A Program Library for Computing the Parameters of Linear Compartment Models in Pharmacokinetics

  • H. Poland
  • A. Giebler
  • R. Woloszczak

Abstract

A program library will be presented with which explicit solutions of linear compartment models can be fitted to pharmacokinetic experimental data. Use is made of the fact that transport constants can be calculated from the numerical solution of such a problem without ambiguity. The nonlinear regression is carried out using the Powell-method. A report of our experience with, e.g. choice of objective function, lag-time, accuracy of the numerical solution, is included.

References

  1. 1.
    H. Röpke and J. Riemann, Analogcomputer in Chemie und Biologie (Springer-Verlag, 1969).Google Scholar
  2. 2.
    J. G. Wagner, Foundations of Clinical Pharmacokinetics (Drug Intelligence Publications, Inc., Hamilton, 1975).Google Scholar
  3. 3.
    M. Milanese and G. P. Molino, Maths. Biosci. 26, 175 (1975).MATHCrossRefGoogle Scholar
  4. 4.
    J. Sedmen and G. Wagner, J. Pharm. Sci. 65, 1006 (1976).CrossRefGoogle Scholar
  5. 5.
    G. Heinzel et al., Drug Research, 27(I), 912 (1977).Google Scholar
  6. 6.
    R. P. Brent, Algorithms for Minimization without Derivates (Prentice Hall, N.J. 1973).Google Scholar

Copyright information

© The World Organisation of General Systems and Cybernetics 1978

Authors and Affiliations

  • H. Poland
    • 1
  • A. Giebler
    • 1
  • R. Woloszczak
    • 1
  1. 1.Dept. AWMSchering A. G.Berlin 65Germany

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