Models of Haemopoiesis
The bone marrow contains stem cells which proliferate and also differentiate into precursors of the various types of blood cell, such as the erythrocytes (red cells) the granulocytes, and the monocytes (types of white cell). The maturing time in the marrow is for example about ten days for granulocytes and about three days for monocytes. In the case of monocytes further development takes place. These cells pass through the blood stream into tissue in about one day, and turn into macrophages. The number of cells of each type that are produced in the marrow of a healthy individual is adapted to the requirements of the body, red cell production being related to the need of tissues for oxygen, and white cell production to the need for defense against infection. General surveys of the topic of blood cell production, or haemopoiesis, can be found in the books by Metcalf and Moore (1971), Cline (1975) and Wickramasinghe (1975).
KeywordsLeukemia Neutropenia Cyclophosphamide Erythropoietin Pancytopenia
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