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Pharmakologie von Sumatriptan

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Migräne

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Zusammenfassung

Die Entwicklung von Sumatriptan basierte ganz wesendich auf der Hypothese einer vaskulären Genese der Migräne, wie sie in den klassischen Untersuchungen von Graham u. Wolff [26] postuliert wurde. Zentraler Punkt in der Auslösung einer Migräneattacke ist nach dieser Theorie die Dilatadon großer meningealer Gefäße, die zur Stimulation afferenter Fasern des N. trigeminus führt. Dicht innervierte Gefäßwände finden sich intrakraniell besonders in der Dura mater, die demnach der Ort der schmerzhaften Dilatation sein müßte. Daß eine Reizung solcher Gefäße Schmerzen erzeugen kann, ist seit langem bekannt [41, 46]. Darüber hinaus konnte kürzlich gezeigt werden, daß die experimentelle Ballondilatadon intrakranieller Gefäße in der Tat schmerzhaft ist [38]. Schließlich wiesen Friberg et al. [22] mit transkranier Dopplersonographie und Single-photon-emissions-Computertomographie nach, daß große intrakra nielle Gefäße während einer Migräneattacke dilatiert sind und daß die erfolgreiche Therapie der Attacke mit einem Verschwinden der Dilatation einhergeht (vgl. Tabelle 13.1).

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Literatur

  1. Apperley E, Feniuk W, Humphrey PPA, Levy GP (1980) Evidence for two types of excitatory receptor for 5-hydroxytryptamine in dog isolated vasculature. Br J Pharmacol 68:215–224

    PubMed  CAS  Google Scholar 

  2. Boer MO den, Villalćn CM, Heiligers JPC, Humphrey PPA, Saxena PR (1992) Role of 5-HT1-like receptors in the reduction of porcine cranial arteriovenous anastomotic shunting by sumatriptan. Br J Pharmacol 102:323–330

    Google Scholar 

  3. Bond RA, Craig DA, Chariton KG, Omstein AG, Clarke DE (1989) Partial agonistic activity of GR 43175 at the inhibitory prejunctional 5-HT1-like receptor in rat kidney. J Auton Pharmacol 9:201–210

    Article  PubMed  CAS  Google Scholar 

  4. Brown EG, Endersby CA, Smith RN, Talbot JCC (1991) The safety and tolerability of sumatriptan: an overview. Eur Neurol 31:339–344

    Article  PubMed  CAS  Google Scholar 

  5. Buzzi MG, Moskowitz MA (1990) The antimigraine drug, sumatriptan (GR 43175), selectively blocks neurogenic plasma extravasation from blood vessels in dura mater. Br J Pharmacdol 99:202–206

    CAS  Google Scholar 

  6. Buzzi MG, Moskowitz MA (1991) Evidence for 5-HT 1B / 1D receptors mediating the antimigraine effect of sumatriptan and dihydroergotamine. Cephalalgia 11: 165-168

    Article  PubMed  CAS  Google Scholar 

  7. Chester AH, Martin GR, Bodelsson M, Ameklo-Nobin B, Tadjkarimi S, Tomebrandt K, Yacoub MH (1990) 5-Hydroxytryptamine receptor profile in healthy and diseased human epicardial coronary arteries. Cardiovasc Res 24:932–937

    Article  PubMed  CAS  Google Scholar 

  8. Connor HE, Feniuk W, Humphrey PPA (1989) Characterisation of 5-HT-receptors mediating contraction of canine and primate basilar artery using GR 43175, a selective 5-HT1-like receptor agonist. Br J Pharmacol 96:379–387

    PubMed  CAS  Google Scholar 

  9. Connor HE, Feniuk W, Humphrey PPA (1989) 5-Hydroxytryptamine contracts human coronary arteries predominandy via 5-HT 2 receptor activation. Eur J Pharmacol 161:91–94

    Article  PubMed  CAS  Google Scholar 

  10. Conti A, Monopoli A, Foriani A, Ongini E, Antona C, Biglioh P (1990) Role of 5-HT 2 receptors in serotonin-induced contraction in the human mammary artery. Eur J Pharmacol 176:207–212

    Article  PubMed  CAS  Google Scholar 

  11. Cutler NR, Hussey EK, Sramek JJ, Clements BD, Paulsgrove LA, Busch MA, Donn KH (1991) Oral sumatriptan in pharmacokinetics in the migrainous state. Cephalalgia 11 [Suppl 11]: 222–223

    Google Scholar 

  12. Dechant KL, Clissold SP (1992) Sumatriptan. A review of its pharmacodynamic and pharmacoklinetic properites, and therapeutic efficacy in the acute treatment of migraine and cluster headache. Drugs 43:776–798

