Zusammenfassung
Beim Einsatz von Psychopharmaka orientiert sich der Kliniker in erster Linie an den „Zielsymptomen“, weil man von einer syndromgerichteten Medikamentenwirkung ausgehen kann [23, 34, 39]. Grohmann [30] untersuchte das Verordnungsverhalten an einer Universitätsklinik und fand, daß bei 62,7% aller Behandlungen im Durchschnitt 2,7 Psychopharmaka verabreicht werden, was verständlich ist, da sich bei in sich heterogenen psychiatrischen Krankheitsbildern eine Kombinationsbehandlung mit verschiedenen Psychopharmaka oft geradezu aufdrängt. Im folgenden Abschnitt wird erörtert, bei welchen psychiatrischen Krankheitsbildern eine Kombinationstherapie sinnvoll, weil einer Monotherapie überlegen, und bei welchen sie nicht sinnvoll ist.
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Literatur
Atsmon A, Blum I (1978) The discovery. In: Roberts E, Amacher P (eds) Propanolol and schizophrenia. Liss, New York, pp 5–38
Baastrup PC, Hollnagel P, Sörensen R, Schou M (1976) Adverse reactions in treatment with lithium carbonate and Haloperidol. JAMA 236:2645–2646
Baldessarini RJ, Lipinski JF (1967) Toxicity and side effects of antipsychotic, antimanic and antidepressant medications. Psychiatr Ann 6:484–493
Beber CR (1971) Psychotropic treatment of anxiety and depression in the elderly. A double blind study. J Flo Med Assoc 58:35–38
Becker RE (1970) Evaluation of an amitriptyline-perphenazine combination in chronic schizophrenia. Am J Psychiatry 127:827–831
Beckmann H, Haas S (1980) High dose Diazepam in schizophrenia. Psychopharmacology 71:79–82
Bennet JA, Hirschowitz, Zemlan F, Thurman DN, Garver DL (1984) Combined thioridazine and desipramine: early antidepressant response. Psychopharmacology 82:263–265
Biedermann J, Lerner Y, Belmaker RH (1979) Combination of lithium carbonate and haloperidol in schizoaffective disorders. Arch Gen Psychiatry 35:327–333
Brodie NH, McGhie RL, O’Hara J et al. (1985) Separate and combined anxiolytic and antidepressant treatment of mixed anxiety/depression. Acta Psychiatr Scand 72:81–88
Carlsen M (1978) Mechanism of the action of neuroleptic drugs. In: Liptin MA, Di Mascio D, Killam KF (eds) Psychopharmacology: a generation of progress. Raven, New York, pp 1057–1070
Carman JS, Bigelow LB, Wyatt RJ (1981) Lithium combined with neuroleptics in chronic schizophrenic and schizoaffective patients. J Clin Psychiatry 42:142–148
Casey JF, Hollister LE, Klett CJ, Lasky JJ, Caffey EM (1961) Combined drug therapy of chronic schizophrenic. Am J Psychiatry 117:997–1003
Chien CP, Cole JO (1973) Depot phenothiazine treatment in acute psychosis. Am J Psychiatry 130:13–17
Chouinard G, Annable L, Serrano M, Albert JM, Charette R (1975) Amitriptyline-perphenazine interaction in ambulatory schizophrenic patients. Arch Gen Psychiatry 32:129–1307
Cohen WJ, Cohen NH (1974) Lithium carbonate, haloperidol, and irreversible brain damage. J Am Med Assoc 230:1283–1287
Collins AD, Dundas J (1967) A double-blind trial of amitriptyline-perphenazine, perphenazine and placebo in chronic withdrawn inert schizophrenics. Br J Psychiatry 113:1425–1429
Cooper SF, Dugal R, Elie R, Albert JM (1979) Metabolic interaction between amitriptylin and perphenazine in psychiatric patients. Prog Neuropsychopharmacol Biol Psychiatry 3:369–376
Creese J, Burt RD, Snyder HS (1978) Biochemic actions of neuroleptic drugs: Focus on the dopamine receptor. In: Iversen LL, Iversen SD, Snyder GS (eds) Handbook of psychopharmacology, vol 10: neuroleptics and schizophrenia. Plenum, New York London
Davis WG (1968) Treating psychical disturbances induced by physical disorders. A doubleblind study of perphenazine-amitriptyline in anxiety and depression. Psychosomatics 9:44–46
Desiverio RV, Rickeis K, Weise CC et al. (1970) Perphenazine-amitriptyline in neurotic depressed outpatients: a controlled collaborative study. Am J Psychiatry 127:322–328
Eibergen RD, Carlson KR (1976) Pharmacol Biochem Behav 5:175–188
El-Yousse FMD, Manier DH (1974) Tricyclic antidepressants and phenothiazines. J Am Med Assoc 229:1419
Freyhan FA (1957) Psychomotilität, extrapyramidale Syndrome und Wirkungsweisen neuroleptischer Therapien (Chlorpromazin, Reserpin, Prochlorperazin). Nervenarzt 28:504–509
General Practitioner Research Group (1967) Chlordiazepoxide with amitriptyline in neurotic depression. Practitioner 202:437–440
Glenn AG, Crayton JW, Klass DB, Evans H, Strizich M (1979) Lithium in chronic schizophrenia. Am J Psychiatry 136:454–455
Goodnick PJ, Meltzer HY (1983) Lithium treatment of schizomania and mania. Paper presented at the Annual Meeting of the American Psychiatric Association, New York, 1983, May 1–6
Gottfried K, Spring (1979) Neurotoxicity with combined use of lithium and thioridazine. J Clin Psychiatry 40:135–138
Gram LF, Overo FK (1972) Drug interaction: inhibitory effect of neuroleptics on metabolism of tricyclic antidepressants in man. Br Med J 1:463–465
Grohmann R, Dirschedl P, Rennig E, Scherer J, Schmidt LG (1986) Methodological problems in assessment of adverse drug reactions with drug combinations. Pharmacopsychiatry 19:300–301
Grohmann R, Strauss A, Gehr C, Rüther E, Hippius H (1980) Zur Praxis der klinischen Therapie mit Psychopharmaka. Retrospektive Untersuchung der Verordnungsgewohnheiten in einer Psychiatrischen Universitätsklinik. Pharmacopsychiatry 13:1–19
Hanlon TE, Ota KY, Agallianos DD, Bergmann SA, Bethan GD, Kobler F, Kurland AA (1969) Combined drug treatment of newly hospitalized acutely ill psychiatric patients. Dis Nerv Syst 30:104–116
Hanlon TE, Ota KY, Kurland AA (1970) Comparative effects of fluphenazine, fluphenazine-chlordiazepoxide and fluphenazine-imipramine. Dis Nerv Syst 31:171–177
Hedberg DL, Houck JH, Glueck BC (1971) Tranylcypromine-trifluoperazine combination in the treatment of schizophrenia. Am J Psychiatry 127:114–1146
Hippius H (1976) The concept of „target symptoms“for drug treatment in psychiatry. In: Advances in the drug therapy of mental illness. WHO, Genf 1976, pp 79–82
Hordern A, Somerville DM (1962) Clinical trials in chronic schizophrenia. Med J Aust 1:40–43
Hordern A, Somerville DM, Krupinski J (1962) Does chronic schizophrenia respond to a combination of a neuroleptic and an antidepressant? J Nerv Ment Dis 134:361–376
Jimerson DC, Van Kämmen DP, Post RM, Docherty JP, Bunney We Jr (1982) Diazepam in schizophrenia: a preliminary double-blind trial. Am J Psychiatry 139:489–491
Karson CN, Weinberger DR, Bigelow L, Wyatt RJ (1982) Clonazepam treatment of chronic schizophrenia: negative results in a double-blind, placebo-controlled trial. Am J Psychiatry 139:1627–1628
Kielholz P (1971) Diagnose und Therapie der Depression für den Praktiker. Lehmann, München
Kuss HJ, Jungkunz G, Dieterle D (1980) Veränderungen der klinischen Wirkung des Amitriptylins durch Kombinationsbehandlung. Arzneiforsch/Drug Res 20:1200
Leonhard K (1986) Aufteilung der endogenen Psychosen und ihre differenzierte Ätiologie. 6. bearb. Auflage. Akademie, Berlin
Lindström LH, Persson E (1980) Propanolol in chronic schizophrenia: a controlled study in neuroleptic-treated patients. Br J Psychiatry 137:126–130
Mena A, Heistad G, Schiele BC, Janecek J (1964) A comparison of tranylcypromine alone with tranylcypromine plus trifluoperazine in the treatment of chronic outpatients. J Neuropsychiatry 5:542–550
Michaux MH, Kurland AA, Agalianos DD (1966) Chlorpromazine-chlordiazepoxide and chlorpromazine-imipramine treatment of newly hospitalized, acutely ill psychiatric patients. CurrTherRes8 [Suppl]:117–152
Myers DH, Campbell PL, Cocks NM, Flowerdew JA, Muir A (1981) A trial of Propanolol in chronic schizophrenia. Br J Psychiatry 139:118–121
Nestoros JN, Nair NPV, Pulman JR, Schwartz G, Bloom D (1983) High doses of Diazepam improve neuroleptic-resistant chronic schizophrenic patients. Psychopharmacology 81:4–47
Olivier-Martin R, Marzin D, Buschsenschutz E, Pichot P, Boissier AJ (1957) Concentrations plasmatiques de l’imipramine et de la desmethylimipramine et effet ante de-presseur au cours d’un traitement contrôle. Psychopharmacol 41:187–195
Prusoff BA, Klermen GL (1983) Rapidity of symptom reduction in depressed outpatients treated with amitriptyline, perphenazine and amitriptyline/perphenazine. Psychopharmacol Bull 19:109–110
Püringer W, Kocher R, Gastpar M (1979) Zur Frage der Inkompatibilität einer Lithium-Neuroleptika Kombinationstherapie. Nervenarzt 50:124–127
Randy PJ, Ming T, Tsuang, Perry J (1977) Concomitant administration of Haloperidol and lithium carbonate in acute mania. Dis Nerv Syst 38:675–676
Rickeis KJ, Hutchinson CC, Weise et al. (1972) Doxepine and amitriptyline-perphenazine in mixed anxious-depressed neurotic outpatients: a collaborative controlled study. Psychopharmacologia (Berlin) 23:305–318
Sassim N, Grohmann R (1988) Adverse drug reactions with Clozapine and simultaneous application of benzodiazepines. Pharmacopsychiatry 21:306–307
Schiele BC, Vestre NC, McNaughton DV (1963) Treatment of hospitalized schizophrenics with trifluoperazine plus tranylcypromine. Compr Psychiatry 4:66–79
Sedval G, Fyro B, Nyback H, Wiesel FA (1975) Actions of dopaminergic antagonists in the striatum. In: Calve DB, Chase TN, Barbeau A (eds) Advances in neurology, vol 9. Ravens, New York, pp 131–140
Seeman P, Chang-Wong, Sidney CHWM, Tedesco J, Wong K (1975) Brain receptors for antipsychotic drugs and dopamine: direct binding assay. Proc Natl Acad Sci USA 72:76–80
Sharpley P, Mena A, Schiele BC, Heistad C (1964) A comparison of pargyline and tranylcypromine with and without the addition of trifluoperazine. Curr Ther Res 6:344–352
Shepperd GP (1979) High dose propanolol in schizophrenia. Br J Psychiatry 134:470–476
Shopsin B, Small JB, Kellams JJ, Milstein V, Moore JE (1976) Combining lithium and neuroleptics. Am J Psychiatry 133:980–981
Small IG, Kellams IJ, Milstein VA (1975) Placebo-controlled study of lithium combined with neuroleptics in chronic schizophrenic patients. Am J Psychiatry 132:1315–1317
Valle Jones JC, Craven JR, Wallis TD, Schiff AA (1983) Mixed anxiety/depressive illness in general practise: a therapeutic comparison of nomifensine with fluphenazine/nortriptyline. Acta Psychiatr Scand 68:494–500
Vestre ND, Dehnel LL, Schiele BC (1969) A sequential comparison of amitriptyline, perphenazine and the amitriptyline-perphenazine combination in recently admitted anergic schizophrenics. Psychosomatics 10:296–303
Yorkston NJ, Gruzelier JH, Zaki SA, Hollander D, Pitcher D, Sergeant NS (1977) Lancet 1:575
Yorkston NJ, Malik MKU, Morrison RC, Harvard CWH (1974) Propanolol in the control of schizophrenic symptoms. Br Med JIV:633–635
Yorkston NJ, Zaki SA, Themen JFA, Havard CWH (1967) Propanolol to control schizophrenic symptoms: 55 patients. Adv Clin Pharmacol 12:91–104
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Franzek, E., Beckmann, H. (1990). Kombinationsbehandlung bei Therapie mit Neuroleptika — Polypragmasie oder Notwendigkeit?. In: Heinrich, K. (eds) Leitlinien neuroleptischer Therapie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-93466-7_8
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