Cytochemie des Nichthämoglobineisens der Erythrocyten nach Splenektomie und bei Milzinsuffizienz

  • K. Hausmann

Cytochemistry of Erythrocytic Non-Hemoglobin Iron after Splenectomy and in Splenic Insufficiency


The non-heme iron of peripheral red blood cells from 100 normal subjects, 63 patients splenectomized for different diseases and 798 patients with a normal or enlarged spleen has been studied cytochemically by means of the Prussian blue reaction and the sulphide silver reaction and related to other hematological criteria, iron metabolism and clinical conditions. Argyrogranular erythrocytes containing small to coarse iron particles which were enlarged by silver coating were encountered in much greater numbers than siderocytes and reticulocytes in the majority of splenectomized cases. Similar cytological and cytochemical features as seen after splenectomy including the appearance of Howell-Jolly bodies and Pappenheimer bodies were observed in 36 patients with acute anemia of alcoholism and in 3 cases with neoplastic blood diseases despite a normal or enlarged spleen. These findings suggest a “pitting” insufficiency of the spleen which is reversible in alcoholics within a few weeks after withdrawal of alcohol.


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© Springer-Verlag Berlin · Heidelberg 1970

Authors and Affiliations

  • K. Hausmann
    • 1
  1. 1.Hämatologische Abt.Allg. Krankenhauses St. GeorgHamburgDeutschland

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