Skip to main content
  • 43 Accesses

Abstract

Late effects of internally deposited radioisotopes include physiological and anatomical changes, neoplasms, and life shortening. Genetic changes inherited in the offspring of the first and subsequent generations can also be considered late effects but will not be considered in this chapter. Previous reviews on this subject include those of Tullis and Johnson (1958), Furth and Tullis (1956), Bloom and Bloom (1954), and Furth and Upton (1953).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 44.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 59.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Anderson, W. A. D., G. E. Zander, and J. F. Kuzma: Cancerogenic effects of Ca45 and Sr89 on bones of CF1 mice. A. M. A. Arch. Path. 62, 262 (1956).

    PubMed  CAS  Google Scholar 

  • Andrews, G. A., R. M. Knisely, E. L. Palmer, and A. L. Kretchmar: Therapeutic usefulness of radioactive colloids, comparative value of gold-198, chronic phosphate (P-32), yttrium-90, and lutecium-177. Proc. Int. Conf. Peaceful Uses of Atomic Energy, Geneva, 1955, Vol. 10. p. 122. New York: United Nations 1956.

    Google Scholar 

  • Anthony, D. S., R. K. Davis, R. N. Cowden, and W. P. Jolley: Experimental data useful in establishing maximum permissible single and multiple exposure to Polonium. Proc. Int. Conf. Peaceful Uses of Atomic Energy, Geneva, 1955, Vol. 13. p. 215. New York: United Nations 1956.

    Google Scholar 

  • — and K. A. Lathrop: Acute radiotoxicity of injected Cerium144 in the rat USAEC Unclassified Report MDDC-1326, 1947. (For sale at Office of Technical Services, Commerce Department, Washington, D. C.).

    Google Scholar 

  • Arnold, J. S., and W. S. S. Jee: Autoradiography in the localization and radiation dosage of Ra226 and Pu239 in the bones of dogs. Lab. Invest. 8, 194, (1959).

    PubMed  CAS  Google Scholar 

  • Ashmore, J., M. L. Karnovsky, and A. B. Hastings: Intermediary metabolism. In Radiation Biology and Medicine, edited by W. D. Claus. Reading, Mass., Addison-Wesley, 1958, p. 738.

    Google Scholar 

  • Aub, J. C., R. D. Evans, L. H. Hempelmann, and H. S. Martland: The late effects of internally deposited radioactive materials in man. Medicine 31, 221 (1952).

    Article  PubMed  CAS  Google Scholar 

  • Basson, J. K., and C. J. Shellabarger: Determination of the RBE of alpha-particles from Astatine-211 as compared to beta-particles from Iodine-132 in the rat thyroid. Radiat. Res. 5, 502 (1956).

    CAS  Google Scholar 

  • Bernard, S. R.: Maximum permissible amounts of natural uranium in the body, air and drinking water based on human experimental data. Hlth. Phys. 1, 288 (1958).

    Article  CAS  Google Scholar 

  • Björnerstedt, R., and A. Engström: Maximum permissible body burden of Strontium-90. Science 129, 327 (1959).

    Article  PubMed  Google Scholar 

  • Blair, H. A.: The shortening of life span by injected radium, polonium and plutonium. United States Atomic Energy Commission Unclassified Report UR-274, 1953. (Available only from USAEC depository libraries.)

    Google Scholar 

  • Blom, P. S., A. Querido, and C. H. W. Leeksma: Acute leukaemia following x-ray and radioiodine treatment of thyroid carcinoma. Brit. J. Radiol. 28, 165 (1955).

    Article  PubMed  CAS  Google Scholar 

  • Bloom, M. A., and W. Bloom: Late effects of radium and plutonium on bone. A. M. A. Arch. Path. 47, 494 (1949).

    CAS  Google Scholar 

  • Bloom, W., and M. A. Bloom: Histological changes after irradiation. In Radiation Biology, Vol. I, edited by A. Hollaender. p. 1091. New York: McGraw-Hill Book Co. 1954.

    Google Scholar 

  • Brues, A.M.: Biological hazards and toxicity of radioactive isotopes. J. clin. Invest. 28, 1286 (1949).

    Article  PubMed  CAS  Google Scholar 

  • Carritt, J., R. Fryxell, J. Kleinschmidt, R. Kleinschmidt, W. Langham, A. San Pietro, R. Schaffer, and B. Schnap: The distribution and excretion of plutonium administered intravenously to the rat. J. biol. Chem. 171, 273 (1947).

    CAS  Google Scholar 

  • Casarett, G. W.: Histopathology of alpha radiation from internally administered polonium. United States Atomic Energy Commission Unclassified Report UR-201, 1952. (Available only from USAEC depository libraries.)

    Google Scholar 

  • — Pathologic effects of orally administered polonium. United States Atomic Energy Commission Unclassified Report Ur-477, 1956. (Available only from USAEC depository libraries.)

    Google Scholar 

  • Cember, H.: Bronchogenic carcinoma from radioactive particulates. Second United Nations Int. Conf. Peaceful Used of Atomic Energy, 1958, A/Conf. 15 paper 900.

    Google Scholar 

  • J. A. Watson, and T. B. Grucci: Pulmonary radiation effects as a function of absorbed energy distribution. Amer. ind. Hyg. Ass. Quart. 17, No. 4, 397 (1956).

    Google Scholar 

  • Cohn, S. H., R. W. Rinehart, J. K. Gong, J. S. Robertson, W. L. Milne, V. P. Bond, and E. P. Cronkite: Internal deposition of radionuclides in human beings and animals. In some effects of ionizing radiation on human beings, USAEC Unclassified Report TID-5353, 1956. (For sale by Superintendent of Documents, Government Printing Office, Washington, D. C.)

    Google Scholar 

  • Comar, C. L., R. H. Wasserman, S. Ullberg, and G. A. Andrews: Strontium metabolism and strontium-calcium discrimination in man. Proc. Soc. exp. Biol. (N. Y.) 95, 386 (1957).

    Article  CAS  Google Scholar 

  • Copp, D. H., D. J. Axelrod, and J. G. Hamilton: The deposition of radioactive metals in bone as a potential health hazard. Amer. J. Roentgenol. 58, 10 (1947).

    CAS  Google Scholar 

  • Cronkite, E. P., V. P. Bond, and C. L. Dunham: Some effects of ionizing radiation on human beings. A report on the Marshallese and Americans Accidentally Exposed to Radiation from Fallout and a Discussion of Radiation Injury in the Human Being, USAEC Unclassified Report TID-5358, 1956. (For sale by Superintendent of Documents, Government Printing Office, Washington, D. C.)

    Google Scholar 

  • Delarue, J., M. Tubiana, and J. Dutreix: Cancer de la thyroïde traité par l’iode radioactif; terminaison par une leucémievaigue après une amélioration importante. Bull. Ass. franc. Cancer 11, 263 (1953).

    Google Scholar 

  • Dent, J. N., E. L. Gadsden, and J. Fürth: Further studies on induction and growth of thyrotropic pituitary tumors in mice. Cancer Res. 16, 171 (1956).

    PubMed  CAS  Google Scholar 

  • Doniach, I.: The effect of radioactive iodine alone and in combination with methylthiouracil and acetylaminofluorene upon tumor production in the rats’ thyroid gland. Brit. J. Cancer 4, 223 (1950).

    Article  PubMed  CAS  Google Scholar 

  • Dougherty, J. H., J. Z. Bowers, R. C. Bay, and P. Keyanonda: Comparison of hematologic effects of internally deposited radium and plutonium in dogs. Radiology 65, 253 (1955).

    PubMed  CAS  Google Scholar 

  • Durbin, P. W., C. W. Asling, M. E. Johnston, and J. G. Hamilton: Long term sequelae of massive doses of I131 in rats. Amer. J. Roentgenol. 79, 1010 (1958).

    PubMed  CAS  Google Scholar 

  • M. W. Parrott, N. Jeung, M. H. Williams, and J. G. Hamilton: The induction of tumors in the rat by Astatine-211. Radiat. Res. 9, 378 (1958).

    Article  PubMed  CAS  Google Scholar 

  • M. H. Williams, M. Gee, R. N. Newman, and J. G. Hamilton: The metabolism of the lanthanons in the rat. Proc. Soc. exp. Biol. (N. Y.) 91, 78 (1956).

    Article  CAS  Google Scholar 

  • Engström, A., R. Björnerstedt, C.-J. Clemedson, and A. Nelson: Bone and radiostrontium. New York: Wiley 1957.

    Google Scholar 

  • Finkel, M. P.: Mice, Men, and fallout. Science 128, 637 (1958).

    Article  PubMed  CAS  Google Scholar 

  • — Relative biological effectiveness of internal emitters. Radiology 67, 665 (1956).

    PubMed  CAS  Google Scholar 

  • — Relative biological effectiveness of radium and other alpha emitters in CF No. 1 female mice. Proc. Soc. exp. Biol. (N. Y.) 83, 494 (1953).

    Article  CAS  Google Scholar 

  • — and B. O. Biskis: Comparative carcinogenicity of Ra226, Sr90 and Ca45 in mice. USAEC Unclassified Report ANL-5916, p. 18, 1958. (For sale at Office of Technical Service, Department of Commerce, Washington, D. C.)

    Google Scholar 

  • — and G. M. Scribner: The influence of strontium-90 upon life span and neoplasms of mice. Second United Nations Int. Conf. Peaceful Uses of Atomic Energy, A/Conf. 15 paper 911, 1958.

    Google Scholar 

  • Finkel, M. P., R. Flynn, J. Clark, G. Scribner, J. Lestina, H. Lisco, and A. Brues: Toxicity of radiostrontium in carnivores: Current status of the long-term cat and dog experiments. USAEC Unclassified Report ANL-5696, p. 16, 1956. (For sale at Office of Technical Services, Department of Commerce, Washington, D. C.)

    Google Scholar 

  • J. Lestina, and D. M. Czajka: Radiostrontium at “optimum carcinogenic level” in the dog: Effect upon morbidity of total blood exchange shortly after injection. USAEC Unclassified Report ANL-5732, p. 15, 1957. (For sale at Office of Technical Services, Department of Commerce, Washington, D. C.)

    Google Scholar 

  • H. Lisco, and A. M. Brues: Toxicity of Strontium89 in mice: Malignant bone tumors. USAEC Unclassified Report ANL-5378, p. 106, 1955. (Available only from USAEC depository libraries.)

    Google Scholar 

  • Furth, J., W. T. Burnett jr., and E. L. Gadsden: Quantitative relationship between thyroid function and growth of pituitary tumors secreting TSH. Cancer Res. 13, 298 (1953).

    PubMed  CAS  Google Scholar 

  • — and J. L. Tullis: Carcinogenesis by radioactive substances. Cancer Res. 16, 5 (1956).

    PubMed  CAS  Google Scholar 

  • — and A. C. Upton: Vertebrate radiobiology: Histopathology and carcinogenesis. Ann. Rev. nuclear Sci. 3, 303 (1953).

    Article  Google Scholar 

  • Glueckauf, E.: Long-Term aspect of fission product disposal. Proc. Int. Conf. Peaceful Uses of Atomic Energy, Geneva 1955, Vol. 9, p. 3. United Nations 1956.

    Google Scholar 

  • Gottschalk, R. G., and H. C. Allen jr.: Uptake of radioactive sulfur by chondrosarcomas in man. Proc. Soc. exp. Biol. (N. Y.) 80, 334 (1952).

    Article  CAS  Google Scholar 

  • — and H. N. Beers: Selective toxicity of radioactive sulfate for mouse cartilage and bone marrow. A. M. A. Arch. Path. 65, 298 (1958).

    PubMed  CAS  Google Scholar 

  • Hahn, P. F., and H. C. Meng: Internal irradiations of dogs with radioactive colloidal gold: Synergistic effect of iron. Cancer 11, 591 (1958).

    Article  PubMed  CAS  Google Scholar 

  • Hamilton, J. G.: The metabolism of the radioactive elements created by nuclear fission. New Engl. J. Med. 240, 863 (1949).

