Simulation of cell Kinetics in the intestinal tract

  • H. P. Meinzer
  • B. Sandblad
Part of the Lecture Notes in Medical Informatics book series (LNMED, volume 25)


The mucosa of the intestinal tract is well suited for Kinetic studies mainly due to its relatively simple geometric structure, its accessibility and the high proliferation rate. Our computer model controls simulation of spatial, structural and time aspects. Comparison with published data allows interesting answers to models and speculations in the field. We suggest a theory for the control of proliferation by the number of generations since leaving the stem cell.


Crypt Cell Paneth Cell Cell Kinetic Cell Cycle Time Mitotic Time 
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  1. [AL-D74]
    Al-Dewachi, H.S., Wright, N.A., Appleton, D.R., Watson, A.J.: The Cell cycle Time in the Rat Jejunal Mucosa. Cell Tissue Kinet 7, 587–594 (1974).PubMedGoogle Scholar
  2. [APPL80]
    Appleton, D.R., Sunter, J.P., Watson, A.J.: Cell Proliferation in the Gastrointestinal Tract. Pitman Medical, Bath, U.K., 1980.Google Scholar
  3. [BJER81]
    BjerKnes, M., Cheng, H.: The Stem-Cell Zone of the Small Intestinal Epithelium. III. Evidence from Columnar, Enteroendocrine, and Mucous Cells in the Adult Mouse. Am.J.Anat. 160 77–91 (1981).PubMedCrossRefGoogle Scholar
  4. [CAIR65]
    Cairnie, A.B., Lamerton, L.F., Steel, G.G.: Cell Proliferation Studies in the Intestinal Epithelium of the Rat. II. Theoretical Aspects. Experimental Cell Research 39, 539–553 (1965).PubMedCrossRefGoogle Scholar
  5. [CHEN]
    Cheng, H., Leblond, C.P.: Origin, Differentiation and Renewal of the Four Main Epithelial Cell Types in the Mouse Small Intestine. 1. Columnar Cell. Am. J. Anat. 141, 461–480.Google Scholar
  6. [LEBL76]
    Leblond, C.P., Cheng, H.: Identification of Stem Cells in the Small Intestine of the Mouse. In Cairnie et al. (eds.): Stem Cells of Renewing Populations. Academic Press, New York, 1976.Google Scholar
  7. [POTT80]
    Potten, C.S.: Proliferative Cell Populations in Surface Epithelia: Bilogical Models for Cell Replacement. In Jäger, W., Rost, H., Tautu, P. (eds.): Biological Growth and Spread, Mathematical Theories and Applications. Proceedings, Heidelberg 1979. Springer-Verlag, Berlin — Heidelberg — New York, pp. 23–35 (1986).Google Scholar
  8. [TSUB81]
    Tsubouchi, S.: Kinetic Analysis of Epithelial Cell Migration in the Mouse Descending Colon. Am. J. Anat. 161, 239–246 (1981).PubMedCrossRefGoogle Scholar
  9. [TUTT73]
    Tutton, P.J.M.: Variations in Crypt Cell Cycle Time and Mitotic Time in the Small Intestine of the Rat. Virchows Arch. Abt. B. Zellpath. 13, 68–78 (1973).Google Scholar
  10. [WRIG72]
    Wright, N., Morley, A., Appleton, D.: Variation in the Duration of Mitosis in the Crypts of Lieberkuhn of the Rat; a Cytokinetic Study Using Vincristine. Cell Tissue Kinet 5, 351–364 (1972).PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • H. P. Meinzer
    • 1
  • B. Sandblad
    • 2
  1. 1.German Cancer Research CenterInstitute of med. and biol. InformaticsHeidelbergGermany
  2. 2.UDACUppsalaSweden

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