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Grundlagen der Schmerztherapie mit Analgetika und Nicht-Analgetika

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Schmerz- Eine interdisziplinäre Herausforderung

Zusammenfassung

Schmerzen werden durch Substanzen unterdrückt, die die Funktionen des nozizeptiven Systems beeinträchtigen. Hierzu gehören an erster Stelle die Analgetika, von denen solche vom Typ des Morphins in der Regel am potentesten sind, da sie an verschiedenen Teilen des Systems angreifen und diese Wirkungen sich summieren. Dazu gehören aber auch Substanzen, die normalerweise unter anderen Indikationen eingesetzt werden, und zwar als Ataraktika, Antidepressiva, Antihypertensiva und Antiepileptika.

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Literatur

  1. Atweh SF, Kuhar MJ, (1983) Distribution and physiological significance of opioid receptors in the brain. Br Med J 39: 47

    CAS  Google Scholar 

  2. Barasi S, (1979) Responses of substantia nigra neurones to noxious stimulation. Brain Res 171: 121

    Article  PubMed  CAS  Google Scholar 

  3. Behar M, Magora F, Olshwang D, Davidson JT, (1979) Epidural morphine in treatment of pain. Lancet 1: 527

    Article  PubMed  CAS  Google Scholar 

  4. Blume W, (1927) Ober die Wirkung des Morphins auf das Rückenmark der dekapitierten Katze. Naunyn-Schmiedeberg’s Arch Pharmacol 119: 24

    Google Scholar 

  5. Braestrup C, Squires RF, (1977) Specific benzodiazepine receptors in rat brain characterized by high-affinity [3H] diazepam binding. Proc Natl Acad Sci USA 74: 805

    Article  Google Scholar 

  6. Brodie BB, Shore PA, Silver SL, Pulver R, (1955) Potentiating action of chlorpromazine and reserpine. Nature 175: 1133

    Article  PubMed  CAS  Google Scholar 

  7. Carlsson KH, Jurna I, Wilcox GL, (1985) In Vorbereitung 8. Chapman CR, Feather BW, (1973) Effects of diazepam on human pain tolerance and pain sensitivity. Psychosom Med 35: 330

    Google Scholar 

  8. Coombs DW, Saunders RL, Lachance D, Savage S, Ragnarsson TS, Jensen LE, (1985) Intrathecal morphine tolerance: use of intrathecal Clonidine, DADLE, and intraventricular morphine. Anesthesiology 62: 358

    Google Scholar 

  9. Courvoisier S, Fournel J, Ducrot R, Kolsky M, Koetschet P, (1953) Propriétés pharmacodynamiques du chlorhydrate de chloro-3 (diméthylamino-3’propyl) phénothiazine (4.560 R.P.). Etude expérimentale d’un nouveau corps utilise dans l’anesthésie potentialisée et dans l’hibernation artificielle. Arch Int Pharmacodyn Thér 92: 305

    Google Scholar 

  10. Cousins MJ, Mather LE, Glynn CW, Wilson PR, Graham JR, (1979) Selective spinal analgesia. Lancet 1: 1141

    Article  PubMed  CAS  Google Scholar 

  11. Crankshaw DP, Raper C, (1970) Mephenesin, methocarbamol, chlordiazepoxide and diazepam: actions on spinal reflexes and ventral root potentials. Br J Pharmacol 38: 148

    PubMed  CAS  Google Scholar 

  12. Cuello AC, (1983) Central distribution of opioid peptides. Br Med Bull 39: 11

    PubMed  CAS  Google Scholar 

  13. Doi T, Jurna I, (1982) Analgesic effect of intrathecal morphine demonstrated in ascending nociceptive activity in the rat spinal cord and ineffectiveness of caerulein and cholecystokinin octapeptide. Brain Res 234: 399

    Article  PubMed  CAS  Google Scholar 

  14. Ouggan AW, (1983) Electrophysiology of opioid peptides and sensory systems. Br Med Bull 39: 65

    Google Scholar 

  15. Feinmann C, (1985) Pain relief by antidepressants: possible modes of action. Pain 23: 1

    Article  PubMed  CAS  Google Scholar 

  16. Ferreira SH, (1972) Prostaglandins, aspirin-like drugs and analgesia. Nature New Biol 240: 200

    Article  PubMed  CAS  Google Scholar 

  17. Grossmann W, Jurna I, Nell T, Theres C, (1973) The dependence of the anti-nociceptive effect of morphine and other analgesic agents on spinal motor activity after central monoamine depletion. Eur J Pharmacol 24: 67