    Article  PubMed  CAS  Google Scholar 

  • P. W. Durbin, and M. Parrott: The accumulative and destructive action of Astatine-211 (eka-iodine) in the thyroid gland of rats and monkeys. J. clin. Endocr. 14, 1161 (1954).

    Article  PubMed  Google Scholar 

  • Hodge, H. C.: Mechanism of uranium poisoning. Proc. Int. Conf. Peaceful Uses of Atomic Energy, Geneva 1955, Vol. 13. p. 229. New York: United Nations 1956.

    Google Scholar 

  • — and R. G. Thomas: The question of health hazards from the inhalation of insoluble uranium and thorium oxides. Second United Nations Int. Conf. Peaceful Uses of Atomic Energy, Geneva, 1958, Vol. 23. p. 302. New York: United Nations 1958.

    Google Scholar 

  • Hursh, J. B., L. T. Steadman, W. B. Looney, and M. Colodzin: The excretion of thorium and thorium daughters after thorotrast administration. Acta radiol. (Stockh.) 47, 418 (1957).

    Article  Google Scholar 

  • ICRP Handbook 1955: Recommendations of the International Commission on Radiological Protection. C. Report of International Sub-committee on permissable dose for internal radiation. Brit. J. Radiol. Suppl. 6, 23 (1955).

    Google Scholar 

  • Inglis, D. R.: Future radiation dosage from weapons tests. Science 127, 1222 (1958).

    Article  PubMed  CAS  Google Scholar 

  • Johansen, C.: Histological changes in man and rabbits after parental thorium administration. In Radiobiology Symposium 1954, edited by Z. M. Bacq and P. Alexander, p. 358. New York: Academic Press 1955.

    Google Scholar 

  • Kamb, B., and L. Pauling: The effects of Strontium-90 on mice. Proc. nat. Acad. Sci. (Wash.) 45, 54 (1959).

    Article  CAS  Google Scholar 

  • Katz, J., H. A. Kornberg, and H. M. Parker: Absorption of plutonium fed chronically to rats. I. Fraction deposited in skeleton and soft tissues following oral administration of solutions of very low mass concentration. Amer. J. Roentgenol. 73, 303 (1955).

    PubMed  CAS  Google Scholar 

  • Koletsky, S., and J. H. Christie: Carcinogenic activity of radioactive phosphorus. Proc. Soc. exp. Biol. (N. Y.) 86, 266 (1954).

    Article  CAS  Google Scholar 

  • — and G. Gustafson: Liver damage in rats from radioactive colloidal gold. Lab. Invest. 1, 312 (1952).

    PubMed  CAS  Google Scholar 

  • Kuzma, J. F., and G. Zander: Cancerogenic effects of Ca45 and Sr89 in Sprague-Dawley rats. A. M. A. Arch. Path. 63, 198 (1957).

    PubMed  CAS  Google Scholar 

  • Lamerton, L. F.: Radiation dosimetry aspects of bone tumor production. Strahlenther. Sonderb. 38, 41 (1958).

    Google Scholar 

  • Langham, W. H.: Potential hazard of world-wide Sr90 fallout from nuclear weapons testing. Hlth. Phys. 1, 105 (1958).

    Article  CAS  Google Scholar 

  • Libby, W. F.: Radioactive fallout and radioactive strontium. Science 123, 657 (1956).

    Article  PubMed  CAS  Google Scholar 

  • Lindsay, S., G. D. Potter, and I. L. Chaikoff: Thyroid neoplasms in the rat: A comparison of naturally occurring and I131 induced tumors. Cancer Res. 17, 183 (1957).

    PubMed  CAS  Google Scholar 

  • Lisco, H., A. M. Brues, M. P. Finkel, and W. Grundhauser: Carcinoma of the colon in rats following the feeding of radioactive yttrium. Cancer Res. 7, 721 (1947).

    Google Scholar 

  • — and M. P. Finkel: Observations on lung pathology following inhalation of radioactive cerium. Fed. Proc. 8, 360 (1949).

    Google Scholar 

  • Loevinger, R., J. G. Holt, and G. J. Hine: Internally administered radioisotopes. In radiation dosimetry, edited by G. J. Hine and G. L. Brownell. p. 801. New York: Academic Press 1956.

    Google Scholar 

  • Looney, W. B.: Effects of radium in man. Science 127, 630 (1958).

    Article  PubMed  CAS  Google Scholar 

  • — Late effects (twenty five to forty years) of the early medical and industrial use of radioactive materials. Their relation to the more accurate establishment of maximum permissible amounts of radio-active elements in the body, Part I. J. Bone Jt. Surg. 37 A, 1169 (1955).

    Google Scholar 

  • — Late effects (twenty five to forty years) of the early medical and industrial use of radioactive materials. Their relation to the more accurate establishment of maximum permissible amounts of radioactive elements in the body, Part II. J. Bone Jt. Surg. 38 A, 175 (1956a).

    Google Scholar 

  • — Late effects (twenty five to forty years) of the early medical and industrial use of radioactive materials. Their relation to the more accurate establishment of maximum permissible amounts of radioactive elements in the body, Part III. J. Bone Jt. Surg. 38 A, 392 (1956b).

    Google Scholar 

  • — and L. A. Woodruff: Investigation of radium deposition in human skeleton by gross and detailed autoradiography. A. M. A. Arch. Path. 56, 1 (1953).

    PubMed  Google Scholar 

  • Lorenz, E.: Radioactivity and lung cancer; a critical review of lung cancer in miners of Schneeberg and Joachimsthal. J. nat. Cancer Inst. 5, 1 (1944).

    Google Scholar 

  • Marinelli, L. D., C. E. Miller, P. F. Gustafson, and R. E. Rowland: The quantitative determination of gamma-ray emitting elements in living persons. Amer. J. Roentgenol. 73, 661 (1955).

    PubMed  CAS  Google Scholar 

  • E. H. Quimby, and G. J. Hine: Dosage determination with radioactive isotopes. II. Practical considerations in therapy and protection. Amer. J. Roentgenol. 59, 260 (1948).

    CAS  Google Scholar 

  • Masouredis, S. P., and J. H. Lawrence: The problem of leukemia in polycythemia vera. Amer. J. med. Sci. 233, 268 (1957).

    Article  PubMed  CAS  Google Scholar 

  • Meneeley, G. R., W. L. Alsobrook, J. M. Merrill, O. J. Balchum, R. L. Weilland, and C. O. T. Ball: Metabolism of the major mineral elements of the animal body. In Radiation Biology and Medicine, edited by W. D. Claus. Reading, Mass., Addison-Wesley, 1958, p. 787.

    Google Scholar 

  • Metcalf, R. G., G. Casarett, and G. A. Boyd: Pathology studies on rats injected with polonium, plutonium, and radium. In biological studies with polonium, radium and plutonium, edited by R. M. Fink. p. 257. New York: McGraw-Hill Book Co. 1950.

    Google Scholar 

  • Mole, R. H.: The dose-response relationship in radiation carcinogenesis. Brit. med. Bull. 14, 184 (1958).

    PubMed  CAS  Google Scholar 

  • Morgan, K. Z.: Current status of the internal dose problem. Hlth. Phys. 1, 125 (1958).

    Article  CAS  Google Scholar 

  • National Bureau of Standards Handbook H 27: Safe handling of radioactive luminous compound, 1941.

    Google Scholar 

  • National Committee on Radiation Protection (NCRP): Maximum permissible body burdens and maximum permissible concentrations of radionuclides in air and in water for occupational exposure. National Bureau of Standards Handbook 69, 1959.

    Google Scholar 

  • Norris, W. P., H. Lisco, and A. M. Brues: The radiotoxicity of cerium and yttrium. In Rare Earth Conf. USAEC Unclassified Report ORINS-12, 1956. (For sale at Office of Technical Services, Commerce Department, Washington, D. C).

    Google Scholar 

  • Palmer, R. F., R. C. Thompson, and H. A. Kornberg: Factors affecting the relative deposition of strontium and calcium in the rat. Science 128, 1505 (1958).

    Article  PubMed  CAS  Google Scholar 

  • Pauling, L.: Genetic and somatic effects of Carbon-14. Science 128, 1183 (1958).

    Article  PubMed  CAS  Google Scholar 

  • Pochin, E. E., N. B. Myant, and B. D. Corbett: Leukaemia following radioiodine treatment of hyperthyroidism. Brit. J. Radiol. 29, 31 (1956).

    Article  PubMed  CAS  Google Scholar 

  • Pohle, E. A., and G. Ritchie: Histological studies of the liver, spleen and bone marrow in rabbits following the intravenous injection of thorium dioxide. Amer. J. Roentgenol. 31, 512 (1934).

    CAS  Google Scholar 

  • Proceedings of the Conference on Radioiodine, Argonne Cancer Research Hospital, Chicago, edited by D. E. Clark. USAEC Unclassified Report ACRH-100, 1956. (For sale at Office of Technical Services, Commerce Department, Washington, D. C.).

    Google Scholar 

  • Rall, J. E., J. B. Alpers, C. G. Lewallen, M. Sonenberg, M. Berman, and R. W. Rawson: Radiation pneumonitis and fibrosis: A complication of radioiodine treatment of pulmonary metastases from cancer of the thyroid. J. clin. Endocr. 17, 1263 (1957).

    Article  PubMed  CAS  Google Scholar 

  • Rosenthal, D. J., and J. H. Lawrence: Radioisotopes in medicine. In Radiation Biology and Medicine, edited by W. D. Claus. p. 471. Reading, Mass.: Addison-Wesley 1958.

    Google Scholar 

  • Rowland, R. E., J. Jowsey, and J. H. Marshall: Structural changes in human bone containing Ra226. Second United Nations Int. Conf. Peaceful Uses of Atomic Energy, A/Conf. 15 paper 910, 1958.

    Google Scholar 

  • Rubin, P., K. C. Brace, H. Gump, R. Swarm, and J. R. Andrews: The radiotoxic effects of S35 in growing cartilage. Consideration of radioactive sulfur (S35) as a possible radiotherapeutic agent in chondrosarcomas. Radiology 69, 711 (1957).

    PubMed  CAS  Google Scholar 

  • Russfield, A. B.: Hypophyseal changes in hypothyroidism induced by radioactive iodine in man. A. M. A. Arch. Path. 66, 79 (1958).

    PubMed  CAS  Google Scholar 

  • Schubert, J.: Removal of radioéléments from the mammalian body. Ann. Rev. Nucl. Sci. 5, 369–412 (1955).

    Article  CAS  Google Scholar 

  • M. P. Finkel, M. R. White, and G. M. Hirsch: Plutonium and yttrium content of blood, liver and skeleton of the rat at different times after intravenous administration. J. biol. Chem. 182, 635 (1950).

    Google Scholar 

  • Seidlin, S. M., E. Siegel, A. A. Yalow, and S. Melamed: Acute myeloid leukemia following prolonged iodine-131 therapy for metastatic thyroid carcinoma. Science 123, 800 (1956).

    Article  PubMed  CAS  Google Scholar 

  • A. A. Yalow, and E. Siegel: Blood radiation dose during radioiodine therapy of metastatic thyroid carcinoma. Radiology 63, 797 (1954).

    PubMed  CAS  Google Scholar 

  • Seil, H. A., C. H. Viol, and M. A. Gordon: The elimination of soluble radium salts taken intravenously and per os. N. Y. med. J. 101, 896 (1915).

    CAS  Google Scholar 

  • Sheppard, C. W.: Facets and fashions in physiological tracer experiments. In Radiation Biology and Medicine, edited by W. D. Claus. p. 713. Reading, Mass.: Addison-Wesley 1958.

    Google Scholar 

  • Silberstein, H. E.: Radium distribution and excretion studies with rats, in Biological studies with polonium, radium, and plutonium, edited by R. M. Fink. p. 179. New York: McGraw-Hill Book Co. 1950.

