Google Scholar 

  142. Kang J, Posner P, Sumners C (1994) Angiotensin type II receptors stimulation of neuronal K+ currents involves an inhibitory G-protein. Am J Physiol 267: C1289-C1297

    Google Scholar 

  143. Kawahara Y, Sunako M, Tsuda T, Fukuzaki H, Fukumoto Y, Takai Y (1988) Angiotensin II induces expression of the c-fos gene through protein kinase C activation and calcium ion mobilization in cultured vascular smooth muscle cells. Biochem Biophys Res Commun 150: 52–59

    CAS  PubMed  Google Scholar 

  144. Khairallah PA, Robertson AL, Davila D (1972) Effects of angiotensin II on DNA, RNA and protein synthesis. In: Genest J, Kolw E (eds) Hypertension. Springer Verlag, New York, 212–220

    Google Scholar 

  145. Kimura B, Sumners C, Phillips MI (1992) Changes in skin angiotensin II receptors in rats during wound healing. Biochem Biophys Res Commun 187: 1083–1090

    CAS  PubMed  Google Scholar 

  146. Kinoshita A, Urata H, Bumpus FM, Husain A (l99l) Multipe determinates for the high substrate specificity of an angiotensin II forming chymase from the human heart. J Biol Chem 266 (29): 19192–19197

    Google Scholar 

  147. Kitami Y, Hiwada K, Kokubu T (1989) Kidney renin gene expression in spontaneously hypertensive rats. J Hypertens 7: 727–731

    CAS  PubMed  Google Scholar 

  148. Klett C, Hellman W, Suzuki F (1988) Induction of angiotensinogen mRNA in hepatocytes by angiotensin II and glucocorticoids. Clin Exp Hypertens AIO: 1009–1022

    Google Scholar 

  149. Kobayashi M, Furkawa Y, Chiba S (1978) Positive chronotropic and inotropic effects of angiotensin II in the dog heart. Eur J Pharmacol 50: 17

    CAS  PubMed  Google Scholar 

  150. Kofir I, Dzau VJ (1987) Endothelial renin-angiotensin pathway: evidence for intracellular synthesis and secretion of angiotensins. Circ Res 60: 422–428

    Google Scholar 

  151. Kohara K, Brosnihan KB, Chappell MC, Khosla MC, Ferrano CM (1991) Angiotensin (1–7): a member of circulating angiotensin peptides. Hypertension 17: 131–138

    CAS  PubMed  Google Scholar 

  152. Koike G, Winer ES, Horiuchi M, Brown DM, Szpires C, Dzau VJ, Jacob HJ (1995) Cloning, characterization and genetic mapping of the rat type 2 angiotensin II receptor gene. Hypertension 26 (6): 998–1002

    CAS  PubMed  Google Scholar 

  153. Kost CK Jr, Jackson EK (1993) Enhanced renin angiotensin II subtype I receptor responses in the spontaneously hypertensive rat. Hypertension 21: 420–431

    CAS  PubMed  Google Scholar 

  154. Krivoy N, Schlüter H, Karas M, Zidek W (1992) Generation of angiotensin II from human plasma by kallikrein. Clin Sci 83: 477–482

    CAS  PubMed  Google Scholar 

  155. Laflamme L, deGasparo M, Gallo JM, Payet MD, Gallo-Payet N (1996) Angiotensin II induction of neurite outgrowth by AT, receptors in NG108–15 cells. J Biol Chem 271: 22729–22735

    CAS  PubMed  Google Scholar 

  156. Lang RE, Rascher W, Heil J, Unger Th, Wiedemann G, Ganten D (1981) Angiotensin stimulates oxytoxin release. Life Sci 29: 1425–1428

    CAS  PubMed  Google Scholar 

  157. Langford KG, Shai SY, Howard TE, Kovac MJ, Overbeek PA, Bernstein KE(1991) Transgenic mice demonstrate a testis specific promoter for angiotensin converting enzyme. J Biol Chem 266: 15559–15562

    CAS  PubMed  Google Scholar 

  158. Lecki BJ, McGhee NK (1980) Reversible activation-inactivation of renin in human plasma. Nature 288: 702–704

    Google Scholar 

  159. Lebrun CJ, Bao G, Möllenhoff E, Culman J, Unger Th (1995) Angiotensin II induces the expression of c-fos mRNA in the central nervous system of the rat. Clin Exp Hyper 17: 877–893

    CAS  Google Scholar 

  160. Lebrun C, Blume A, Herdegen T, Seifert K, Bravo R, Unger Th (1995) Angiotensin II induces a complex activation of transcription factors in the rat brain: expression of Fos, Jun and Krox proteins. Neurosci 65: 93–99

    Google Scholar 

  161. Leung KH, Smith RD, Timmermans PBMWM, Chiù AT (1991) Regional distribution of the two subtypes of angiotensin II receptor in rat brain using selective non-peptide antagonists. Neurosci Lett 123: 95–98

    CAS  PubMed  Google Scholar 

  162. Lindpaintner K, Wilhelm MJ, Man wen J (1987) Tissue renin-angiotensin systems: focus on the heart. J Hypertens 5 [suppl 2]: S33-S38

    CAS  Google Scholar 

  163. Lindpaintner K, Jin M, Niedermeyer N, Wilhelm MJ, Ganten D (1990) Cardiac angiotensinogen and its local activation in the isolated perfused beating heart. Circ Res 67: 564–573

    CAS  PubMed  Google Scholar 

  164. Lu D, Yu K, Raizada MK (1995) Retrovirus-mediated transfer on an angiotensin type I receptor (AT,-R) antisense sequence decreases AT,-Rs and angiotensin II action in astrologial and neuronal cells in primary cultures from brain. Proc Natl Acad Sci USA 92: 1162–1166

    Google Scholar 

  165. Lu D, Raizada MK (1995) Delivery of angiotensin II type 1 receptor antisense inhibits angiotensin action in neurons from hypertensive rat brain. Proc Natl Acad Sci USA 92: 2914–2918

    CAS  PubMed Central  PubMed  Google Scholar 

  166. Lu LM, Song HY, Tao T (1995) Effect of angiotensin II on vasopressin gene transcription in the hypothalamus of rats. Sheng Li Hsueh Pao 47: 378–380

    Google Scholar 

  167. Lucius R, Galliant S, Rosenstiel P, Herdegen T, Sievers J, Unger Th (1998) The angiotensin AT, receptor promotes axonal regeneration of rat retinal ganglion cells. J Exp Med 188: 661–670

    CAS  PubMed Central  PubMed  Google Scholar 

  168. Liischer TF, Boulanger CM, Dohi Y, Yang Z (1992) Endothelium-derived contacting factors. Hypertension 19:117–130

    Google Scholar 

  169. Lyall F, Doman ES, McQueen J, Bosewell F, Kelly M (1992) Angiotensin II increases protooncogene expression and phosphoinositide turnover in vascular smooth muscle cells via angiotensin AT, receptor. J Hypertens 10:1463–1469

    CAS  PubMed  Google Scholar 

  170. Lynch KR, Peach MJ (1991) Molecular biology of angiotensinogen. Hypertension 17: 263–269

    CAS  PubMed  Google Scholar 

  171. Malik KU, Nasjletti A (1976) Facilitation of adrenergic transmission by locally generated angiotensin II in rat mesenteric arteries. Circ Res 38: 26–30

    CAS  PubMed  Google Scholar 

  172. Marrero MB, Schieffer B, Paxton WG, Heerdt L, Berk BC, Deleafontaine P, Bernstein KE (1995) Direct stimulation of Jak/STAT pathway by the angiotensin II AT, receptor. Nature 375: 247–250

    CAS  PubMed  Google Scholar 

  173. Marshall JJ, Konros HA (1990) Endothelium-derived relaxing factors. A perspective from in vivo data. Hypertension 16: 371–386

    CAS  PubMed  Google Scholar 

  174. Martin MM, Su B, Elton TS (1994) Molecular cloning of the human angiotensin II type 2 receptor cDNA. Biochem Biophys Res Commun 205 (1): 645–651

    CAS  PubMed  Google Scholar 

  175. Mebazzaa A, Chevalier B, Mercadier JJ, Echter E, Rappaport L, Swynghedouw B (1989) A review of the renin-angiotensin system in the normal heart. J Cardiovasc Pharmacol 14 [suppl 4]: 16–20

    Google Scholar 

  176. Meffert S, Stoll M, Steckelings UM, Bottari SP, Unger Th (1996) The angiotensin IIAT2 receptor inhibits proliferation and promotes differentiation in PC12W cells. Mol Cell Endocrinol 122: 59–67

    CAS  PubMed  Google Scholar 

  177. Menard J, Bouhnik J, Clauser E, Richoux JP, Corvol P (1983) Biochemistry and regulation of angiotensinogen. Clin Exp Hypertens A5 [7&8]: 1005–1019

    CAS  Google Scholar 

  178. Meng H, Wielbo D, Gyurko R, Phillips MI (1994) Antisense oligodeoxynucleotide to AT, receptor mRNA inhibits central angiotensin induced thirst and vasopressin. Rep Pept 54: 543–551

    CAS  Google Scholar 

  179. Mendelsohn FAO, Lloyd CJ, Kachel C, Funder JW (1982) Induction by glucocorticoids of angiotensin converting enzyme production from bovine endothelial cells in culture and rat lung in vivo. J Clin Invest 70: 684–692

    CAS  PubMed Central  PubMed  Google Scholar 

  180. Metsärinne KP, Stoll M, Gohlke P, Paul M, Unger Th (1992) Angiotensin II is antimitogenic in vitro for heart capillary endothelial cells. Pharm Pharmacol Lett 2: 150–152

    Google Scholar 

  181. Millan MA, Jacobowitz DM, Aguilera G, Catt KJ (1991) Differential distribution of AT, and AT2 angiotensin II receptor subtypes in the rat brain during development. Proc Natl Acad Sci USA 88: 11440–11444

    CAS  PubMed Central  PubMed  Google Scholar 

  182. Mitchell KD, Navar LG (1990) Interactive effects of angiotensin II on renal hemodynamics and tubular reabsorptive function. Kidney Int 38: S69-S73

    Google Scholar 

  183. Mitchell KD, Navar LG (1991) Influence of intrarenally generated angiotensin II on renal hemodynamics and tubular absorption. Renal Physiol Biochem 14: 155–163

    CAS  PubMed  Google Scholar 

  184. Miyazaki H, Fukamizu A, Hirose S (1984) Structure of the human renin gene. Proc Natl Acad Sci USA 81: 5999–6003

    CAS  PubMed Central  PubMed  Google Scholar 

  185. Moffert RB, McGowan RA, Gross KW (1986) Modulation of kidney renin messenger RNA levels during experimentally induced hypertension. Hypertension 8: 874–882

    Google Scholar 

  186. Morduchowicz GA, Sheikh-Hamad D, Dwyer BE, Stern N, Jo OD, Yanagawa N (1991) Angiotensin II directly increases rabbit renal brush-border membrane sodium transport: presence of local signal transduction system. J Membrane Biol 122: 43–53

    CAS  Google Scholar 

  187. Morris BJ (1989) Human renin protein and gene structures: present and future targets for a renin blockade in treatment of hypertension. J Hypertens 7 (2): S9-S14

    CAS  Google Scholar 

  188. Mullins JJ, Burt DW, Windass JD, McTurk P, George H, Brammar WJ (1982) Molecular cloning of two distinct renin genes from the DBA/2 mouse. EMBO J 1: 1461–1466

