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First Clinical Experience with ð-ALA Assisted Photodynamic Diagnosis of Bladder Cancer

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Laser in der Medizin / Laser in Medicine

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Abstract

Visualization of early stage bladder cancer is considerably improved using 5-Aminolevulinic acid (ALA) a.s tumor marking agent. This is due to an intracellular accumulation of fluorescing Protoporphyrin IX (PP IX) in tissue following intravesical instillation of ALA in a pH-neutral solution.

ALA induced fluorescence was studied in 68 patients with bladder cancer. Tumors were detected endoscopically with naked eyes by fluorescence in the red spectral range. Histological examination of nearly 300 biopsies taken from fluorescing and nonfluorescing areas gave a specifity of 84% and a sensitivity of 100% up to now.

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References

  1. Baumgartner, R., Kriegmair, M., Jocham, D., Hofstetter, A., Huber, R., Karg, O. and Haussinger, K.: Photodynamic diagnosis (PDD) of early stage malignancies — Preliminary results in urology and pneumology. In: Physiological Monitoring and Early Detection Diagnostic Methods. Edited by T.S. Mang Proc. Spie., 1641, pp. 107–112, 1992.

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  3. Kriegmair, M., Baumgartner, R., Lumper, W., Riesenberg, R., Stocker, S. and Hofstetter, A.: Fluorescence cystoscopy following intravesical instillation of aminolevulinic acid (ALA). J. Urol., vol. 149, 240A, 1993.

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Author information

Authors and Affiliations

  1. Laser-Forschungslabor an der Klinik für Urologie, Universität München, Deutschland

    M. Kriegmair, R. Baumgartner, H. Stepp & A. Hofstetter

  2. Institut für Pathologie, Universität Regensburg, Deutschland

    R. Knüchel

Authors
  1. M. Kriegmair
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  2. R. Baumgartner
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  3. R. Knüchel
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  4. H. Stepp
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  5. A. Hofstetter
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Editor information

Editors and Affiliations

  1. Instituts für Medizinische Optik, Universität München, Deutschland

    Wilhelm Waidelich (Universitätsprofessor, em. Vorstand, em. Direktor) (Universitätsprofessor, em. Vorstand, em. Direktor)

  2. Instituts für Angewandte Optik, Gesellschaft für Strahlen- und Umweltforschung, Neuherberg, Deutschland

    Wilhelm Waidelich (Universitätsprofessor, em. Vorstand, em. Direktor) (Universitätsprofessor, em. Vorstand, em. Direktor)

  3. Urologische Klinik, Klinikum Großhadern, Universität München, Deutschland

    Raphaela Waidelich

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© 1994 Springer-Verlag Berlin Heidelberg

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Kriegmair, M., Baumgartner, R., Knüchel, R., Stepp, H., Hofstetter, A. (1994). First Clinical Experience with ð-ALA Assisted Photodynamic Diagnosis of Bladder Cancer. In: Waidelich, W., Waidelich, R., Hofstetter, A. (eds) Laser in der Medizin / Laser in Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-93548-0_12

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  • DOI: https://doi.org/10.1007/978-3-642-93548-0_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-57441-5

  • Online ISBN: 978-3-642-93548-0

  • eBook Packages: Springer Book Archive

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