Skip to main content
SpringerLink
Log in

Differentialtherapeutische Überlegungen zur Stoffwechselwirksamkeit verschiedener Antihypertensiva unter besonderer Berüx der Hochdrucktherapie bei postmenopausalen Frauen

  • Conference paper
Bluthochdruck nach der Menopause

  • 23 Accesses

Zusammenfassung

Der arterielle Blutdruck zeigt in den industrialisierten Ländern bei Männern und Frauen einen altersabhängigen Anstieg. Während im jugendlichen und mittleren Lebensalter bei den Männern der Blutdruck und damit auch die Prävalenz der arteriellen Hypertonie höher als bei Frauen ist, verändert sich dieses Verhältnis nach dem 50. Lebensjahr. Durch einen deutlicheren Blutdruckanstieg bei den Frauen kommt es zur Angleichung der Prävalenz, die im Altersbereich von 55–64 Jahren in Deutschland über 30% beträgt [9]. Als Ursache wird die verminderte Ovarialfunktion und abnehmende Östrogenproduktion nach der Menopause angenommen.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 49.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 59.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Baba T, Kodam T, Ishizaki T. Effect of chronic treatment with enalapril on glucose tolerance and serum insulin response to glucose load in non-insulin resistant Japanese patients with essential hypertension. Eur J Clin Pharmacol 1993; 45: 23–27

    Article  PubMed  CAS  Google Scholar 

  2. Bengtsson C, Blohme G, Lapidus L, Lindquist O, Lundgren H, Nyström E, Petersen K, Si- gurdsson JA. Do antihypertensive drugs precipitate diabetes? BMJ 1984; 289: 1495–1497

    Article  PubMed  CAS  Google Scholar 

  3. Chambers TJ, Stimpel M, Hatton R. Role of the renin-angiotensin system in the regulation of bone resorption. In: Stimpel M, Zanchetti A (Eds): Hypertension after menopause. Walter de Gruyter Berlin, New York 1997, S. 77–84

    Google Scholar 

  4. Chellingsworth MC, Kendall MJ, Wright AD, Singh BM, Pasi J. The effects of verapamil, dil- tiazem, nifedipine, and propranolol on metabolic control in hypertensives with non-insulin- dependent diabetes mellitus. J Human Hypertension 1989; 3: 35–39

    CAS  Google Scholar 

  5. Collins R, Peto R, MacMahon S, Hebert P, Fiebach NH, Eberlein KA, Godwin J, Qizilbash N, Taylor JO, Hennekens CH. Blood pressure, stroke and coronary heart disease. Part 2, Short- term reductions in blood pressure: overview of randomized drug trials in their epidemiological context. Lancet 1990; 335: 827–838

    Google Scholar 

  6. Cubeddu LX, Pool JL, Bloomfield R, Klotman PE, Pickering BI, Wombolt DG, Nelson EB, Halperin A. Effect of doxazosin monotherapy on blood pressure and plasma lipids in patients with essential hypertension. Am J Hypertension 1988; 1: 158–167

    CAS  Google Scholar 

  7. Deutsche Liga zur Bekämpfung des hohen Blutdruckes. Empfehlungen zur Hochdruckbehandlung in der Praxis und zur Behandlung hypertensiver Notfälle. Heidelberg 1996

    Google Scholar 

  8. Felson DT, Sloutskis D, Anderson JJ, Anthony JM, Kiel DP. Thiazide diuretics and the risk of hip fracture. Results from the Framingham Study. J Am Med Ass 1991; 265: 370–373

    Google Scholar 

  9. Hense HW, Stieber J, Filipiak B, Keil U. Five-year changes in population blood pressure and hypertension prevalence. Results from the MONICA Augsburg Surveys 1984/85 and 1989/90. Ann Epidemiol 1993; 3: 410–416

    Article  PubMed  CAS  Google Scholar 

  10. Jauch KW, Hartl W, Wicklmayr M, Rett K. Captopril enhances insulin responsiveness of forearm muscle tissue in non-insulin dependent diabetes mellitus. Eur J Clin Invest 1987; 17: 448–454

    Article  PubMed  CAS  Google Scholar 

  11. Julius S. Coronary disease in hypertension: a new mosaic. J Hypertension 1997; 15 (suppl 2): S3–S10

    CAS  Google Scholar 

  12. Kasiske BL, Kalil RS, Ma JZ, Liao M, Keane WF. Effect of antihypertensive therapy on the kidney in patients with diabetes: a meta-regression analysis. Ann Intern Med 1993; 118: 129–138

    PubMed  CAS  Google Scholar 

  13. Lithell HO. The effect of ACE inhibitors and other antihypertensive agents on insulin resistance. Nephrol Dial Transplant 1995; 10: 589–591

    PubMed  CAS  Google Scholar 

  14. Lithell HO. Hyperinsulinemia, insulin resistance, and the treatment of hypertension. Am J Hypertension 1996; 9: 150S–54S

    Article  CAS  Google Scholar 

  15. Middler S, Pak CY, Murad F, Bartter FC. Thiazide diuretics and calcium metabolism. Metabolism 1973; 22: 139–146

    Article  PubMed  CAS  Google Scholar 

  16. Neaton JD, Grimm RH, Prineas RJ, Stamler J, Grandits GA, Elmer PJ, Cutler JA, Flack JM, Schoenberger JA,McDonald R, Lewis CE, Liebson PR, for the Treament of Mild Hypertension Study Research Group. Treatment of mild hypertension study: final results. J Amer Med Ass 1993; 270: 713–724

    Article  CAS  Google Scholar 

  17. Newnham HH, Silberberg J. Women’s hearts are hard to break. Lancet 1997; 349: S13–S16

    Article  Google Scholar 

  18. Pollare T, Lithell HO, Selinus I, Berne C. Application of prazosin is associated with an increase of insulin sensitivity in obese patients with hypertension. Diabetologia 1988; 31:415– 420

    Article  PubMed  CAS  Google Scholar 

  19. Portaluppi F, Pansini F, Manfredini R, Mollica G. Relative influence of menopausal status, age, and body mass index on blood pressure. Hypertension 1997; 29: 976–979

    PubMed  CAS  Google Scholar 

  20. Proudler A, Felton C, Stevenson J. Ageing and the response of plasma insulin, glucose and C-peptide concentrations to intravenous glucose in postmenopausal women. Clin Sei 1992; 83: 489–494

    CAS  Google Scholar 

  21. Ray WA, Downey W, Griffin MR, Melton III JL. Long-term use of thiazide diuretics and risk of hip fracture Lancet 1989; 1: 687–690

    CAS  Google Scholar 

  22. Rett K, Wicklmayr M, Tschollar G, Dietze G, Mehnert H. Role of angiotensin-converting-en- zyme inhibitors in early antihypertensive treatment in non-insulin-dependent diabetes mellitus. Postgrad Med J 1988; 64 (suppl 3): 69–73

    PubMed  Google Scholar 

  23. Rich-Edwards JW, Manson JE, Hennekens CH, Buring JE. The primary prevention of coronary heart disease in women. New England J Med 1995; 332: 1758–1766

    Article  CAS  Google Scholar 

  24. Schäfers RF, Philipp T. Hochdruck beim Diabetiker. In: Manuale hypertonologicum. Hrsg. Klaus D. Dustri-Verlag, Deisenhofen 1997, S. VII-7,1–32

    Google Scholar 

  25. Schernthauer G. Metabolisches Syndrom. In: Manuale hypertonologicum. Hrsg. Klaus D. Dustri-Verlag, Deisenhofen 1997, S. VII-6, 1–18

    Google Scholar 

  26. Schmieder RE, Marius P, Klingbeil A. Reversal of left ventricular hypertrophy in essential hypertension. A meta-analysis of randomized double-blind studies. JAMA 1996; 275:1507– 1513

    Google Scholar 

  27. Schwartz J, Freeman R, Frishman W. Clinical pharmacology of estrogens: cardiovascular actions and cardioprotective benefits of replacement therapy in postmenopausal women. J Clin Pharmacol 1995; 35: 314–329

    PubMed  CAS  Google Scholar 

  28. Staessen JA, Bieniaszewski L, Brosens I, Fagard R. The epidemiology of menopause and associated cardiovascular disease. In: Stimpel M, Zanchetti A (Eds) Hypertension after menopause. Walter de Gruyter, Berlin New York 1997, S. 21–30

    Google Scholar 

  29. Stein PP, Black HR. Drug treament of hypertension in patients with diabetes mellitus. Diabetes Care 1991; 14: 425–448

    Article  PubMed  CAS  Google Scholar 

  30. Suter PM, Vetter W. Metabolic effects of antihypertensive drugs. J Hypertension 1995; 13 (suppl 4): S11–17

    Article  CAS  Google Scholar 

  31. Teuscher AU, Weidmann PU. Requirements for antihypertensive therapy in diabetic patients: metabolic aspects. J Hypertension 1997; 15 (suppl 2): S67–S75

    CAS  Google Scholar 

Download references

Authors
  1. H.-D. Faulhaber
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Medizinischen Poliklinik, Humboldt-Universität - Charité, Luisenstr. 11-13A, 10117, Berlin, Deutschland

    Jürgen Scholze (Direktor) (Direktor)

  2. ISIS PHARMA GmbH, Galileistr. 6, 08056, Zwickau, Deutschland

    Michael Stoeter (Referatsleiter Medizin) (Referatsleiter Medizin)

Rights and permissions

Reprints and permissions

Copyright information

© 1998 Dr. Dietrich Steinkopff Verlag, Darmstadt

About this paper

Cite this paper

Faulhaber, HD. (1998). Differentialtherapeutische Überlegungen zur Stoffwechselwirksamkeit verschiedener Antihypertensiva unter besonderer Berüx der Hochdrucktherapie bei postmenopausalen Frauen. In: Scholze, J., Stoeter, M. (eds) Bluthochdruck nach der Menopause. Steinkopff. https://doi.org/10.1007/978-3-642-93699-9_3

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-93699-9_3

  • Publisher Name: Steinkopff

  • Print ISBN: 978-3-7985-1124-8

  • Online ISBN: 978-3-642-93699-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation