A Program Library for Computing the Parameters of Linear Compartment Models in Pharmacokinetics
A program library will be presented with which explicit solutions of linear compartment models can be fitted to pharmacokinetic experimental data. Use is made of the fact that transport constants can be calculated from the numerical solution of such a problem without ambiguity. The nonlinear regression is carried out using the Powell-method. A report of our experience with, e.g. choice of objective function, lag-time, accuracy of the numerical solution, is included.
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