Vergleich von Splenektomie und immunsuppressiver Therapie bei M. Werlhof
Splenectomy and Immunosuppressive Therapy in Idiopathic Thrombocytopenic Purpura
20 patients with ITP were submitted to immunosuppressive treatment. The results were compared with the data from a group of 18 patients with ITP who were treated by splenectomy.
Splenectomy was performed when there was evidence for platelet destruction by the spleen. Immunosuppressive treatment was restricted to the cases with platelet sequestration in the liver and to patients where splenectomy was not possible.
As immunosuppressive agent we preferred actinomycin C: in ten cases we obtained an extensive remission after an average total dose of 11.9 mg actinomycin C. In four cases actinomycin therapy was not effective.
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