Treatment departure and survival analysis in a randomized trial on the value of pre- and postoperative radiotherapy in breast cancer

  • Arne Wallgren
  • Britta Mattsson
  • Leif Karnström
Conference paper
Part of the Lecture Notes in Medical Informatics book series (LNMED, volume 4)

Abstract

Some trials on the value of various modalities of local or systemic treatment in breast cancer have been complicated by a large number of treatment deviations. When reporting the results of such trials the patients who had not been treated according to the protocol sometimes were excluded from the analyses, assuming that the reasons for the deviations from treatment were not of a nature which could bias the results.

Keywords

Shrinkage Allo 

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References

  1. 1.
    de Schryver, A.: The Stockholm breast cancer trial: Preliminary report of a randomized study concerning the value of pre-operative or post-operative radiotherapy in operable disease. Int.J.Radiat.Oncol.Biol.Phys. 1: 601–609, 1976.PubMedCrossRefGoogle Scholar
  2. 2.
    Wallgren, A., Arner, O., Bergström, J.,Blomstedt, B., Granberg,P-O., Karnström, L., Räf, L., and Silfverswärd, C.: Preoperative radiotherapy in operable breast cancer. Results in the Stockholm breast cancer trial. Cancer 42: 1120–1125, 1978Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1979

Authors and Affiliations

  • Arne Wallgren
    • 1
  • Britta Mattsson
    • 1
  • Leif Karnström
    • 1
  1. 1.The Oncologic CentreRadiumhemmetStockholmSweden

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