Skip to main content
SpringerLink
Log in

Pharmacological Studies with Propranolol

  • Conference paper
Beta-Rezeptoren-Blockade

Part of the book series: Kreislauf-Bücherei ((KARDIOLOGIE,volume 23))

Abstract

For many years it has been assumed that coronary vasodilatation is the method of choice in the treatment of angina. This was the logical result of correlating the clinical effectiveness of glyceryl trinitrate with its vasodilator activity in animals. However, much evidence has now accumulated which suggests that glyceryl trinitrate does not act in this way (Rowe, 1964; Win-bury, 1964). If it is assumed that it is not possible to relieve angina by increasing flow through the coronary arteries, new approaches to the treatment of angina must be found.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 44.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 59.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Ahlquist, R. P., A study of the adrenotropac receptors. Amer. J. Physiol. 153, 586 bis 600 (1948).

    PubMed  CAS  Google Scholar 

  • Alcock, S.J. and P.A. Bond, Observations on the toxicity of Alderlin (pronethalol) in laboratory animals. Proc. Europ. Soc. Study of Drug Toxicity 4, 30–39 (1964).

    CAS  Google Scholar 

  • Alleyne, G., A. O., Dickinson, C. J., Dornhorst, A. C., Fulton, R. M., Green, K. G., Hill, I. D., Hurst, P., Laurence, D. R., Pilkington, T., Prichard, B.N.C., Robinson, B. and M. L. Rosenheim, Effect of pronethalol in angina pectoris. Brit. Med. J. 1963/II, 1226–1229.

    Google Scholar 

  • Apthorp, G. H., Chamberlain, D. A. and G. W. Hayward, The effects of sympathectomy on the electrocardiogram and effort tolerance in angina pectoris. Brit. Heart J. 26, 218–226 (1964).

    Article  PubMed  CAS  Google Scholar 

  • Beck, C. S., Coronary artery disease: physiologic concepts: surgical operation. Ann. Surg. 145, 439–447 (1957).

    Article  PubMed  CAS  Google Scholar 

  • Black, J. W. and J. S. Stevenson, Pharmacology of a new adrenergic beta-receptor-blocking compound (nethalide). Lancet 1962/II, 311–314.

    Google Scholar 

  • Black, J, W., Crowther, A. F., Shanks, R. G., Smith, L. H. and A. C. Dornhorst, A new adrenergic beta-receptor antagonist. Lancet 1964/I, 1080–1081.

    Google Scholar 

  • Levy, B. and R. P. Ahlquist, An analysis of adrenergic blocking activity. J. Pharmacol. exp. Ther. 133, 202 (1961).

    PubMed  CAS  Google Scholar 

  • Moran, N. C. and M. E. Perkins, Adrenergic blockade of the mammalian heart by a dicholoro analogue of isoproterenol. J. Pharmacol. exp. Ther. 124, 223–237 (1958).

    PubMed  CAS  Google Scholar 

  • Moran, N. C. and M. E. Perkins, An evaluation of adrenergic blockade of the mammalian heart. J. Pharmacol. exp. Ther. 133, 192–201 (1961).

    PubMed  CAS  Google Scholar 

  • Orlans, F. B. H., Finger, K. F. and B. B. Brodie, Pharmacological consequences of the selective release of peripheral norepinephrine by syrosingopine (SU 3118). J. Pharmacol. exp. Ther. 128, 131–139 (1960).

    PubMed  CAS  Google Scholar 

  • Powell, C. E. and I. H. Slater, Blocking of inhibitory adrenergic receptors by a dichloro analog of isoproterenol. J. Pharmacol. exp. Ther. 122, 480 bis 488 (1958).

    PubMed  CAS  Google Scholar 

  • Raab, W., The sympathogenic biochemical trigger mechanism of angina pectoris. Amer. J. Cardiol. 2, 576–590 (1962).

    Article  Google Scholar 

  • Rowe, G. G.: Coronary vasodilator therapy for angina pectoris. Amer. Heart J. 68, 691–696 (1964).

    Article  PubMed  CAS  Google Scholar 

  • Shanks, R. G., Methods for the evaluation of adrenergic ß receptor antagonists. Methods in drug evaluation: North Holland Publ. Co. 1966.

    Google Scholar 

  • Smith, G. and D. A. Lawson, Experimental coronary artery occlusion: effects of the administration of oxygen under pressure. Scot. med. J. 3, 346–350 (1958).

    PubMed  CAS  Google Scholar 

  • Stock, J. P. P. and N. Dale, Beta-adrenergic receptor blockade in cardiac arrhythmias. Brit. med. J. 1963/II, 1230–1233.

    Google Scholar 

  • Tucker, M. J., Alcock, S. J. and S. B. de C. Baker, A comparsion of the carcinogenicity of pronethalol and propranolol in mice. Brit. med. J. 1965/II, 363.

    Google Scholar 

  • Winbury, M. M., Experimental approaches to the development of antianginal drugs. Advances in Pharmacology, 3, 1–82 (1964).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Imperial Chemical Industries Ltd., Alderley Park, Macclesfield, Cheshire, England

    Dr. R. G. Shanks

Authors
  1. Dr. R. G. Shanks
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. I. Medizinische Universitäts-Klinik Hamburg-Eppendorf, Deutschland

    Dieter Haan

Rights and permissions

Reprints and permissions

Copyright information

© 1967 Dietrich Steinkopff Verlag, Darmstadt

About this paper

Cite this paper

Shanks, R.G. (1967). Pharmacological Studies with Propranolol. In: Haan, D. (eds) Beta-Rezeptoren-Blockade. Kreislauf-Bücherei, vol 23. Steinkopff. https://doi.org/10.1007/978-3-642-93659-3_2

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-93659-3_2

  • Publisher Name: Steinkopff

  • Print ISBN: 978-3-642-48995-2

  • Online ISBN: 978-3-642-93659-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation