Operable Breast Cancer with Positive Axillary Nodes: The Experience of the Milan Cancer Institute
The course of breast cancer following potentially curative local-regional modality, i.e. radical mastectomy (RM) plus or minus postoperative irradiation (RT), has been critically re-evaluated during the past few years. The analysis of prospective controlled studies (4,6) has clearly indicated the limits of treatment based only on anatomical principles (5). Furthermore, the histological status of axillary lymph nodes has proved to be the single most useful prognostic factor in women with operable breast cancer. In fact, slightly less than one fourth of women with histologically positive axillary nodes (N+) remained relapse-free at 10 years compared to about three fourths of patients with negative nodes (N-) (4,6).
KeywordsMethotrexate Cyclophosphamide Phenylalanine Fluorouracile Carbone
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