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Enkephalinase Activity in Plasma and Cerebrospinal Fluid in Primary Headache

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Updating in Headache

Abstract

The distribution in the central and peripheral nervous system of endogenous opioid peptides, enkephalins in particular, and their receptors is an argument in favor of their possible neurotransmitter function [5, 6].

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References

  1. Ad Hoc Committee on Classification of Headache (1962) Classification of headache. JAMA 179:717–718

    Article  Google Scholar 

  2. Atweh SF, Kuhar M J (1977) Autoradiographic localization of opiate receptors in rat brain. Brain Res 124: 53–67

    Article  PubMed  CAS  Google Scholar 

  3. Baldi E, Salmon S, Cappelli G, Brocchi A, Spillantini MG, Sicuteri F (1982 a) Intermittent hy-poendorphinemia in migraine attack. Cephalalgia 2:77–81

    Article  PubMed  CAS  Google Scholar 

  4. Baldi E, Conti P, Conti R, Michelacci S, Salmon S, Spillantini MG, Sicuteri F (1982 b) Livelli liquorali di β-endorfina nei pazienti cefalalgici. G Neuropsicofarmacologia 2: 58

    Google Scholar 

  5. Bloom FE, Rossier J, Battenberg ELF, Bayon A, French A, Henriksen SJ, Siggins GR, Desal D, Browne R, Ling N, Guillemin R (1978) β-endorphin, cellular localization, electrophysiological and behavioral effects. Adv Biochem Psychopharmacol 18: 89–109

    PubMed  CAS  Google Scholar 

  6. Cuello AC, Paxinos G (1978) Evidence for a long leu-enkephalin striopallidal pathway in rat brain. Nature 271:178–180

    Article  PubMed  CAS  Google Scholar 

  7. Facchinetti F, Nappi G, Savoldi F, Genazzani AR (1981) Primary headaches: reduced circulating β-lipotropin and β-endorphin levels with impaired reactivity to acupuncture. Cephalalgia 1: 195–201

    Article  PubMed  CAS  Google Scholar 

  8. Henry JC (1982) Relation of substance P to pain transmission: neurophysiological evidence. In: Porter R, O’Connor M (eds) Substance P in the nervous system (CIBA foundation symposium 91). Pitman, London, pp 206–224

    Google Scholar 

  9. Hökfelt T, Ljungdahl A, Terenius L, Elde R, Nilsson G (1977) Immunohistochemical analysis of peptide pathways possibly related to pain and analgesia: enkephalin and substance P. Proc Natl Acad Sci USA 74: 3081–3085

    Article  PubMed  Google Scholar 

  10. Hökfelt T, Johansson O, Ljungdahl A, Lundberg JM, Schultzberg M (1980) Peptidergic neurons. Nature 284: 515–521

    Article  PubMed  Google Scholar 

  11. Hughes J (1975) Isolation of an endogenous compound from the brain with pharmacologucal properties similar to morphine. Brain Res 88: 295–308

    Article  PubMed  CAS  Google Scholar 

  12. Malfroy B, Swerts JP, Llorens C, Schartz JC (1979) Regional distribution of a high affinity enkephalin degradating peptidase (enkephalinase) and effects of lesions suggest localization in the vicinity of opioid receptors. Neurosci Lett 11: 329

    Article  PubMed  CAS  Google Scholar 

  13. Pert CB, Kuhar MJ, Snyder SH (1976) Opiate receptors: autoradiographic localization in rat brain. Proc Natl Acad Sci USA 73: 3729

    Article  PubMed  CAS  Google Scholar 

  14. Schwartz JC, Malfroy B, De la Baume S (1981) Biological inactivation of enkephalin and the role of enkephalin dipeptidyl carboxypeptidase (enkephalinase) as neuropeptidase. Life Sci 29: 1715–1740

    Article  PubMed  CAS  Google Scholar 

  15. Sicuteri F (1977) Headache as metonymy of nonorganic central pain. In: Sicuteri F (ed) Headache: new vistas. Biomedical, Florence, pp 19–67

    Google Scholar 

  16. Sicuteri F (1978) Minireview: endorphines, opiate receptors and migraine headache. Headache 17:253–257

    Article  PubMed  CAS  Google Scholar 

  17. Sicuteri F, Anselmi B, Curradi C, Michelacci S, Sassi A (1978) Morphine-like factors in CSF of headache patients. Adv Biochem Psychopharmacol 18: 363–366

    PubMed  CAS  Google Scholar 

  18. Spillantini MG, Fanciullacci M, Di Tommaso M, Rainò L, Sicuteri F (1983 a) Enkephalinase activity in human plasma and CSF in both physiological and pathological conditions. Proceedings of the 1st international meeting of the Italian society of endocrinology: Recent progress in opioid research. II Section: central and peripheral endorphins. Raven, New York

    Google Scholar 

  19. Spillantini MG, Malfroy B, Schwartz JC (1983 b) Characterization of enkephalinase activity in human plasma, CSF and amniotic fluid by a spectrophotofluorimetric method. J Neurochem (in press)

    Google Scholar 

  20. Terenius L (1979) Endorphins in chronic pain. In: Bonica JJ, Liebeskind JC, Albe-Fessard DG (eds) Adv Pain Res Ther 3: 459–471

    Google Scholar 

  21. Viveros OH, Wilson SP (1983) The adrenal chromaffin cell as a model to study the co-secretion of enkephalins and catecholamines. J Auton Nerv Syst 7: 41–58

    Article  PubMed  CAS  Google Scholar 

  22. Vogel Z, Miron T, Altstein M, Wilchek M (1978) Spontaneous inactivation of enkephalin. Biochem Biophys Res Commun 85: 226–233

    Article  PubMed  CAS  Google Scholar 

  23. Wine R, Mosnaim A, Wolf M, Diamond S (1982) Plasma methionine-enkephalin levels during migraine episodes. Abstract book: The migraine trust. 22–23 September 1982, London

    Google Scholar 

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© 1985 Springer-Verlag Berlin Heidelberg

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Spillantini, M.G., Fanciullacci, M., Michelacci, S., Baldi, E., Sicuteri, F. (1985). Enkephalinase Activity in Plasma and Cerebrospinal Fluid in Primary Headache. In: Pfaffenrath, V., Lundberg, PO., Sjaastad, O. (eds) Updating in Headache. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-88581-5_42

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  • DOI: https://doi.org/10.1007/978-3-642-88581-5_42

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-15318-4

  • Online ISBN: 978-3-642-88581-5

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