Estimation of the Characteristics of Rare Variants
Part of the
Lecture Notes in Biomathematics
book series (LNBM, volume 19)
This paper arises in connection with a study of the data on rare protein variants in American Indian populations. Several American Indian tribes have been extensively sampled (Neel 1973), and the variants found range from those present only in a single individual or nuclear family, through those that have spread through a village or to several villages, to one which has achieved polymorphic frequencies in a single tribe. It is perhaps doubtful whether this last should be considered a “rare variant”, but we include it since it is fairly certain that it has arisen since tribal differentiation, and in spite of inter-tribal migration it has not spread to neighbouring tribes. For variants apparently localised in areas where sampling has been intensive, accurate estimates of the total number of individuals carrying the variant allele may be made.
KeywordsRare Variant Offspring Distribution Neutral Allele American Indian Population Migration Matrix
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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