    Article  PubMed  CAS  Google Scholar 

  13. Edvinsson L, Jansen I (1989) Characterization of 5-HT receptors mediating contraction of human cerebral, meningeal and temporal arteries: target for GR 43175 in acute treatment of migraine? Cephalalgia 9 [Suppl 10]: 39–40

    Google Scholar 

  14. Edvinsson L, Jansen I, Olesen J (1991) Analysis of the vasoconstrictor effects of sumatriptan on human cranial arteries. Cephalalgia 11 [Suppl 11]: 210–21

    Google Scholar 

  15. Engel G, Göthert M, Müller-Schweinitzer E, Schlicker E, Sistonen L, Stadler PA (1983) Evidence for common pharmacological properties of [3H]-5-hydroxy- tryptamine binding sites, presynaptic 5-hydroxytryptamine autoreceptors in CNS and inhibitory presynaptic 5-hydroxytryptamine receptors on sympathetic nerves. Naunyn Schmiedebergs Arch Pharmacol 324:116–124

    Article  PubMed  CAS  Google Scholar 

  16. Feniuk W, Humphrey PPA, Perren MJ, Ws AD (1985) A comparison of 5-hydroxytryptamine receptors mediating contraction in rabbit aorta and dog saphenous vein: evidence for different receptor types obtained by use of selective agonists and antagonists. Br J Pharmacol 86:697–704

    PubMed  CAS  Google Scholar 

  17. Feniuk W, Humphrey PPA, Perren MJ (1989) GR 43175 does not share the complex pharmacology of the ergots. Cephalalgia 9 [Suppl 9]: 35–39

    PubMed  Google Scholar 

  18. Feniuk W, Humphrey PPA, Perren MJ (1989) The selective carotid arterial vasoconstrictor action of GR 43175 in anaesthetized dogs. Br J Pharmacol 96:83–90

    PubMed  CAS  Google Scholar 

  19. Feniuk W, Humphrey PPA, Perren MJ, Connor HE, Whalley ET (1991) Rationale for the use of 5-HT1-like agonists in the treatment of migraine. J Neurol 238 [Suppl 1]: S57-S61

    Article  PubMed  Google Scholar 

  20. Fowler PA, Thomas M, Lacey LF, Andrew P, Dallas FAA (1989) Early studies with the novel 5-HT1-like agonist GR 43175 in healthy volunteers. Cephalalgia 9 [Suppl 9]: 51–62

    Google Scholar 

  21. Fowler PA, Lacey LF, Thomas M, Keene ON, Tanner RJN, Baber NS (1991) The clinical pharmacology, pharmacokinetics and metabolism of sumatriptan. Eur Neurol 31:291–294

    Article  PubMed  CAS  Google Scholar 

  22. Friberg L, Olesen J, Iversen HK, Sperling B (1991) Migraine pain associated with middle cerebral artery dilatation: reversal by sumatriptan. Lancet 338:13–17

    Article  PubMed  CAS  Google Scholar 

  23. Goadsby PJ, Edvinsson L (1991) Sumatriptan reverses the changes in calcitonin gene-related peptide seen in the headache phase of migraine. Cephalalgia 11 [Suppl 11]: 3–4

    Google Scholar 

  24. Goadsby PJ, Edvinsson L, Ekman R (1988) Release of vasoactive peptides in the extracerebral circulation of man and the cat during activation of the trigémino- vascular system. Ann Neurol 23:193–196

    Article  PubMed  CAS  Google Scholar 

  25. Goadsby PJ, Edvinsson L, Ekman R (1990) Vasoactive peptide release in the extracerebral circulation of humans during migraine headache. Ann Neurol 28:183–187

    Article  PubMed  CAS  Google Scholar 

  26. Graham JR, Wolff HG (1938) Mechanism of migraine headache and action of ergotamine tartrate. Arch Neurol Psychiatry 39:737–763

    CAS  Google Scholar 

  27. Hamel E, Bouchard D (1991) Contractile 5-HT1 receptors in human isolated pial arterioles: correlation with HTID binding sites. Br J Parmacol 102:227–233

    CAS  Google Scholar 

  28. Hoyer D, Middlemiss DN (1989) Species differences in the pharmacology of terminal 5-HT autoreceptors in mammalian brain. Trends Pharmacol Sci 10:130–132

    Article  PubMed  CAS  Google Scholar 

  29. Humphrey PPA, Feniuk W (1991) Mode of action of the anti-migraine drug sumatriptan. Trends Pharmacol Sci 12:444–446

    Article  PubMed  CAS  Google Scholar 

  30. Humphrey PPA, Feniuk W, Penen MJ, Connor HE, Oxford AW, Coates IH, Butina D (1988) GR 43175, a selective agonist for the 5-HT1-like receptor in dog isolated saphenous vein. Br J Pharmacol 94:1123–1132

