Skip to main content
SpringerLink
Log in

The Spleenless State in Man

  • Chapter
Die Milz / The Spleen

Abstract

Until a hundred years ago the spleenless state was considered a condition shortening the life-span and interfering with the well-being of man (CROSBY, 1963). Numerous clinical and experimental observations during the following years have given us information about some of the functions of the normal spleen. However, today in 1969, as you have heard during this conference, many questions remain still to be answered and the spleenless state still represents a challenge to medical science.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 69.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  • Ask Upmark, E.: The remote effects of removal of the normal spleen. Svenska Lak.-Sallsk. Forh. 61, 137 (1935).

    Google Scholar 

  • Aster, R. H.: Pooling of platelets in the spleen: Role in the pathogenesis of “hypersplenic” thrombocytopenia. J. clin. Invest. 45, 645–657 (1966).

    Article  PubMed  CAS  Google Scholar 

  • Baldini, M.: Idiopathic thrombocytopenic purpura. New Engl. J. Med. 274, 1301–1306 (1966).

    Article  PubMed  CAS  Google Scholar 

  • Bjørkman, S. E.: The splenic circulation, with special reference to the function of the spleen sinus wall. Acta med. scand., Suppl. 191 (1947).

    Google Scholar 

  • Blaustein, A.: The spleen, pp. 1–18. New York: McGraw-Hill Book Comp. Inc. 1963.

    Google Scholar 

  • Breu, H., Reimer, E. E., Schneider, R.: Spatuntersuchungen nach Milzentfernung beim Gesunden. Med. Klin. 47, 1176–1182 (1952).

    CAS  Google Scholar 

  • Corvalho, I. F., Borel, Y., Miescher, P. A.: Influence of splenectomy in rats on the formation of 19 S and 7S antibodies. Immunology 12, 505–515 (1967).

    Google Scholar 

  • Crosby, W. H.: Normal functions of the spleen relative to red blood cells. Blood 14, 399–408 (1959).

    PubMed  CAS  Google Scholar 

  • Crosby, W. H.: Hyposplenism: An inquiry into normal functions of the spleen. Ann. Rev. Med. 14, 349–370 (1963).

    Article  PubMed  CAS  Google Scholar 

  • Cutbutch, M., Mollison, P. L.: Relation between characteristics of blood-group antibodies in vitro and associated patterns of red cell destruction in vitro. Brit. J. Haemat. 4, 115–128 (1958).

    Article  Google Scholar 

  • Dameshek, W.: Hyposplenism. J. Amer. med. Ass. 157, 613 (1955).

    Article  Google Scholar 

  • Dell, J. M., JR., Klinefelter, H. F.: Roentgen studies of the spleen. Amer. J. med. Sci. 211, 437–442 (1946).

    PubMed  Google Scholar 

  • Ek, J. I., Rayner, S.: An analytical study of splenectomized cases after traumatic rupture of healthy spleens. Acta med. scand. 137, 417–435 (1950).

    Article  PubMed  CAS  Google Scholar 

  • Ellis, E. F., Smith, R. T.: The role of the spleen in immunity. Pediatrics 37, 111–119 (1966).

    PubMed  CAS  Google Scholar 

  • Erickson, W. D., Burgert, E. O., Jr., Lynn, H. B.: The hazard of infection following splenectomy in children. Amer. J. Dis. Child. 116, 1–12 (1968).

    PubMed  CAS  Google Scholar 

  • Erslev, A. J., McKenna, P. J.: Effect of splenectomy on red cell production. Ann. intern. Med. 67, 990–997 (1967).

    PubMed  CAS  Google Scholar 

  • Gilbert, E. F., Nishimura, K., Wedum, B. G.: Congenital malformations of the heart associated with splenic agenesis. Circulation 17, 72–86 (1958).

    PubMed  CAS  Google Scholar 

  • Horan, M., Colebatch, J. H.: Relation between splenectomy and subsequent infection. Arch. Dis. Child. 37, 398–412 (1962).

    Article  PubMed  CAS  Google Scholar 

  • Ivemark, B. T.: Implications of agenesis of the spleen on the pathogenesis of cono-truncus anomalies in childhood. An analysis of the heart malformations in the splenic agenesis syndrome with fourteen new cases. Acta paediat., Suppl. 104, 44, (110 pp.) (1955).

    Google Scholar 

  • Kevy, S. V., Tefft, M., Vawter, G. F., Rosen, F. S.: Hereditary splenic hypoplasia. Pediatrics 42, 752–757 (1968).

    PubMed  CAS  Google Scholar 

  • King, H., Shumacker, H. B., Jr.: Splenic studies: I. Susceptibility to infection after splenectomy performed in infancy. Ann. Surg. 136, 239–242 (1952).

    Article  PubMed  CAS  Google Scholar 

  • Kotilainen, M.: Platelet kinetics in normal subjects and in haematological disorders. Scand. J. Haemat., Suppl. 5, 45–65 (1969).

