Skip to main content
SpringerLink
Log in

Pharmakologische Grundlagen der Behandlung der koronaren Herzkrankheit

  • Chapter
Interventionen am Herzen

  • 33 Accesses

Zusammenfassung

Der koronaren Herzkrankheit (KHK) liegt eine Störung der Koronararterien zugrunde, die fast immer als progrediente morphologische Einengung der arteriellen Strombahn imponiert. Das klinische Bild wird nicht nur durch die subintimale Atheromatose großer und mittelgroßer Koronararterien verursacht, sondern in unterschiedlichem Ausmaß durch Vasospasmen und Störungen der Blutgerinnung. Aus allen drei Faktoren resultiert eine myokardiale Ischämie. Sie manifestiert sich asyptomatisch als „Stumme Ischämie“, symptomatisch als stabile oder instabile Angina pectoris, als Herzinfarkt oder plötzlicher Herztod.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 59.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 74.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Bassenger E (1988) Experimentelle Befunde zur Nitratwirkung. In: Roskamp(Hrsg) Nitroglycerin VI. de Gruyter, Berlin New York, S 53–65

    Google Scholar 

  2. Bertel O, Naegeli B (1989) Nitrattherapie bei ischämischer Herzkrankheit und Herzinsuffizienz. Dtsch Med Wochenschr 114: 1749–1753

    Article  PubMed  CAS  Google Scholar 

  3. Boden WE, Gibson RS, Bough EW, Beller GA, Schlechtmann KB, Roberts R (1988) Effect of high-dose diltiazem on global and regional left ventricular function during the early course of acute non-Q-wave myocardial infarction. Am J Noninvas Cardiol 2: 1–9

    Google Scholar 

  4. Bussmann WD, Haller M (1983) Hinweis auf eine Abnahme der Früh- und Spätmortalität beim frischen Herzinfarkt unter Nitroglycerintherapie. Klin Wochenschr 61: 417–422

    Article  PubMed  CAS  Google Scholar 

  5. Bussmann WD, Micke G, Hildenbrand R, Klepzig H jr (1992) Einfluß auf Infarktgröße und Rhythmusstörungen. Dtsch Med Wochenschr 117: 651–657

    Article  PubMed  CAS  Google Scholar 

  6. Cohn PF, Lawson WE (1989) Effects of long-acting propranolol an a.m. and p.m. peaks in silent myocardial ischemia. Am J Cardiol 63: 872–873

    Article  PubMed  CAS  Google Scholar 

  7. Conant J, Engler R, Janowsky D et al. (1989) Central nervous system side effects of beta-adrenergic blocking agents with high and low lipid solubility. J Cardiovasc Pharmacol 13: 656–661

    PubMed  CAS  Google Scholar 

  8. The CONSENSUS Trial Study Group (1987) Effects of enalapril on mortality in severe congestive heart failure: results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS). N Engl J Med 316: 1429–1435

    Article  Google Scholar 

  9. Cushman DW, Wang FL, Fung WC et al. (1989) Comparisons in vitro, ex vivo, and in vivo of the actions of seven structurally diverse inhibitors of angiotensin converting enzyme (ACE). Br J Clin Pharmac 28: 115S–131S

    CAS  Google Scholar 

  10. Daly PA, Rouleau JL (1989) Conversions-Enzym-Hemmung bei Patienten mit Angina pectoris. Münch Med Wochenschr 131 (Suppl 1): S31–S35

    Google Scholar 

  11. Deanfield J, Wright C, Krikler S et al. (1984) Cigarette smoking and the treatment of angina with propranolol, atenolol and nifedipine. N Engl J Med 310: 951–954

    Article  PubMed  CAS  Google Scholar 

  12. Ertl G (1989) Angiotensin-Conversions-Enzym-Hemmer und ischämische Herzerkrankung. Münch Med Wochenschr 131 (Suppl 1):S4–S8

    Google Scholar 

  13. Fletcher AE, Bulpitt CJ, Chase DM et al. (1992) Quality of life with three antihypertensive treatments: Cilazapril, Atenolol, Nifedipine. Hypertension 19: 499–507

    PubMed  CAS  Google Scholar 

  14. Förstermann U, Schmidt HHH, Pollock JS et al. (1991) Isoforms of nitric oxid synthase. Characterization and purification from different cell types. Biochem Pharmacol 42: 1849–1857

    Article  PubMed  Google Scholar 

  15. Förstermann U, Pollock S, Nakane M (1993) Nitric oxid synthases in the cardiovascular system. Trends Cardiovasc Med 3: 104–110

    Article  PubMed  Google Scholar 

  16. Ghio S, De Servi S, Ferrario M, Poma E, Bramucci E, Angoli L, Specchia G (1988) Acute haemodynamic effects of diltiazem in patients with recent Q-wave myocardial infarction. Eur Heart J 9: 740–745

    PubMed  CAS  Google Scholar 

  17. Conzales JI, Hill JA, Kolb R et al. (1990) Effects of atenolol and nifedipine alone and in combination on ambulant myocardial ischemia in minimally symptomatic patients (abstract). J Am Coll Cardiol 15: 120A

    Google Scholar 

  18. ISIS-1 (first international study of infarct survival) collaborative Group (1986) Randomised trial of intravenous atenolol among 16027 cases of suspected acute myocardial infarction: ISIS-1. Lancet II: 57–65

    Google Scholar 

  19. Jansen W, Hendricks W, Weidmann B, Grewe R, Tauchert M (1989) Die Behandlung der koronaren Herzkrankheit mit Molsidominretard: Akut- und Langzeitwirkung auf den Pulmonalarteriendruck und die Belastungstoleranz. Herz Kreislauf 21: 12–19

    Google Scholar 

  20. Jugdutt BI, Warnica JW (1988) Intravenous nitroglycerin therapy to limit myocardial infarct size, expansion, and complications: Effect of timing, dosage, and infarct location. Circulation 78: 906–919

    Article  PubMed  CAS  Google Scholar 

  21. Jugdutt BI, Neimann JC, Michorowski BL et al. (1990) Persistent improvement in left ventricular geometry and function by prolonged nitroglycerin therapy after acute transmural anterior myocardial infarction. J Am Coll Cardiol 15: 214A

    Google Scholar 

  22. Julian DG, Prescott RJ, Jackson FS, Szekely P (1982) Controlled trial of sotalol for one year after myocardial infarction. Lancet II: 1142–1147

    Article  Google Scholar 

  23. Kostis JB, Rosen RC (1987) Central nervous system effects of beta-adrenergic blocking drugs: the role of ancillary properties. Circulation 75: 204–212

    Article  PubMed  CAS  Google Scholar 

  24. Lessem JM, Singh BN (1989) Calcium channel antagonism and beta-blockade in combination: A therapeutic alternative and cardiovascular disorder (a review). Cardiovasc Drugs Ther 3: 355–373

    Article  PubMed  CAS  Google Scholar 

  25. Lichtlen PR, Hugenholtz P, Rafflenbeul W, INTACT Group (1990) Retardation of the angiographic progression of coronary artery disease in man by the calcium channel blocker nifedipine: Results of the international nifedipine trial of antiatherosclerotic therapy (INTACT). Lancet 335: 1109–1113

    Article  Google Scholar 

  26. Mauser M, Voelker W, Ickrath O, Kühlkamp V, Karsch KR (1990) Myocardiale Wirkung der Calciumantagonisten Nifedipin, Nisoldipin und Isradipin bei koronarer Herzkrankheit. Dtsch Med Wochenschr 115: 723–729

    Article  PubMed  CAS  Google Scholar 

  27. Mclean AJ, Knight R, Harrison PM et al. (1985) Clearance based oral drug interaction between verapamil and metoprolol and comparison with atenolol. Am J Cardiol 55: 1628–1629

    Article  PubMed  CAS  Google Scholar 

  28. The Miami Trial Research Group (1985) Metoprolol in acute myocardial infarction (MIAMI). A randomised placebo-controlled international trial. Eur Heart J 6:199–226

    Google Scholar 

  29. Nagler WG (1990) Classification and tissue selectivity of calcium antagonists. Z Kardiol 79 (Suppl 3): 107–111

    Google Scholar 

  30. Noak E (1990) Mechanisms of nitrate tolerance — influence of the metabolic activation pathways. Z Kardiol 79 (Suppl 3): 51–55

    Google Scholar 

  31. Opie LH (1990) Clinical use of Calcium Antagonist Drugs. Kluwer Academic Publishers, Boston

    Google Scholar 

  32. Opie LH (1991) Drugs for the heart. Saunders, Philadelphia London Toronto Montreal Sydney Tokio

    Google Scholar 

  33. Packer M (1989) Combined beta-adrenergic and calcium entry blockade in angina pectoris. N Engl J Med 320:709–718

    Article  PubMed  CAS  Google Scholar 

  34. Parodi O, Simonetti I, Michelassi C, Carpeggiani C, Biagini A, LAbbate A, Maseri A (1986) Comparison of verapamil and propranolol therapy for angina pectoris at rest: A randomized, multiple crossover, controlled trial in the coronary care unit. Am J Cardiol 57: 899–906

    Article  PubMed  CAS  Google Scholar 

  35. Parker JO, Farrell B, Lahey KA et al. (1987) Effect of intervals between doses on the development of tolerance to iso-sorbide dinitrate. N Engl J Med 316:1440–1444

    Article  PubMed  CAS  Google Scholar 

  36. Peart I, Bullock RE, Albers C, Hall RJC (1989) Cold intolerance in patients with angina pectoris: Effect of Nifedipine and propranolol. Br Heart J 61: 521–528

    Article  PubMed  CAS  Google Scholar 

  37. Pfeffer MA, Braunwald E, Moyé LA, SAVE investigators (1992) Effect of Captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. Results of the survival and ventricular enlargement trial. N Engl J Med 327: 669–677

    Article  PubMed  CAS  Google Scholar 

  38. Prichard BNC (1990) Pharmacological and clinical aspects of drug therapy in coronary heart disease: clinical aspects of therapy with beta-adrenoceptor antagonists. Z Kardiol (Suppl 3): 99–103

    Google Scholar 

  39. Quyyumi AA, Crake T, Wright CM et al. (1987) Medical treatment of patients with severe exertional and rest angina: Double blind comparison of beta-blocker, calcium antagonist, and nitrate. Br Heart J 57: 505–511

    Article  PubMed  CAS  Google Scholar 

  40. Rapaport E (1985) Influence of long-acting nitrate therapy on the risk of reinfarction, sudden death, and total mortality in survivors of acute myocardal infarction. Am Heart J 110: 276–280

    Article  PubMed  CAS  Google Scholar 

  41. Reithmann C, Werdan K (1990) Regulation der Beta-Rezeptoren — Praktische Konsequenzen für die Therapie. Internist 31: 625–631

    PubMed  CAS  Google Scholar 

  42. Reichek, N (1989) Intermittent nitrate therapy in angina pectoris. Eur Heart J 10 (Suppl A): 7–10

    PubMed  Google Scholar 

  43. Robertson RM, Wood AJJ, Vaughn WK, Robertson D (1982) Exacerbation of vasotonic angina by propranolol. Circulation 65: 281–285

    Article  PubMed  CAS  Google Scholar 

  44. Scheidt S, Le Winter MM, Hermanovich J et al. (1986) Efficacy and safety of nicardipine for chronic, stable angina pectoris: A multicenter randomized trial. Am J Cardiol 58: 715–721

    Article  PubMed  CAS  Google Scholar 

  45. Schmidt J (1989) Postinfarkt-Behandlung. Ergebnisse aus Studien zur medikamentösen Sekundärprophylaxe des Herzinfarkts. Gedon & Reuss, München

    Google Scholar 

  46. Silber S (1989) Kombination antianginöser Medikamente. Z Kardiol 78 (Suppl 2): 160–174

    PubMed  Google Scholar 

  47. Singh S, Doherty J, Udjoji V et al. (1989) Amlodipine versus nadolol in patients with stable angina pectoris. Am Heart J 118: 1137–1138

    Article  PubMed  CAS  Google Scholar 

  48. The SOLVD Investigators (1991) Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. N Engl J Med 325: 293–302

    Article  Google Scholar 

  49. Strauss WE, Parisi AF (1988) Combined use of calcium channel and beta-adrenergic blockers for the treatment of chronic stable angina. Ann Intern Med 109: 570–581

    PubMed  CAS  Google Scholar 

  50. Swedberg K, Held P, Kjekshus J, CONSENSUS II Study Group (1992) Effects of the early administration of enalapril on mortality in patients with acute myocardial infarction. Results of the Cooperative New Scandinavian Enalapril Survival Study II (CONSENSUS II). N Engl J Med 327: 678–684

    Article  PubMed  CAS  Google Scholar 

  51. Tauchert M, Jansen W (1990) Pulmonary arterial pressure and working capacity as parameters for checking the development of tolerance under nitrate therapy. Z Kardiol 79 (Suppl 3):67–77

    PubMed  Google Scholar 

  52. Thadani U, Friedman R, Jones JP et al. (1989) Nitrate tolerance: Eccentric versus concentric twice daily therapy with isosorbide-5-mononitrate in angina pectoris. Circulation 80 (Suppl II): II–216

    Google Scholar 

  53. TIMI Study Group (1989) Comparison of invasive and conservative strategies after treatment with intravenous tissue plasminogen activator in acute myocardial infarction: Results of the thrombolysis in myocardial infarction (TIMI) Phase II Trial. N Engl J Med 320: 618–627

    Article  Google Scholar 

  54. Verdecchia P, Gatteschi C, Benemio G et al. (1989) Increased exercise tolerance and reduced electrocardiographic ischaemia 3 and 12 hours after oral felodipine in effort angina. Eur Heart J 10: 70–76

    PubMed  CAS  Google Scholar 

  55. Yusuf S, McMahon S, Collins R et al. (1988) Effect of intravenous nitrates on mortality and acute myocardial infarction: An overview of the randomized trials. Lancet I: 1088–1092

    Article  Google Scholar 

Download references

Authors
  1. D.-M. Rose
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H. A. Dieterich
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Herzchirurgie Salzburg, Müllner Hauptstraße 48, A-5020, Salzburg, Österreich

    Felix Unger

  2. Medizinische Klinik, Diakonissenkrankenhaus Mannheim, Akademisches Lehrkrankenhaus der Universität Heidelberg, Speyerer Straße 91-93, D-68163, Mannheim, Deutschland

    Hubert Mörl

  3. Fachpharmakologe DGPT, Am Huhlchen 5, D-55130, Mainz, Deutschland

    Hans Armin Dieterich

  4. School of Medicine, Dpts. of Medicine and Pharmacology, Georgetown University, Washington D.C., USA

    Hans Armin Dieterich

Rights and permissions

Reprints and permissions

Copyright information

© 1995 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Rose, DM., Dieterich, H.A. (1995). Pharmakologische Grundlagen der Behandlung der koronaren Herzkrankheit. In: Unger, F., Mörl, H., Dieterich, H.A. (eds) Interventionen am Herzen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-93558-9_5

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-93558-9_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-93559-6

  • Online ISBN: 978-3-642-93558-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation