Erythrocyte Choline Levels in Cluster Headache

  • J. De Belleroche
  • G. E. Cook
  • R. Joseph
  • I. Das
  • I. Tresidder
  • R. Petty
  • F. Clifford Rose
Conference paper


Lithium is known to be beneficial in the treatment of cluster headache (CH) [4, 9, 11,13]. Patients with both episodic and chronic forms of CH show a high degree of improvement with it, although the mode of action of lithium in this condition is unknown. Lithium treatment has, however, been shown to markedly elevate erythrocyte choline levels in manic-depressive patients where it is also used in treatment [6, 7]. In addition, choline levels prior to treatment differ significantly between controls and manic-depressive patients, as well as between controls and two other conditions which have been investigated, Gilles de la Tourette syndrome and dementia [1, 3, 5,6,8]. In view of these observations, we have measured choline levels in erythrocytes and plasma of CH patients in comparison with age-matched controls to establish whether abnormal choline levels also occur in this condition.


Cluster Headache Lithium Treatment Chronic Cluster Headache Cluster Headache Patient Elevated Cholesterol Level 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Barclay LL, Blass JP, Kopp U, Hanin I (1982) N Engl J Med 307: 501PubMedGoogle Scholar
  2. 2.
    Chapman BE, Beilharz GR, York MJ, Kuchel PW (1982) Biochem Biophys Res Commun 105: 1280–1287PubMedCrossRefGoogle Scholar
  3. 3.
    Comings DE, Gursey BT, Avelino E, Kopp W, Hanin I (1982) In: Friedhoff AS, Chase IN (eds) Gilles de la Tourette syndrome. Raven, New York, pp 255–258Google Scholar
  4. 4.
    Ekbom KA (1974) Opusc Med 19:148–156Google Scholar
  5. 5.
    Hanin I, Kopp U, Spiker DG, Neil JF, Shaw DH, Kupfer DJ (1980) Psychiatry Res 3: 345–355PubMedCrossRefGoogle Scholar
  6. 6.
    Hanin I, Spiker DG, Mallinger AG, Kopp U, Himmelhoch JM, Neil JF, Kupfer DF (1981) In: Pepen G, Ladinsky H (eds) Cholinergic mechanisms. Plenum, New York, pp 901–919Google Scholar
  7. 7.
    Jope RS, Jenden DJ, Ehrlich B, Diamond JM (1978) N Engl J Med 299: 833–834PubMedGoogle Scholar
  8. 8.
    Jope RS, Jenden DJ, Ehrlich B, Diamond JM (1980) Proc Natl Acad Sci USA 77:6144–6146PubMedCrossRefGoogle Scholar
  9. 9.
    Kudrow L (1977) Headache 17:15–18PubMedCrossRefGoogle Scholar
  10. 10.
    Lee G, Lingsch C, Lyle PT, Martin K (1974) Br J Clin Pharmacol 1: 365–370PubMedGoogle Scholar
  11. 11.
    Lieb J, Zeff A (1978) Br J Psychiatry 133: 556–558PubMedCrossRefGoogle Scholar
  12. 12.
    Martin K (1968) J Gen Physiol 51: 497–516PubMedCrossRefGoogle Scholar
  13. 13.
    Mathew K (1978) Headache 10: 26–30CrossRefGoogle Scholar
  14. 14.
    Olesen J (1977) Acta Neurol Scand 56: 461–464PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • J. De Belleroche
  • G. E. Cook
  • R. Joseph
  • I. Das
  • I. Tresidder
  • R. Petty
  • F. Clifford Rose

There are no affiliations available

Personalised recommendations