    PubMed  CAS  Google Scholar 

  31. Humphrey PPA, Feniuk W, Marriott AS, Tanner RJN, Jackson MR, Tucker ML (1991) Preclinical studies on the anti-migraine drug, sumatriptan. Eur Neurol 31:282–290

    Article  PubMed  CAS  Google Scholar 

  32. Kerber CW, Newton TH (1973) The macro- and microvasculature of the dura mater. Neuroradiology 6:175–179

    Article  PubMed  CAS  Google Scholar 

  33. Kimball RW, Friedman AP, Vallejo E (1960) Effect of serotonin in migraine patients. Neurology 10:107–111

    PubMed  CAS  Google Scholar 

  34. Lance JW, Anthony M, Hinterberger H (1967) The control of cranial arteries by humoral mechanisms and its relation to the migraine syndrome. Headache 7:93–102

    Article  PubMed  CAS  Google Scholar 

  35. McCarthy BG, Peroutka SJ (1989) Comparative neuropharmacology of dihydro- ergotamine and sumatriptan (GR 43175). Headache 29:420–422

    Article  PubMed  CAS  Google Scholar 

  36. Middlemiss DN, Bremer ME, Smith SM (1988) A pharmacological analysis of the 5-HT receptor mediating inhibition of 5-HT release in the guinea-pig frontal cortex. Eur J Pharmacol 157:101–107

    Article  PubMed  CAS  Google Scholar 

  37. Moskowitz MA (1984) The neurobiology of vascular head pain. Ann Neurol 16:157–168

    Article  PubMed  CAS  Google Scholar 

  38. Nichols FT, Mawad M, Möhr JP, Stein B, Hilal S, Michelsen WJ (1990) Focal headache during balloon inflation in the internal carotid and middle cerebral arteries. Stroke 21:555–559

    Article  PubMed  Google Scholar 

  39. Nielsen TH, Tfelt-Hansen I (1989) Lack of effect of GR 43175 on peripheral arteries in man. Cephalalgia 9 [Suppl 9]: 93–95

    PubMed  Google Scholar 

  40. Parsons AA, Whalley ET, Feniuk W, Connor HE, Humphrey PPA (1989) 5-HT1-like receptors mediate 5-hydroxytryptamine-induced contracdon of human isolated basilar artery. Br J Pharmacol 96:434–449

    PubMed  CAS  Google Scholar 

  41. Penfield W (1935) A contribution to the mechanism of intracranial pain. Proc Assoc Res Nerv Ment Dis 15:399–416

    Google Scholar 

  42. Peroutka SJ (1992) Phylogenetic tree analysis of G-protein-coupled 5-HT receptors: implications for receptor nomenclature. Neuropharmacology 31:609–613

    Article  PubMed  CAS  Google Scholar 

  43. Peroutka SJ, Marthy BG (1989) Sumatriptan (GR 43175) interacts selectively with 5-HTIB and HTM binding sites. Eur J Pharmacol 163:133–136

    Article  PubMed  CAS  Google Scholar 

  44. Perren MJ, Feniuk W, Humphrey PPA (1989) The selecdve closure of feline arteriovenous anastomoses (AVAs) by GR 43175. Cephalalgia 9 [Suppl 9]: 41–46

    PubMed  Google Scholar 

  45. Perren MJ, Feniuk W, Humphrey PPA (1991) Vascular 5-HT1-hke receptors which mediate contracdon of the isolated dog saphenous vein and carodd arterial vasoconstriction in anaesthetised dogs are not of the 5-HT 1A or HT 1D subtype. Br J Pharmacol 102:191–197

    PubMed  CAS  Google Scholar 

  46. Ray BS, Wolff HG (1940) Experimental studies on headache. Painsensitive structures of the head and their significance in headache. Arch Surg 41:813–856

    Article  Google Scholar 

  47. Saito K, Markowitz S, Moskowitz MA (1988) Ergot alkaloids block neurogenic extravasation in dura mater: proposed action in vascular headaches. Ann Neurol 24:732–737

    Article  PubMed  CAS  Google Scholar 

  48. Saxena PR (1972) The effects of antimigraine drugs on the vascular responses evoked by 5-hydroxytryptamine and related biogenic substances on the external carotid bed of dogs: Possible pharmacological implications to their andmigraine action. Headache 12:44–54

    Article  PubMed  CAS  Google Scholar 

  49. Saxena PR (1974) Selective vasoconstriction in carotid vascular bed by methysergide: possible relevance to its antimigraine effect. Eur J Pharmacol 27:99–105

    Article  PubMed  CAS  Google Scholar 

  50. Schlicker E, Fink K, Göthert M, Hoyer D, Moiderings G, Roschke I, Schoeffter P (1989) The pharmacological properties of the presynaptic autoreceptor in the guinea-pig brain cortex conform to the HTID receptor subtype. Naunyn Schmiedebergs Arch Pharmacol 340:45–51

