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Competing Risk Methods in Early Breast Cancer Trials

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Clinical Trials in ‘Early’ Breast Cancer

Part of the book series: Lecture Notes in Medical Informatics ((LNMED,volume 4))

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Summary

Recent work on the analysis of failure time data with competing risks is reviewed and is discussed in relation to early breast cancer trials. Central to the discussion is the modelling, estimation and interpretation of cause-specific failure rates. Possible uses of such failure rate estimators are indicated for the study of differential treatment effects on local and distant recurrence and for the identification of dependent censorship.

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References

  • Cox, D.R. (1972). Regression models and life tables (with discussion). Journal of the Royal Statistical Society, Series B 34, 187–220.

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  • Peto, R., Pike, M.C., Armitage, P., Breslow, N.E., Cox, D.R., Howard, S.V., Mantel, N., McPherson, K., Peto, J., and Smith, P.G. (1976). Design and analysis of randomized clinical trials requiring prolonged observation of each patient. Part 1. Introduction and design. British Journal of Cancer 34, 585–612.

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  • Prentice, R.L., Kalbfleisch, J.D., Petersen, A.V., Flournoy, N., Farewell, V.T. and Breslow, N.E. (1978). The analysis of failure times in the presence of competing risks. Biometrics 34, 541–554.

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  • Turnbull, B.W. and Mitchell, T.J. (1978). Exploratory analysis of disease prevalence from survival/sacrifice data. Biometrics 34, 555–570.

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  • Wong, O. (1977). A competing-risk model based on the life table procedure in epidemiological studies. International Journal of Epidemiology 6, 153–159.

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Author information

Authors and Affiliations

  1. Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

    R. L. Prentice

  2. Department of Biostatistics, University of Washington, Seattle, USA

    R. L. Prentice

Authors
  1. R. L. Prentice
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Editor information

Editors and Affiliations

  1. Institut für Medizinische Dokumentation, Statistik und Datenverarbeitung der Universität, Im Neuenheimer Feld 325, D-6900, Heidelberg 1, Deutschland

    H. R. Scheurlen , G. Weckesser  & I. Armbruster ,  & 

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© 1979 Springer-Verlag Berlin Heidelberg

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Prentice, R.L. (1979). Competing Risk Methods in Early Breast Cancer Trials. In: Scheurlen, H.R., Weckesser, G., Armbruster, I. (eds) Clinical Trials in ‘Early’ Breast Cancer. Lecture Notes in Medical Informatics, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-93118-5_20

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  • DOI: https://doi.org/10.1007/978-3-642-93118-5_20

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-09530-9

  • Online ISBN: 978-3-642-93118-5

  • eBook Packages: Springer Book Archive

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