Experimentelle Erzeugung von enzymhaltigen Heinzschen Innenkörpern

Summary

Heinz bodies in erythrocytes of newborn or splenectomized humans exhibit a strongly positive alpha naphthyl acetate esterase reaction. In contrast, Heinz bodies formed by in vitro treatment of erythrocytes with phenylhydrazine show no enzyme activity. In rabbits acetylphenylhydrazine treatment also results in the production of enzyme-negative Heinz bodies in circulating erythrocytes, whereas bone marrow erythroblasts yield Heinz bodies of a distinctly enzyme-positive type. Erythrocytes with strongly enzyme-positive Heinz bodies are detectable in the blood of acetylphenylhydrazine-injected animals a few days later. This indicates that formation of enzyme-positive Heinz bodies results from an effect on the bone marrow.

Thus, distinction between the action of Heinz body-inducing agents on bone marrow and on the peripheral blood is possible as shown by our experiments.