Ribosomes and Thyroid Hormones

  • J. R. Tata
Conference paper
Part of the 18. Colloquium der Gesellschaft für Physiologische Chemie Vom 5. bis 8. April 1967 in Mosbach/Baden book series (MOSBACH, volume 18)


Thyroid hormones are a good example of the shift in emphasis that has taken place in the last five years in work on the action of hormones. Until a few years ago, most hormones were considered to act by modifying the rates of enzymes directly concerned with the ultimate biological effects (Tepperman and Tepperman, 1960), whereas it is now accepted that hormones may act by controlling the synthesis of specific cell constituents. My own feeling is that the same hormone at different doses or in different systems can act in many different ways. This is certainly true of thyroid hormones which have an immediate catabolic or toxic effect by acting at the level of mitochondria but also have a slow action under other conditions in which they control the rate of synthesis of specific constituents. It is this action of thyroid hormones which is manifested in growth and development of the target cell that I shall be dealing with in this paper.


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  1. Bennett, T. P., and E. Frieden: In Comparative Biochemistry vol. 4, p. 484. Ed. by Florkin, M., and H. S. Mason. New York: Academic Press, Inc. 1962.Google Scholar
  2. Freinkel, N.: In The Thyroid, vol. 1, p. 131. Ed. by Pitt-Rivers, R., and W. R. Trotter. London: Butterworths 1964.Google Scholar
  3. Hamilton, T. H., C. C. Widnell, and J. R. Tata: Biochim. biophys. Acta (Amst.) 108, 168 (1965).Google Scholar
  4. Henshaw, E. C., T. B. Bojarski, and H. H. Hiatt: J. molec. Biol. 7, 122 (1963).PubMedCrossRefGoogle Scholar
  5. Henshaw, E. C., M. Revel, and H. H. Hiatt: J. molec. Biol. 14, 241 (1965).PubMedCrossRefGoogle Scholar
  6. Karlson, P.: Perspect. Biol. Med. 6, 203 (1963).PubMedGoogle Scholar
  7. Korner, A.: Recent Progr. Hormone Res. 21, 205 (1965a).PubMedGoogle Scholar
  8. Korner, A.: Biochem. J. 92, 449 (1965b).Google Scholar
  9. Mueller, G. C.: In Mechanisms of hormone action, p. 228. Ed. by Karlson, P. Stuttgart: Thieme 1965.Google Scholar
  10. Palade, G. E., P. Siekevitz, and L. G. Caro: In The exocrine pancreas, p. 234. Ed. by De Reuck, A. V. S., and M. Cameron. London: J. & A. Churchill, Ltd. 1962.Google Scholar
  11. Pegg, A. A., and A. Korner: Nature (Lond.) 205, 904 (1965).CrossRefGoogle Scholar
  12. Reich, E., and I. H. Goldberg: Progr. Nucleic Acid Res. and Molec. Biol. 3, 184 (1964).Google Scholar
  13. Sekeris, C. E.: In Mechanisms of hormone action, p. 149. Ed. by Karlson, P. Stuttgart: Thieme 1965.Google Scholar
  14. Siegel, E. S., and C. A. Tobias: Nature (Lond.) 212, 1318 (1966).CrossRefGoogle Scholar
  15. Tata, J. R.: In Actions of hormones on molecular processes, p. 58. Ed. by Litwack, G., and D. Kritchevsky. New York: John Wiley and Sons, Inc. 1964.Google Scholar
  16. Tata, J. R.: In Developmental and metabolic control mechanisms and neoplasis, p. 335. Baltimore: Williams & Wilkins Co. 1965a.Google Scholar
  17. Tata, J. R.: Nature (Lond.) 207, 378 (1965b).CrossRefGoogle Scholar
  18. Tata, J. R.: Progr. Nuc. Acid Res. and Molec. Biol. 5, 191 (1966a).CrossRefGoogle Scholar
  19. Tata, J. R.: Nature (Lond.) 212, 1312 (1966b).CrossRefGoogle Scholar
  20. Tata, J. R.: Biochem. J. 104, 1 (1967a).PubMedGoogle Scholar
  21. Tata, J. R.: Biochem. J. In press. (1967b).Google Scholar
  22. Tata, J. R.: Nature (Lond.) 213, 566 (1967c).CrossRefGoogle Scholar
  23. Tata, J. R., L. Ernster, O. Lindberg, E. Arrhenius, S. Pedersen, and R. Hedman: Biochem. J. 86, 408 (1963).PubMedGoogle Scholar
  24. Tata, J. R., and C. C. Widnell: Biochem. J. 98, 604 (1966).PubMedGoogle Scholar
  25. Tepperman, J., and H. M. Tepperman: Pharmacol. Rev. 12, 301 (1960).PubMedGoogle Scholar
  26. Widnell, C. C., and J. R. Tata: Biochem. J. 98, 621 (1966a).PubMedGoogle Scholar
  27. Widnell, C. C., and J. R. Tata:Biochim. biophys. Acta (Amst.) 123, 478 (1966b).Google Scholar
  28. Williams-Ashman, H. G., S. Liao, R. L. Hancock, L. Jurkovitz, and D. A. Silverman: Recent Progr. Hormone Res. 20, 247 (1964).PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1967

Authors and Affiliations

  • J. R. Tata
    • 1
  1. 1.National Institute for Medical ResearchLondonEngland

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