Einsatz von Frischblut zur Therapie von Hämostasestörungen

  • M. Aulmann
Conference paper

Zusammenfassung

Der therapeutische Gebrauch von homologem Frischblut hat in den 80er Jahren einen gravierenden Umbruch erfahren. Während bis Mitte des letzten Jahrzehnts Frischblut in der Anästhesiologie, Chirurgie und vereinzelt auch in der Inneren Medizin zur Therapie hämostasiologischer Störungen eine breite Anwendung fand, werden seit Ende des vergangenen Jahrzehnts Frischblutkonserven äußerst restriktiv transfundiert. Die wesentlichen Gründe für diese ablehnende Haltung gegenüber homologen Frischbluttransfusionen sind ein erhöhtes Infektionsrisiko durch HIV (Aids) und HCV (Hepatitis C), in der Regel in ausreichender Zahl zur Verfugung stehende Blutkomponenten (Erythrozyten- und Thrombozytenkonzentrate sowie gefrorenes Frischplasma), die eine vollständige Untersuchung der geforderten Infektionsparameter aufweisen, und bei elektiven Eingriffen die sich durchsetzende Gewinnung von autologem Frischblut mittels perioperativer Hämodilution [4, 10, 31, 40, 68, 69, 100].

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Literatur

  1. 1.
    Abrams CS, Ellison N, Budzynski AZ, Shattil SJ, (1990) Direct detection of activated platelets and platelet-derived microparticles in humans. Blood 75: 128–138PubMedGoogle Scholar
  2. 2.
    Adelman B, Michelson AD, Loscalzo J et al. (1985) Plasmin effect on platelet glycoprotein lbvon Willebrand factor interactions. Blood 65: 32–40PubMedGoogle Scholar
  3. 3.
    Aulmann HM, Indorf Y, Stangel W (1990) Veränderungen der Thrombozytenzahl und -dichte in Thrombozytenkonzentraten während der Lagerung unter Berücksichtigung der Thrombozytenkonzentration und der Folienstruktur. Beitr Infusionsther 26: 109–111PubMedGoogle Scholar
  4. 4.
    Bermann H (1988) Die Indikation zur Transfusion von Blut und Blutbestandteilen. Anästh Intensivmed 29: 97–105Google Scholar
  5. 5.
    Blajchman MA, Bardossy L, Carmen R et al. (1993) Allogeneic blood transfusion- induced enhancement of tumor growth: two animal models showing amelioration by leukodepletion and passive transfer using spleen cells. Blood 81: 1880–1882PubMedGoogle Scholar
  6. 6.
    Bode AP (1990) Platelet activation may explain the storage lesion in platelet concentrates. Blood Cells 16: 109–126PubMedGoogle Scholar
  7. 7.
    Bode AP, Miller DT (1986) Generation and degeneration of fibrinopeptide A in stored platelet concentrate. Vox Sang 51: 192–196PubMedCrossRefGoogle Scholar
  8. 8.
    Bode AP, Miller DT (1988) Preservation of in vitro function of platelets stored in the presence of inhibitors of platelet activation and a specific inhibitor of thrombin. J Lab Clin Med 111: 118–124PubMedGoogle Scholar
  9. 9.
    Bode AP, Orton SM, Frye MJ, Udis BJ (1991) Vesiculation of platelets during in vitro aging. Blood 77: 887–895PubMedGoogle Scholar
  10. 10.
    Bum HP, Holländer LP (1982) Verabreichung von Blut und Blutbestandteilen, Einrichtung eines Blutspendedienstes. In: Benzer H, Frey R, Hügin W, Mayrhofer O (Hrsg) Anaesthesiologie Intensivmedizin und Reanimatologie. Springer, Berlin Heidelberg New York, 726–742Google Scholar
  11. 11.
    Cesar JM, Navarro JL (1990) Arachidonic acid metabolism in platelets stored for 5 days. Br J Haematol 74: 295–299PubMedCrossRefGoogle Scholar
  12. 12.
    Chow TW, Heliums JD, Moake JL, Kroll MH (1992) Shear stress-induced von Willebrand factor binding to platelet glycoprotein lb initiates calcium influx associated with aggregation. Blood 80: 113–120PubMedGoogle Scholar
  13. 13.
    Cramer EM, Lu H, Caen JP et al. (1991) Differential redistribution of platelet glycoproteins lb and IlbIIIa after plasmin stimulation. Blood 77: 694–699PubMedGoogle Scholar
  14. 14.
    Dzik WH, Neckers L (1984) Mononuclear cell-surface antigens during storage of banked blood. Transplantation 38: 67–71PubMedCrossRefGoogle Scholar
  15. 15.
    Edenbrandt CM, Murphy S (1990) Adenine and guanine nucleotide metabolism during platelet storage at 22 °C. Blood 76: 1884–1892PubMedGoogle Scholar
  16. 16.
    Edmunds LH jr (1989) Blood platelets and bypass (invited letter). J Thorac Cardiovasc Surg 97: 470–471PubMedGoogle Scholar
  17. 17.
    Edmunds LH jr, Ellison N, Colman RW et al. (1982) Platelet function during cardiac operation comparison of membrane and bubble oxygenators. J Thorac Cardiovasc Surg 83: 805–812PubMedGoogle Scholar
  18. 18.
    Fijnheer R, Modderman PW, Veldman H et al. (1990) Detection of platelet activation with monoclonal antibodies and flow cytometry. Changes during platelet storage. Transfusion 30: 20–25PubMedCrossRefGoogle Scholar
  19. 19.
    Fijnheer R, Pietersz RNI, Körte D de et al. (1990) Platelet activation during preparation of platelet concentrates: a comparison of the platelet-rich plasma and the buffy coat methods. Transfusion 30: 634–638PubMedCrossRefGoogle Scholar
  20. 20.
    Filip DJ, Aster RH (1978) Relative hemostatic effectiveness of human platelets stored at 4° and 22°C. J Lab Clin Med 91: 618–624PubMedGoogle Scholar
  21. 21.
    Filip DJ, Eckstein JD, Sibley CA (1975) The effect of platelet concentrate storage temperature on adenine nucleotide metabolism. Blood 45: 749–756PubMedGoogle Scholar
  22. 22.
    George JN (1992) Changes in platelet membrane glycoproteins during blood bank storage. Blood Cells 18: 501–511PubMedGoogle Scholar
  23. 23.
    George JN, Pickett EB, Saucerman S et al. (1986) Platelet surface glycoproteins. Studies on resting and activated platelets and platelet membrane microparticles in normal subjects, and observations in patients during adult respiratory distress syndrome and cardiac surgery. J Clin Invest 78: 340–348PubMedCrossRefGoogle Scholar
  24. 24.
    Gilliksson H (1990) Adenylate kinase as a marker for platelet lysis. Transfusion 30: 536–540CrossRefGoogle Scholar
  25. 25.
    Glaser A, Böck M, Rüschmeyer G et al. (1993) Lagerung von Thrombozyten- konzentraten: Qualitätskontrolle durch In-vitro-Blutungstest. Infusionsther Transfusionsmed 20: 14–16PubMedGoogle Scholar
  26. 26.
    Grode G, Miripol J, Garber J. (1985) Extended storage of platelets in a new plastic container. I. Biochemical and morphologic changes. Transfusion 25: 204–208PubMedCrossRefGoogle Scholar
  27. 27.
    Guppy M, Attwood PV, Hansen et al. (1992) pH, temperature and lactate production in human red blood cells: implications for blood storage and glycolytic control. Vox Sang 62: 70–75PubMedCrossRefGoogle Scholar
  28. 28.
    Harker LA (1986) Bleeding after cardiopulmonary bypass. N Engl J Med 314: 1446–1447PubMedCrossRefGoogle Scholar
  29. 29.
    Harker LA, Malpass TW, Branso HE et al. (1980) Mechanism of abnormal bleeding in patients undergoing cardiopulmonary bypass: aquired transient platelet dysfunction associated with selective — granule release. Blood 56: 824–834PubMedGoogle Scholar
  30. 30.
    Hindriks G, Ijsseldijk MJW, Sonnenberg A et al. (1992) Platelet adhesion to laminin: role of Ca2+ and Mg2+ ions, shear rate, and platelet membrane glycoproteins. Blood 79: 928–935PubMedGoogle Scholar
  31. 31.
    Höhne M, Riemer J (1992) Infusionslösungen, Blut, Blutersatzmittel. In: Doenicke A, Kettler D, List WF et al. (Hrsg) Lehrbuch der Anästhesiologie und Intensivmedizin: Anästhesiologie. Springer, Berlin Heidelberg New York Tokyo, S228–246Google Scholar
  32. 32.
    Holme S, Heaton WA, Courtright M (1987) Platelet storage lesion in second-generation containers: correlation with platelet ATP levels. Vox Sang 53: 214–220PubMedCrossRefGoogle Scholar
  33. 33.
    Holme S, Heaton WA, Whitley P (1990) Platelet storage lesions in second-generation containers: correlation with in vivo behavior with storage up to 14 days. Vox Sang 59: 12–18PubMedCrossRefGoogle Scholar
  34. 34.
    Holme S, Murphy S (1978) Quantitative measurements of platelet shape by light transmission studies; application to storage of platelets for transfusion. J Lab Clin Med 92: 53–64PubMedGoogle Scholar
  35. 35.
    Hourdille P, Gralnick HR, Heilmann E et al. (1992) von Willebrand factor bound to glycoprotein lb is cleared from platelet surface after platelet activation by thrombin. Blood 79: 2011–2021PubMedGoogle Scholar
  36. 36.
    Hundelshausen B von, Tempel G, Schneck HJ (1988) Massivtransfusion. Anästh Intensivmed 29: 17–20Google Scholar
  37. 37.
    Hunt BJ, Sack D, Amin S, Yacoub MH (1992) The perioperative use of blood components during heart and heart-lung transplantation. Transfusion 32: 57–62PubMedCrossRefGoogle Scholar
  38. 38.
    Jensen LS, Andersen AJ, Christiansen PM et al. (1992) Postoperative infection and natural killer cell function following blood transfusion in patients undergoing elective colorectal surgery. Br J Surg 79: 513–516PubMedCrossRefGoogle Scholar
  39. 39.
    Kickler TS (1991) Improving the quality of stored platelets. Transfusion 31: 1–3PubMedCrossRefGoogle Scholar
  40. 40.
    Kirklin JW, Barratt-Boyes BG (1993) Hypothermia, circulatora arrest and cardiopulmonary bypass. In: Kirklin JW, Barrat-Boyes BG (Hrsg) Cardiac surgery, vol 1. Livingstone, New York Edinburgh London Melbourne Tokyo, pp 61–127Google Scholar
  41. 41.
    Kirklin JK, Westaby S, Blackstone EH et al. (1983) Complement and the damaging effects of cardiopulmonary bypass. J Thorac Cardiovasc Surg 86: 845–857PubMedGoogle Scholar
  42. 42.
    Lavee J, Martinowitz U, Mohr R et al. (1989) The effect of transfusion of fresh whole blood versus platelet concentrates after cardiac operations. J Thorac Cardiovasc Surg 97: 204–212PubMedGoogle Scholar
  43. 43.
    Leslie SD, Toy PTCY (1991) Laboratory hemostatic abnormalities in massively transfused patients given red blood cells and crystalloid. Am J Clin Pathol 96: 770–773PubMedGoogle Scholar
  44. 44.
    Levin RD, Kwaan HC, Ivanovich P (1978) Changes in platelet function during hemodialysis. J Lab Clin Med 92: 779–786PubMedGoogle Scholar
  45. 45.
    Lu H, Soria C, Cramer EM et al. (1991) Temperture dependence of plasmin-induced activation or inhibition of human platelets. Blood 77: 996–1005PubMedGoogle Scholar
  46. 46.
    Lundsgaard-Hansen P (1982) Das Komponentenkonzept in der chirurgischen Hämotherapie. Diagn Intensivther 12: 297–310Google Scholar
  47. 47.
    Lundsgaard-Hansen P (1992) Treatment of acute blood loss (Review). Vox Sang 63: 241–246PubMedCrossRefGoogle Scholar
  48. 48.