    Article  PubMed  CAS  Google Scholar 

  51. Schoeffter P, Hoyer D (1989) How selective is GR 43175? Interactions with functional 5-HT 1A , 5HT 1B , 5-HTIC and HT 1D receptors. Naunyn Schmiedebergs Arch Pharmacol 340:135–138

    PubMed  CAS  Google Scholar 

  52. Schoeffter P, Hoyer D (1990) 5-Hydroxytryptamin (5-HT)-induced endothelium- dependent relaxation of pig coronary arteries is mediated by 5-HT receptors similar to the 5-HTID receptor subtype. J Pharmacol Exp Ther 252:387–395

    PubMed  CAS  Google Scholar 

  53. Schoeffter PC, Waeber C, Palacios JM, Hoyer D (1988) The 5-hydroxytryptamine HTID receptor subtype is negatively coupled to adenylate cyclase in calf substantia nigra. Naunyn Schmiedebergs Arch Pharmacol 337:602–608

    Article  PubMed  CAS  Google Scholar 

  54. Scott AK, Walley T, Breckenridge AM, Lacey LF, Fowler PA (1991) Lack of an interaction between propranolol and sumatriptan. Br J Pharmacol 32:581–584

    CAS  Google Scholar 

  55. Skingle M, Birch PJ, Leighton GE, Humphrey PPA (1990) Lack of antinociceptive activity of sumatriptan in rodents. Cephalalgia 10:207–212

    Article  PubMed  CAS  Google Scholar 

  56. Sleight AJ, Cervenka A, Peroutka SJ (1990) In vivo effects of sumatriptan (GR 43175) on extracellular levels of 5-HT in the guinea pig. Neuropharmacology 29:522–523

    Article  Google Scholar 

  57. Sperling B, Tfelt-Hansen P, Winter PDO’B (1991) Initial study of the peripheral vascular effects of a combination of sumatriptan and ergotamine in man. Cephalalgia 11 [Suppl 11]: 230–231

    Google Scholar 

  58. Sumner MJ, Humphrey PPA (1990) Sumatriptan (GR 43175) inhibits cyclic-AMP accumulation in dog isolated sapheneous vein. Br J Pharmacol 99:219–220

    PubMed  CAS  Google Scholar 

  59. Tansey MJB (1991) Sumatriptan — long term data and future developments (Abstract). Proceedings Vth Int. Headache Congress, Washington DC

    Google Scholar 

  60. The Finnish Sumatriptan Group and the Cardiovascular Clinical Research Group (1991) A placebo-controlled study of intranasal sumatriptan for the acute treatment of migraine. Eur Neurol 31:332–338

    Article  Google Scholar 

  61. The Multinational Oral Sumatriptan and Cafergot Comparative Study Group (1991) A randomized, double-blind comparison of sumatriptan and cafergot in the acute treatment of migraine. Eur Neurol 31:314–322

    Article  Google Scholar 

  62. The Oral Sumatriptan and Aspirin plus Metoclopramide Comparative Study Group (1992) A study to compare oral sumatriptan with oral aspirin plus oral metoclopramide in the acute treatment of migraine. Eur J Pharmacol 32:177–184

    Google Scholar 

  63. The Sumatriptan Cluster Headache Study Group (1991) Treatment of acute cluster headache with sumatriptan. N Engl J Med 325:322–326

    Article  Google Scholar 

  64. Van Wijngaarden I, Tulp MTLM, Soudijn W (1990) The concept of selectivity in 5-HT receptor research. Eur J Pharmacol 188:301–312

    Article  PubMed  Google Scholar 

  65. Waeber C, Dietl MM, Hoyer D, Probst A, Palacios JM (1988) Visualization of a novel serotonin recognition site (HT 1D ) in the human brain by autoradiography. Neurosci Lett 88:11–16

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. Martin J. Lohse
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  2. Franz Bernhard M. Ensink
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Editors and Affiliations

  1. Zentrum Anaesthesiologie, Rettungs- und Intensivmedizin, Universität Göttingen, Robert-Koch-Straße 40, 37075, Göttingen, Deutschland

    Franz Bernhard M. Ensink

  2. Klinik für Neurologie, Universität Kiel, Niemannsweg 147, 24105, Kiel, Deutschland

    Dieter Soyka

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© 1994 Springer-Verlag Berlin Heidelberg

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Lohse, M.J., Ensink, F.B.M. (1994). Pharmakologie von Sumatriptan. In: Ensink, F.B.M., Soyka, D. (eds) Migräne. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-93522-0_16

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  • DOI: https://doi.org/10.1007/978-3-642-93522-0_16

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  • Print ISBN: 978-3-642-93523-7

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