Metoprolol, a Beta1-Selective Beta-Blocker, in Prophylactic Treatment of Migraine

  • P. G. Andersson
  • C. Hedman
  • P. Kangasniemi
Conference paper


Several remedies with different pharmacologic approaches have been used in the prophylactic treatment of migraine patients. At present 5-HT antagonists (i. e., pizotifen) or beta-blocking agents (i.e., propranolol) are recommended as the drugs of first choice [1].


Angina Pectoris Migraine Attack Migraine Patient Prophylactic Effect Migraine Prophylaxis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Peatfield R (1983) Migraine — Current concepts of pathogenesis and treatment. Drugs 26: 364–371PubMedCrossRefGoogle Scholar
  2. 2.
    Rabkin R, Stables DP, Levin NW, Suzman MM (1966) Propranolol and prophylaxis of angina pectoris. Am J Cardiol 18: 370–380PubMedCrossRefGoogle Scholar
  3. 3.
    Wykes P (1968) The treatment of angina pectoris with co-existing migraine. Practitioner 200: 702–704PubMedGoogle Scholar
  4. 4.
    Weber R, Reinmuth O (1972) The treatment of migraine with propranolol. Neurology 22: 366–369PubMedGoogle Scholar
  5. 5.
    Diamond S, Medina J (1976) Double-blind study of propranolol for migraine prophylaxis. Headache 16: 24–27PubMedCrossRefGoogle Scholar
  6. 6.
    Forssman B, Henriksson K-G, Johansson V, Lindvall L, Lundin H (1976) Propranolol for migraine prophylaxis. Headache 16:238–245PubMedCrossRefGoogle Scholar
  7. 7.
    Briggs RS, Millac PA (1979) Timolol in migraine prophylaxis. Headache 19: 379–381PubMedCrossRefGoogle Scholar
  8. 8.
    Standnes B (1982) The prophylactic effect of timolol versus propranolol and placebo in common migraine: beta-blockers in migraine. Cephalalgia 2:165–170PubMedCrossRefGoogle Scholar
  9. 9.
    Stensrud P, Sjaastad O (1980) Comparative trial of Tenormin (atenolol) and Inderal (propranolol) in migraine. Headache 20: 204–207PubMedCrossRefGoogle Scholar
  10. 10.
    Forssman B, Lindblad GJ, Zbornikova V (1983) Atenolol for migraine prophylaxis. Headache 23:188–190PubMedCrossRefGoogle Scholar
  11. 11.
    Ekbom K (1975) Alprenolol for migraine prophylaxis. Headache 15:129–132PubMedCrossRefGoogle Scholar
  12. 12.
    Ekbom K, Zetterman M (1977) Oxprenolol in the treatment of migraine. Acta Neurol Scand 56: 181–184PubMedCrossRefGoogle Scholar
  13. 13.
    Nanda RN, Johnson RH, Gray J, Keugh HJ, Melville ID (1979) A double-blind trial of acebuto-lol for migraine prophylaxis. Headache 18: 379–381Google Scholar
  14. 14.
    Sjaastad O, Stensrud P (1972) Clinical trial of a beta-receptor blocking agent (LB 46) in migraine prophylaxis. Acta Neurol Scand 48:124–128PubMedCrossRefGoogle Scholar
  15. 15.
    Ekbom K, Lundberg PO (1972) Clinical trial of LB 46, an adrenergic beta-receptor blocking agent in migraine prophylaxis. Headache 12:15–17PubMedCrossRefGoogle Scholar
  16. 16.
    Ljung O (1981) Metoprolol in migraine. Cephalalgia 1:142PubMedCrossRefGoogle Scholar
  17. 17.
    Andersson PG, Dahl S, Hansen JH, Hansen PE, Hedman C, Nygaard Kristensen T, De Fine Olivarius B (1983) Prophylactic treatment of classical and non-classical migraine with metopro-lol — a comparison with placebo. Cephalalgia 3, 207–212PubMedCrossRefGoogle Scholar
  18. 18.
    Cochrane Al (1970) Third migraine symposium, April 1969. Background to migraine. Heineman, London, pp180–181Google Scholar
  19. 19.
    Vahlquist B (1955) Migraine in children. Int Arch Allergi 7: 348–355CrossRefGoogle Scholar
  20. 20.
    Kangasniemi P, Hedman C (1984) Metoprolol and propranolol in the prophylactic treatment of classical and common migraine. A double-blind study. Cephalalgia (in press)Google Scholar
  21. 21.
    Sercombe R, Aubineau P, Edvinsson L, Mamo H, Owman CH, Seylaz J (1977) Pharmacological evidence in vitro and in vivo for functional beta!-receptors in cerebral circulation. Pflugers Arch 368:241–244PubMedCrossRefGoogle Scholar
  22. 22.
    Hanington E, Amess JAL, Jones RJ, Wachowicz B (1981) Migraine: a platelet disorder. Lancet 11:720–723CrossRefGoogle Scholar
  23. 23.
    Weksler B, Gillick M, Pink J (1977) Effect of propranolol on platelet function. Blood 49: 185–195PubMedGoogle Scholar
  24. 24.
    Graham RM, Campbell WB, Jackson EK (1982) Effects of short-term beta blockade on blood pressure, plasma thromboxane B2, and plasma in urinary prostaglandins E2 and F2alpha in normal subjects. Clin Pharmacol Ther 31: 324–329PubMedCrossRefGoogle Scholar
  25. 25.
    Stensrud P, Sjaastad O (1976) Short-term clinical trial of propranolol in racemic form (Inderal), d-propranolol and placebo in migraine. Acta Neurol Scand 53: 229–232PubMedCrossRefGoogle Scholar
  26. 26.
    Kendall MJ (1981) Are selective beta-adrenoceptor-blocking drugs an advantage? JR Coll Physicians Lond 15:33–40Google Scholar
  27. 27.
    Galbo H, Christensen NJ, Hoist JJ (1977) Glucose-induced decrease in glucagon and epinephrine responses in man. Appl Physiol 42: 525–530Google Scholar
  28. 28.
    Lundborg P, Åström H, Bengtsson C, Fellenius E, von Schenck H, Svensson L, Smith U (1981) Effect of β-adrenoceptor blockade on exercise performance and metabolism. Clin Sci 61: 299–305PubMedGoogle Scholar
  29. 29.
    Johnsson G, Jordö L, Lundborg P, Regärdh CG, Rönn O (1980) Plasma levels and pharmacological effects of metoprolol administered as controlled release (Durules) and ordinary tablets in healthy volunteers. Int J Clin Pharmacol Ther Toxicol 18:292–297PubMedGoogle Scholar
  30. 30.
    Editorial (1977) Br Med J 1: 793CrossRefGoogle Scholar
  31. 31.
    Langohr HD, Gerber WE, Koletzki E, Schroth G (1983) Clomipramine and metoprolol in migraine prophylaxis: A double-blind cross-over study. Abstract of the 1st international headache congress, 14–16 Sept. 1983, MunichGoogle Scholar
  32. 32.
    Olsson JE, Behring HC, Hedman C, Hedman G, Johansson F, Kinnman J, Pålhagen S-E, Samu-elsson M, Strandman E (to be published) Metoprolol and propranolol in the prophylactic treatment of classical and common migraine — A double-blind multicentre study. Acta Neurol ScandGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • P. G. Andersson
  • C. Hedman
  • P. Kangasniemi

There are no affiliations available

Personalised recommendations