Statistical Analysis of the Coding Capacity of Complementary DNA Strands
A method that allows a statistical evaluation of the protein coding capacity of any sequenced DNA fragment is presented.
The method, applied to a limited number of protein coding gene sequences, allows the identification of some hypothetical protein genes which are coded by the the DNA strand complementary to the coding DNA strand. The finding that some proteins are indeed encoded on opposite DNA strands and that the two genes have complementary codon sequences, led us to investigate a much larger sample of DNA sequences, included in our DNA data bank.
The results of this exhaustive investigation demonstrate the existence of a new class of protein coding gene sequences that are coded by the complementary DNA strand.
KeywordsCodon Recombination Polypeptide Kelly Gingeras
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