    Google Scholar 

  • W. L. Minto, R. M. Fink, G. A. Boyd, R. G. Metcalf, W. Mann, C. P. Kimball, and A. T. Gorham: Polonium distribution and excretion experiments with animals. p. 35. New York: McGraw-Hill Book Co. 1950.

    Google Scholar 

  • Sinclair, W. K.: Basic radiation dosimetry relevant to the internal administration of I181. Dose variations due to physiological factors and histological structure. In Proc. of Conf. on Radioiodine, edited by D. E. Clark. USAEC Unclassified Report ACRH-100, p. 1, 1956. (For sale at Office of Technical Services, Commerce Department, Washington, D. C.).

    Google Scholar 

  • Stannard, J. N.: An evaluation of inhalation hazards in the nuclear energy industry. Second United Nations Int. Conf. Peaceful Uses of Atomic Energy, Geneva, 1958, Vol. 23. p. 306. New York: United Nations 1958.

    Google Scholar 

  • H. A. Blair, and R. C. Baxter: The effects of a maintained body burden of polonium in the rat. III. Mortality, life span, and growth. USAEC Unclassified Report UR-395, 1955. (Available only from USAEC depository libraries.)

    Google Scholar 

  • Temple, L. A., D. H. Willard, S. Marks, and W. J. Bair: Induction of lung tumors by radioactive particles. Nature (Lond.) 183, 408 (1959).

    Article  CAS  Google Scholar 

  • Thomas, S. F., G. W. Henry, and H. S. Kaplan: Hepatolienography: past, present, future. Radiology 57, 669 (1951).

    PubMed  CAS  Google Scholar 

  • Thompson, R. C., W. J. Bair, S. Marks, and M. F. Sullivan: Evaluation of internal exposure hazards for several radioisotopes encountered in reactor operations. Second United Nations Int. Conf. Peaceful Uses of Atomic Energy, Geneva, 1958, Vol. 23, p. 283. New York: United Nations 1958.

    Google Scholar 

  • Totter, J. R., M. R. Zelle, and H. Hollister: Hazard to man of Carbon-14. Science 128, 1490 (1958).

    Article  PubMed  CAS  Google Scholar 

  • Tullis, J. L., and H. A. Johnson: The biological significance of some important internal emitters. In Radiation Biology and Medicine, edited by W. D. Claus. p. 341. Reading, Mass.: Addison-Wesley 1958.

    Google Scholar 

  • United Nations: Report of the United Nations Scientific Committee on the Effects of Atomic Radiation. General Assembly, Official Records, Thirteenth Session Supplement No. 17 (A/3838): New York 1958.

    Google Scholar 

  • Upton, A. C., J. Fürth, and W. T. Burnett jr.: Liver damage and hepatomas in mice produced by radioactive colloidal gold. Cancer Res. 16, 211 (1956).

    PubMed  CAS  Google Scholar 

  • VAN Middlesworth, L.: Iodine-131 fallout in bovine fetus. Science 128, 597 (1958).

    Article  Google Scholar 

  • Voegtlin, C., and H. C. Hodge: The pharmacology and toxicology of uranium compounds. Chronic inhalation and other studies. New York: McGraw-Hill Book Co. 1953.

    Google Scholar 

  • Werner, S. C., B. Coelho, and E. H. Quimby: Ten year results of I131 therapy of hyperthyroidism. Bull. N. Y. Acad. Med. 33, 783 (1957).

    PubMed  CAS  Google Scholar 

  • — and E. H. Quimby: Acute leukemia after radioactive Iodine (I131) therapy for hyperthyroidism. J. Amer. med. Ass. 165, 1558 (1957).

    Article  CAS  Google Scholar 

Download references

Authors

Editor information

H. Schwiegk F. Turba

Rights and permissions

Reprints and permissions

Copyright information

© 1961 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Odell, T.T., Upton, A.C. (1961). Late Effects of Internally Deposited Radioisotopes. In: Schwiegk, H., Turba, F. (eds) Künstliche Radioaktive Isotope in Physiologie Diagnostik und Therapie/Radioactive Isotopes in Physiology Diagnostics and Therapy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-92819-2_7

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-92819-2_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-49048-4

  • Online ISBN: 978-3-642-92819-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics