Treatment departure and survival analysis in a randomized trial on the value of pre- and postoperative radiotherapy in breast cancer
Some trials on the value of various modalities of local or systemic treatment in breast cancer have been complicated by a large number of treatment deviations. When reporting the results of such trials the patients who had not been treated according to the protocol sometimes were excluded from the analyses, assuming that the reasons for the deviations from treatment were not of a nature which could bias the results.
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