Antibiotische Therapie der bakteriellen Meningitis

  • H. Isenberg

Zusammenfassung

Der Liquor cerebrospinalis ist pharmakologisch ein tiefes Kompartiment, in dem Wirkstoffe verspätet und mit geringerer Konzentration als im Blutplasma auftreten. Die Schwankungen der Liquorgängigkeit und Konzentration handelsüblicher Antibiotika sind dadurch bedingt, daβ die Penetration in den Liquorraum vom Entzündungsgrad der Meningen abhängig ist und daβ die Wirkstoffe sich innerhalb des Liquorraumes ungleichmäβig verteilen. Selbst die intrathekale Applikationsweise führt nicht zu einer gleichmäβigen Konzentrationsverteilung der Antibiotika.

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Copyright information

© Dr. Dietrich Steinkopff Verlag, GmbH & Co. KG, Darmstadt 1998

Authors and Affiliations

  • H. Isenberg
    • 1
  1. 1.Perinatalzentrum an den Darmstädter Kinderkliniken Prinzessin MargaretDarmstadtDeutschland

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