    CAS  PubMed Central  PubMed  Google Scholar 

  189. Mullins JJ, Peters J, Ganten D (1990) Fulminant hypertension in transgenic rat harbouring the mouse mRen- 2 gene. Nature 344: 541–544

    CAS  PubMed  Google Scholar 

  190. Mukoyama M, Nakajama M, Horiuchi M, Sasamura H, Pratt RE, Dzau VJ (1993) Expression cloning of type 2 angiotensin II receptor reveals a unique class of seventransmembrane receptors. J Biol Chem 268: 24539–24542

    CAS  PubMed  Google Scholar 

  191. Munzenmaier DH, Greene AS (1996) Opposing actions of angiotensin II on microvascular growth and arterial blood pressure. Hypertension 27: 760–765

    CAS  PubMed  Google Scholar 

  192. Murphy TJ, Alexander RW, Griendling KK, Runge MS, Bernstein KE (1991) Isolation of a cDN A encoding the vascular type 1 angiotensin II receptor. Nature 351: 233–236

    CAS  PubMed  Google Scholar 

  193. Naftilan AJ, Pratt RE, Dzau VJ (1989) Induction of platelet-derived growth factor A-chain and c-myc gene expression by angiotensin II in cultured rat vascular smooth muscle cells. J Clin Invest 83: 1419–1424

    CAS  PubMed Central  PubMed  Google Scholar 

  194. Naftilan AJ, Pratt RE, Eldridge CS, Dzau VJ (1989) Angiotensin II induces c-fos expression in smooth muscle cells via transcriptional contron. Hypertension 13: 706–711

    CAS  PubMed  Google Scholar 

  195. Naftilan AJ, Zuo WM, Ingeliinger JR, Ryan T, Pratt T, Dzau VJ (1991) Localization and differential regulation of angiotensinogen mRNA expression in the vessel wall. J Clin Invest 87: 1300–1311

    CAS  PubMed Central  PubMed  Google Scholar 

  196. Nahmias C, Strosberg DA (1995) The angiotensin AT, receptor: searching for signal transduction pathways and physiological function. TIPS 16: 223–225

    CAS  PubMed  Google Scholar 

  197. Nahmias C, Strosberg AD (1996) Structure and function of human and murine AT, receptors (abstract). Scientific meeting in New York, May 11

    Google Scholar 

  198. Nakajima M, Mukoyama M, Pratt RE, Horiuchi M, Dzau VJ (1993) Cloning of cDNA and analysis of the gene for the mouse angiotensin II type 2 receptor. Biochem Biophys Res Commun 197 (2): 393–399

    CAS  PubMed  Google Scholar 

  199. Nakajima M, Hutchinson HG, Fujinaga M, Hayashida W, Morishita R, Zhang L, Horiuchi M, Pratt RE, Dzau VJ (1995) The angiotensin II type 2 (AT,) receptor antagonizes the growth effects of the AT, receptor: gain-of-function study using gene transfer. Proc Natl Acad Sci USA 92 (23): 10663–10667

    CAS  PubMed Central  PubMed  Google Scholar 

  200. Neuß M, Regitz-Zagrosek V, Fleck E (1994) Human cardiac fibroblasts express an angiotensin receptor with unusal binding characteristics. Biochem Biophys Res Commun 204: 1334–1339

    PubMed  Google Scholar 

  201. Nio Y, Matsubara H, Murasawa S, Kanasaki M, Inada M (1995) Regulation of gene transcription of angiotensin II receptor subtypes in myocardial infarction. J Clin Invest 95: 46–54

    CAS  PubMed Central  PubMed  Google Scholar 

  202. Obermüller N, Unger Th, Culman J, Gohlke P, de Gasparo M, Bottari SP (1991) Distribution of angiotensin II receptor subtypes in rat brain nuclei. Neurosci Lett 132: 11–15

    PubMed  Google Scholar 

  203. Oelkers W, Brown JJ, Eraser R (1974) Sensitization of the adrenal cortex to angiotensin II in sodiumdeplete man. Circ Res 34: 69

    CAS  Google Scholar 

  204. Ohkubo H, Kageyama R, Ujihara M, Hirose T, Inayama S (1983) Cloning and sequence analysis of cDNA of rat angiotensinogen. Proc Natl Acad Sci USA 80: 2196–2200

    CAS  PubMed Central  PubMed  Google Scholar 

  205. Okunishi H, Miyazaki M, Okamura T, Toda N (1987) Different distribution of two types of angiotensin Il-generating enzymes in the aortic wall. Biochem Biophys Res Commun 149: 1186–1192

    CAS  PubMed  Google Scholar 

  206. Oldfield BJ, Ganten D, McKinley MJ (1989) An ultrastructural analysis of the distribution of angiotensin II in the rat brain. J Neuroendocrinol 1: 121–128

    CAS  PubMed  Google Scholar 

  207. Owens GK, Rabinowitch PS, Schwartz SM (1981) Smooth muscle cell hypertrophy versus hyperplasia in hypertension. Proc Natl Acad Sci USA 78: 7759–7763

    CAS  PubMed Central  PubMed  Google Scholar 

  208. Page IH, Helmer OM (1940) Angiotensin activator, renin, and angiotonin inhibitor and the mechanism of angiotonin tachyphylaxis in normal, hypertensive and nephrectomized animals. J Exp Med 71: 485–519

    Google Scholar 

  209. Page JH, McSwain B, Knapp GM, Andrus WD (1941) Origin of renin activator. Am J Physiol 135: 214–235

    CAS  Google Scholar 

  210. Paguet JL, Baudouin-Legros M, Marchel P, Meyer P (1989) Enhanced proliferation activity of cultured smooth muscle cells from spontaneously hypertensive rats. Am J Hypertens 13: 295–304

    Google Scholar 

  211. Paquet JC, Bandomin-Legros M, Brunelle G, Meyer P (1990) Angiotensin ll-induced proliferation of aortic myocytes in spontaneously hypertensive rats. J Hypertens 8: 565–572