    Manno CS, Hedberg KW, Kim HC et al. (1991) Comparison of the hemostatic effects of fresh whole blood, stored whole blood, and components after open heart surgery in children. Blood 77: 930–936PubMedGoogle Scholar
  49. 49.
    McGill M (1978) Temperature cycling preserves platelet shape and enhances in vitro test scores during storage at 4 °C. J Lab Clin Med 92: 971–982PubMedGoogle Scholar
  50. 50.
    McGill M, Brindley DC (1979) Effects of storage on platelet reactivity to arterial subendothelium during blood flow. J Lab Clin Med 94: 370–380PubMedGoogle Scholar
  51. 51.
    Metzelaar MJ, Korteweg J, Sixma J J, Nieuwenhuis HK (1993) Comparison of platelet membrane markers for the detection of platelet activation in vitro and during pla telet storage and cardiopulmonary bypass surgery. J Lab. Clin Med 121: 579–587PubMedGoogle Scholar
  52. 52.
    Michelson AD, Adelman B, Barnard MR et al. (1988) Platelet storage results in a redistribution of glycoprotein lb molecules. Evidence for a large intrapletelet pool of glycoprotein Ib. J Clin Invest 81: 1734–1740PubMedCrossRefGoogle Scholar
  53. 53.
    Michelson AD, Ellis PA, Barnard MR et al. (1993) Downregulation of the platelet surface glycoprotein Ib-IX complex in whole blood stimulated by thrombin, adenosine diphosphate, or an in vivo wound. Blood 81: 1407–1409Google Scholar
  54. 54.
    Moake JL, Turner NA, Stathopoulos NA et al. (1988) Shear-induced platelet aggregation can be mediated by vWF released from platelets, as well as by exogenous large or unusually large vWF multimers, requires adenosine diphosphate, and is resistant to aspirin. Blood 71: 1366–1374PubMedGoogle Scholar
  55. 55.
    Mohr R, Golan M, Martinowitz U et al. (1986) Effect of cardiac operation on platelets. J Thorac Cardiovasc Surg 92: 434–441PubMedGoogle Scholar
  56. 56.
    Mohr R, Martinowitz U, Lavee J et al. (1988) The hemostatic effect of transfusing fresh whole blood versus platelet concentrates after cardiac operations. J Thorac Cardiovasc Surg 96: 530–534PubMedGoogle Scholar
  57. 57.
    Moroff G, Holme S, Keegan T, Heaton A (1990) Storage of ADSOL-preserved red cells at 2.5 and 5.5 °C: comparable retention of in vitro properties. Vox Sang 59: 136–139PubMedCrossRefGoogle Scholar
  58. 58.
    Murphy S (1986) Platelet storage for transfusion. Beitr Infusionsther klin Ernähr 15: 93–106Google Scholar
  59. 59.
    Murphy S, Gardner FH (1969) Platelet preservation. Effect of storage temperature on maintenance of platelet viability-deleterious effect of refrigerated storage. N Engl J Med 280: 1094–1098PubMedCrossRefGoogle Scholar
  60. 60.
    Murphy PJ, Connery C, Hicks GL jr, Blumberg N (1992) Homologous blood transfusion as a risk factor for postoperative infection after coronary artery bypass graft operations. J Thorac Cardiovasc Surg 104: 1092–1099PubMedGoogle Scholar
  61. 61.
    Naesh O, Frijs JT, Hindberg I, Winther K (1985) Platelet function in surgical stress. Thromb Haemost 54: 849–852PubMedGoogle Scholar
  62. 62.
    Oost BA van, Timmermans APM, Sixma JJ (1984) Evidence that platelet density depends on the — granule contend in platelets. Blood 63: 482–485PubMedGoogle Scholar
  63. 63.
    Owens M, Holme S, Heaton A et al. (1992) Post-transfusion recovery of function of 5-day stored platelet concentrates. Br J Haematol 80: 539–544PubMedCrossRefGoogle Scholar
  64. 64.
    Patscheke H (1992) Qualitätskontrolle von Thrombozytenpräparaten mit einem rheooptischen Formkriterium. In: van de Loo J, Asbeck F (Hrsg) Hämostase, Thrombophilie und Arteriosklerose. Schattauer, Stuttgart, S 764–767Google Scholar
  65. 65.
    Peterson DM, Stathopoulos NA, Giorgio TD et al. (1987) Shear-induced platelet aggregation requires von Willebrand factor and platelet membrane glycoprotein Ib and IIb/IIIa, Blood 69: 625–628PubMedGoogle Scholar
  66. 66.
    Phillips MD, Moake JL, Nolasco L, Turner N (1988) Aurin triacarboxylic acid: a novel inhibitor of the association of von Willebrand factor and platelets. Blood 72: 1898–1903PubMedGoogle Scholar
  67. 67.
    Pietersz RNI, Loos JA, Reesink HW (1987) Survival in vivo of platelets stored for 48 h in the bufiycoat at 4°C compared to platelet rich plasma stored at 22 °C. Blut 54: 201–206PubMedCrossRefGoogle Scholar
  68. 68.
    Pisciotto PT, Snyder EL (1988) Use and administration of blood and components. In: Chernow B (ed) The pharmacologic approach to the critcally III patient. William & Wilkins, Baltimore pp 254–275Google Scholar
  69. 69.
    Pulliam MW (1981) Use of blood and Its components. Clin Neurosurg 28: 14–70PubMedGoogle Scholar
  70. 70.
    Pumphrey CW, Dawes J (1983) Platelet alpha granule depletion: findings in patients with prosthetic heart valves and following cardiopulmonary bypass surgery. Thromb Res 30: 257–264PubMedCrossRefGoogle Scholar
  71. 71.
    Rao GHR (1992) Influence of storage on signal transduction pathways on platelet function. Blood Cells 18: 383–396PubMedGoogle Scholar
  72. 72.
    Remuzzi G, Livio M, Marchiaro G et al. (1978) Bleeding in renal failure: altered platelet function in chronic uraemia only partially corrected by haemodialysis. Nephron 22: 347–353PubMedCrossRefGoogle Scholar
  73. 73.
    Rinder HM, Snyder EL (1992) Activation of platelet concentrate during preparation and storage. Blood Cells 18: 445–456PubMedGoogle Scholar
  74. 74.
    Rinder HM, Murphy M, Mitchell JG et al. (1991) Progressive platelet activation with storage: evidance for shortened survival of activated platelets after transfusion. Transfusion 31: 409–414PubMedCrossRefGoogle Scholar
  75. 75.
    Rock G, Sherring A, Tittley P (1984) Five-day storage of platelet concentrates. Transfusion 24: 147–152PubMedCrossRefGoogle Scholar
  76. 76.
    Rodgers SE, Lloyd JV, Rüssel WJ (1985) Platelet function in platelet concentrates and in whole blood. Anaesth Intens Care 13: 355–361Google Scholar
  77. 77.
    Roth GJ (1991) Developing relationships: platelet adhesion, glycoprotein lb, and leucinerich glycoproteins. Blood 77: 5–19PubMedGoogle Scholar
  78. 78.
    Seidel J, Stangel W (1987) Leukoctes in transfusion medicine — an overview of functions and clinical implications. In: Smit sibinga CTh, Das PC, Engelfriet CP (eds) White cells and platelets in blood transfusion. Martinus Nijhoff, Boston Dordrecht Lancaster, pp 17–35CrossRefGoogle Scholar
  79. 79.
    Shenaq SA, Yawan DH, Saleem A et al. (1986) Effect of profound hypothermia on leukocytes and platelets. Ann Clin Lab Sci 16: 130–133PubMedGoogle Scholar
  80. 80.
    Sheppeck RA, Bentz M, Dickson C et al. (1991) Examination of the roles of glycoprotein Ib and glycoprotein IIb/IIIa in platelet deposition on an artificial surface using clinical antiplatelet agents and monoclonal antibody blockade. Blood 78: 673–680PubMedGoogle Scholar
  81. 81.
    Shimizu T, Kato K (1986) Sequestration of serotonin in stored platelets. Transfusion 26: 274–277PubMedCrossRefGoogle Scholar
  82. 82.
    Shukla SD, Morrison WJ, Klachko DM (1989) Response to platelet-activating factor in human platelets stored and aged in plasma. Decrease in aggregation, phosphoinostide turnover, and receptor affinity. Transfusion 29: 528–533PubMedCrossRefGoogle Scholar
  83. 83.
    Sloand EM, Sloand JA, Prodouz K et al. (1991) Reduction of platelet glycoprotein lb in uraemia. Br J Haematol 77: 375–381PubMedCrossRefGoogle Scholar
  84. 84.
    Snyder EL (1992) Activation during preparation and storage in platelet concentrates. Transfusion 32: 500–502PubMedCrossRefGoogle Scholar
  85. 85.
    Snyder EL, Koerner TAW, Kakaiya R jr. et al. (1983) Effect of mode of agitation on storage of platelet concentrates in Pl-732 containers for 5 days. Vox Sang 44: 300–304PubMedCrossRefGoogle Scholar
  86. 86.
    Snyder EL, Dunn BE, Giometti CS et al. (1987) Protein changes occurring during storage of platelet concentrates. A two dimensional gel electrophoretic analysis. Transfusion 27: 335–341PubMedCrossRefGoogle Scholar
  87. 87.
    Snyder EL, Hörne WC, Napychank P et al. (1989) Calcium-dependent proteolysis of actin during storage of platelet concentrates. Blood 73: 1380–1385PubMedGoogle Scholar
  88. 88.
    Solberg C, Holme S, Little C (1986) Morphological changes associated with pH changes during storage of platelet concentrates. Beitr Infusionsther klin Ernähr 15: 107–117Google Scholar
  89. 89.
    Solum NO (1985) Platelet membrane proteins. Semin Hematol 22: 289–302PubMedGoogle Scholar
  90. 90.
    Sweeney D, Williams V (1987) The effect of halothane general anaesthesia on platelet function. Anaesth Intens Care 15: 278–281, 1987Google Scholar
  91. 91.
    Urbaniak SJ, Cash JD (1977) Blood replacement therapy. Br Med Bull 33: 273–282PubMedGoogle Scholar
  92. 92.
    Wakefield TW, Whitehouse WM jr, Stanley JC (1984) Depressed cardiovascular function and altered platelet kinetics following protamine sulfate reversal of heparin activity. J Vase Surg 1: 346–355Google Scholar
  93. 93.
    Wallvik J, Stenke L, Akerblom O (1990) The effect of different agitation modes on platelet metabolism, thromboxane formation, and alphagranular release during platelet storage. Transfusion 30: 639–643PubMedCrossRefGoogle Scholar
  94. 94.
    Ware JA, Kang J, DeCenzo MT et al. (1991) Platelet activation by a synthetic hydrophobic polymer, polymethylmethacrylate. Blood 78: 1713–1721PubMedGoogle Scholar
  95. 95.
    Wasser MNJM, Houbiers JGA, Amaro JD et al. (1989) The effect of fresh versus stored blood on post-operative bleeding after coronary bypass surgery: a prospective randomized study. Br J Haematol 72: 81–84PubMedCrossRefGoogle Scholar
  96. 96.
    Wenger RK, Lukasiewicz H, Mikuta BS et al. (1989) Loss of platelet fibrinogen receptors during clinical cardiopulmonary bypass. J Thorac Cardiovasc Surg 97: 235–239PubMedGoogle Scholar
  97. 97.
    Wun T, Paglieroni T, Sazama K, Holland P (1992) Detection of plasmapheresis- induced platelet activation using monoclonal antibodies. Transfusion 32: 534–540PubMedCrossRefGoogle Scholar
  98. 98.
    Zilla P (1989) Blood platelets and bypass. J Thorac Cardiovasc Surg 97: 797–800Google Scholar
  99. 99.
    Zilla P, Fasol R, Groscurth P et al. (1989) Blood platelets in cardiopulmonary bypass operations. J Thorac Cardiovasc Surg 97: 379–388PubMedGoogle Scholar
  100. 100.
    Zistl F (1988) Notfalltransfusion. Anasth Intensivmed 29: 21–24Google Scholar

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