Vergleich von Splenektomie und immunsuppressiver Therapie bei M. Werlhof

  • J. C. F. Schubert
  • K. Breddin
  • H. Martin

Splenectomy and Immunosuppressive Therapy in Idiopathic Thrombocytopenic Purpura


20 patients with ITP were submitted to immunosuppressive treatment. The results were compared with the data from a group of 18 patients with ITP who were treated by splenectomy.

Splenectomy was performed when there was evidence for platelet destruction by the spleen. Immunosuppressive treatment was restricted to the cases with platelet sequestration in the liver and to patients where splenectomy was not possible.

As immunosuppressive agent we preferred actinomycin C: in ten cases we obtained an extensive remission after an average total dose of 11.9 mg actinomycin C. In four cases actinomycin therapy was not effective.


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Copyright information

© Springer-Verlag Berlin · Heidelberg 1970

Authors and Affiliations

  • J. C. F. Schubert
  • K. Breddin
  • H. Martin
    • 1
  1. 1.Abteilung für Hämatologie des Zentrums der Inneren MedizinJ. W. Goethe-UniversitätFrankfurt a. M.Deutschland

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