    Google Scholar 

  • Libre, E. P., Corvan, D. H., Watkins, S. P., Jr., Shuhman, N. R.: Relationship between spleen, platelets and factor VIII levels. Blood 31, 358–368 (1968).

    PubMed  CAS  Google Scholar 

  • Marsh, G. W., Lewis, S. M., Szur, L.: The use of 51Cr labelled heat-damaged red cells to study splenic function. Brit. J. Haemat. 12, 161–171 (1966).

    Article  PubMed  CAS  Google Scholar 

  • Mauck, H. P., Segatol-Islami, Z., Lester, R. G.: Splenic agenesis associated with severe congenital heart disease. Long survival unassociated with pulmonary stenosis. Dis. Chest. 49, 436–440 (1966).

    Article  Google Scholar 

  • Mccormick, F. M., Kvashgarian, M.: The weight of the adult spleen. Amer. J. clin. Path. 43, 332–333 (1965).

    CAS  Google Scholar 

  • Miller, F. J. W.: Childhood morbidity and mortality in Newcastle-upon-Tyne: Further report on the thousand family study. New Engl. J. Med. 275, 683–690 (1966).

    Article  PubMed  CAS  Google Scholar 

  • Mills, H., Lucia, S. P.: Familial hypochromic anemia associated with postsplenectomy erythrocytic inclusion bodies. Blood 4, 891–904 (1949).

    PubMed  CAS  Google Scholar 

  • Nordøy, A., Neset, G.: Splenectomy in hematologic diseases. Acta med. Scand. 183, 117–126 (1968).

    Article  PubMed  Google Scholar 

  • Norman, J. G., Covelli, V. H., Sise, H. S.: Transplantation of the spleen: Experimental cure of hemophilia. Surgery 64, 1–14 (1968).

    PubMed  CAS  Google Scholar 

  • Pedersen, B., Videbaek, A.: On the late effects of removal of the normal spleen. Acta chir. scand. 131, 89–97 (1966).

    PubMed  CAS  Google Scholar 

  • Penny, R., Rozenberg, M. C., Firkin, B. G.: The splenic platelet pool. Blood 27, 1–16 (1966).

    PubMed  CAS  Google Scholar 

  • Pierce, J. C., Hume, D. M.: The effect of splenectomy on the survival of first and second renal homotransplants in man. Surg. Gynec. Obstet. 127, 1300–1306 (1968).

    PubMed  CAS  Google Scholar 

  • Pohlius, J. C.: Casum Anatomicum de Defectu Lienis Sistitet de Liene. In Genere Quaedam Disserit Simulque Collegium Disputatorium Publicum Indicit, Lipsiae, 1740, p. 3.

    Google Scholar 

  • Putschar, W. G. J., Manion, W. C.: Congenital abscence of the spleen and associate anomalies. Amer. J. clin. Path. 26, 424–469 (1956).

    Google Scholar 

  • Rowley, D. A.: The formation of circulating antibody in the splectomized human being following intravenous injection of heterologous erythrocytes. J. Immunol. 65, 515–521 (1950).

    PubMed  CAS  Google Scholar 

  • Selwyn, J. G.: Heinz bodies in red cells after splenectomy and after phenacetin administration. Brit. J. Haemat. 1, 173–183 (1955).

    Article  PubMed  CAS  Google Scholar 

  • Tenze, L.: Modificazioni morfologiche delle piastrine indotte dalla splenectomia nel morbo di Werlhof e nei traumatizzati. Minerva med. 53, 1049–1051 (1962).

    PubMed  CAS  Google Scholar 

  • Webster, W. P., Reddick, R. L., Roberts, H. R., Penick, G. D.: Release of factor VIII (antihaemophilic factor) from perfused organs and tissues. Nature (Lond.) 213, 1146 (1967).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Medical Department A, Rikshospitalet, University Hospital, Oslo, Norway

    A. Nordøy

Authors
  1. A. Nordøy
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Pathologischen Instituts, Universität Kiel, Deutschland

    Karl Lennert o. Prof. Dr. (Direktor, Präsident des 14. Deutschen Hämatologenkongresses Kiel) & Dieter Harms Dr. (Wissenschaftlicher Assistent, Sekretär des 14. Deutschen Hämatologenkongresses) (Direktor, Präsident des 14. Deutschen Hämatologenkongresses Kiel) &  (Wissenschaftlicher Assistent, Sekretär des 14. Deutschen Hämatologenkongresses)

Rights and permissions

Reprints and permissions

Copyright information

© 1970 Springer-Verlag Berlin · Heidelberg

About this chapter

Cite this chapter

Nordøy, A. (1970). The Spleenless State in Man. In: Lennert, K., Harms, D. (eds) Die Milz / The Spleen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-92998-4_52

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-92998-4_52

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-92999-1

  • Online ISBN: 978-3-642-92998-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation