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Antiarrhythmika: neuere Erkenntnisse zu Klassifikation und Wirkmechanismen

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Interventionen am Herzen

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Zusammenfassung

Seit Vaughan Williams zu Beginn der 70er Jahre eine erste Klassifikation von Antiarrhythmika vorstellte, ist der Wissensstand zur Entstehung und Therapie von Herzrhythmusstörungen erheblich erweitert worden [34]. Hierzu haben mehrere parallele Forschungsrichtungen beigetragen: die Entdeckung bzw. Synthese einer großen Zahl neuer antiarrhythmisch wirksamer Substanzen, die Ergebnisse aus experimentellen und klinischen Untersuchungen sowie die aus sog. Metaanalysen gewonnenen Erkenntnisse.

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Literatur

  1. β-Blocker Heart Attack Trial (BHAT) (1982) A randomized trial of propranolol in patients with acute myocardial infarction. I. Mortality results. J Am Med Assoc 247:1707–1714

    Article  Google Scholar 

  2. Cairns JA, Connolly SJ, Gent M, Roberts R (1991) Postmyocardial infarction mortality in patients with ventricular premature depolarizations. Canadian Amiodarone Myocardial Infarction Arrhythmia Trial Pilot Study. Circulation 84: 550–557

    PubMed  CAS  Google Scholar 

  3. CAST Investigators (1989) Preliminary report: effect of encainide and flecainide on mortality in a randomized trial of arrhythmia suppression after myocardial infarction. New Engl J Med 321: 406–412

    Article  Google Scholar 

  4. CAST Investigators (1990) Preliminary report: Effect of encainide and flecainide on mortality in a randomized trial of arrhythmia suppression after myocardial infarction. New Engl J Med 321: 406–412

    Google Scholar 

  5. Catterall WA (1988) Structure and function of voltage-sensitive ion channels. Science 242: 50–61

    Article  PubMed  CAS  Google Scholar 

  6. Catterall WA (1992) Cellular and molecular biology of voltage-gated sodium channels. Physiol Rev 72: S15–S48

    PubMed  CAS  Google Scholar 

  7. Cohen SA, Barchi RL (1992) Cardiac sodium channel structure and function. Trends Cardiovasc Med 2: 133–140

    Article  PubMed  CAS  Google Scholar 

  8. Colatsky TJ, Follmer CH, Starmer CF (1990) Chanrel specificity in antiarrhythmic drug action: Mechanism of potassium channel block and its role in suppressing and aggravating cardiac arrhythmias. Circulation 82: 2235–2242

    Article  PubMed  CAS  Google Scholar 

  9. Collaborative Group (1971) Phenytoin after recovery from myocardial infarction: controlled trial in 568 patients. Lancet II: 1055–1057

    Google Scholar 

  10. Danish Study Group on Verapamil in Myocardial Infarction (1984) Verapamil in acute myocardial infarction. Eur Heart J 5: 516–528

    Google Scholar 

  11. DiFrancesco D, Ferroni A, Mazzanti M, Tromba C (1986) Properties of the hyperpolarizing-activated current (if) in cells isolated from the rabbit sinoatrial node. J Physiol (London) 377: 61–88

    CAS  Google Scholar 

  12. Gottlieb SH, Achuff SC, Mellits ED et al. (1987) Prophylactic antiarrhythmic therapy high-risk survivors of myocardial infarction: lower mortality at 1 month but not at 1 year. Circulation 75: 792–799

    Article  PubMed  CAS  Google Scholar 

  13. Hansteen V, Moinichen E, Lorentsen E et al. (1982) One year’s treatment with propranolol after myocardial infarction: preliminary report of Norwegian multicenter trial. Br Med J 284: 155–160

    Article  CAS  Google Scholar 

  14. Hondeghem LM, Katzung BG (1977) Time- and voltagedependent interactions of antiarrhythmic drugs with cardiac sodium channels. Biochim Biophys Acta 472: 373–398

    PubMed  CAS  Google Scholar 

  15. Hondeghem LM, Katzung BG (1984) Antiarrhythmic agents: The modulated receptor mechanism of action of sodium and calcium channel blocking drugs. Ann Rev Pharmacol 24: 387–423

    Article  CAS  Google Scholar 

  16. Hondeghem LM, Snyders DJ (1990) Class III antiarrhythmic agents have a lot of potential, but a long way to go: reduced effectiveness and dangers of reversed use-dependence. Circulation 81: 686–690

    Article  PubMed  CAS  Google Scholar 

  17. Honerjäger P (1990) Neue Aspekte der molekularen Wirkung von Antiarrhythmika. Herz 15: 70–78

    PubMed  Google Scholar 

  18. IMPACT Research Group (1984) International mexiletine and placebo antiarrhythmic coronary trial: I. Report on arrhythmia and other findings. J Am Coll Cardiol 4: 1148–1163

    Article  Google Scholar 

  19. Julian DG, Jackson FS, Prescott RJ, Szekely P (1982) Controlled trial of Sotalol for one year after myocardial infarction. Lancet I: 1142–1150

    Article  Google Scholar 

  20. Kaufmann R, Theophile U (1967) Automatie-fördernde Dehnungseffekte an Purkinje-Fäden, Papillarmuskeln und Vorhoftrabekeln von Rhesus-Affen. Pflügers Arch 297: 174–189

    Article  CAS  Google Scholar 

  21. Kosowsky BD, Taylor J, Lown B, Ritchie RF (1973) Longterm use of procain amide following acute myocardial infarction. Circulation 47:1204–1210

    PubMed  CAS  Google Scholar 

  22. Lynch JJ, Sanguinetti MC, Kimura S, Bassett AL (1992) Therapeutic potential of modulating potassium currents in the diseased myocardium. FASEB J 6: 2952–2960

    PubMed  Google Scholar 

  23. Millar JS, Vaughan Williams EM (1981) Anion antagonism: A fifth class of antiarrhythmic action? Lancet 1:1291–1293

    Article  PubMed  CAS  Google Scholar 

  24. Nattel S (1991) Antiarrhythmic drug classifications. A critical appraisal of their history, present status, and clinical relevance. Drugs 41: 672–701

    Article  PubMed  CAS  Google Scholar 

  25. Nattel S, Singh BN (1994) Comparative mechanisms of action of antiarrhythmic drugs. In: Singh BN, Wellens HJJ, Hiraoka M (Hrsg) Electrophysiological Control of Cardiac Arrhythmias. Futura Publ Co, Mount Kisco, New York, pp 207–224

    Google Scholar 

  26. Norwegian Multicenter Study Group (1981) Timolol-induced reduction in mortality and reinfarction in patients surviving acute myocardial infarction. N Engl J Med 304: 801–807

    Article  Google Scholar 

  27. Peter T, Ross D, Duffield A, Luxton M, Harper R et al. (1978) Effect on survival after myocardial infarction of longterm treatment with phenytoin. Br Heart J 40: 1356–1360

    Article  PubMed  CAS  Google Scholar 

  28. Roberds SL, Knoth KM, Po S, Blair TA, Bennett PB, Hartshorne RP, Snyders DJ,Tamkun MM (1993) Molecular biology of the voltage-gated potassium channels of the cardiovascular system. J Cardiovasc Electrophysiol 4: 68–80

    Article  PubMed  CAS  Google Scholar 

  29. Rosen MR, Schwartz PJ for Task Force of the Working Group on Arrhythmias of the European scciety of Cardiology (1991) The Sicilian Gambit. A new approach to the classification of antiarrhythmic drugs based on their actions on arrhythmogenic mechanisms. Circulation 84:1831–1851

    Google Scholar 

  30. Sanguinetti MC, Jurkiewicz NK (1990) Two components of cardiac delayed rectifier K+ current. Differential sensitivity to block by class III antiarrhythmic agents. J Gen Physiol 96:195–215

    Article  PubMed  CAS  Google Scholar 

  31. Singh BN, Ahmed R (1994) Class III antiarrhythmic drugs. Current Opinion Cardiol 9: 12–22

    Article  CAS  Google Scholar 

  32. Starmer CF, Grant AE, Strauss HC (1984) Mechanisms of use-dependent block of sodium channels in excitable membranes by local anesthetics. Biophys J 46: 15–27

    Article  PubMed  CAS  Google Scholar 

  33. Teo KK, Yusuf S, Furberg CD (1993) Effects of prophylactic antiarrhythmic drug therapy in acute myocardial infarction. J Am Med Ass 270:1589–1595

    Article  CAS  Google Scholar 

  34. Vaughan Williams EM (1975) Classification of antidysrhythmic drugs. Pharmacol Ther B 1: 115–138

    PubMed  CAS  Google Scholar 

  35. Vaughan Williams EM (1984) A classification of antiarrhythmic actions reassessed after a decade of new drugs. J Clin Pharmacol 24: 129–147

    PubMed  CAS  Google Scholar 

  36. Vaughan Williams EM (1992) Classifying antiarrhythmic actions: By facts or speculation. J Clin Pharmacol 32: 964–977

    PubMed  CAS  Google Scholar 

  37. Weirich J, Antoni H (1991) Neue Aspekte zur frequenzabhängigen Wirkung von Klasse-1-Antiarrhythmika. Eine kritische Analyse der gebräuchlichen Subklassifikation. Z Kardiol 80: 177–186

    PubMed  CAS  Google Scholar 

  38. Wilhelmsson C, Vedin JA, Wilhelmsen L, Tibblin G, Werko L (1974) Reduction of sudden deaths after myocardial infarction by treatment with alprenolol. Lancet II: 1157–1160

    Article  Google Scholar 

  39. Wit AL (1990) Reentrant excitation in the ventricles. In: Rosen MR, Janse MJ, Wit AL (eds) Cardiac electrophysiology: A textbook. Futury Publ Co, Mount Kisco, New York, pp 603–622

    Google Scholar 

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Authors
  1. U. Ravens
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Editors and Affiliations

  1. Herzchirurgie Salzburg, Müllner Hauptstraße 48, A-5020, Salzburg, Österreich

    Felix Unger

  2. Medizinische Klinik, Diakonissenkrankenhaus Mannheim, Akademisches Lehrkrankenhaus der Universität Heidelberg, Speyerer Straße 91-93, D-68163, Mannheim, Deutschland

    Hubert Mörl

  3. Fachpharmakologe DGPT, Am Huhlchen 5, D-55130, Mainz, Deutschland

    Hans Armin Dieterich

  4. School of Medicine, Dpts. of Medicine and Pharmacology, Georgetown University, Washington D.C., USA

    Hans Armin Dieterich

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© 1995 Springer-Verlag Berlin Heidelberg

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Ravens, U. (1995). Antiarrhythmika: neuere Erkenntnisse zu Klassifikation und Wirkmechanismen. In: Unger, F., Mörl, H., Dieterich, H.A. (eds) Interventionen am Herzen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-93558-9_27

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  • DOI: https://doi.org/10.1007/978-3-642-93558-9_27

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-93559-6

  • Online ISBN: 978-3-642-93558-9

  • eBook Packages: Springer Book Archive

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