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Interferonrezeptoren: Charakterisierung und mögliche klinische Bedeutung

  • Chapter
Interferone

Zusammenfassung

Moleküle der interzellulären Kommunikation mit Proteinstruktur, wie z.B. Lymphokine, Wachstumsfaktoren und Hormone, vermitteln ihre Wirkung auf die Zielzellen über spezifische Bindungsstellen auf der Zelloberfläche, die Rezeptoren. Dabei handelt es sich meist um Glykoproteine, die als integrale Bestandteile der Zellmembran häufig in Form von dimeren oder tetrameren Strukturen mit homologen oder heterologen Untereinheiten organisiert sind (Abb. 1). Je nach Zell- bzw. Rezeptortyp, aber auch beeinflußt durch ihr Dif-ferenzierungsstadium, besitzt die einzelne Zelle einige hundert bis mehrere zehntausend Rezeptoren.

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Authors
  1. G. Kummer
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  2. O. Kloke
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  3. N. Niederle
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Editors and Affiliations

  1. Med. Klinik III - Onkologie und Hämatologie, Städtisches Krankenhaus, Dhünnberg 60, D-5090, Leverkusen, Deutschland

    Norbert Niederle

  2. Abteilung Immunologie und Transfusionsmedizin, Medizinische Hochschule Hannover, Konstanty-Gutschow-Str. 8, D-3000, Hannover 61, Deutschland

    Peter von Wussow

  3. Zentrum für Innere Medizin und Dermatologie, Medizinische Hochschule Hannover, Konstanty-Gutschow-Str. 8, D-3000, Hannover 61, Deutschland

    Peter von Wussow

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Kummer, G., Kloke, O., Niederle, N. (1990). Interferonrezeptoren: Charakterisierung und mögliche klinische Bedeutung. In: Niederle, N., von Wussow, P. (eds) Interferone. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-93383-7_4

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