Development of an Expert System for the Detection of Adverse Drug Reactions

  • O. Juan-Babot
  • P. Ferrer-Salvans
  • L. Alonso-Vallès
  • I. Ferrer-Salvans
  • C. Castells-Nat
  • E. Vidal-Casas
  • R. Rubio-García
Conference paper
Part of the Lecture Notes in Medical Informatics book series (LNMED, volume 45)

Abstract

The development of an expert system for the detection of adverse drug reactions based on the epidemiological approach and careful monitorization of a random sample of inpatients is proposed. Clinical parameters at the time of admission to hospital are taken as a starting point to assess new manifestations appearing during hospitalization. The newly developed signs and symptoms are sequentially introduced in a data base and analyzed using causality algorithms and statistical tests. Any statistically significant observation made or causality association established are entered into a medical knowledge data base. The expert system proposed may be used as a consultation tool or therapeutical decision aid.

Keywords

Europe Titration Toxicology Valino 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • O. Juan-Babot
    • 1
  • P. Ferrer-Salvans
    • 1
  • L. Alonso-Vallès
    • 1
  • I. Ferrer-Salvans
    • 1
  • C. Castells-Nat
    • 1
  • E. Vidal-Casas
    • 1
  • R. Rubio-García
    • 2
  1. 1.Unitat de Farmacologia Clínica. Ciutat Sanitària de BellvitgeHospital Duran i ReynalsL’Hospitalet de Llobregat, BarcelonaSpain
  2. 2.Andersen ConsultingMadridSpain

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