    CAS  PubMed  Google Scholar 

  212. Panthier JJ, Holm I, Rougeon F (1982) The mouse Rn locus: S allele of the renin regulator gene results from a single structural gene duplication. EMBO J 1: 1417–1421

    CAS  PubMed Central  PubMed  Google Scholar 

  213. Paul M, Printz M, Harms E, Unger Th, Lang RE, Ganten D (1985) Localization of renin and converting enzyme in nerve endings of rat brain. Brain Res 334: 315–324

    CAS  PubMed  Google Scholar 

  214. Paul M, Wagner D, Metzger R (1988) Quantification of renin mRNA in various mouse tissues by a novel solution hybridization assay. J Hypertens 6: 247–252

    CAS  PubMed  Google Scholar 

  215. Peach MJ, Cline WH, Watts DT (1966) Release of adrenal catecholamines by angiotensin IL Circ Res 19: 571–575

    CAS  Google Scholar 

  216. Peach MJ (1981) Molecular actions of angiotensins. Biochem Pharmacol 30: 2745–2751

    CAS  PubMed  Google Scholar 

  217. Peters J, Mtinter K, Bader M, Hackental E, Mullins JJ, Ganten D (1993) Increased adrenal renin in transgenic hypertensive rats, TGR(mRen2)27, and its regulation by cAMP, angiotensin II, and calcium. J Clin Invest 91: 742–747

    CAS  PubMed Central  PubMed  Google Scholar 

  218. Phillips MJ, Speakman EA, Kimura B (1993) Levels of angiotensin and molecular biology of the tissue renin-angiotensin systems. Reg Pept 43: 1–20

    CAS  Google Scholar 

  219. Phillips MI, Speakman EA, Kimura B (1993) Levels of angiotensin and molecular biology of the tissue renin angiotensin system. Regul Pept 43: 1–20

    CAS  PubMed  Google Scholar 

  220. Piccini N, Knopf JL, Gross KW (1982) A DNA polymorphism, consistent with gene duplication, correlated with high renin levels in the mouse submaxillary gland. Cell 30: 205–213

    CAS  PubMed  Google Scholar 

  221. Pipili E, Manolopoulos V, Carravas J(1989) Angiotensin converting enzyme activity is present in the endothelium denuded aorta. Br J Pharmacol 98: 333–335

    CAS  PubMed Central  PubMed  Google Scholar 

  222. Pratt RE, Zou WM, Naftilan AJ, Ingelfinger JR, Dzau VJ (1989) Altered sodium regulation of renal angiotensinogen mRNA in the spontaneously hypertensive rat. Am J Physiol 256: 469–474

    Google Scholar 

  223. Pucell AG, Hodges JC, Sen I, Bumpus FM, Husain A (1991) Biochemical properties of the ovarian granulosa cell type 2 angiotensin II receptor. Endocrinology 128: 1947–1959

    CAS  PubMed  Google Scholar 

  224. Quadri F, Culman J, Veltmar A, Maas K, Rascher W, Unger Th (1993) The angiotensin Il-induced vasopressin release is mediated through alpha-adrenoreceptors and angiotensin II AT, receptors in the supraoptic nucleus. J Pharmacol Exp Ther 267 (2): 567–574

    Google Scholar 

  225. Quadri F, Edling O, Wolf A, Gohlke P, Culman J, Unger Th (1994) Release of angiotensin in the paraventricular nucleus in response to hyperosmotic stimulation in conscious rats: a microdialysis study. Brain Res 637: 45–49

    Google Scholar 

  226. Raizada MK, Rydzewski B, Lu D, Sumners C (1993) Angiotensin II type 1 receptor-mediated stimulation of c-fos gene expression in astrologial cultures. Am J Physiol 265: C1046–1049

    Google Scholar 

  227. Rasmussen S, Nielson MD, Giese J (1981) Captopril combined with thiazide-lowers renin substrate concentration: implications for methodology in renin assays. Clin Sci 60: 591–593

    CAS  PubMed  Google Scholar 

  228. Ray PE, Castren E, Ruley EJ, Saveedra JM (1990) Different effects of sodium or chloride depletion on angiotensin II receptors in rats. Am J Physiol 258: R1008-R1015

    CAS  PubMed  Google Scholar 

  229. Ray PE, Aguilera G, Kopp JB, Horikoshi S, Klotman PE (1991) Angiotensin II receptor-mediated proliferation of cultured human fetal mesangial cells. Kidney Int 40: 764–771

    CAS  PubMed  Google Scholar 

  230. Re R, Fallon JT, Dzau VJ, Quay SC, Haber S (1982) Renin synthesis by canine aortic smooth muscle cells in culture. Life Sci 30: 99–106

    CAS  PubMed  Google Scholar 

  231. Re RN (1989) The cellular biology of angiotensin: paracrine, autocrine and intracrine actions in cardiovascular tissues. J Mol Cell Cardiol 21 [suppl V]: 63–69

    CAS  PubMed  Google Scholar 

  232. Rix E, Ganten D, Schiill B, Unger Th, Taugner R (1981) Converting enzyme in the choroid plexus, brain and kidney: immunocytochemistry and biochemical studies in rats. Neurosci Lett 22: 125–130

    CAS  PubMed  Google Scholar 

  233. Roberts KA, Krebs LT, Kramar EA, Shaffer MJ, Harding JW, Wright JW (1995) Autoradiographic identification of brain angiotensin IV binding sites and differential c-fos expression following intracerebroventric- ular injection of angiotensin II and IV in rats. Brain Res 682: 13–21

    CAS  PubMed  Google Scholar 

  234. Rogerson FM, Chai SY, Schlawe I, Murray KW, Marley PD, Mendelsohn FAO (1992) Presence of angiotensin converting enzyme in the adventitia of large blood vessels. J Hypertens 10: 615–620

    CAS  PubMed  Google Scholar 

  235. Rohmeiss P, Beyer C, Hocher B, Quadri F, Gretz N, Strauch M, Unger Th (1995) Osmotically induced natriuresis and blood pressure involves angiotensin AT, receptors in the subfornical organ. J Hypertens 13: 1399–1404

    CAS  PubMed  Google Scholar 

  236. Rohmeiss P, Beyer C, Nagy E, Tschöpe C, Höhle S, Strauch M, Unger Th (1995) NaCl injections in brain induce natriuresis and blood pressure responses sensitive to Ang II AT, receptors. Am J Physiol 269: F282-F288

    CAS  PubMed  Google Scholar 

  237. Rougeon F, Chambraud B, Foote S, Panthier JJ, Nageotte R (1981) Molecular cloning of a mouse- submaxillary gland renin cDNA fragment. Proc Natl Acad Sci USA 78: 6367–6371

    CAS  PubMed Central  PubMed  Google Scholar 

  238. Rowe BP, Grove KL, Saylor DL, Speth RC (1991) Discrimination of angiotensin II receptor subtype distribution in the rat brain using non-peptide receptor antagonists. Regul Pept 33: 45–53

    CAS  PubMed  Google Scholar 

  239. Rowland NE, Li BH, Fregly MJ, Smith GC (1995) Fos induced in brain of spontaneously hypertensive rats by angiotensin II and colocalization with AT, receptors. Brain Res 675: 127–134

    CAS  PubMed  Google Scholar 

  240. Roy SN, Kusari J, Soffer RL, Lai CY, Sen GC (1988) Isolation of cDNA clones of rabbit angiotensin converting enzyme: identification of two distinct mRNAs for the pulmonary and the testicular isoenzymes. Biochem Biophys Res Commun 155: 678–684

    CAS  PubMed  Google Scholar 

  241. Ryan US, Tyan JW, Whitaker C, Chiù A (1976) Localization of angiotensin converting enzyme (kininase II). II. Immunocytochemistry and immunofluorescence. Tissue Cell 8(1): 125–146

    CAS  PubMed  Google Scholar 

  242. Ryan JW (1989) Peptidase enzymes of the pulmonary vascular surface. Am J Physiol 257: L53-L60

    CAS  PubMed  Google Scholar 

  243. Samani NJ, Swales JD, Brammar WJ (1988) Expression of renin gene in extra-renal tissues of the rat. BiochemJ 253: 907–910

    CAS  Google Scholar 

  244. Samani NJ, Godfrey NP, Major JS, Brammar WJ, Swales JD (1989) Kidney renin mRNA levels in the early and chronic phases of two kidney, one clip hypertension in the rat. J Hypertens 7: 105–112

    CAS  PubMed  Google Scholar 

  245. Saveedra JM (1992) Brain and pituitary angiotensin. Endocr Rev 13: 329–380

    Google Scholar 

  246. Saye JA, Singer HA, Peach MJ (1984) Role of endothelium in conversion of angiotensin II to angiotensin II in rabbit aorta. Hypertension 6: 216–221

    CAS  PubMed  Google Scholar 

  247. Schelling P, Ganten U, Sponer G, Unger Th, Ganten D (1980) Components of the renin-angiotensin system in the cerebospinal fluid of rats and dogs with special consideration of the origin and the fate of angiotensin IL Neuroendocrinol 31: 297–308

    CAS  Google Scholar 

  248. Schinke M, Doods HN, Ganten D, Wienen W, Entzeroth M (1991) Characterization of rat intestinal angiotensin II receptors. Eur J Pharmacol 204: 165–170

    CAS  PubMed  Google Scholar 

  249. Schunkert H, Hirsch AT, Mankodi S, Talsness C, Dzau VJ, Ingelfinger JR (1989) Renal angiotensinogen gene expression in experimental heart failure: effect of angiotensin converting enzyme inhibition (abstract). Clin Res 37:584A

    Google Scholar 

  250. Schwartz ML, Shneidman PS, Bruce J, Schlaepfer WW (1992) Actinomycin prevents the destabilization of neurofilament mRNA in primary sensory neurons. J Biol Chem 267: 24596–24600

    CAS  PubMed  Google Scholar 

  251. Sealey JE, Adas SA, Laragh JH (1980) Prorenin and other large molecular weight forms of renin. Endocr Rev I: 365–392

    Google Scholar 

  252. Sechi LA, Grady EF, Griffin CA, Kalinyak JE, Schambelan M (1992) Distribution of angiotensin II receptor subtypes in rat and human kidney. Am J Physiol 262: F236-F240

    CAS  PubMed  Google Scholar 

  253. Seikaly MG, Arant BS Jr, Seney FD (1990) Endogenous angiotensin concentrations in specific intrarenal fluid compartments of the rat. J Clin Invest 86: 1352–1357

    CAS  PubMed Central  PubMed  Google Scholar 

  254. Sen I, Rajasekaran AK (1991) Angiotensin Il-binding protein in adult and neonatal rat heart. J Mol Cardiol 23:563–572

    CAS  Google Scholar 

  255. Shepherd JT, Katusic ZS (1991) Endothelium-derived relaxing factors: endothelium dependent relaxation. Hypertension 18 [suppl III]: III-76-III85

    Google Scholar 

  256. Shimizu K, Share L, Claybaugh JR (1973) Potentiation by angiotensin II of the vasopressin response to an increasing plasma osmolality. Endocrinology 93: 42–50

    CAS  PubMed  Google Scholar 

  257. Siemens IR, Reagan LP, Yee DK, Fluharty SJ (1994) Biochemical characterization of two distinct angiotensin AT2 receptor populations in murine neuroblastoma NIE-115 cells. J Neurochem 62: 2106–2115

    CAS  PubMed  Google Scholar 

  258. Simon M, Flügge A, Fuchs E, Grone HJ (1991) Evidence for two angiotensin II receptor subtypes in human fetal and adult kidney demonstrated by the All receptor antagonist losartan and PD 123177. FASEB J 5: A870

    Google Scholar 

  259. Siragy HM, Carey RM (1997) The subtype (AT2) angiotensin receptor mediates renal production of nitric oxide in conscious rats. J Clin Invest 100 (2): 264–269

    CAS  PubMed Central  PubMed  Google Scholar 

  260. Skeggs LT, Kahn JR, Shumway NP (1956) The preparation and function of the hypertensive converting enzyme. J Exp Med 103: 295–299

    CAS  PubMed Central  PubMed  Google Scholar 

  261. Skidgel RA, Schulz WW, Tam LT, Erdös EG (1987) Human renal angiotensin converting enzyme and neutral endopeptidase. Kidney Int 31 [suppl 20]: S45-S48

    Google Scholar 

  262. Skott O, Jensen BL (1993) Cellular and intrarenal control of renin secretion. Clin Sci 84: 1–10

    CAS  PubMed  Google Scholar 

  263. Soubrier F, Panthier JJ, Corvol P, Rougeon F (1983) Molecular cloning and nucleotide sequence of a human renin cDNA. Nucleic Acid Res 11: 7181–7190

    CAS  PubMed Central  PubMed  Google Scholar 

  264. Soubrier F, Alhenc-Gelas F, Hubert C (1988) Two putative active centers in human angiotensin I converting enzyme revealed by molecular cloning. Proc Nad Acad Sci USA 85: 386–390

    Google Scholar 

  265. Stadler T, Veltmar A, Quadri F, Unger Th (1992) Angiotensin II evokes noradrenaline release from the paraventricular nucleus in conscious rats. Brain Res 569: 117–122

    CAS  PubMed  Google Scholar 

  266. Stanislas-Leguern G, Mordeler Dambrine M, Dusser D, Huesca M, Chretien J, Huchon GJ (1986) In vitro synthesis of angiotensin converdng enzyme by alveolar macrophages is increased in disseminated sarcoidosis. Lung 164: 269–277

    CAS  PubMed  Google Scholar 

  267. Stauss H, Unger Th (1991) Role of angiotensin II in thirst-induced drinking. FASEB J 5 (4): A658

    Google Scholar 

  268. Stauss H, Busch O, Unger Th (1992) Positiv inotroper Effekt von zentralem Angiotensin II. Nieren und Hochdruckkrankheiten 11: 634–636

    Google Scholar 

  269. Steckelings U, Obermüller N, Bottari SP, Quadri F, Veltmar A, Unger Th (1992) Brain angiotensin: receptors, actions and possible role in hypertension. Pharmacol Toxicol 70 [suppl II]: 23–27

    Google Scholar 

  270. Stoll M, Steckelings UM, Bottari SP, Unger Th (1993) Regulation of endothelial cell growth: role of the angiotensin 11AT2 receptor. Circulation 88 [suppl 4, part 2]: 1–469

    Google Scholar 

  271. Stoll M, Steckelings UM, Paul M, Bottari SP, Metzger R, Unger Th (1995) The angiotensin AT2-receptor mediates inhibition of cell proliferation in coronary endothelial cells. J Clin Invest 95: 651–657

    CAS  PubMed Central  PubMed  Google Scholar 

  272. Stoll M, Meffert S, Stroth U, Unger Th (1995) Growth or antigrowth: angiotensin and the endothelium. J Hypertens 13: 1529–1534

    CAS  PubMed  Google Scholar 

  273. Stouffer GA, Owens GK (1992) Angiotensin Il-induced mitogenesis of spontaneously hypertensive rat derived cultured smooth muscle cells is dependent on autocrine production of transforming growth factor ßl.Circ Res 70: 820–828

    CAS  PubMed  Google Scholar 

  274. Stroth U, Meffert S, Galliant S, Unger Th (1998) Angiotensin II and NGF differentially influence microtubule proteins in PC12W cells: role of the AT2 receptor. Mol Brain Res 53: 187–195

    CAS  PubMed  Google Scholar 

  275. Sumners C, Tang W, Zelezna B, Raizada MK (1991) Angiotensin II receptor subtypes are coupled with distinct signal-transduction mechanisms in neurons and astrocytes from rat brain. Proc Natl Acad Sci USA 88: 7567–7571

    CAS  PubMed Central  PubMed  Google Scholar 

  276. Suzuki F, Ludwig G, Hellmann W (1988) Renin gene expression in rat tissues: a new quantitative assay method for rat renin mRNA using synthetic cDNA. Clin Exp Hypertens AIO: 345–359

    Google Scholar 

  277. Swanson GN, Hannesworth JN, Sardinia MF (1992) Discovery of a distinct binding site for angiotensin (3–8) a putative angiotensin IV receptor. Regul Pept 40: 409–419

    CAS  PubMed  Google Scholar 

  278. Takeuchi K, Nakamura N, Cook NS, Pratt RE, Dzau VJ (1990) Angiotensin II can regulate gene expression by the AP-1 binding sequence via a protein kinase C-dependent pathway. Biochem Biophys Res Commun 172(3): 1189–1194

    CAS  PubMed  Google Scholar 

  279. Tanaka M, Ohnishi J, Ozawa Y, Sugimoto M, Usuki S, Naruse M (1995) Characterization of angiotensin II receptor type 2 during differentiation and apoptosis of rat ovarian cultured granulosa cells. Biochem Biophys Res Comm 207 (2): 593–598

    CAS  PubMed  Google Scholar 

  280. Tang J, James MNG, Hsu IN, Jenkins A, Blundell TL (1978) Structural evidence for gene duplication in the evolution of acid proteases. Nature 271: 618–622

    CAS  PubMed  Google Scholar 

  281. Tang SS, Loscalzo J, Dzau VJ (1989) Tissue plasminogen activator activates renin-angiotensin in vitro. J Vase Med Biol 1:67–74

    Google Scholar 

  282. Taubman MB, Berk BC, Izumo S, Tsuda T, Alexander RW, Nadal-Ginard B (1989) Angiotensin II induces c-fos mRNA in aortic smooth muscle. J Biol Chem 264: 526–530

    CAS  PubMed  Google Scholar 

  283. Tigerstedt R, Bergmann PG (1898) Niere und Kreislauf. Scand Arch Physiol 8: 223–271

    Google Scholar 

  284. Timmermans PBMWM, Wong PC, Chiù AT, Herblin WF, Benfield P, Carini DJ, Lee RJ, Wexler RR, Saye JAM, Smith RD (1993) Angiotensin II receptors and angiotensin II receptor antagonists. Pharmacol Rev 45: 205–251

    CAS  PubMed  Google Scholar 

  285. Tobian L (1960) Interrelationship of electrolytes, juxtaglomerular cells and hypertension. Physiol Rev 40: 280–312

    CAS  PubMed  Google Scholar 

  286. Trolliet MR, Phillips MP (1992) The effect of chronic bilateral nephrectomy on plasma and brain angiotensin. J Hypertens 10: 29–36

    CAS  PubMed  Google Scholar 

  287. Tsutsumi K, Saveedra JM (1991) Characterization and development of angiotensin II receptor subtypes (AT, and AT2) in rat brain. Am J Physiol 261: R209-R2I6

    CAS  PubMed  Google Scholar 

  288. Tsutsumi K, Strömberg C, Viswanathan M, Saveedra JM (1991) Angiotensin II receptor subtypes in fetal tissue of the rat: autoradiography, guanine nucleotide sensitivity, and association with phosphoinoside hydrolysis. Endocrinology 129: 1075–1082

    CAS  PubMed  Google Scholar 

  289. Tsutsumi K, Saveedra JM (1992) Heterogeneity of angiotensin II AT2 receptors in the rat brain. Mol Pharmacol 41: 290–297

    CAS  PubMed  Google Scholar 

  290. Tsuzuki S, Ichiki T, Nakakubo H, Kitami Y, Guo DF, Shirai H, Inagami T (1994) Molecular cloning and expression of the gene encoding human angiotensin II type 2 receptor. Biochem Biophys Res Commun 20 (3): 1449–1454

    Google Scholar 

  291. Unger Th, Rascher W, Schuster C (1981) Central blood pressure effects of substance P and angiotensin II: Role of the sympathetic nervous system and vasopressin. Eur J Pharmacol 71: 33–42

    CAS  PubMed  Google Scholar 

  292. Unger Th, Schiill B, Hübner D (1981) Plasma converting enzyme activity does not reflect effectiveness of oral treatment with Captopril. Eur J Pharmacol 72: 255–259

    CAS  PubMed  Google Scholar 

  293. Unger Th, Yukimura T, Martin-Grez M, Lang RE, Rascher W, Ganten D (1982) SA446, a new orally active converting enzyme inhibitor: antihypertensive action and comparison with Captopril in stroke-prone spontaneously hypertensive rats. Eur J Pharmacol 78: 411–420

    CAS  PubMed  Google Scholar 

  294. Unger Th, Ganten D, Lang RE, Schölkens BA (1984) Is tissue converting enzyme inhibition a determinant of the antihypertensive efficacy of converting enzyme inhibitors? Studies with two different compounds, HOE498 and MK421, in spontaneously hypertensive rats. J Cardiovasc Pharmacol 6: 872–880

    CAS  PubMed  Google Scholar 

  295. Unger Th, Becker H, Petty M (1985) Differential effects of central angiotensin II and substance P on sympathetic nerve activity in conscious rats. Circ Res 56: 563–575

    CAS  PubMed  Google Scholar 

  296. Unger Th, Moursi M, Ganten D, Hermann K, Lang RE (1986) Antihypertensive action of the converting enzyme inhibitor perindopril (S9490–3) in spontaneously hypertensive rats: comparison with enalapril (MK421) and ramipril (HOE498). J Cardiovasc Pharmacol 8: 276–285

    CAS  PubMed  Google Scholar 

  297. Unger Th, Badoer E, Ganten D, Lang RE, Rettig R (1988) Brain angiotensin: pathways and pharmacology. Circulation 77 [suppl I]: 140–154

    Google Scholar 

  298. Unger Th, Horst PJ, Bauer M, Demmert G, Rettig R, Rohmeiss P(1989) Natriuretic action of central angiotensin II in conscious rats. Brain Res 486: 33–38

    Google Scholar 

  299. Unger Th, Gohlke P, Gruber MG (1990) Converting enzyme inhibitors. In: Ganten D, Mulrow PJ (eds) Handbook of experimental pharmacology, vol 93. Springer-Verlag, Berlin, Heidelberg; 377–481

    Google Scholar 

  300. Unger Th, Gohlke P, Paul M, Rettig R (1991) Tissue renin angiotensin system: fact or fiction? J Cardiovasc Pharmacol 19 [suppl 2]: S20–S25

    Google Scholar 

  301. Unger Th, Chung O, Csikos T, Culman J, Gallinat S, Gohlke P, Höhle S, Meffert S, Stoll M, Stroht U, Zhu YZ (1996) Angiotensin receptors. J Hypertens 14 (suppl 5): S95–S103

    CAS  Google Scholar 

  302. Urata H, Healy B, Stewart RW, Bumpus FM, Husain A (1989) Angiotensin II receptors in normal and failing human hearts. J Clin Endocrinol Metab 69: 54–66

    CAS  PubMed  Google Scholar 

  303. Urata H, Konoshita A, Misono KS, Bumpus FM, Husain A (1990) Identification of a highly specific chymase as the major angiotensin II forming enzyme in the human heart. J Biol Chem 265 (36): 22348–22357

