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Pharmakodynamik der Calciumantagonisten

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Calciumantagonisten

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Zusammenfassung

Transsarkolemnale Ca2+-Einströme spielen die Schlüsselrolle in der elektromechanischen Koppelung der Herzmuskulatur und der glatten Muskulatur. Diese Ca2+ -Ströme tragen wesentlich zu den transmembranären Strömen bei, die Aktionspotentiale auslösen (Impulsbildung) oder sie durch Myokardabschnitte mit langsamer Erregungsausbreitung leiten (SA, AV-Leitung). Auch für die elektrische Aktivität glatter Muskelzellen sind Ca2+-Einströme von entscheidender Wichtigkeit. Die Einführung von Ca2+ -Einstrom-hemmenden Verbindungen durch Fleckenstein eröffnete das Verständnis der Ca2+-Abhängigkeit vieler physiologischer und pathophysiologischer Prozesse, vor allem bei Herzkreislauferkrankungen. Dies schuf neue therapeutische Wege, die mit großem klinischen Erfolg begangen wurden.

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  1. Abteilung Innere Medizin III, Medizinische Universitätsklinik, Bergheimer Straße 58, 69115, Heidelberg, Deutschland

    Wolfgang Kübler

  2. Institut für Medizinische Physik und Biophysik, Harrachgasse 21, A-8010, Graz, Österreich

    Helmut A. Tritthart

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© 1996 Dr. Dietrich Steinkopff Verlag, GmbH & Co. KG, Darmstadt

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Tritthart, H.A. (1996). Pharmakodynamik der Calciumantagonisten. In: Kübler, W., Tritthart, H.A. (eds) Calciumantagonisten. Steinkopff. https://doi.org/10.1007/978-3-642-93678-4_2

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