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Diagnostik und Therapie der entzündlichen Kardiomyopathie

  • Conference paper
Chronischer Myokardschaden

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Zusammenfassung

Unter einer Myokarditis wird ein sich herdförmig oder diffus im Herzmuskel ausbreitender, akut oder chronisch-rezidivierend verlaufender Entzündungsprozeß verstanden, der durch direkte oder indirekte Einwirkung von Erregern, von toxischen, chemischen oder physikalischen Agenzien oder bisher nicht verstandenen und somit unbekannten Ursachen hervorgerufen wird. Die Mehrzahl aller Myokarditiden verläuft klinisch inapperent. Dies gilt besonders für virusinduzierte Myokarditiden, die nach dem Rückgang bakteriell verursachter Infektionskrankheiten den Hauptanteil aller Myokarditiden ausmachen. Obwohl zahlreiche kardiotrope Viren als Erreger prinzipiell in Betracht kommen, stehen aufgrund epidemiologischer Untersuchungen Enteroviren (RNA-Viren), speziell Coxsackie-Viren der Gruppe B (CBV), als auslösendes Agens an erster Stelle.

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Literatur

  1. Archard CC, Bowles NE, Olsen EGJ, Richardson PJ (1987) Detection of persistent coxsackie-B-virus RNA in dilated cardiomyopathy and myocarditis. Eur Heart J, J8: 437–440

    Google Scholar 

  2. Archard LC, Bowles NE, Cunningham L, Freeke CA, Olsen EG, Rose ML, Meany B, Why HJF, Richardson FJ (1991) Molecular probes for detection of persisting enterovirus infection of human heart and their prognostic value. Eur Heart J 12 (Suppl D): 56–59

    PubMed  Google Scholar 

  3. Bowles NE, Ohlsen EGJ, Richardson PJ, Archard LC (1986) Detection of Cocksackie B-virus-specific RNA sequences in myocardial biopsy samples from patients with myocarditis and dilated cardiomyopathy. Lancet 1: 1120–1122

    Article  PubMed  CAS  Google Scholar 

  4. Dec WG, Palacios I, Yasuda T, Fallon JT, Ban an Hhaw, Strauss HW, Haber E (1990) Antimyosin antibody cardiac imaging: Its role in the diagnosisis of myocarditis. J Am Coll Cardiol 16: 97–104

    Article  PubMed  CAS  Google Scholar 

  5. DeSa DJ (1985) Isolated myocarditis in the first year. Arch Sis Child 60: 484–485

    Article  CAS  Google Scholar 

  6. Hauck AJ, Kearney DL, Edwards WD (1989) Evaluation of postmortem endomyocardial biopsy specimen from 38 patients with lymphocytic myocarditis: Implication for role of sampling error. Mayo Clin Proc 64: 1235–1245

    PubMed  CAS  Google Scholar 

  7. Herskowitz A, Wu T-C, Willoughby SB, Vlahov D, Amsari AA, Beschorner WE, Baughman KL (1994) Myocarditis and cardiotropic viral infection associated with severe left ventricular dysfunction in late-stage infection with human immunodeficency virus. J Am Coll Cardiol 24: 1025–1032

    Article  PubMed  CAS  Google Scholar 

  8. Jin O, Sole MJ, Butany JW, Chia W-K, McLaughlin PR, Liu P, Liew C-C (1990) Detection of enterovirus RNA in myocardial biopsies from patients with myocarditis and cardiomyopathy using gene amplification by polymerase chain reaction. Circulation 82: 8–16

    Article  PubMed  CAS  Google Scholar 

  9. Kandolf R, Kirschner P, Ameis D, Canu A, Erdmann E, Schultheiß HP, Kempkes B, Hofschneider PH (1988) Enteroviral heart disease: diagnosis by in-situ hybridization. In: Schultheiß HP (ed) New Concepts in Viral Heart Disease. Springer, Berlin Heidelberg New York, pp 337–348

    Chapter  Google Scholar 

  10. Kandolf R, Klingel K, Mertsching H, Canu A, Hohenadl C, Zell R, Reimann BY, Heim A, McManus BM, Foulis AK, Schultheiss HP, Erdmann E, Riecker G (1991) Molecular studies on enteroviral heart disease: patterns of acute and persistent infections. Eur Heart J 12 (Suppl D): 49–55

    PubMed  Google Scholar 

  11. Koide H, Kitaura Y, Deguchi H (1992) Genomic detection of enteroviruses in the myocardium — studies on animal hearts with Coxsackievirus B3 myocarditis and endomyocardial biopsies from patients with myocarditis and dilated cardiomyopathy. Jpn Circ J 56: 1081–1093

    Article  PubMed  CAS  Google Scholar 

  12. Kühl U, Toussaint M, Ulrich G, Wagner D, Wolff P, Schultheiss HP (1988) Evaluation of immunohistological data for the diagnosis of myocarditis. In: Schultheiss HP (ed) New Concepts of Viral Heart Disease. Springer-Verlag, Berlin, Heidelberg, New York, pp 325–336

    Chapter  Google Scholar 

  13. Kühl U, Melzner B, Schäfer B, Schultheiß HP, Strauer BE (1991) The Ca-channel as cardiac autoantigen. Eur Heart J 12: 99–104

    PubMed  Google Scholar 

  14. Kühl U, Noutsias M, Seeberg B, Schannwell M, Welp LB, Schultheiss HP (1994) Chronic inflammation in the myocardium of patients with clinically suspected dilated cardiomyopathy. J Card Failure l: 13–27

    Google Scholar 

  15. Kühl U, Noutsias M, Seeberg B, Schannwell M, Welp LB, Schultheiss HP (1994) Immunohistological evaluation of myocardial biopsies from patients with dilated cardiomyopathy. J Heart Failure 9: 231–245

    Google Scholar 

  16. Kühl U, Schultheiss HP, Strauer BE (1994) Methylprednisolone in chronic myocarditis. Postgrad Med J 70: S35 — S42

    Google Scholar 

  17. Kühl U, Seeberg B, Noutsias M, Schultheiß HP (1995) Immunohistochemical analysis of the chronic inflammatory process in dilated cardiomyopathy. Brit Heart J 75: 295–300

    Article  Google Scholar 

  18. Kühl U, Pauschinger M, Schultheiß HP (1997) Neue Konzepte zur Diagnostik der entzündlichen Herzmuskelerkrankung. DMW 122: 690–698

    Article  Google Scholar 

  19. Kühl U, Pauschinger M, Schultheiß HP (1997) Ätiopathogenetische Differenzierung der entzündlichen Kardiomyopathie. Internist 38: 590–601

    Article  PubMed  Google Scholar 

  20. Limas CJ, Goldenberg JF, Limas C (1989) Autoantibodies angainst ß-adrenoceptors in human idiopathic dilated cardiomyopathy. Circ Res 64: 97–103

    PubMed  CAS  Google Scholar 

  21. Martin AB, Webber S, Fricker FJ, Jaffe R, Demmler G, Kearny D, Zhang YH, Bodurtha J, Gelb B, Ni J, Bricker JT, Towbin JA (1994) Acute myocarditis, rapid diagnosis py PCR in children. Circulation 90: 330–339

    PubMed  CAS  Google Scholar 

  22. Matsumori A, Yoshiki M, Sasayama S (1995) Dilated cardiomyopathy associated with Hepatitis C virus infection, Circulation 92: 2519–2525

    PubMed  CAS  Google Scholar 

  23. Neu N, Beisel KW, Traysman MD, Rose NR, Craig SW (1987) Autoantibodies specific for cardiac myosin isoform are found in mice susceptible to Coxsackie B3-induced myocarditis. J Immunol 138: 2488–2492

    PubMed  CAS  Google Scholar 

  24. Pauschinger M, Preis S, Triesch A, Dömer A, Schultheiß HP (1994) Detection of Enteroviral RNA in endomyocardial biopsies in patients having myocarditis (MC) or dilated cardiomyopathy (DCM). Circulation 90: I - 219

    Google Scholar 

  25. Report of the 1995 World Health Organization/International Society and Federation of Cardiology Task Force on The Definition and Classification of Cardiomyopathies. Circulation 93 (1996), 841–842

    Google Scholar 

  26. Schultheiss HP, Schwimmbeck P, Bolte HD (1983) Autoantibodies against the adenine nucleotide translocator in myocarditis and dilated cardiomyopathy, in Bolte HD (ed): Viral Heart Disease. Berlin/New York, Springer Verlag, pp 131–43

    Google Scholar 

  27. Schultheiss HP, Schwimmbeck P, Bolte HD, Klingenberg M (1985) The antigenic characteristics and the significance of the adenine nucleotide translocator as a major autoantigen to antimitochondrial antibodies in dilated cardiomyopathy. Adv Myocardiol 6: 311–327

    PubMed  CAS  Google Scholar 

  28. Schultheiss HP (1987) The mitochondrium as antigen in inflammatory heart disease. Eur Heart J 8 (Suppl J): 203–10

    CAS  Google Scholar 

  29. Schultheiss HP, Ulrich G, Janda I, Kühl U, Morad M (1988) Antibody-mediated enhancement of calcium permeability in cardiac myocytes. J Exp Med 168: 2105–2119

    Article  PubMed  CAS  Google Scholar 

  30. Schultheiss HP (1989) The significance of autoantibodies against ADP/ATP carrier for the pathogenesis of myocarditis and dilated cardiomyopathy — clinical and experimental data. Semin Immunopath 11: 15–30

    CAS  Google Scholar 

  31. Schultheiss HP, Kühl U, Schulze K, Schwimmbeck P, Strauer BE (1990) Biomolecular changes in dilated cardiomyopathy. In: Baroldi G, Camarini F, Goodwin JF (eds) Advances in Cardiomyopathies. Springer Verlag Berlin, Heidelberg, pp 221–234

    Chapter  Google Scholar 

  32. Schultheiss HP (1992) Dysfunction of the ADP/ATP carrier as a causative factor for the disturbance of the myocardial energy metabolism in dilated cardiomyopathy. Basic Res Cardiol 87: 311–320

    PubMed  CAS  Google Scholar 

  33. Schultheiss HP, Kühl U, Janda I, Schanwell M, Strauer BE (1992) Immunosuppressive therapie in myocarditis? Herz 17: 112–121

    PubMed  CAS  Google Scholar 

  34. Schultheiss HP (1992) Immunsuppressive Therapie bei Myokarditis und dilatativer Kardiomyopathie. Internist 33: 650–662

    PubMed  CAS  Google Scholar 

  35. Schultheiss HP (1993) Disturbance of the myocardial energy metabolism in dilated cardiomyopathy due to autoimmunological mechanisms. Circulation 87: IV 43–148

    Google Scholar 

  36. Schulze K, Becker BF, Schultheiss HP (1989) Antibodies to the ADP/ATP carrier, an autoantigen in myocarditis and dilated cardiomyopathy, penetrate into myocardial cells and disturb energy metabolism in vivo. Circ Res 64: 179–192

    PubMed  CAS  Google Scholar 

  37. Schulze K, Becker BF, Schauer R, Schultheiss HP (1990) Antibodies to the ADP/ATP carrier — an autoantigen in myocarditis and dilated cardiomyopathy — impair cardiac function. Circulation 81: 959–969

    Article  PubMed  CAS  Google Scholar 

  38. Shanes JG, Ghali J, Billingham ME, Ferrans VJ, Fenoglio JJ, Edwards WD, Tsai CC, Saffitz JE, Isner J, Fumer S, Subramanian R (1987) Interobserver variability in the pathologic interpretation of endomyocardial biopsy results. Circulation 75: 401–405

    Article  PubMed  CAS  Google Scholar 

  39. Steenbergen C, Kolbeck PC, Wolfe JA, Anthony RM, Sanfilippo FP, Jennings RB (1986) Detection of lymphocytes in endomyocardium using immunohistochemical techniques. Relevance to evaluation of endomyocardial biopsies in suspected cases of lymphocytic myocarditis. J Appl Cardiol 1: 63–73

    Google Scholar 

  40. Towbin JA (1996) Newsletters of the scientific council on cardiomyopathies, Nov

    Google Scholar 

  41. Tracy S, Chapman NM, McManus BM, Pallansch MA, Beck MA, Carstens J (1990) A molecular and serologic evaluation of enteroviral involvement in human myocarditis. J Mol Cell Cardiol 22: 403–414

    Article  PubMed  CAS  Google Scholar 

  42. Wolff P, Kühl U, Schultheiss HP (1989) Laminin distribution and autoantibodies to laminin in dilated cardiomyopathy and myocarditis. Am Heart J 117: 1303–1309

    Article  PubMed  CAS  Google Scholar 

  43. Zee-Cheng CS, Tsai CC, Palmer DC, Codd JE, Pennington DG, Williams GA (1984) High incidence of myocarditis by endomyocardial biopsy in patients with idiopathic congestive cardiomyopathy. J Am Coll Cardiol 3: 63–70

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Medizinische Klinik II, Abteilung für Kardiologie/Pulmonologie, Klinikum Benjamin Franklin, Freie Universität Berlin, Hindenburgdamm 30, 12200, Berlin (Steglitz), Deutschland

    Uwe Kühl PhD

  2. Abteilung für Kardiologie und Pulmonologie, Benjamin Franklin Klinikum, Freie Universität Berlin, Deutschland

    Uwe Kühl PhD, M. Pauschinger & H.-P. Schultheiss

Authors
  1. Uwe Kühl PhD
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  2. M. Pauschinger
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  3. H.-P. Schultheiss
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Editors and Affiliations

  1. Fachklinik für Herz- und Kreislauferkrankungen, Klinik am See, Seebad 84, 15562, Rüdersdorf, Deutschland

    Heinz Völler (Ärztlicher Leiter) (Ärztlicher Leiter)

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© 1999 Dr. Dietrich Steinkopff Verlag GmbH & Co. KG, Darmstadt

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Kühl, U., Pauschinger, M., Schultheiss, HP. (1999). Diagnostik und Therapie der entzündlichen Kardiomyopathie. In: Völler, H. (eds) Chronischer Myokardschaden. Steinkopff. https://doi.org/10.1007/978-3-642-93703-3_9

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  • DOI: https://doi.org/10.1007/978-3-642-93703-3_9

  • Publisher Name: Steinkopff

  • Print ISBN: 978-3-7985-1154-5

  • Online ISBN: 978-3-642-93703-3

  • eBook Packages: Springer Book Archive

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