    CAS  PubMed  Google Scholar 

  304. Velletri P, Bean BL (1982) The effects of Captopril on rat aortic angiotensin-converting enzyme. J Cardiovasc Pharmacol 4: 315–325

    CAS  PubMed  Google Scholar 

  305. Veltmar A, Culman J, Quadri F, Rascher W, Unger Th (1992) Involvement of adrenergic and angio- tensinergic receptors in the paraventricular nucleus in the angiotensin Il-induced vasopressin release. J Pharmacol Exp Ther 263: 1253–1260

    CAS  PubMed  Google Scholar 

  306. Viswanathan M, Tsutsumi K,Correa FMA, Saveedra JM(1991) Changes in expression of angiotensin receptor subtypes in the rat aorta during development. Biochem Biophys Res Commun 179: 1361–1367

    Google Scholar 

  307. Waldmann T, Qadri F, Rascher W, Culman J, Unger Th (1994) Differential contribution of angiotensinergic and cholinergic receptors in the paraventricular nucleus and supraoptic nucleus to osmotically induced vasopressin release. J Hypertens 12 [suppl 3]: 1069

    Google Scholar 

  308. Wang L, Eberhard M, Erne P (1995) Stimulation of cDNA and RNA synthesis of cultured rabbit cardiac fibroblasts by angiotensin IV Eur Heart J 16 [suppl]: 451

    Google Scholar 

  309. Wei L, Alhenc-Gelas F, Corvol P, Clauser E (1992) The two homologous domains of human angiotensin-I converting enzyme are both catalytically active. J Biol Chem 266: 9002–9008

    Google Scholar 

  310. Weintroub B, Klickstein LB, Dzau VJ, Watt KWK (1984) Granulocyte-angiotensin system. Identification of angiotensinogen as substrate of leukocyte cathepsin G. Biochemistry 23: 227–232

    Google Scholar 

  311. Welches WR, Santos RAS, Chappell MC, Brosnihan KB, Green LJ, Ferrario CM (1991) Evidence that prolyl endopeptidase participates in the processing of brain angiotensin. J Hypertens 9: 631–638

    CAS  PubMed  Google Scholar 

  312. Whitebread S, Meie M, Kamber B, deGasparo M (1989) Preliminary biochemical characterization of two angiotensin II receptor subtypes. Biochem Biophys Res Commun 163 (1): 284–291

    CAS  PubMed  Google Scholar 

  313. Wilkes BM (1987) Reduced glomerular angiotensin II receptor density in diabetes mellitus in the rat: time course and mechanism. Endocrinology 120: 1291–1298

    CAS  PubMed  Google Scholar 

  314. Wilkes BM, Pion I, Sollott S, Michaels S, Kiesel G (1988) Intrarenal renin-angiotensin system modulates glomerular angiotensin receptors in the rat. Am J Physiol 254: F345–F350

    CAS  PubMed  Google Scholar 

  315. Wilkes BM (1988) Increased angiotensin II receptor binding with age in isolated rat glomeruli. Kidney Int 34: 241–247

    CAS  PubMed  Google Scholar 

  316. Wilson SK, Lynch DR, Snyder SH(1987) Angiotensin converting enzyme labelled with [3H]captopril. Tissue localizadons and changes in different models of hypertension in the rat. J Clin Invest 80: 841–851

    Google Scholar 

  317. Wolf G, Neilson EC (1990) Angiotensin II induces hypertrophy in cultured murine proximal tubular cells. Am J Physiol 259: F768–F777

    CAS  PubMed  Google Scholar 

  318. Yamada H, Fabris B, Allen AM, Jackson B, Johnston CI, Mendelsohn FAO (1991) Localization of angiotensin converting enzyme in rat heart. Circ Res 68: 141–149

    CAS  PubMed  Google Scholar 

  319. Yamada T, Horiuchi M, Dzau VJ (1996) Angiotensin II type 2 receptor mediates programmed cell death. Proc Natl Acad Sci USA 93: 156–160

    CAS  PubMed Central  PubMed  Google Scholar 

  320. Ye MQ, Healy DP (1992) Characterizadon of an angiotensin type-1 receptor partial cDNAfrom rat kidney: evidence for a novel AT, receptor subtype. Biochem Biophys Res Commun 186: 1042–1049

    Google Scholar 

  321. Yoshida H, Kakuchi J, Guo DF (1992) Analysis of the evoludon of angiotensin II type 1 receptor gene in mammals (mouse, rat, bovine, human). Biochem Biophys Res Commun 186: 1042–1049

    CAS  PubMed  Google Scholar 

  322. Zhuo J, Song K, Harris PJ, Mendelsohn FAO (1992) In vitro autoradiography reveals predominandy AT, angiotensin II receptors in rat kidney. Renal Physiol Biochem 15: 231–239

    CAS  PubMed  Google Scholar 

  323. Zimmerman BG (1981) Adrenergic facilitation by angiotensin: does it serve a physiological funcdon. Clin Sci 60: 343–348

    CAS  PubMed  Google Scholar 

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  1. Institut für Pharmakologie, Klinikum der Christian-Albrechts-Univ. Kiel, Hospitalstraße 4, 24105, Kiel, Deutschland

    Prof. Dr. med. Thomas Unger

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  1. S. Gallinat
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  2. O. Edling
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  1. Institut für experimentelle und klinische Pharmakologie und Toxikologie, Med. Universität zu Lübeck, Ratzeburger Allee 160, D-23538, Lübeck, Deutschland

    Peter Dominiak

  2. Institut für Pharmakologie, Klinikum der Christian-Albrechts-Universität zu Kiel, Hospitalstraße 4, D-24105, Kiel, Deutschland

    Thomas Unger

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Gallinat, S., Edling, O., Unger, T. (1999). Das Renin-Angiotensin-System: Physiologie und Pathophysiologie. In: Dominiak, P., Unger, T. (eds) Angiotensin II AT1-Rezeptorantagonisten. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-642-93705-7_1

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