Congenital Rubella Syndrome (C.R.S.): Models of Disease Control by Vaccination

  • Roy M. Anderson
Conference paper
Part of the Lecture Notes in Biomathematics book series (LNBM, volume 57)

Abstract

An important consequence of mass immunization programmes is their tendency to increase the average age at which an individual typically acquires an infection over that which pertained before vaccination. As emphasized in a number of recent papers, such an increase in the average age at infection may, under certain circumstances, result in an increased incidence of infection among older age classes of the community than was the case before the implementation of immunization (Knox, 1980; Dietz, 1981; Cvjetanovic, Grab and Dixon, 1982; Hethcote, 1983; Anderson and May, 1983a). This observation is a cause for concern if the effects of infection are typically more severe among adults than among children.

Keywords

Measle Rubella Myelitis 

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References

  1. Anderson, R.M. and May, R.M. (1983a). Vaccination against: rubella and measles: quantitative investigations of different policies. Journal of Hygiene, 90, 259–325.CrossRefGoogle Scholar
  2. Anderson, R.M. and May, R.M. (1983b). Two-stage vaccination programme against rubella. Lancet 17th. December 1983, 1416–17.Google Scholar
  3. Cvjetanovic, B., Grab, B. and Dixon, H. (1982). Epidemiological models of poliomyelitis and measles and their application in the planning of immunization programmes. Bulletin of the World Health Organization 60, 405–22.Google Scholar
  4. Dietz, K. (1976). The incidence of infectious diseases under the influence of seasonal fluctuations. Lecture Notes in Biomathematics 11, 1–15.Google Scholar
  5. Dietz, K. (1981). The evaluation of rubella vaccination strategies. In Mathematical Theory of the Dynamics of Biological Populations vol. II (ed. R.W. Hiorns and D. Cooke), pp. 81–98, London, Academic Press.Google Scholar
  6. Hethcote, H. (1983). Measles and rubella in the United States. American Journal of Epidemiology. 117, 2–21.Google Scholar
  7. Hoppensteadt, F.C. (1974). An age-dependent epidemic model. Journal of the Franklin Institute 297, 325–33.CrossRefMATHGoogle Scholar
  8. Knox, E.G. (1980). Strategy for rubella vaccination. International Journal for Epidemiology 9, 13–23.CrossRefGoogle Scholar
  9. Schenzle, D. (1984). Control of virus transmission in age-structured populations. Mathematics in Biology and Medicine. (V. Capasso et al. Eds.). Lecture Notes in Biomathematics, Springer-Verlag, to appear.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • Roy M. Anderson
    • 1
  1. 1.Department of Pure and Applied Biology, Imperial CollegeLondon UniversityLondonUK

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