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Pharmakologische Aspekte der Neuroleptikawirkung

  • Conference paper
Leitlinien neuroleptischer Therapie

Zusammenfassung

Seit Anfang der 50er Jahre die selektive antipsychotische Wirksamkeit des Chlor-promazins und des Reserpins gefunden wurde, hat sich die psychopharmakologische Forschung sehr intensiv bemüht, den Mechanismus der antipsychotischen Wirkung beider Substanzen und der vielen von ihnen abgeleiteten Verbindungen aufzuklären, Bemühungen, die von klinischer Seite immer mit höchstem Interesse verfolgt worden sind. Dieses außergewöhnliche Interesse der klinischen Psychiatrie an einem pharmakologischen Wirkungsmechanismus hat sicher nicht nur den Grund, daß die Kenntnis des Wirkungsmechanismus eines Pharmakons eine der Grundlagen für eine rationale Pharmakotherapie ist. Wie bei vielen anderen Psychopharmaka war in der klinischen Psychiatrie das Interesse an dem Wirkungsmechanismus der Neuroleptika wesentlich von der Hoffnung geprägt, über den biochemischen Wirkungsmechanismus dieser bei Symptomen der Schizophrenie wirksamen Arzneimittel einen Schlüssel zum Verständnis der Pathogenese der Erkrankung in die Hand zu bekommen.

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Author information

Authors and Affiliations

  1. Abteilung Psychopharmakologie, Zentralinstitut für Seelische Gesundheit, D-6800, Mannheim, Deutschland

    Prof. Dr. Walter E. Müller

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  1. Prof. Dr. Walter E. Müller
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Editors and Affiliations

  1. Psychiatrische Klinik, Rheinische Landesklinik, Heinrich-Heine-Universität, Bergische Landstr. 2, 4000, Düsseldorf 12, Deutschland

    Kurt Heinrich

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Müller, W.E. (1990). Pharmakologische Aspekte der Neuroleptikawirkung. In: Heinrich, K. (eds) Leitlinien neuroleptischer Therapie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-93466-7_2

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  • DOI: https://doi.org/10.1007/978-3-642-93466-7_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-52723-7

  • Online ISBN: 978-3-642-93466-7

  • eBook Packages: Springer Book Archive

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