    Article  PubMed  CAS  Google Scholar 

  18. Hall GM, Whitwam JG, Morgan M, (1974) Effect of diazepam on experimentally induced pain thresholds. Br J Anaesth 46: 50

    Article  PubMed  CAS  Google Scholar 

  19. Han S, Terenius L, (1982) Neurochemical basis of acupuncture analgesia. Ann Rev Pharmacol Toxicol 22: 193

    Article  CAS  Google Scholar 

  20. Handwerker HO, (1976) Influences of algogenic substances and prostaglandins on the discharges of unmyelinated cutaneous nerve fibres identified as nociceptors. In: Bonica JJ, Albe-Fessard D, (eds) Advances in pain research and therapy. Vol 1, Raven Press, New York p 41

    Google Scholar 

  21. Hollt V, (1983) Multiple endogenous opioid peptides. Trends in Neurosciences 6: 24

    Article  Google Scholar 

  22. Jurna I, (1980) Neurophysiological properties of neuroleptic agents in animals. Handbook of Experimental Pharmacology 55 /1: 111

    Article  CAS  Google Scholar 

  23. Jurna I, (1984) Depression of nociceptive sensory activity in the rat spinal cord due to the intrathecal administration of drugs: effect of diazepam. Neurosurgery 15: 917

    Article  PubMed  CAS  Google Scholar 

  24. Jurna I, (1985) Mechanismen der Schmerzunterdruckung durch Pharmaka. Munch Med Wochenschr 127: 573

    Google Scholar 

  25. Jurna I, (1985) Electrophysiological effects of antiepileptic drugs. Handbook of Experimental Pharmacology, Vol 74: 611

    Article  CAS  Google Scholar 

  26. Jurna I, Grossmann W, (1976) The effect of morphine on the activity evoked in ventrolateral tract axons of the cat spinal cord. Exp Brain Res 24: 473

    Article  PubMed  CAS  Google Scholar 

  27. Jurna I, Heinz G, (1979) Differential effects of morphine and opioid analgesics on A and C fibre-evoked activity in ascending axons of the rat spinal cord. Brain Res 171: 573

    Article  PubMed  CAS  Google Scholar 

  28. Jurna I, Heinz G, (1979) Anti-nociceptive effect of morphine, opioid analgesics and haloperidol injected into the caudate nucleus of the rat. Naunyn-Schmiedeberg’s Arch Pharmacol 309: 145

    Article  PubMed  CAS  Google Scholar 

  29. Jurna I, Zetler G, (1985) Effects on ascending nociceptive activity in the rat spinal cord produced by cholecystokinin octapeptide, ceruletide and morphine injected into the periaqueductal gray matter. Ann NY Acad Sci 448: 609

    Article  CAS  Google Scholar 

  30. Kline NS, Cooper TB, (1980) Monoamine oxidase inhibitors as antidepressants. Handbook of Experimental Pharmacology 55 /1: 367

    Google Scholar 

  31. Laborit H, Huguenard P, (1951) L’hibernation artificielle par moyens pharmacodynamiques et physiques. Presse Méd 59: 1329

    PubMed  CAS  Google Scholar 

  32. Lipman JJ, Spencer PSJ, (1979) Further evidence for a central site of action for the antinociceptive effect of clonidine-1ike drugs. Neuropharmacology 18: 731

    Article  PubMed  CAS  Google Scholar 

  33. Möhler H, Okada T, (1977) Benzodiazepine receptor: demonstration in the central nervous system. Science 198: 849

    Article  PubMed  Google Scholar 

  34. Montgomery BJ, (1978) Psychotropic agents finding analgesic use. J Am Med Ass 240: 1225

    Article  CAS  Google Scholar 

  35. Møller Nielsen I, (1980) Tricyclic antidepressants: general pharmacology. Handbook of Experimental Pharmacology 55 /1: 399

    Google Scholar 

  36. Olsen RW, (1981) GABA-benzodiazepine-barbiturate receptor interactions’. J Neurochem 37: 1

    Article  PubMed  CAS  Google Scholar 

  37. Paalzow L, (1974) Analgesia produced by Clonidine in mice and rats. J Pharm Pharmacol 26: 361

    Article  PubMed  CAS  Google Scholar 

  38. Pay S, Barasi S, (1982) A study of the connections of nociceptive substantia nigra neurones. Pain 12: 75

    Article  PubMed  CAS  Google Scholar 

  39. Pole P, Möhler H, Haefely W, (1974) The effect of diazepam on spinal cord activities: possible sites and mechanisms of action. Naunyn-Schmiedeberg’s Arch Pharmacol 284: 319

    Article  Google Scholar 

  40. Schlosser W, (1971) Action of diazepam on the spinal cord. Arch Int Pharmacodyn Ther 194: 93

    PubMed  CAS  Google Scholar 

  41. Schmidt RF, Vogel ME, Zimmermann M, (1967) Die Wirkung von Diazepam auf präsynaptische Hemmung und andere Rückenmarksreflexe. Naunyn-Schmiedeberg’s Arch Pharmacol 258: 69

    CAS  Google Scholar 

  42. Sjölund BH, Eriksson MBE, (1979) The influence of naloxone on analgesia produced by peripheral conditioning stimulation. Brain Res 173: 295

    Article  PubMed  Google Scholar 

  43. Spaulding TC, Fielding S, Venafro JJ, Lai H, (1979) Antinociceptive activity of Clonidine and its potentiation of morphine analgesia. Eur J Pharmacol 58: 19

    Article  PubMed  CAS  Google Scholar 

  44. Sternbach RA, Janowsky DS, Huey LY, Segal DS, (1976) Effects of altering brain serotonin activity on human chronic pain. In: Bonica JJ, Atbe-Fessard D, (eds) Advances in pain research and therapy. Raven Press, New York Vol 1 p 601

    Google Scholar 

  45. Stratten WP, Barnes CD, (1971) Diazepam and presynaptic inhibition. Neuropharmacology 10: 685

    Article  PubMed  CAS  Google Scholar 

  46. Strube PJ, Lavies NG, Rubin J, (1984) Epidural Clonidine. Anaesthesia 39: 834

    Article  PubMed  CAS  Google Scholar 

  47. Swerdlow M, (1984) Anticonvulsant drugs and chronic pain. Clin Neuropharmacology 7: 51

    Article  CAS  Google Scholar 

  48. Swerdlow M, Cundill JG, (1981) Anticonvulsant drugs used in the treatment of lancinating pain. Anaesthesia 36: 1129

    Article  PubMed  CAS  Google Scholar 

  49. Torda TA, (1979) Epidural analgesia with morphine. A preliminary communication. Anaesth Intens Care 7: 367

    CAS  Google Scholar 

  50. Vane JR, (1971) Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature New Biol 231: 232

    PubMed  CAS  Google Scholar 

  51. Wang JK, Nauss EA, Thomas JE, (1979) Pain relief by intrathecally applied morphine in man. Anesthesiology 50: 149

    Article  PubMed  CAS  Google Scholar 

  52. Yaksh TL, Reddy SVR, (1981) Studies on the analgetic effects of intrathecal opiates, α-adrenergic agonists and baclofen: their pharmacology in the primate. Anesthesiology 54: 451

    Article  PubMed  CAS  Google Scholar 

  53. Yaksh TL, Rudy TA, (1976) Analgesia mediated by a direct spinal action of narcotics. Science 192: 1357

    Article  PubMed  CAS  Google Scholar 

  54. Yaksh TL, Yeung JC, Rudy TA, (1976) Systematic examination in the rat of brain sites sensitive to the direct application of morphine: Observation of differential effects within the periaqueductal gray. Brain Res 114: 83

    Google Scholar 

  55. Zieglgänsberger W, (1984) Opioid actions on mammalian spinal neurons. Int Rev Neurobiol 25: 243

    Article  PubMed  Google Scholar 

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Authors
  1. I. Jurna
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Editors and Affiliations

  1. Institut für Anaesthesiologie, Bereich Poliklinik, LMU, Pettenkoferstr. 8 a, 8000, München 2, Deutschland

    A. Doenicke

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© 1986 Springer-Verlag, Berlin Heidelberg

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Jurna, I. (1986). Grundlagen der Schmerztherapie mit Analgetika und Nicht-Analgetika. In: Doenicke, A. (eds) Schmerz- Eine interdisziplinäre Herausforderung. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-93322-6_2

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  • DOI: https://doi.org/10.1007/978-3-642-93322-6_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-16603-0

  • Online ISBN: 978-3-642-93322-6

  • eBook Packages: Springer Book Archive

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