Zusammenfassung
Pro Jahr werden allein in Deutschland bis zu 100.000 Menschen nach einem nicht traumatisch bedingten Herz-Kreislauf-Stillstand prähospital reanimiert. Zwischen 25 und 50% dieser Patienten können initial hämodynamisch stabilisiert werden. Zu einer Krankenhausentlassung kommt es jedoch nur bei etwa 10–15% dieser Patienten [8, 37]. Eine der wesentlichen Ursachen für die hohe intrahospitale Mortalität ist die neurologische bzw. zerebrale Schädigung der Patienten [30,41]. Der individuelle, soziale und volkswirtschaftliche Schaden im Zusammenhang mit der zerebralen Schädigung nach Herz-Kreislauf-Stillstand ist erheblich. Da bisher klinisch keine Therapie zur Verbesserung des neurologischen Outcome nach einem Herz-Kreislauf-Stillstand verfügbar ist [14, 15], fokussieren aktuelle klinische Ansätze auf die therapeutische Anwendung der milden Hypothermie und auf die Thrombolyse während der kardiopulmonalen Reanimation [3,9,11,41].
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Böttiger, B.W., Padosch, S.A., Martin, E. (2002). Gerinnungsaktivierung bei Reanimation — Gibt es klinische Konsequenzen?. In: Martin, E., Nawroth, P. (eds) Fachübergreifende Aspekte der Hämostaseologie V. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-93394-3_9
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