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Medikamentöse Beeinflussung von Synthese und Abbau der Purine

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Book cover Hyperurikämie, Gicht und andere Störungen des Purinhaushalts

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Zusammenfassung

Zahlreiche Substanzen beeinflussen die Harnsäurebildung durch Hemmung verschiedener Enzyme des Purinstoffwechsels. Es handelt sich hierbei im wesentlichen um Analoga des Glutamins (z. B. Azaserin, Diazooxonorleucin), Analoga der Folsäure (z. B. Methotrexat, Aminopterin) sowie Analoga von Purinbasen (z. B. Allopurinol, Oxipurinol, 6-Mercaptopurin, 6-Thioguanin, 2,6-Diaminopurin) (Abb. 4.19). In der Langzeittherapie der Hyperurikämie und Gicht hat sich unter den Hemmstoffen der Harnsäuresynthese wegen der geringen Toxizität nur Allopurinol durchgesetzt.

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    Nepomuk Zöllner

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Gröbner, W. (1990). Medikamentöse Beeinflussung von Synthese und Abbau der Purine. In: Zöllner, N. (eds) Hyperurikämie, Gicht und andere Störungen des Purinhaushalts. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-93422-3_17

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