Abstract
A specialized control strategy was devised for a production system used to support simulation system CELLSIM; CELLSIM, in turn, was designed to simulate, and thereby to assist in analysing, the complex of locomotory activity and social behaviour of cells in vitro. The specialized control strategy is based on action chaining, backtracking into variable depth, dynamic variation of action priorities, ordering, and pseudorandom selection. The algorithm complexity has been lessened by the introduction of excluding rule subsets. The application of CELLSIM to the assessment of the migratory behaviour of malignant cells in vitro has provided some insight into the processes leading to the formation of a single-cell-derived colony, in the sense of structuralization of diese processes. A practical result of the simulation is an algorithm for quantitative estimation of the total distance travelled by all cells in a colony, based on the length of the minimal graph skeleton; the mean cell area; and the number of cells in the resultant colony.
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© 1989 Springer-Verlag Berlin Heidelberg
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Zicha, D., Vesely, P. (1989). The Use of a Production System for Simulation Analysis of Tumour Cell Migration in vitro: Development of a Specialized Control Strategy. In: Hunter, J., Cookson, J., Wyatt, J. (eds) AIME 89. Lecture Notes in Medical Informatics, vol 38. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-93437-7_30
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DOI: https://doi.org/10.1007/978-3-642-93437-7_30
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-51543-2
Online ISBN: 978-3-642-93437-7
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