Abstract
The rate of response of a tissue to the action of a drug can be studied in two way:
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(1)
Measurement of some graded action. The following are simple examples of this type of response: the contracture of plain or of skeletal muscle; the inhibition of the mechanical response of cardiac muscle; the relaxation of plain muscle.
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(2)
Measurement of the rate of incidence of some all-or-none effect. The following are important measurements of this type: death of micro-organisms; haemolysis of red blood corpuscles; paralysis or death or small organisms.
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References
Hill, A. V.: J. of Physiol. 39, 361 (1909).
Rosenblueth, A.: Amer. J. Physiol. 101, 149 (1932).
Ing, H. E., and W. M. Weight: Proc. roy. Soc. B. 109, 337 (1932).
Braun, I.: Arch. f. exper. Path. 108, 96 (1925).
Gaddum, J. H.: J. of Physiol. 61, 141 (1926).
Mendez, R.: J. Pharmacol. Baltimore 32, 451 (1928).
Issekutz, B. von, and M. V. Leinzinger: Arch. f. exper. Path. 128, 165 (1928).
Rothlin, E.: J. Pharmacol. Baltimore 36, 657 (1929).
Nanda, T. C.: J. Pharmacol. Baltimore 42, 9 (1931).
Webster, M. D.: J. Pharmacol. Baltimore 53, 340 (1935).
Gray, J.: J. of exper. Biol. 9, 277 (1932).
Henri, V.: C. r. Soc. Biol. Paris 58, 37 (1905).
Chick, H.: J. of Hyg. 8, 92 (1908).
Chick, H., and C. J. Martin: J. of Physiol. 40, 104 (1910).
Chick, H., and C. J. Martin: J. of Physiol. 43, 1 (1911).
Chick, H., and C. J. Martin: J. of Physiol. 45, 61 (1912).
Arrhenius, S.: Quantitative Laws in Biological Chemistry. London: Bell and Sons 1915.
Blau, M., and K. Altenburger: Z. Physik 12, 315 (1922).
Chick, H.: Med. Res. Counc. System of Bacteriol. 1, 179 (1930).
Rahn, O.: J. gen. Physiol. 13, 179, 396 (1930).
Rahn, O.: J. gen. Physiol. 14, 319 (1931).
Rahn, O.: Symposia Quant. Biol. 2, 76 (1935).
Clark, A. J.: The Mode of Action of Drugs on Cells, p. 163-168. London: Arnold and Co. 1933.
Brooks, S. C.: J. gen. Physiol. 1, 61 (1919).
Chick, H.: J. of Hyg. 10, 237 (1910).
Arrhenius, S.: Quantitative Laws in Biological Chemistry. London: Bell and Sons 1915.
Chick, H., and C. J. Martin: J. of Physiol. 43, 1 (1911).
Lewis, P. S.: Biochemic. J. 20, 978 (1926).
Chick, H., and C. J. Martin: J. of Physiol. 40, 404 (1910).
Lewis, P. S.: Biochemic. J. 20, 965 (1926).
Hartridge, H.: J. of Physiol. 44, 34 (1912).
Fischer, A.: Nature (Lond.) 137, 576 (1936).
Svedberg, T.: Kolloid-Z. 51, 10 (1930).
Astbury, W., S. Dickenson and K. Bailey: Biochemic. J. 29, 2351 (1935).
Cooper, E. A.: and R. B. Haines: J. of Hyg. 28, 162 (1928).
Cooper, E. A.: Biochemic. J. 6, 362 (1912).
Cooper, E. A.: Biochemic. J. 6, 362 (1912).
Geppert, J.: Berl. klin. Wschr. 26, 789, 819 (1889).
Mioni, G.: O. r. Soc. Biol. Paris 58, 192 (1905).
Peters, R. A.: J. of Physiol. 54, 260 (1920).
Yule, J. Udny: J. Statist. Soc. 73, 26 (1910).
Rahn, O.: J. gen. Physiol. 13, 179, 396 (1930); 14, 315 (1931).
Galton, F.: Proc. roy. Soc. 39, 365 (1879).
MacAlister, D.: Proc. roy. Soc. 29, 367 (1879).
Kapteyn, J. C.: Rec. Trav. bot. néerl. 13(2), 105 (1916).
Reiner, L.: Proc. Soc. exper. Biol. a. Med. 30, 574 (1933).
Reiner, L.: J. gen. Physiol. 19, 419 (1936).
Sibree, J. O.: Trans. Farad. Soc. 26, 26 (1930).
Irwin, M.: J. gen. Physiol. 8, 147 (1925/26).
Cook, S. F.: J. gen. Physiol. 9, 575, 631, 735 (1925/26).
Cook, S. F.: J. gen. Physiol. 9, 575, 631 (1925/26).
Cook, S. F.: J. gen. Physiol. 9, 735 (1925/26).
Cook, S. F.: J. gen. Physiol. 9, 575, 631, 735 (1925/26).
Cooper, E. A.: Biochemic. J. 6, 362 (1912).
Reichel, H.: Biochem. Z. 22, 149 (1909).
Rahn, O., and M. N. Barnes: J. gen. Physiol. 16, 579 (1933).
Herzog, R. A., and R. Betzel: Hoppe-Seylers Z. 74, 221 (1911).
Garner, W. E.: Trans. Farad. Soc. 22, 433, 461 (1926).
Cooper, E. A.: Biochemic. J. 6, 362 (1912).
Küster, E., and Rothaub: Z. Hyg. 73, 205 (1913).
Cooper, E. A., and D. L. Woodhouse: Biochemie. J. 17, 600 (1923).
Christophers, S. R.: Indian J. med. Res. 17, 544 (1929).
Brownlee, I.: J. roy. Statist. Soc. 82, 34 (1919).
Pearl, R.: The Rate of Living. New York 1928.
Szabo, L.: Quart. Rev. Biol. 6, 462 (1931).
Gowen, J. W.: J. gen. Physiol. 14, 463 (1931).
Gowen, J. W.: Symposium quantit. Biol. 2, 128 (1934).
Chesney, A. M. C.: J. of exper. Med. 24, 387 (1916).
Henderson Smith, J.: Ann. appl. Biol. 8, 27 (1921).
Blau, M., and K. Altenburger: Z. Physik 12, 315 (1922).
Crowther, J. A.: Proc. roy. Soc. B. 100, 396 (1926).
Curie, P.: C. r. Acad. Sci. Paris 188, 202 (1929).
Holweek, F., and Lacassagne A.: C. r. Soc. Biol. Paris 103, 766 (1930).
Wyckoff, R. W. G.: J. of exper. Med. 52, 435, 769 (1930).
Pugsley, A. T., T. H. Oddie and C. E. Eddy: Proc. roy. Soc. B. 118, 276 (1935).
Packard, C.: Quart. Rev. Biol. 6, 253 (1931).
Wyckoff, R. W. G.: J. gen. Physiol. 15, 351 (1932).
Rahn, O.: Symposia Quant. Biol. 2, 70 (1935).
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Clark, A.J. (1937). The Rate of Action of Drugs on Cells. In: General Pharmacology. Handbuch der Experimentellen Pharmakologie, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-91463-8_13
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