Enkephalinase Activity in Plasma and Cerebrospinal Fluid in Primary Headache

  • Maria Grazia Spillantini
  • Marcello Fanciullacci
  • Sergio Michelacci
  • Elisabetta Baldi
  • Federigo Sicuteri
Conference paper

Abstract

The distribution in the central and peripheral nervous system of endogenous opioid peptides, enkephalins in particular, and their receptors is an argument in favor of their possible neurotransmitter function [5, 6].

Keywords

Migraine Morphine Catecholamine Captopril Bestatin 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Ad Hoc Committee on Classification of Headache (1962) Classification of headache. JAMA 179:717–718CrossRefGoogle Scholar
  2. 2.
    Atweh SF, Kuhar M J (1977) Autoradiographic localization of opiate receptors in rat brain. Brain Res 124: 53–67PubMedCrossRefGoogle Scholar
  3. 3.
    Baldi E, Salmon S, Cappelli G, Brocchi A, Spillantini MG, Sicuteri F (1982 a) Intermittent hy-poendorphinemia in migraine attack. Cephalalgia 2:77–81PubMedCrossRefGoogle Scholar
  4. 4.
    Baldi E, Conti P, Conti R, Michelacci S, Salmon S, Spillantini MG, Sicuteri F (1982 b) Livelli liquorali di β-endorfina nei pazienti cefalalgici. G Neuropsicofarmacologia 2: 58Google Scholar
  5. 5.
    Bloom FE, Rossier J, Battenberg ELF, Bayon A, French A, Henriksen SJ, Siggins GR, Desal D, Browne R, Ling N, Guillemin R (1978) β-endorphin, cellular localization, electrophysiological and behavioral effects. Adv Biochem Psychopharmacol 18: 89–109PubMedGoogle Scholar
  6. 6.
    Cuello AC, Paxinos G (1978) Evidence for a long leu-enkephalin striopallidal pathway in rat brain. Nature 271:178–180PubMedCrossRefGoogle Scholar
  7. 7.
    Facchinetti F, Nappi G, Savoldi F, Genazzani AR (1981) Primary headaches: reduced circulating β-lipotropin and β-endorphin levels with impaired reactivity to acupuncture. Cephalalgia 1: 195–201PubMedCrossRefGoogle Scholar
  8. 8.
    Henry JC (1982) Relation of substance P to pain transmission: neurophysiological evidence. In: Porter R, O’Connor M (eds) Substance P in the nervous system (CIBA foundation symposium 91). Pitman, London, pp 206–224Google Scholar
  9. 9.
    Hökfelt T, Ljungdahl A, Terenius L, Elde R, Nilsson G (1977) Immunohistochemical analysis of peptide pathways possibly related to pain and analgesia: enkephalin and substance P. Proc Natl Acad Sci USA 74: 3081–3085PubMedCrossRefGoogle Scholar
  10. 10.
    Hökfelt T, Johansson O, Ljungdahl A, Lundberg JM, Schultzberg M (1980) Peptidergic neurons. Nature 284: 515–521PubMedCrossRefGoogle Scholar
  11. 11.
    Hughes J (1975) Isolation of an endogenous compound from the brain with pharmacologucal properties similar to morphine. Brain Res 88: 295–308PubMedCrossRefGoogle Scholar
  12. 12.
    Malfroy B, Swerts JP, Llorens C, Schartz JC (1979) Regional distribution of a high affinity enkephalin degradating peptidase (enkephalinase) and effects of lesions suggest localization in the vicinity of opioid receptors. Neurosci Lett 11: 329PubMedCrossRefGoogle Scholar
  13. 13.
    Pert CB, Kuhar MJ, Snyder SH (1976) Opiate receptors: autoradiographic localization in rat brain. Proc Natl Acad Sci USA 73: 3729PubMedCrossRefGoogle Scholar
  14. 14.
    Schwartz JC, Malfroy B, De la Baume S (1981) Biological inactivation of enkephalin and the role of enkephalin dipeptidyl carboxypeptidase (enkephalinase) as neuropeptidase. Life Sci 29: 1715–1740PubMedCrossRefGoogle Scholar
  15. 15.
    Sicuteri F (1977) Headache as metonymy of nonorganic central pain. In: Sicuteri F (ed) Headache: new vistas. Biomedical, Florence, pp 19–67Google Scholar
  16. 16.
    Sicuteri F (1978) Minireview: endorphines, opiate receptors and migraine headache. Headache 17:253–257PubMedCrossRefGoogle Scholar
  17. 17.
    Sicuteri F, Anselmi B, Curradi C, Michelacci S, Sassi A (1978) Morphine-like factors in CSF of headache patients. Adv Biochem Psychopharmacol 18: 363–366PubMedGoogle Scholar
  18. 18.
    Spillantini MG, Fanciullacci M, Di Tommaso M, Rainò L, Sicuteri F (1983 a) Enkephalinase activity in human plasma and CSF in both physiological and pathological conditions. Proceedings of the 1st international meeting of the Italian society of endocrinology: Recent progress in opioid research. II Section: central and peripheral endorphins. Raven, New YorkGoogle Scholar
  19. 19.
    Spillantini MG, Malfroy B, Schwartz JC (1983 b) Characterization of enkephalinase activity in human plasma, CSF and amniotic fluid by a spectrophotofluorimetric method. J Neurochem (in press)Google Scholar
  20. 20.
    Terenius L (1979) Endorphins in chronic pain. In: Bonica JJ, Liebeskind JC, Albe-Fessard DG (eds) Adv Pain Res Ther 3: 459–471Google Scholar
  21. 21.
    Viveros OH, Wilson SP (1983) The adrenal chromaffin cell as a model to study the co-secretion of enkephalins and catecholamines. J Auton Nerv Syst 7: 41–58PubMedCrossRefGoogle Scholar
  22. 22.
    Vogel Z, Miron T, Altstein M, Wilchek M (1978) Spontaneous inactivation of enkephalin. Biochem Biophys Res Commun 85: 226–233PubMedCrossRefGoogle Scholar
  23. 23.
    Wine R, Mosnaim A, Wolf M, Diamond S (1982) Plasma methionine-enkephalin levels during migraine episodes. Abstract book: The migraine trust. 22–23 September 1982, LondonGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • Maria Grazia Spillantini
  • Marcello Fanciullacci
  • Sergio Michelacci
  • Elisabetta Baldi
  • Federigo Sicuteri

There are no affiliations available

Personalised recommendations