Metoprolol, a Beta1-Selective Beta-Blocker, in Prophylactic Treatment of Migraine

  • P. G. Andersson
  • C. Hedman
  • P. Kangasniemi
Conference paper

Abstract

Several remedies with different pharmacologic approaches have been used in the prophylactic treatment of migraine patients. At present 5-HT antagonists (i. e., pizotifen) or beta-blocking agents (i.e., propranolol) are recommended as the drugs of first choice [1].

Keywords

Placebo Migraine Neurol Propranolol Glucagon 

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References

  1. 1.
    Peatfield R (1983) Migraine — Current concepts of pathogenesis and treatment. Drugs 26: 364–371PubMedCrossRefGoogle Scholar
  2. 2.
    Rabkin R, Stables DP, Levin NW, Suzman MM (1966) Propranolol and prophylaxis of angina pectoris. Am J Cardiol 18: 370–380PubMedCrossRefGoogle Scholar
  3. 3.
    Wykes P (1968) The treatment of angina pectoris with co-existing migraine. Practitioner 200: 702–704PubMedGoogle Scholar
  4. 4.
    Weber R, Reinmuth O (1972) The treatment of migraine with propranolol. Neurology 22: 366–369PubMedGoogle Scholar
  5. 5.
    Diamond S, Medina J (1976) Double-blind study of propranolol for migraine prophylaxis. Headache 16: 24–27PubMedCrossRefGoogle Scholar
  6. 6.
    Forssman B, Henriksson K-G, Johansson V, Lindvall L, Lundin H (1976) Propranolol for migraine prophylaxis. Headache 16:238–245PubMedCrossRefGoogle Scholar
  7. 7.
    Briggs RS, Millac PA (1979) Timolol in migraine prophylaxis. Headache 19: 379–381PubMedCrossRefGoogle Scholar
  8. 8.
    Standnes B (1982) The prophylactic effect of timolol versus propranolol and placebo in common migraine: beta-blockers in migraine. Cephalalgia 2:165–170PubMedCrossRefGoogle Scholar
  9. 9.
    Stensrud P, Sjaastad O (1980) Comparative trial of Tenormin (atenolol) and Inderal (propranolol) in migraine. Headache 20: 204–207PubMedCrossRefGoogle Scholar
  10. 10.
    Forssman B, Lindblad GJ, Zbornikova V (1983) Atenolol for migraine prophylaxis. Headache 23:188–190PubMedCrossRefGoogle Scholar
  11. 11.
    Ekbom K (1975) Alprenolol for migraine prophylaxis. Headache 15:129–132PubMedCrossRefGoogle Scholar
  12. 12.
    Ekbom K, Zetterman M (1977) Oxprenolol in the treatment of migraine. Acta Neurol Scand 56: 181–184PubMedCrossRefGoogle Scholar
  13. 13.
    Nanda RN, Johnson RH, Gray J, Keugh HJ, Melville ID (1979) A double-blind trial of acebuto-lol for migraine prophylaxis. Headache 18: 379–381Google Scholar
  14. 14.
    Sjaastad O, Stensrud P (1972) Clinical trial of a beta-receptor blocking agent (LB 46) in migraine prophylaxis. Acta Neurol Scand 48:124–128PubMedCrossRefGoogle Scholar
  15. 15.
    Ekbom K, Lundberg PO (1972) Clinical trial of LB 46, an adrenergic beta-receptor blocking agent in migraine prophylaxis. Headache 12:15–17PubMedCrossRefGoogle Scholar
  16. 16.
    Ljung O (1981) Metoprolol in migraine. Cephalalgia 1:142PubMedCrossRefGoogle Scholar
  17. 17.
    Andersson PG, Dahl S, Hansen JH, Hansen PE, Hedman C, Nygaard Kristensen T, De Fine Olivarius B (1983) Prophylactic treatment of classical and non-classical migraine with metopro-lol — a comparison with placebo. Cephalalgia 3, 207–212PubMedCrossRefGoogle Scholar
  18. 18.
    Cochrane Al (1970) Third migraine symposium, April 1969. Background to migraine. Heineman, London, pp180–181Google Scholar
  19. 19.
    Vahlquist B (1955) Migraine in children. Int Arch Allergi 7: 348–355CrossRefGoogle Scholar
  20. 20.
    Kangasniemi P, Hedman C (1984) Metoprolol and propranolol in the prophylactic treatment of classical and common migraine. A double-blind study. Cephalalgia (in press)Google Scholar
  21. 21.
    Sercombe R, Aubineau P, Edvinsson L, Mamo H, Owman CH, Seylaz J (1977) Pharmacological evidence in vitro and in vivo for functional beta!-receptors in cerebral circulation. Pflugers Arch 368:241–244PubMedCrossRefGoogle Scholar
  22. 22.
    Hanington E, Amess JAL, Jones RJ, Wachowicz B (1981) Migraine: a platelet disorder. Lancet 11:720–723CrossRefGoogle Scholar
  23. 23.
    Weksler B, Gillick M, Pink J (1977) Effect of propranolol on platelet function. Blood 49: 185–195PubMedGoogle Scholar
  24. 24.
    Graham RM, Campbell WB, Jackson EK (1982) Effects of short-term beta blockade on blood pressure, plasma thromboxane B2, and plasma in urinary prostaglandins E2 and F2alpha in normal subjects. Clin Pharmacol Ther 31: 324–329PubMedCrossRefGoogle Scholar
  25. 25.
    Stensrud P, Sjaastad O (1976) Short-term clinical trial of propranolol in racemic form (Inderal), d-propranolol and placebo in migraine. Acta Neurol Scand 53: 229–232PubMedCrossRefGoogle Scholar
  26. 26.
    Kendall MJ (1981) Are selective beta-adrenoceptor-blocking drugs an advantage? JR Coll Physicians Lond 15:33–40Google Scholar
  27. 27.
    Galbo H, Christensen NJ, Hoist JJ (1977) Glucose-induced decrease in glucagon and epinephrine responses in man. Appl Physiol 42: 525–530Google Scholar
  28. 28.
    Lundborg P, Åström H, Bengtsson C, Fellenius E, von Schenck H, Svensson L, Smith U (1981) Effect of β-adrenoceptor blockade on exercise performance and metabolism. Clin Sci 61: 299–305PubMedGoogle Scholar
  29. 29.
    Johnsson G, Jordö L, Lundborg P, Regärdh CG, Rönn O (1980) Plasma levels and pharmacological effects of metoprolol administered as controlled release (Durules) and ordinary tablets in healthy volunteers. Int J Clin Pharmacol Ther Toxicol 18:292–297PubMedGoogle Scholar
  30. 30.
    Editorial (1977) Br Med J 1: 793CrossRefGoogle Scholar
  31. 31.
    Langohr HD, Gerber WE, Koletzki E, Schroth G (1983) Clomipramine and metoprolol in migraine prophylaxis: A double-blind cross-over study. Abstract of the 1st international headache congress, 14–16 Sept. 1983, MunichGoogle Scholar
  32. 32.
    Olsson JE, Behring HC, Hedman C, Hedman G, Johansson F, Kinnman J, Pålhagen S-E, Samu-elsson M, Strandman E (to be published) Metoprolol and propranolol in the prophylactic treatment of classical and common migraine — A double-blind multicentre study. Acta Neurol ScandGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • P. G. Andersson
  • C. Hedman
  • P. Kangasniemi

There are no affiliations available

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